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46 条记录 (耗时 0.04 秒)

    Direct Differentiation Method for Making Cardiomyocytes from Human Embryonic Stem Cells
    33.
    发明申请
    Direct Differentiation Method for Making Cardiomyocytes from Human Embryonic Stem Cells 有权
    从人类胚胎干细胞制备心肌细胞的直接分化方法

    公开(公告)号：US20090047739A1

    公开(公告)日：2009-02-19

    申请号：US12210779

    申请日：2008-09-15

    申请人： Joseph D. Gold ,  Mohammad Hassanipour ,  Lila R. Collins ,  Chunhui Xu

    发明人： Joseph D. Gold ,  Mohammad Hassanipour ,  Lila R. Collins ,  Chunhui Xu

    IPC分类号： C12N5/06

    CPC分类号： C12N5/0657 ,  C12N2500/25 ,  C12N2500/90 ,  C12N2501/155 ,  C12N2501/16 ,  C12N2506/02

    摘要： This invention provides a new procedure for generating cardiomyocyte lineage cells from embryonic stem cells for use in regenerative medicine. Differentiating by way of embryoid body formation or in serum is no longer required. Instead, the stem cells are plated onto a solid substrate, and differentiated in the presence of select factors and morphogens. After enrichment for cells with the appropriate phenotype, the cells are allowed to cluster into Cardiac Bodies™, which are remarkably homogeneous and suitable for the treatment of heart disease.

    摘要翻译： 本发明提供了用于从再生医学中使用的胚胎干细胞产生心肌细胞谱系细胞的新方法。 不再需要通过胚状体形成或血清分化。 相反，将干细胞铺在固体底物上，并在存在选择因子和形态发生的情况下分化。 在具有适当表型的细胞富集后，允许细胞聚集到心脏体（TM）中，其是非常均匀的并且适合于治疗心脏病。

    Compound Screening Using Cardiomyocytes
    34.
    发明申请
    Compound Screening Using Cardiomyocytes 有权
    化合物筛选使用心肌细胞

    公开(公告)号：US20090017465A1

    公开(公告)日：2009-01-15

    申请号：US12234916

    申请日：2008-09-22

    申请人： Chunhui Xu

    发明人： Chunhui Xu

    IPC分类号： C12Q1/68 ,  C12Q1/02

    CPC分类号： C12N5/0657 ,  A61K35/12 ,  C12N5/0606 ,  C12N2500/30 ,  C12N2500/44 ,  C12N2500/62 ,  C12N2501/06 ,  C12N2501/105 ,  C12N2501/15 ,  C12N2501/155 ,  C12N2501/385 ,  C12N2501/999 ,  C12N2503/02 ,  C12N2506/02 ,  C12N2510/00

    摘要： This invention provides populations human cells of the cardiomyocyte lineage. The cells are obtained by causing cultures of pluripotent stem cells to differentiate in vitro, and then harvesting cells with certain phenotypic features. Differentiated cells bear cell surface and morphologic markers characteristic of cardiomyocytes, and a proportion of them undergo spontaneous periodic contraction. Highly enriched populations of cardiomyocytes and their replicating precursors can be obtained, suitable for use in a variety of applications, such as drug screening and therapy for cardiac disease.

    摘要翻译： 本发明提供了心肌细胞谱系的群体人细胞。 通过使多能干细胞的培养物在体外分化获得细胞，然后收获具有某些表型特征的细胞。 分化细胞具有心肌细胞特征的细胞表面和形态学标记，其中一部分经历自发性周期性收缩。 可以获得高度富集的心肌细胞群及其复制前体，适用于各种应用，如药物筛选和心脏病治疗。

    Performance monitoring in an optical communication system
    35.
    发明授权
    Performance monitoring in an optical communication system 有权
    光通信系统中的性能监控

    公开(公告)号：US07460785B2

    公开(公告)日：2008-12-02

    申请号：US10109623

    申请日：2002-03-28

    申请人： Mihaela Dinu ,  Hernando Garcia ,  Daniel Kilper ,  Wayne H. Knox ,  Howard R. Stuart ,  Chunhui Xu

    发明人： Mihaela Dinu ,  Hernando Garcia ,  Daniel Kilper ,  Wayne H. Knox ,  Howard R. Stuart ,  Chunhui Xu

    IPC分类号： H04B17/00

    CPC分类号： H04B10/0795 ,  H04B10/27 ,  H04J14/02

    摘要： An optical performance monitor (OPM), e.g., for use in an optical network. The OPM may be configured to characterize one or more impairments in an optical signal modulated with data. The OPM has an optical autocorrelator configured to sample the autocorrelation function of the optical signal, e.g., using two-photon absorption. Autocorrelation points at various bit delays independently or in combination with average optical power may be used to detect and/or quantify one or more of the following: loss of data modulation, signal contrast, pulse broadening, peak power fluctuations, timing jitter, and deviations from the pseudo-random character of data. In addition, the OPM may be configured to perform Fourier transformation based on the autocorrelation points to obtain corresponding spectral components. The spectral components may be used to detect and/or quantify one or more of chromatic dispersion, polarization mode dispersion, and misalignment of a pulse carver and data modulator. The OPM may be further configured to generate feedback, e.g., to network operators to improve network performance.

    摘要翻译： 光学性能监视器（OPM），例如用于光网络。 OPM可以被配置为表征用数据调制的光信号中的一个或多个损伤。 OPM具有配置成对光信号的自相关函数进行采样的光自相关器，例如使用双光子吸收。 独立地或与平均光功率组合的各种位延迟的自相关点可用于检测和/或量化以下中的一个或多个：数据调制丢失，信号对比度，脉冲展宽，峰值功率波动，定时抖动和偏差 从数据的伪随机字符。 此外，OPM可以被配置为基于自相关点执行傅里叶变换，以获得相应的光谱分量。 频谱分量可用于检测和/或量化脉冲编码器和数据调制器的色散，偏振模色散和未对准中的一个或多个。 OPM可以被进一步配置为产生反馈，例如，向网络运营商产生改善网络性能的反馈。

    Optical device for generating pulsed light
    39.
    发明授权
    Optical device for generating pulsed light 有权
    用于产生脉冲光的光学装置

    公开(公告)号：US06795617B2

    公开(公告)日：2004-09-21

    申请号：US10426900

    申请日：2003-04-30

    申请人： Mihaela Dinu ,  Charles Kerbage ,  Xiang Liu ,  Francesco Quochi ,  Robert S. Windeler ,  Chunhui Xu

    发明人： Mihaela Dinu ,  Charles Kerbage ,  Xiang Liu ,  Francesco Quochi ,  Robert S. Windeler ,  Chunhui Xu

    IPC分类号： G02B626

    CPC分类号： G02B6/266 ,  G02B6/02366 ,  G02B6/02376 ,  G02B6/0239

    摘要： An optical device including a microstructured fiber pumped by an external pulsed-light source. In one embodiment, the microstructured fiber includes two waist regions functioning as a tunable attenuator and a wavelength shifter, respectively. Output wavelength of the optical device is selected by attenuating the pump light in the first waist region and then passing the light through the second waist region to shift the pump energy to a new spectral band. An optical device of the invention configured with two or more microstructured fibers generates two or more synchronized pulsed beams, each at a different characteristic wavelength. Certain embodiments of the invention provide an inexpensive, compact, energy-efficient multi-wavelength synchronized pulsed-light source.

    摘要翻译： 包括由外部脉冲光源泵浦的微结构纤维的光学装置。 在一个实施例中，微结构纤维包括分别用作可调谐衰减器和波长移位器的两个腰部区域。 通过衰减第一腰围区域中的泵浦光，然后使光通过第二腰区，将泵浦能量转移到新的光谱带，来选择光学装置的输出波长。 配置有两个或多个微结构纤维的本发明的光学器件产生两个或更多个同步的脉冲束，每个具有不同的特征波长。 本发明的某些实施例提供了一种廉价，紧凑，节能的多波长同步脉冲光源。