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49 条记录 (耗时 0.065 秒)

    Methods of populating data structures for use in evolutionary simulations
    31.
    发明申请
    Methods of populating data structures for use in evolutionary simulations 有权

    公开(公告)号：US20080040045A1

    公开(公告)日：2008-02-14

    申请号：US11973805

    申请日：2007-10-09

    申请人： Sergey Selifonov ,  Willem Stemmer

    发明人： Sergey Selifonov ,  Willem Stemmer

    IPC分类号： G01N33/48

    CPC分类号： G06N3/126 ,  G06F19/14 ,  G06F19/18 ,  G06F19/22 ,  G06F19/24

    摘要： In particular, this invention provides novel methods of populating data structures for use in evolutionary modeling. In particular, this invention provides methods of populating a data structure with a plurality of character strings. The methods involve encoding two or more a biological molecules into character strings to provide a collection of two or more different initial character strings; selecting at least two substrings from the pool of character strings; concatenating the substrings to form one or more product strings about the same length as one or more of the initial character strings; adding the product strings to a collection of strings; and optionally repeating this process using one or more of the product strings as an initial string in the collection of initial character strings.

    Proteinaceous pharmaceuticals and uses thereof
    32.
    发明申请
    Proteinaceous pharmaceuticals and uses thereof 审中-公开
    蛋白质药物及其用途

    公开(公告)号：US20070191272A1

    公开(公告)日：2007-08-16

    申请号：US11528927

    申请日：2006-09-27

    申请人： Willem Stemmer ,  Volker Schellenberger ,  Martin Bader ,  Michael Scholle

    发明人： Willem Stemmer ,  Volker Schellenberger ,  Martin Bader ,  Michael Scholle

    IPC分类号： A61K38/16 ,  C40B40/08 ,  C40B40/10 ,  C07K14/47

    CPC分类号： G01N33/6845 ,  C07K14/001 ,  C07K14/415 ,  C12N15/1044

    摘要： The present invention provides cysteine-containing scaffolds and/or proteins, expression vectors, host cell and display systems harboring and/or expressing such cysteine-containing products. The present invention also provides methods of designing libraries of such products, methods of screening such libraries to yield entities exhibiting binding specificities towards a target molecule. Further provided by the invention are pharmaceutical compositions comprising the cysteine-containing products of the present invention.

    摘要翻译： 本发明提供含半胱氨酸的支架和/或蛋白质，表达载体，宿主细胞和含有和/或表达这种含半胱氨酸的产品的显示系统。 本发明还提供了设计这样的产物的文库的方法，筛选这些文库以产生显示针对目标分子的结合特异性的实体的方法。 本发明进一步提供的是包含本发明的含半胱氨酸的产品的药物组合物。

    Methods and compositions for cellular and metabolic engineering
    34.
    发明申请
    Methods and compositions for cellular and metabolic engineering 审中-公开

    公开(公告)号：US20060257890A1

    公开(公告)日：2006-11-16

    申请号：US11350407

    申请日：2006-02-07

    申请人： Jeremy Minshull ,  Willem Stemmer

    发明人： Jeremy Minshull ,  Willem Stemmer

    IPC分类号： C40B30/06 ,  C40B40/08

    CPC分类号： C12N15/1027 ,  C12N15/1058

    摘要： The present invention is generally directed to the evolution of new metabolic pathways and the enhancement of bioprocessing through a process herein termed recursive sequence recombination. Recursive sequence recombination entails performing iterative cycles of recombination and screening or selection to “evolve” individual genes, whole plasmids or viruses, multigene clusters, or even whole genomes. Such techniques do not require the extensive analysis and computation required by conventional methods for metabolic engineering.