摘要:
The present invention provides a method for testing a blood unit for viral contamination without rendering the blood unit unusable for therapeutic applications. The method comprises the steps of: removing and collecting from a blood unit a majority of the leukocytes present therein with a leukocyte filter; and using the leukocytes collected in and on the filter to test the blood unit for viral contamination. The present invention also provides a method for validating viral inactivation processes.
摘要:
A device for separating and isolating components of a biological fluid comprising a container for containing the fluid to be processed, a tube cap assembly for closing the container while providing filling and extraction communication therewith, a float assembly disposed within the container for funneling and controlling biological fluid flow into an inverted domed shaped isolation chamber within the float and controlling the biological fluid flow out of the isolation chamber for effecting an encapsulation or a sealed isolation of at least one component or fraction of the biological fluid flow within the isolation chamber during a centrifugation process. The device further comprising a flexible tube for connecting an extraction passageway disposed within the float assembly and an extraction valve of the tube cap assembly for allowing extraction of at least the one component or fraction encapsulated or isolated within the chamber.
摘要:
A device for separating and isolating components of a biological fluid comprising a container for containing the fluid to be processed, a tube cap assembly for closing the container while providing filling and extraction communication therewith, a float assembly disposed within the container for funneling and controlling biological fluid flow into an inverted domed shaped isolation chamber within the float and controlling the biological fluid flow out of the isolation chamber for effecting an encapsulation or a sealed isolation of at least one component or fraction of the biological fluid flow within the isolation chamber during a centrifugation process. The device further comprising a flexible tube for connecting an extraction passageway disposed within the float assembly and an extraction valve of the tube cap assembly for allowing extraction of at least the one component or fraction encapsulated or isolated within the chamber.
摘要:
A method combining the techniques of immunoaffinity separation and continuous flow centrifugal separation is provided for selective separation of a nucleated heterogeneous cell population from a heterogeneous cell mixture. The heterogeneous cell mixture is intimately contacted to promote binding thereto by particles having attached a substance that actively binds to a specific desired type of cell out of the cell mixture. The particles are selected so that the sedimentation velocity of the particle/cell conjugate differs sufficiently from those of other cells in the cell mixture to allow its separation by means of a continuous flow cell separator. The method rapidly processes large volumes of cell mixture with the high accuracy expected of immunoaffinity separation and can be used to separate, for example, various types of leukocytes from whole blood, bone marrow concentrate, or a peripheral blood stem cell concentrate; or precursors of lymphokine activated killer cells, tumor infiltrating lymphocyte cells, or activated killer monocytes from lymphocyte or monocyte cell concentrates or from a tissue cell preparation.
摘要:
An ion source for a mass spectrometer has a continuous flow probe (FIG. 2) having a mesh defining a surface, a capillary for supplying liquid sample to the surface and a porous body disposed at the periphery of the mesh. An ion source generates a beam of ionising radiation to which sample supplied to the surface is exposed. Sample supplied by the inlet tube spreads across the surface and surplus sample reaching the periphery of the mesh is absorbed by the porous body.
摘要:
A linear no-back device for transmitting bi-directional linear motion from an input shaft to an output shaft while preventing motion of the output shaft independently of the input shaft and enabling movement of the input shaft when the output shaft is jammed. The linear no-back device has a fixed member having a bore with a pair of spring discs loosely mounted on the output shaft and having flexible ears at the periphery thereof in engagement with a wall of the bore. A pair of spaced-apart stop rings on the output shaft limit separating movement of the spring discs axially of the output shaft and a preloaded compression coil spring urges the spring discs away from each other. Actuating members associated with the input shaft are effective upon movement of the input shaft in either linear direction to effectively disengage the spring discs from the wall of the bore and transmit motion of the input shaft to the output shaft through a motion-transmitting connection including the preloaded compression coil spring. Further compression of the preloaded compression coil spring enables movement of the input shaft relative to the output shaft when the latter is jammed.
摘要:
According to the invention a housing is provided defining concentric, cylindrical first and second braking surfaces. First and second cylindrical, concentric torque tubes are provided within the annular gap between braking surfaces and are each split lengthwise sufficiently to permit slight, radial deflection into engagement with the respective braking surfaces on the housing to which it is adjacent. An input carrier is provided to transmit the torque between a prime mover and an output position on the torque tubes. The carrier has a plurality of fingers which project between and are aligned axially with the torque tubes. Each of the torque tubes is operatively engaged with an output member so that the torque imparted by a common drive to each output can be simultaneously controlled.