公开(公告)号：US20080050782A1

公开(公告)日：2008-02-28

申请号：US11975638

申请日：2007-10-18

申请人： Sergey Selifonov ,  Willem Stemmer ,  Claes Gustafsson ,  Matthew Tobin ,  Stephen Cardayre ,  Phillip Patten ,  Jeremy Minshull ,  Lorraine Giver

发明人： Sergey Selifonov ,  Willem Stemmer ,  Claes Gustafsson ,  Matthew Tobin ,  Stephen Cardayre ,  Phillip Patten ,  Jeremy Minshull ,  Lorraine Giver

IPC分类号： C12P19/34 ,  C40B30/02 ,  C40B60/04

CPC分类号： G06F19/16 ,  B01J2219/007 ,  C40B50/02 ,  G06F19/14 ,  G06F19/18 ,  G06F19/22 ,  G06F19/24

摘要： In silico nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.

公开(公告)号：US20080040045A1

公开(公告)日：2008-02-14

申请号：US11973805

申请日：2007-10-09

申请人： Sergey Selifonov ,  Willem Stemmer

发明人： Sergey Selifonov ,  Willem Stemmer

IPC分类号： G01N33/48

CPC分类号： G06N3/126 ,  G06F19/14 ,  G06F19/18 ,  G06F19/22 ,  G06F19/24

摘要： In particular, this invention provides novel methods of populating data structures for use in evolutionary modeling. In particular, this invention provides methods of populating a data structure with a plurality of character strings. The methods involve encoding two or more a biological molecules into character strings to provide a collection of two or more different initial character strings; selecting at least two substrings from the pool of character strings; concatenating the substrings to form one or more product strings about the same length as one or more of the initial character strings; adding the product strings to a collection of strings; and optionally repeating this process using one or more of the product strings as an initial string in the collection of initial character strings.

公开(公告)号：US20060142950A1

公开(公告)日：2006-06-29

申请号：US11339090

申请日：2006-01-24

申请人： Sergey Selifonov ,  Willem Stemmer ,  Claes Gustafsson ,  Matthew Tobin ,  Stephen del Cardayre ,  Phillip Patten ,  Jeremy Minshull ,  Lorraine Giver

发明人： Sergey Selifonov ,  Willem Stemmer ,  Claes Gustafsson ,  Matthew Tobin ,  Stephen del Cardayre ,  Phillip Patten ,  Jeremy Minshull ,  Lorraine Giver

IPC分类号： G06F19/00

CPC分类号： G06F19/16 ,  B01J2219/007 ,  C40B50/02 ,  G06F19/14 ,  G06F19/18 ,  G06F19/22 ,  G06F19/24

摘要： In silico nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.

摘要翻译： 在硅胶核酸重组方法中，提供了利用遗传算子和通过计算机改组方法制备的文库的相关综合系统。

公开(公告)号：US20060117409A1

公开(公告)日：2006-06-01

申请号：US11291311

申请日：2005-12-01

申请人： Willem Stemmer ,  Venkitswaran Subramanian ,  Genhai Zhu ,  Lu Liu ,  Sergey Selifonov

发明人： Willem Stemmer ,  Venkitswaran Subramanian ,  Genhai Zhu ,  Lu Liu ,  Sergey Selifonov

IPC分类号： A01H1/00 ,  C40B40/08 ,  C12Q1/68

CPC分类号： C12N15/8245 ,  C12N9/88 ,  C12N15/8243

摘要： The invention relates to methods and compositions for generating, modifying, adapting, and optimizing polynucleotide sequences that encode proteins having Rubisco biosynthetic enzyme activities which are useful for introduction into plant species, agronomically-important microorganisms, and other hosts, and related aspects.

摘要翻译： 本发明涉及用于产生，修饰，适应和优化编码具有Rubisco生物合成酶活性的蛋白质的多核苷酸序列的方法和组合物，其可用于引入植物物种，农艺学重要的微生物和其他宿主及相关方面。

公开(公告)号：US20060047611A1

公开(公告)日：2006-03-02

申请号：US11210239

申请日：2005-08-22

申请人： Sergey Selifonov ,  Willem Stemmer

发明人： Sergey Selifonov ,  Willem Stemmer

IPC分类号： G06N3/00 ,  G06F15/18 ,  G06G7/58 ,  G06N3/12 ,  G06G7/48 ,  C12Q1/68

CPC分类号： G06N3/126 ,  G06F19/14 ,  G06F19/18 ,  G06F19/22 ,  G06F19/24

摘要： In particular, this invention provides novel methods of populating data structures for use in evolutionary modeling. In particular, this invention provides methods of populating a data structure with a plurality of character strings. The methods involve encoding two or more a biological molecules into character strings to provide a collection of two or more different initial character strings; selecting at least two substrings from the pool of character strings; concatenating the substrings to form one or more product strings about the same length as one or more of the initial character strings; adding the product strings to a collection of strings; and optionally repeating this process using one or more of the product strings as an initial string in the collection of initial character strings.

公开(公告)号：US20050191688A1

公开(公告)日：2005-09-01

申请号：US11075231

申请日：2005-03-07

申请人： Sergey Selifonov ,  Willem Stemmer ,  Claes Gustafsson ,  Matthew Tobin ,  Stephen del Cardayre ,  Phillip Patten ,  Jeremy Minshull

发明人： Sergey Selifonov ,  Willem Stemmer ,  Claes Gustafsson ,  Matthew Tobin ,  Stephen del Cardayre ,  Phillip Patten ,  Jeremy Minshull

IPC分类号： A61K39/00 ,  C07K14/16 ,  C07K14/505 ,  C07K14/535 ,  C12N9/16 ,  C12N15/10 ,  C12N15/11 ,  G06F19/00 ,  C12Q1/68 ,  G01N33/48 ,  G01N33/50

CPC分类号： C12N15/1031 ,  A61K39/00 ,  C07K14/005 ,  C07K14/505 ,  C07K14/535 ,  C12N9/16 ,  C12N15/1027 ,  C12N15/11 ,  C12N2740/16122

摘要： “In silico” nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.

公开(公告)号：US08716448B2

公开(公告)日：2014-05-06

申请号：US12806005

申请日：2010-08-02

申请人： Volker Schellenberger ,  Joshua Silverman ,  Willem Stemmer ,  Chia-wei Wang ,  Benjamin Spink ,  Nathan Geething ,  Wayne To

发明人： Volker Schellenberger ,  Joshua Silverman ,  Willem Stemmer ,  Chia-wei Wang ,  Benjamin Spink ,  Nathan Geething ,  Wayne To

IPC分类号： A61K38/36 ,  C07K14/745

CPC分类号： C12N9/644 ,  A61K38/00 ,  C07K14/001 ,  C07K2319/00 ,  C07K2319/31 ,  C07K2319/50 ,  C12N9/6437 ,  C12N15/70 ,  C12Y304/21022

摘要： The present invention relates to compositions comprising factor VII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.

摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子VII凝血因子的组合物，编码组合物的分离的核酸和载体以及含有它们的宿主细胞，以及制备和使用这些组合物治疗凝血因子相关的方法 疾病，病症和状况。

公开(公告)号：US20080019988A1

公开(公告)日：2008-01-24

申请号：US11713514

申请日：2007-03-01

申请人： Juha Punnonen ,  Willem Stemmer ,  Russell Howard ,  Phillip Patten

发明人： Juha Punnonen ,  Willem Stemmer ,  Russell Howard ,  Phillip Patten

IPC分类号： A61K39/12 ,  A61P31/12 ,  C07K14/00 ,  C12N15/09

CPC分类号： A61K39/385 ,  A61K39/00 ,  A61K2039/53 ,  A61K2039/6037 ,  A61K2039/605 ,  C12N15/1037 ,  C12N15/85 ,  C12N2810/50 ,  C12N2810/85 ,  C12N2810/859

摘要： This invention provides methods of obtaining reagents for increasing the specificity of genetic vaccines for a desired target cell or tissue type. The invention also provides delivery vehicles for use to improve genetic vaccine specificity for a target cell or tissue type.

摘要翻译： 本发明提供获得用于增加所需靶细胞或组织类型的遗传疫苗的特异性的试剂的方法。 本发明还提供用于改善靶细胞或组织类型的遗传疫苗特异性的递送载体。

公开(公告)号：US20060286603A1

公开(公告)日：2006-12-21

申请号：US11392108

申请日：2006-03-28

申请人： Joost Kolkman ,  Willem Stemmer ,  Per-Ola Freskgard

发明人： Joost Kolkman ,  Willem Stemmer ,  Per-Ola Freskgard

IPC分类号： C40B30/06 ,  C40B40/10

CPC分类号： C40B30/04 ,  A61K47/62 ,  B01J2219/00659 ,  B01J2219/00702 ,  B01J2219/00725 ,  C07K1/047 ,  C40B40/10 ,  G01N33/6845

摘要： Methods for identifying discrete monomer domains and immuno-domains with a desired property are provided. Methods for generating multimers from two or more selected discrete monomer domains are also provided, along with methods for identifying multimers possessing a desired property. Presentation systems are also provided which present the discrete monomer and/or immuno-domains, selected monomer and/or immuno-domains, multimers and/or selected multimers to allow their selection. Compositions, libraries and cells that express one or more library member, along with kits and integrated systems, are also included in the present invention.

公开(公告)号：US20050059109A1

公开(公告)日：2005-03-17

申请号：US10667868

申请日：2003-09-22

申请人： Phillip Patten ,  Willem Stemmer

发明人： Phillip Patten ,  Willem Stemmer

IPC分类号： C12N15/09 ,  A61K38/45 ,  A61K48/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/545 ,  C07K14/56 ,  C07K16/00 ,  C12N7/00 ,  C12N9/02 ,  C12N9/10 ,  C12N9/12 ,  C12N9/38 ,  C12N9/86 ,  C12N15/10 ,  C12N15/52 ,  C12N15/64 ,  C12P21/02 ,  C12Q1/68 ,  C40B40/02 ,  G01N33/68 ,  C12N15/85 ,  C12P19/34

CPC分类号： C12N15/1031 ,  A61K38/45 ,  A61K48/00 ,  C07K14/43595 ,  C07K14/545 ,  C07K14/56 ,  C07K16/00 ,  C07K2317/565 ,  C07K2317/622 ,  C12N7/00 ,  C12N9/0069 ,  C12N9/1007 ,  C12N9/16 ,  C12N9/86 ,  C12N15/10 ,  C12N15/1027 ,  C12N15/1034 ,  C12N15/1037 ,  C12N15/1058 ,  C12N15/52 ,  C12N15/64 ,  C12N15/67 ,  C12N2795/14043 ,  C12N2795/14143 ,  C12Q1/6811 ,  C12Q1/6853 ,  C12Q1/686 ,  C40B40/02 ,  C40B40/08 ,  C40B50/06 ,  G01N33/68 ,  G01N33/6845

摘要： Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting recombination and selection. Compositions produced by these methods are also disclosed.

摘要翻译： 提供了用于工业和医药兴趣蛋白质进化的方法，包括进行重组和选择的方法。 还公开了通过这些方法制备的组合物。