公开(公告)号：US06505971B2

公开(公告)日：2003-01-14

申请号：US09897523

申请日：2001-07-02

Applicant: Mamoru Sugimoto ,  Toru Okuda ,  Akihiro Ikenoue ,  Takeshi Tanaka

Inventor： Mamoru Sugimoto ,  Toru Okuda ,  Akihiro Ikenoue ,  Takeshi Tanaka

IPC: F16C1702

CPC classification number: F16C33/104 ,  B22F2999/00 ,  F16C17/02 ,  F16C17/10 ,  F16C23/041 ,  F16C23/045 ,  F16C33/145 ,  F16C2204/60 ,  F16C2220/20 ,  F16C2223/04 ,  Y10S384/902 ,  Y10T29/49668 ,  B22F5/10

Abstract: A sintered oil retaining bearing has a bearing bore through which a rotary shaft is inserted formed at a bearing main unit made of a porous sintered alloy. The inner circumferential wall serving as the bearing bore includes a center inner circumferential wall located at the center region of the inner circumferential wall, and one end side inner circumferential wall and other end side inner circumferential wall, located at one end side and the other end side, respectively, of the center inner circumferential wall in the direction of the rotary shaft. The center inner circumferential wall has a blinded portion where the air permeability is not more than 0.3×10−3 darcy, and air permeability lower than that of the one end side and other end side inner circumferential wall.

Abstract translation: 烧结保油轴承具有轴承孔，旋转轴通过该轴承孔形成在由多孔烧结合金制成的轴承主体上。 用作轴承孔的内周壁包括位于内周壁的中心区域的中心内周壁，一端侧内周壁和另一端侧内周壁，位于一端侧，另一端 侧分别为中心内周壁的旋转轴方向。 中心内周壁具有透气度不大于0.3×10 -3达西的透气性，并且透气性低于一端侧和另一端侧内周壁的透气性。

公开(公告)号：US06247912B1

公开(公告)日：2001-06-19

申请号：US09444558

申请日：1999-11-19

Applicant: Mamoru Sugimoto ,  Jiro Tanaka

Inventor： Mamoru Sugimoto ,  Jiro Tanaka

IPC: B22F0303

CPC classification number: B22F5/085 ,  B21K1/30 ,  B22F5/08 ,  B22F2998/00 ,  B30B11/02 ,  B30B11/027 ,  Y10S425/058

Abstract: A spiral bevel gear having right and left tooth flanks having such a small pitch angle that either right or left ones are not seen in plan from the apex side of cone is molded by a powder molding device so as not to interfere with a die of the device when removed from the die. The die has teeth for molding and is rotatably supported. A fixed guide mechanism for guiding the die is provided. Guide portions of the guide mechanism have a predetermined lead so that the die is rotated guided by the guide portions when the molded article is punched out of the die. Thus, the teeth formed on the molded article reliably disengage from the teeth for molding. This makes it possible to reliably punch the molded article out of the die.

Abstract translation: 具有左右齿面的螺旋锥齿轮由粉末成形装置模制而成，其具有从锥体的顶点侧的平面中看不到右侧或左侧的左右齿面，从而不会干扰 设备从模具中取出时。 模具具有用于模制的齿并被可旋转地支撑。 提供了用于引导模具的固定引导机构。 引导机构的引导部分具有预定的引线，使得当模制品冲压出模具时，模具被引导部分引导。 因此，形成在模制品上的齿可以与用于模制的齿可靠地脱开。 这使得可以将模制品可靠地冲压出模具。

公开(公告)号：US5470962A

公开(公告)日：1995-11-28

申请号：US108672

申请日：1993-09-07

Applicant: Tomoya Ogawa ,  Shigeki Nunomura ,  Mamoru Sugimoto

Inventor： Tomoya Ogawa ,  Shigeki Nunomura ,  Mamoru Sugimoto

IPC: A61K31/70 ,  A61K31/7028 ,  A61K31/715 ,  A61P35/00 ,  A61P37/04 ,  C07H3/06 ,  C07H15/04 ,  C07H15/18 ,  C07H15/26 ,  C08B37/00 ,  C07H5/06

CPC classification number: C07H15/04 ,  C07H15/18 ,  C07H15/26 ,  C07H3/06 ,  Y02P20/55

Abstract: An oligosialyl-1,2-dialkyl-sn-glycerol represented by the following formula (I): ##STR1## wherein each R.sup.1 independently represents a group selected from the group consisting of a hydrogen atom and alkali metal atoms, each R.sup.2 independently represents an alkyl group having 14 to 18 carbon atoms, Ac represents an acetyl group, and n represents an integer of from 0 to 20, and synthetic intermediates for their preparation useful as an immuno-stimulating agent, an antitumor agent, and a diagnostic and therapeutic agent for cancers.

Abstract translation: 由下式（I）表示的唾液酸-1,2-二烷基-sn-甘油：其中每个R 1独立地表示选自氢原子和碱金属原子的基团，每个R 2 独立地表示具有14至18个碳原子的烷基，Ac表示乙酰基，n表示0至20的整数，其制备用作免疫刺激剂的合成中间体，抗肿瘤剂和诊断 和癌症治疗剂。

公开(公告)号：US5173420A

公开(公告)日：1992-12-22

申请号：US310654

申请日：1989-02-15

Applicant: Reiji Kannagi ,  Yoshiko Kirihata ,  Tomoya Ogawa ,  Masaaki Numata ,  Mamoru Sugimoto

Inventor： Reiji Kannagi ,  Yoshiko Kirihata ,  Tomoya Ogawa ,  Masaaki Numata ,  Mamoru Sugimoto

IPC: G01N33/574 ,  A61K38/00 ,  A61K39/395 ,  A61P35/00 ,  C07K16/30 ,  C07K16/44 ,  C12N5/10 ,  C12N5/20 ,  C12N15/02 ,  C12P21/00 ,  C12P21/08 ,  C12R1/91 ,  G01N33/577

CPC classification number: C07K16/30 ,  C07K16/44 ,  A61K38/00

Abstract: A monoclonal antibody A exhibits specificity to the sialic acid glycolipid containing the epitope NeuAc.alpha.2.fwdarw.9NeuAc terminal. A monoclonal antibody B exhibits specificity to the sialic acid glycolipid containing the epitope NeuAc.alpha.2.fwdarw.6Gal.beta. terminal. A monoclonal antibody C exhibits specificity to the sialic acid glycolipid containing at least one epitope selected from the group of NeuAc.alpha.2.fwdarw.9NeuAc terminal, NeuAc.alpha.2.fwdarw.6Gal.beta. terminal and NeuAc.alpha.2.fwdarw.1Cer. Hybridomas are prepared which produce antibodies A, B and C. A process for producing the hybridomas is disclosed including the step of fusing a myeloma cell and a B cell (lymphocyte) produced by the immunization of animal using as an antigen, the sialic acid glycolipid containing at least one epitope of the group NeuAc.alpha.2.fwdarw.9NeuAc terminal, NeuAc.alpha.2.fwdarw.6Gal.beta. terminal and NeuAc.alpha.2.fwdarw.1Cer.

公开(公告)号：US4992533A

公开(公告)日：1991-02-12

申请号：US413441

申请日：1989-09-27

Applicant: Masanori Kobayashi ,  Mamoru Sugimoto ,  Kenkichi Tomita ,  Yukishige Ito ,  Tomoya Ogawa

Inventor： Masanori Kobayashi ,  Mamoru Sugimoto ,  Kenkichi Tomita ,  Yukishige Ito ,  Tomoya Ogawa

IPC: C07H11/00 ,  C07H13/04 ,  C07H15/10 ,  C07H15/18 ,  C07H19/04

CPC classification number: C07H13/04 ,  C07H11/00 ,  C07H15/10 ,  C07H15/18

Abstract: The present invention relates to sulfated oligosaccharides or their derivatives such as the following compound and being useful for diagnosing or treating diseases such as immunity-related diseases and mucopolysaccharide diseases. ##STR1## (M is an alkali metal).

公开(公告)号：US4730058A

公开(公告)日：1988-03-08

申请号：US36445

申请日：1987-04-09

Applicant: Tomoya Ogawa ,  Mamoru Sugimoto ,  Masaaki Numata ,  Yoshiyasu Shitori ,  Masayoshi Ito

Inventor： Tomoya Ogawa ,  Mamoru Sugimoto ,  Masaaki Numata ,  Yoshiyasu Shitori ,  Masayoshi Ito

IPC: C07H7/027 ,  C07H15/04 ,  C07H15/10 ,  C07D309/00 ,  C07D309/02

CPC classification number: C07H15/10

Abstract: This invention provides a novel compound expressed by the following formula (1): ##STR1## [wherein R.sup.1 denotes a hydrogen atom or CH.sub.3 CO--, R.sup.2 denotes --COOR.sup.4 (R.sup.4 denotes Na or a methyl group) or ##STR2## (R.sup.5 denotes a hydrogen atom, --COC.sub.6 H.sub.5 or --Si(C.sub.6 H.sub.5).sub.2 C(CH.sub.3).sub.3 and R.sup.3 denotes ##STR3## (R.sup.5 denotes a hydrogen atom, --COC.sub.6 H.sub.5 or --Si(C.sub.6 H.sub.5).sub.2 C(CH.sub.3).sub.3) when R.sup.2 is --COOR.sup.4 (R.sup.4 denotes Na or a methyl group) or denotes --COOR.sup.4 when R.sup.2 is ##STR4## and a method of preparation thereof. The above novel compounds of present invention are useful as a tumor maker, a molecular marker for cells having the ability of differential induction, or an intermediate of the synthesis thereof. 'Y

公开(公告)号：US4308202A

公开(公告)日：1981-12-29

申请号：US88326

申请日：1979-10-25

Applicant: Setsuro Fujii ,  Mamoru Sugimoto ,  Takashi Yaegashi

Inventor： Setsuro Fujii ,  Mamoru Sugimoto ,  Takashi Yaegashi

IPC: C07K5/097 ,  C12Q1/37 ,  C07C103/52 ,  C12Q1/56

CPC classification number: C07K5/0823 ,  C12Q1/37 ,  Y10S530/802

Abstract: A prolylphenylalanylarginine derivative represented by the formula, ##STR1## wherein R.sub.1 represents hydrogen or benzoyl; R.sub.2 represents naphthyl or 6-bromo-2-naphthyl. The above compound is useful as an excellent substrate for various enzymes, such as trypsin, plasmin, kallikrein, urokinase, Clesterase and the like. Accordingly, the activity of enzymes can be measured by use of said compound as a substrate.

Abstract translation: 由下式表示的脯氨酰苯丙氨酰精氨酸衍生物，其中R1表示氢或苯甲酰基; R2代表萘基或6-溴-2-萘基。 上述化合物可用作各种酶如胰蛋白酶，纤溶酶，激肽释放酶，尿激酶，胆固醇等的优异底物。 因此，可以通过使用所述化合物作为底物来测量酶的活性。

公开(公告)号：US08319469B2

公开(公告)日：2012-11-27

申请号：US13299667

申请日：2011-11-18

Applicant: Keshatoshi Takeuchi ,  Mamoru Sugimoto ,  Yojiro Okakura

Inventor： Keshatoshi Takeuchi ,  Mamoru Sugimoto ,  Yojiro Okakura

IPC: H02K41/00

CPC classification number: H02K29/08 ,  B60L3/0061 ,  B60L7/14 ,  B60L11/007 ,  B60L11/1803 ,  B60L15/007 ,  B60L15/20 ,  B60L2200/12 ,  B60L2220/14 ,  B60L2220/16 ,  B60L2220/44 ,  B60L2220/50 ,  H02K1/02 ,  H02K3/02 ,  H02K5/08 ,  H02K21/24 ,  Y02T10/641 ,  Y02T10/645 ,  Y02T10/7005 ,  Y02T10/72 ,  Y02T10/7275

Abstract: The brushless electric machine includes a first drive member (30U) having a plurality of permanent magnets (32U); a second drive member (10) having a plurality of electromagnetic coils and capable of movement relative to the first drive member (30U); and a third drive member (30L) disposed at the opposite side from the first drive member (30U) with the second drive member (10) therebetween. The second drive member (10) has magnetic sensors (40A, 40B) for detecting the relative position of the first and second drive members. The third drive member (30L) has at locations facing the permanent magnets of the first drive member (30U) a plurality of magnetic field strengthening members (32L) for strengthening the magnetic field at the location of the second drive member (10) in conjunction with the permanent magnets.

Abstract translation: 无刷电机包括具有多个永磁体（32U）的第一驱动部件（30U）。 具有多个电磁线圈并能够相对于第一驱动构件（30U）移动的第二驱动构件（10）; 以及第三驱动构件（30L），其与第一驱动构件（30U）的相对侧设置有第二驱动构件（10）。 第二驱动构件（10）具有用于检测第一和第二驱动构件的相对位置的磁传感器（40A，40B）。 第三驱动构件（30L）在与第一驱动构件（30U）的永磁体相对的位置处具有用于在第二驱动构件（10）的位置处加强磁场的多个磁场强化构件（32L） 与永磁体。

公开(公告)号：US06337390B1

公开(公告)日：2002-01-08

申请号：US09180618

申请日：1999-01-19

Applicant: Shuji Fujita ,  Masaaki Numata ,  Kazuo Suzuki ,  Shigeki Nunomura ,  Mamoru Sugimoto ,  Masaki Terada

Inventor： Shuji Fujita ,  Masaaki Numata ,  Kazuo Suzuki ,  Shigeki Nunomura ,  Mamoru Sugimoto ,  Masaki Terada

IPC: C07H1500

CPC classification number: C07H15/06 ,  C07H15/04 ,  C07H15/10 ,  C07H15/14 ,  C07H15/203 ,  Y10S514/934

Abstract: In order to provide the anti-retrovirus active compound with low anti-coagulant action and low cytotoxicity, compounds comprising glycoside or the salt thereof wherein lipid is linked to position 2 of sialic acid having all hydroxyl groups at positions 4, 7, 8 and 9 completely sulfated, or KDN (2-keto-3-deoxy-D-glycero-2-nononic acid) having all hydroxyl groups at positions 4, 5, 7, 8 and 9 completely sulfated are provided.

Abstract translation: 为了提供具有低抗凝血作用和低细胞毒性的抗逆转录病毒活性化合物，包含糖苷或其盐的化合物，其中脂质连接到位于第4,7,8和9位具有所有羟基的唾液酸的位置2 或完全硫酸化的第4,5,7,8和9位具有全羟基的KDN（2-酮-3-脱氧-D-甘油-2-壬二酸）完全硫酸化。

公开(公告)号：US6113848A

公开(公告)日：2000-09-05

申请号：US141734

申请日：1998-08-27

Applicant: Mamoru Sugimoto ,  Jiro Tanaka

Inventor： Mamoru Sugimoto ,  Jiro Tanaka

IPC: B21K1/30 ,  B22F3/02 ,  B22F3/035 ,  B22F5/08 ,  B30B11/02 ,  C22C33/02

CPC classification number: B22F5/085 ,  B21K1/30 ,  B22F5/08 ,  B30B11/02 ,  B30B11/027 ,  B22F2998/00 ,  Y10S425/058

Abstract: A spiral helical gear having right and left tooth flanks having such a small pitch angle that either right or left ones are not seen in plan from the apex side of cone is molded by a powder molding device so as not to interfere with a die of the device when removed from the die. The die has teeth for molding and is rotatably supported. A fixed guide mechanism for guiding the die is provided. Guide portions of the guide mechanism have a predetermined lead so that the die is rotated guided by the guide portions when the molded article is punched out of the die. Thus, the teeth formed on the molded article reliably disengage from the teeth for molding. This makes it possible to reliably punch the molded article out of the die.

Abstract translation: 具有左右齿面的螺旋斜齿轮由粉末成型装置模制而成，具有如右侧或左侧所示的左右齿面从锥体的顶端侧看不到平面的左右齿面，以免与 设备从模具中取出时。 模具具有用于模制的齿并被可旋转地支撑。 提供了用于引导模具的固定引导机构。 引导机构的引导部分具有预定的引线，使得当模制品冲压出模具时，模具被引导部分引导。 因此，形成在模制品上的齿可以与用于模制的齿可靠地脱开。 这使得可以将模制品可靠地冲压出模具。