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340 条记录 (耗时 0.039 秒)

    Assay for toxin induced neuronal degeneration and viability in C. elegans
    1.
    发明授权
    Assay for toxin induced neuronal degeneration and viability in C. elegans 失效
    测定毒素诱导的神经元变性和秀丽隐杆线虫的活力

    公开(公告)号：US07531713B2

    公开(公告)日：2009-05-12

    申请号：US11029895

    申请日：2005-01-05

    申请人： Randy D. Blakely ,  Richard Nass ,  David Miller

    发明人： Randy D. Blakely ,  Richard Nass ,  David Miller

    IPC分类号： G01N33/00 ,  C12N15/00 ,  C12N15/09

    CPC分类号： G01N33/5014 ,  A01K67/0336 ,  A01K2217/05 ,  A01K2227/703 ,  A01K2267/035 ,  A01K2267/0393 ,  C12N2830/008 ,  G01N33/5008 ,  G01N33/5058 ,  G01N2500/00

    摘要： Provided are in vivo screening methods to detect and identify substances that affect neuronal viability, and/or prevent neurodegeneration, and/or confer neuroprotective effects The screening methods utilize recombinant C. elegans expressing a detectable marker in neuronal sub-groups and the use of neurotoxins specific to specific neuronal cells. Also provided are methods for identifying modulators of neurotransmitter transporters such as the dopamine transporter. Therefore, the invention provides methods for identifying substances that can be used in the prevention and therapy of neurodegenerative diseases.

    摘要翻译： 提供了用于检测和鉴定影响神经元存活力和/或预防神经变性和/或赋予神经保护作用的物质的体内筛选方法。筛选方法利用在神经元亚组中表达可检测标记的重组秀丽隐杆线虫和神经毒素的使用 特异性的特定神经细胞。 还提供了用于鉴定神经递质转运蛋白如多巴胺转运蛋白的调节剂的方法。 因此，本发明提供了用于鉴定可用于预防和治疗神经变性疾病的物质的方法。

    Assay for toxin induced neuronal degeneration and viability in C. elegans
    2.
    发明授权
    Assay for toxin induced neuronal degeneration and viability in C. elegans 失效
    测定毒素诱导的神经元变性和秀丽隐杆线虫的活力

    公开(公告)号：US06894205B2

    公开(公告)日：2005-05-17

    申请号：US09888233

    申请日：2001-06-22

    申请人： Randy D. Blakely ,  Richard Nass ,  David Miller

    发明人： Randy D. Blakely ,  Richard Nass ,  David Miller

    IPC分类号： A01K67/033 ,  C12N5/02 ,  G01N33/50 ,  G01N33/00 ,  A01K67/00

    CPC分类号： G01N33/5014 ,  A01K67/0336 ,  A01K2217/05 ,  A01K2227/703 ,  A01K2267/035 ,  A01K2267/0393 ,  C12N2830/008 ,  G01N33/5008 ,  G01N33/5058 ,  G01N2500/00

    摘要： Provided are in vivo screening methods to detect and identify substances that affect neuronal viability, and/or prevent neurodegeneration, and/or confer neuroprotective effects. The screening methods utilize recombinant C. elegans expressing a detectable marker in neuronal sub-groups and the use of neurotoxins specific to specific neuronal cells. Also provided are methods for identifying modulators of neurotransmitter transporters such as the dopamine transporter. Therefore, the invention provides methods for identifying substances that can be used in the prevention and therapy of neurodegenerative diseases.

    摘要翻译： 提供了体内筛选方法来检测和鉴定影响神经元活力，和/或预防神经变性和/或赋予神经保护作用的物质。 筛选方法利用在神经元亚组中表达可检测标记的重组秀丽隐杆线虫和使用特异性神经元细胞的神经毒素。 还提供了用于鉴定神经递质转运蛋白如多巴胺转运蛋白的调节剂的方法。 因此，本发明提供了用于鉴定可用于预防和治疗神经变性疾病的物质的方法。

    Assay for toxin induced neuronal degeneration and viability in C. elegans
    3.
    发明申请
    Assay for toxin induced neuronal degeneration and viability in C. elegans 失效
    测定毒素诱导的神经元变性和秀丽隐杆线虫的活力

    公开(公告)号：US20050160482A1

    公开(公告)日：2005-07-21

    申请号：US11029895

    申请日：2005-01-05

    申请人： Randy Blakely ,  Richard Nass ,  David Miller

    发明人： Randy Blakely ,  Richard Nass ,  David Miller

    IPC分类号： A01K67/033 ,  C12N5/02 ,  G01N33/50

    CPC分类号： G01N33/5014 ,  A01K67/0336 ,  A01K2217/05 ,  A01K2227/703 ,  A01K2267/035 ,  A01K2267/0393 ,  C12N2830/008 ,  G01N33/5008 ,  G01N33/5058 ,  G01N2500/00

    摘要： Provided are in vivo screening methods to detect and identify substances that affect neuronal viability, and/or prevent neurodegeneration, and/or confer neuroprotective effects The screening methods utilize recombinant C. elegans expressing a detectable marker in neuronal sub-groups and the use of neurotoxins specific to specific neuronal cells. Also provided are methods for identifying modulators of neurotransmitter transporters such as the dopamine transporter. Therefore, the invention provides methods for identifying substances that can be used in the prevention and therapy of neurodegenerative diseases.

    摘要翻译： 提供了用于检测和鉴定影响神经元存活力和/或预防神经变性和/或赋予神经保护作用的物质的体内筛选方法。筛选方法利用在神经元亚组中表达可检测标记的重组秀丽隐杆线虫和神经毒素的使用 特异性的特定神经细胞。 还提供了用于鉴定神经递质转运蛋白如多巴胺转运蛋白的调节剂的方法。 因此，本发明提供了用于鉴定可用于预防和治疗神经变性疾病的物质的方法。

    Pickleball barrier
    4.
    发明授权
    Pickleball barrier 有权

    公开(公告)号：US11007416B2

    公开(公告)日：2021-05-18

    申请号：US16406636

    申请日：2019-05-08

    申请人： David Miller

    发明人： David Miller

    IPC分类号： A63B71/02 ,  E04H17/16 ,  A63B69/00

    摘要： A deployable pickleball barrier includes a plurality of panels having a first rigid surface, a second rigid surface, and a substantially straight channel coupling the rigid surfaces. Each of the plurality of panels are coupled with another of the plurality of panels by an interpanel joint that includes a rigid bond and a plurality of fold lines formed in the first rigid surface to form a rightwardly biasing hinge. Each of the plurality of panels includes an intrapanel joint including a plurality of fold lines formed in the second rigid surface to form a leftwardly biasing hinge. The deployable pickleball barrier can be folded at each of the hinges to alternate between a deployed configuration and a folded configuration.

    Tissue resection device
    5.
    发明授权
    Tissue resection device 有权

    公开(公告)号：US10363087B2

    公开(公告)日：2019-07-30

    申请号：US12902747

    申请日：2010-10-12

    申请人： David Miller ,  Todd Dalton ,  Mitch Gilkey

    发明人： David Miller ,  Todd Dalton ,  Mitch Gilkey

    IPC分类号： A61B18/14

    摘要： Instruments and methods are provided for performing submucosal medical procedures in a desired area of the digestive tract using endoscopy. The instruments include a mucosal resection device, a tissue grasper and a snare. Systems include a combination of one or more of such instruments. Embodiments of various methods for performing the procedures are also provided.

    Systems and methods for securely monitoring an individual
    6.
    发明授权
    Systems and methods for securely monitoring an individual 有权
    用于安全监控个人的系统和方法

    公开(公告)号：US09584496B2

    公开(公告)日：2017-02-28

    申请号：US13497123

    申请日：2012-09-05

    申请人： Rick V. Murakami ,  David Miller ,  Matthew W. Pettit ,  Larry V. Lunt

    发明人： Rick V. Murakami ,  David Miller ,  Matthew W. Pettit ,  Larry V. Lunt

    IPC分类号： G05B19/00 ,  G06F7/00 ,  G08B29/00 ,  H04L9/00 ,  H04L29/06 ,  G06F21/32 ,  G06F21/34 ,  G06F21/62 ,  G06K9/00 ,  H04M1/67

    CPC分类号： H04L63/08 ,  G06F21/32 ,  G06F21/34 ,  G06F21/6245 ,  G06K9/00885 ,  G06K9/00979 ,  H04L63/166 ,  H04M1/67

    摘要： A biometric sensor may be coupled to a portable communications device, such as a cellular telephone. The biometric sensor may be configured to acquire one or more measurements of biological characteristics of an individual. One or more of the measurements may relate to internal, sub-epidermal characteristics of the individual, such as non-volitional processes occurring within the individual, sub-epidermal structures within the individual, or the like. A biometric marker may be derived from one or more of the measurements. The portable communications device may be activated responsive to deriving the biometric marker. The activation may include transmitting the measurements and/or biometric markers derived therefrom to a receiver using the portable communications device.

    摘要翻译： 生物测定传感器可以耦合到诸如蜂窝电话的便携式通信设备。 生物测定传感器可以被配置为获取个体的生物学特征的一个或多个测量值。 一个或多个测量可以涉及个体的内部，亚表皮特征，例如个体内发生的非传染性过程，个体内的亚表皮结构等。 可以从一个或多个测量中导出生物特征标记。 可以响应于导出生物特征标记来激活便携式通信设备。 激活可以包括使用便携式通信设备将从其导出的测量和/或生物测定标记传送到接收机。

    GLAZING PANEL ROOFING SYSTEM
    7.
    发明申请
    GLAZING PANEL ROOFING SYSTEM 有权
    玻璃面板系统

    公开(公告)号：US20160333585A1

    公开(公告)日：2016-11-17

    申请号：US15153521

    申请日：2016-05-12

    申请人： David Miller ,  Frank Kosciolek

    发明人： David Miller ,  Frank Kosciolek

    IPC分类号： E04D13/03 ,  F16B33/00 ,  F16B25/10

    CPC分类号： E04D3/08 ,  E04D2003/0818 ,  E04D2003/0856 ,  F16B25/10 ,  F16B2005/0678

    摘要： A glazing panel roofing system includes a glazing panel and glazing panel brackets configured to clamp upon one of the side edge surfaces of the glazing panel. The glazing panel includes two flat face surfaces and two side edge surfaces. The glazing panel brackets are configured to clamp upon one of the side edge surfaces of the glazing panel. Each glazing panel bracket includes a base clamping feature including a base gripping feature surface configured to abut a first surface of the flat face surfaces, a top clamping feature including a top gripping feature surface configured to abut a second surface of the flat face surfaces, and a threaded fastener securing the top clamping feature to the base clamping feature, wherein torque applied to the threaded fastener changes a clamping force applied between the top clamping feature and the base clamping feature upon the glazing panel.

    摘要翻译： 玻璃幕墙屋顶系统包括玻璃板和玻璃板支架，其构造成夹紧在玻璃板的一个侧边缘表面上。 上光板包括两个平面表面和两个侧边缘表面。 玻璃板支架被配置为夹紧玻璃板的一个侧边缘表面。 每个上光板托架包括基部夹紧特征，其包括构造成邻接平坦表面的第一表面的基部夹持特征表面，顶部夹持特征，包括构造成邻接平坦表面的第二表面的顶部抓握特征表面，以及 将顶部夹紧特征固定到基部夹紧特征的螺纹紧固件，其中施加到螺纹紧固件的扭矩将施加在顶部夹紧特征和基部夹持特征之间的夹紧力改变在玻璃板上。

    Catheter control systems
    10.
    发明授权
    Catheter control systems 有权
    导管控制系统

    公开(公告)号：US09101735B2

    公开(公告)日：2015-08-11

    申请号：US12499011

    申请日：2009-07-07

    申请人： Chris A. Rothe ,  Juan Diego Perea ,  David Miller ,  Vahid Saadat ,  Zachary J. Malchano ,  Ruey-Feng Peh

    发明人： Chris A. Rothe ,  Juan Diego Perea ,  David Miller ,  Vahid Saadat ,  Zachary J. Malchano ,  Ruey-Feng Peh

    IPC分类号： A61B1/01 ,  A61M25/01 ,  A61M25/00

    CPC分类号： A61M25/0147 ,  A61M25/0074 ,  A61M25/0082 ,  A61M25/0105 ,  A61M25/0136 ,  A61M2025/015

    摘要： Catheter control systems which facilitate the tracking of an angle of deflection of a catheter distal end can be used for any number of procedures where catheter orientation relative to the body is desirable, e.g., in transseptal access procedures where an accurate angle of puncture of the septal wall is desirable. Such control systems may comprise a steerable handle which is oriented relative to the catheter steerable section to provide for consistent catheter articulation upon corresponding manipulation of the steering ring. Another variation may utilize an orientation indicator to track the deflectable distal end. For instance, an orientation marker as visualized through an imaging hood on the distal end may correspond to identical orientation markers on the control handle such that articulation of a steering mechanism in a direction relative to the orientation markers deflects the catheter distal end in a corresponding direction relative to the visualized orientation markers.

    摘要翻译： 促进跟踪导管远端的偏转角度的导管控制系统可用于任何数量的程序，其中导管相对于身体的取向是期望的，例如在中间通道的准确的穿刺角度 墙是理想的。 这样的控制系统可以包括相对于导管可转向部分定向的可操纵手柄，以在相应操纵转向环时提供一致的导管关节运动。 另一种变型可以利用取向指示器来跟踪可偏转的远端。 例如，通过远端上的成像罩可视化的取向标记可以对应于控制手柄上的相同的取向标记，使得转向机构在相对于定向标记的方向上的关节转动导管远端在相应方向 相对于可视化的取向标记。