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31.发明授权Method for the production of a solution, associated arrangement and uses of the method and arrangement 有权解决方案的生产方法，相关安排和使用方法和安排公开(公告)号：US08518343B2
公开(公告)日：2013-08-27
申请号：US11587572
申请日：2005-04-26
IPC分类号： G01N21/75
CPC分类号： B01F15/0205 , B01F1/00 , B01F13/0059 , B01F15/021 , Y10T436/25
摘要： Solid matter in a cavity is used to produce a solution of at least one solid matter in a solvent. The solid matter which is soluble in the solvent in initially covered and/or surrounded in the cavity by a medium which is insoluble in a solvent, such that dissolving of the solid matter is prevented. Subsequently the solvent is guided to the cavity and the medium which is insoluble in the solvent is treated in such a manner that contact is made between the solvent and the soluble solid matter, enabling the solid matter to dissolve in the solvent. Solutions including two or more solid matter can be produced in an advantageous manner.
摘要翻译： 空腔中的固体物质用于在溶剂中产生至少一种固体物质的溶液。 首先被溶解在溶剂中的固体物质通过不溶于溶剂的介质在空腔中被包覆和/或包围，从而防止固体物质的溶解。 随后将溶剂引导到空腔中，并且不溶于溶剂的介质以在溶剂和可溶性固体物质之间接触使得固体物质溶解在溶剂中的方式被处理。 可以以有利的方式制备包含两种或更多种固体物质的溶液。
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32.发明申请公开(公告)号：US20120108456A1
公开(公告)日：2012-05-03
申请号：US13262578
申请日：2010-03-02
CPC分类号： G01N27/3277 , G01N33/5438
摘要： A device for detecting chemical or biochemical substances in fluids includes a first carrier having a sensor array with a plurality of electrochemical sensors. A second carrier includes a porous layer having at least one functional region, in which specifically binding capturing molecules are immobilized. The at least one functional region is arranged directly adjacent to at least one non-functionalized region. Assigned to the at least one functional region and the at least one non-functionalized region are several sensors of the sensor array, for use as an electrochemical camera.
摘要翻译： 用于检测流体中的化学或生化物质的装置包括具有传感器阵列的多个电化学传感器的第一载体。 第二载体包括具有至少一个功能区的多孔层，其中固定有特异性结合的捕获分子。 所述至少一个功能区域直接邻近至少一个非功能化区域布置。 分配给至少一个功能区域和至少一个非功能化区域是传感器阵列的几个传感器，用作电化学照相机。
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33.发明授权Method for carrying out an electrochemical measurement on a liquid measuring sample in a measuring chamber that can be accessed by lines, and corresponding arrangement 有权在可以通过线路访问的测量室中的液体测量样品上进行电化学测量的方法和相应的布置公开(公告)号：US07851227B2
公开(公告)日：2010-12-14
申请号：US11665331
申请日：2005-10-17
申请人： Heike Barlag , Siegfried Birkle , Walter Gumbrecht , Daniela Kühn , Peter Paulicka , Manfred Stanzel
发明人： Heike Barlag , Siegfried Birkle , Walter Gumbrecht , Daniela Kühn , Peter Paulicka , Manfred Stanzel
CPC分类号： B01L3/5027 , B01L3/502707 , B01L3/502723 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： Especially in order to carry out the so-called enzyme-coupled DNA hybridization test in a closed cartridge including a microfluid system, using stored dry reagents, the reagents must be dissolved in the microfluid system and transported into the measuring chamber directly before the measurement. During the dissolution of the reagents in water, air cushions that cannot reach the measuring chamber must absolutely be prevented from forming upstream of the reagent liquid. According to an embodiment of the invention, the liquid measuring sample and the liquid reagents are transported in such a way that the air cushion is directed into the waste line and the measuring sample and the reagents are then introduced into the measuring chamber without any air bubbles. In this way, measuring errors can be avoided.
摘要翻译： 特别是为了在包含微流体系统的封闭筒中进行所谓的酶偶联DNA杂交试验，使用储存的干试剂，试剂必须溶解在微流体系统中，并在测量前直接运送到测量室中。 在将试剂溶解在水中时，必须绝对防止不能到达测量室的气垫在试剂液体的上游形成。 根据本发明的一个实施例，液体测量样品和液体试剂以这样一种方式运输，使得气垫被引导到废液管线中，然后将测量样品和试剂引入测量室，而没有任何气泡 。 这样可以避免测量误差。
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公开(公告)号：US20100248242A1
公开(公告)日：2010-09-30
申请号：US12734934
申请日：2008-11-03
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12Q1/6825 , C12Q1/6834 , C12Q1/6837 , Y10T436/143333 , C12Q2527/107 , C12Q2537/125 , C12Q2565/543
摘要： A process concentrates nucleic acid molecules to be detected of a sample on a surface, with capture molecules that specifically bind the nucleic acid molecules. A support material has a capture probe that can specifically be linked to the nucleic acid molecules to be detected to give complexes. The support material and the nucleic acid molecules of the sample are incubated to form the complexes. The complexes are moved to the surface. At least one portion of the complexes becomes bound to the capture molecules via the capture probe.
摘要翻译： 一种方法将待检测的样品的核酸分子浓缩在表面上，其中捕获分子特异性结合核酸分子。 载体材料具有捕获探针，其可以特异性地连接到待检测的核酸分子以得到复合物。 将样品的载体材料和核酸分子孵育以形成复合物。 络合物移动到表面。 复合物的至少一部分经由捕获探针与捕获分子结合。
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35.发明申请Method for carrying out an electrochemical measurement on a liquid measuring sample in a measuring chamber that can be accessed by lines, and corresponding arrangement 有权在可以通过线路访问的测量室中的液体测量样品上进行电化学测量的方法和相应的布置公开(公告)号：US20090136922A1
公开(公告)日：2009-05-28
申请号：US11665331
申请日：2005-10-17
申请人： Heike Barlag , Siegfried Birkle , Walter Gumbrecht , Daniela Kuhn , Peter Paulicka , Manfred Stanzel
发明人： Heike Barlag , Siegfried Birkle , Walter Gumbrecht , Daniela Kuhn , Peter Paulicka , Manfred Stanzel
CPC分类号： B01L3/5027 , B01L3/502707 , B01L3/502723 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： Especially in order to carry out the so-called enzyme-coupled DNA hybridisation test in a closed cartridge including a microfluid system, using stored dry reagents, the reagents must be dissolved in the microfluid system and transported into the measuring chamber directly before the measurement. During the dissolution of the reagents in water, air cushions that cannot reach the measuring chamber must absolutely be prevented from forming upstream of the reagent liquid. According to an embodiment of the invention, the liquid measuring sample and the liquid reagents are transported in such a way that the air cushion is directed into the waste line and the measuring sample and the reagents are then introduced into the measuring chamber without any air bubbles. In this way, measuring errors can be avoided.
摘要翻译： 特别是为了在包括微流体系统的封闭式筒体中进行所谓的酶偶联DNA杂交试验，使用储存的干试剂，试剂必须溶解在微流体系统中，并在测量前直接输送到测量室中。 在将试剂溶解在水中时，必须绝对防止不能到达测量室的气垫在试剂液体的上游形成。 根据本发明的一个实施例，液体测量样品和液体试剂以这样一种方式运输，使得气垫被引导到废液管线中，然后将测量样品和试剂引入测量室，而没有任何气泡 。 这样可以避免测量误差。
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36.发明申请Method for the Combined Isolation of Magnet-Beads From a Liquid Sample and Subsequent Thermocyclisation for the Polymerase Chain Reaction (Pcr) and Associated Arrangement 有权用于从液体样品中组合分离磁珠的方法和用于聚合酶链反应（Pcr）和相关布置的随后的热环化公开(公告)号：US20070264649A1
公开(公告)日：2007-11-15
申请号：US11665376
申请日：2005-10-14
CPC分类号： B01L7/52 , B01L3/502761 , B01L2200/0668 , B01L2300/0816 , B01L2300/0877 , B01L2300/1822 , B01L2400/0661 , G01N35/0098
摘要： Embodiments generally relate to a PCR wherein a magnetic field is focused in a localised area and also to the possibility of a cyclic transfer of heat. According to at least one embodiment of the invention, a magnetic field gradient is constructed along the direction of flow and the transfer of heat is carried out in a manner perpendicular to the direction of flow. Suitable things are provided therefore. The magnetic field is, in particular, focused by Mumetal® which is arranged on both sides of the flow channel and the temperature is controlled by way of Peltier elements, cooling bodies, and thermal coupling plates.
摘要翻译： 实施方案通常涉及PCR，其中磁场聚焦在局部区域中，并且还涉及循环传递热的可能性。 根据本发明的至少一个实施例，沿着流动方向构造磁场梯度，并且以垂直于流动方向的方式进行热传递。 因此提供合适的东西。 特别地，磁场被布置在流动通道两侧的Mumetal聚焦，并且温度通过珀耳帖元件，冷却体和热耦合板来控制。
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37.发明申请Method for the Production of a Solution, Associated Arrangement and Uses of the Method and Arrangement 有权解决方案的生产方法，相关安排和方法和安排的使用公开(公告)号：US20070212708A1
公开(公告)日：2007-09-13
申请号：US11587572
申请日：2005-04-26
CPC分类号： B01F15/0205 , B01F1/00 , B01F13/0059 , B01F15/021 , Y10T436/25
摘要： Solid matter in a cavity is used to produce a solution of at least one solid matter in a solvent. The solid matter which is soluble in the solvent in initially covered and/or surrounded in the cavity by a medium which is insoluble in a solvent, such that dissolving of the solid matter is prevented. Subsequently the solvent is guided to the cavity and the medium which is insoluble in the solvent is treated in such a manner that contact is made between the solvent and the soluble solid matter, enabling the solid matter to dissolve in the solvent. Solutions including two or more solid matter can be produced in an advantageous manner.
摘要翻译： 空腔中的固体物质用于在溶剂中产生至少一种固体物质的溶液。 首先被溶解在溶剂中的固体物质通过不溶于溶剂的介质在空腔中被包覆和/或包围，从而防止固体物质的溶解。 随后将溶剂引导到空腔中，并且不溶于溶剂的介质以在溶剂和可溶性固体物质之间接触使得固体物质溶解在溶剂中的方式被处理。 可以以有利的方式制备包含两种或更多种固体物质的溶液。
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公开(公告)号：US20080283397A1
公开(公告)日：2008-11-20
申请号：US10587745
申请日：2005-01-26
申请人： Heike Barlag , Walter Gumbrecht , Manfred Stanzel
发明人： Heike Barlag , Walter Gumbrecht , Manfred Stanzel
IPC分类号： G01N33/487
CPC分类号： G01N27/403
摘要： Electrochemical transducer arrays are already known from the prior art. According to the invention, the transducer array is provided with at least one flexible, planar metal substrate on which at least one flexible insulator having a firm connection between the metal surface and the insulator surface is disposed. The metal substrate and the insulator disposed thereon are structured in such a manner as to give metal areas which are electrically insulated the one from the other and which serve as sensor areas. The metal substrate used is self-contained so that the structured metal areas can be contacted from the lower side.
摘要翻译： 电化学换能器阵列从现有技术已经是已知的。 根据本发明，换能器阵列设置有至少一个柔性的平面金属基底，其上布置有在金属表面和绝缘体表面之间具有牢固连接的至少一个柔性绝缘体。 金属基板和设置在其上的绝缘体以使得彼此电绝缘并用作传感器区域的金属区域的方式构造。 使用的金属基板是独立的，使得结构化金属区域可以从下侧接触。
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39.发明授权Method for preventing chemical crosstalk in enzyme-linked reactions, and associated system 有权防止酶联反应中化学串扰的方法及相关系统公开(公告)号：US07838261B2
公开(公告)日：2010-11-23
申请号：US10432782
申请日：2001-11-26
IPC分类号： G01N33/58
CPC分类号： B01J19/0093 , B01J19/0046 , B01J2219/00317 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00608 , B01J2219/00612 , B01J2219/00621 , B01J2219/00644 , B01J2219/00659 , B01J2219/00783 , B01J2219/00828 , B01J2219/0086 , B01J2219/00867 , B01L3/502 , B01L3/50853 , B01L2200/0642 , B01L2200/0673 , B01L2300/0819 , B01L2300/0829 , C40B60/14 , G01N27/3277
摘要： A method for biochemical analysis uses a micro-reaction array with at least two reaction chambers for materials which react together chemically or biochemically. The reaction chambers are smaller than 1 μl, the reaction chambers are filled together by throughflow, the chemical or biochemical reactions of the substances retained therein then occurs in the individual isolated reaction chambers, thus preventing an interference between the reactions in the individual reaction chambers and the reaction products remain enclosed in the relevant reaction chambers. In the system the planar array has at least two reaction chambers for substances, whereby the reaction chambers are closed with the goal of preventing an exchange of substances.
摘要翻译： 用于生化分析的方法使用具有至少两个反应室的微反应阵列用于化学或生化反应的材料。 反应室小于1μl，反应室通过通流填充在一起，其中保留的物质的化学或生物化学反应发生在各个分离的反应室中，从而防止各反应室中的反应与 反应产物保持封闭在相关反应室中。 在系统中，平面阵列具有至少两个用于物质的反应室，由此反应室被封闭，目的是防止物质交换。
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40.发明授权Method and device for PCR-amplification and detection of nucleotide sequences 有权用于PCR扩增和检测核苷酸序列的方法和装置公开(公告)号：US07642053B2
公开(公告)日：2010-01-05
申请号：US10539437
申请日：2003-12-15
申请人： Walter Gumbrecht , Manfred Stanzel
发明人： Walter Gumbrecht , Manfred Stanzel
CPC分类号： C12Q1/686 , C12Q2565/607 , C12Q2565/501
摘要： A DNA-Chip includes a flat carrier and an array of spots containing probe molecules (oligonucleotides) which are arranged on said carrier. Each spot is associated with a microelectrode arrangement for impedance spectroscopic detection of binding events occurring between the probe molecules and target molecules (DNA fragments) applied by way of an analyte solution. In order to increase the sensitivity or the binding specific measuring effects of the biochip, the electrode arrangement is at least partially embedded in a hydrophilic reaction layer containing probe molecules and which is permeable to target molecules.
摘要翻译： DNA芯片包括布置在所述载体上的平坦载体和含有探针分子（寡核苷酸）的斑点阵列。 每个点与微电极装置相关联，用于阻抗光谱检测在通过分析物溶液施加的探针分子和靶分子（DNA片段）之间发生的结合事件。 为了增加生物芯片的灵敏度或结合特异性测量效果，电极布置至少部分地嵌入含有探针分子的亲水性反应层，并且其可渗透靶分子。
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