摘要:
This invention relates to an aggregation sensor useful for the detection and analysis of aggregants in a sample, and methods, articles and compositions relating to such a sensor. The sensor comprises first and second optically active units, where energy may be transferred from an excited state of the first optically active unit to the second optically active unit. The second optically active unit is present in a lesser amount, but its relative concentration is increased upon aggregation, increasing its absorption of energy from the first optically active units. This increase in energy transfer can be detected in variety of formats to produce an aggregation sensing system for various aggregants, including for quantitation. Other variations of the inventions are described further herein.
摘要:
Urea containing compounds that inhibit MAP kinases, pharmaceutical compositions including such compounds and methods for using these compounds to treat inflammatory diseases and cancer are described herein.
摘要:
This invention provides novel prostate cancer specific internalizing human antibodies. The antibodies are useful by themselves to prevent growth and/or proliferation of prostate cancer cells. The antibodies can also be formulated as chimeric molecules to direct an effector (e.g. a cytotoxin, an imaging reagent, a drug, etc.) to a prostate tumor site.
摘要:
A display support device includes a connecting member and a lower tube. The connecting member is adapted to be mounted on a rear surface of a flat display, and includes an upper tube. The lower tube is disposed below the upper tube. One of the upper and lower tubes has an internally threaded portion, and the other of the upper and lower tubes has an externally threaded portion engaging the internally threaded portion to allow for rotation and therefore movement of the lower tube relative to the upper tube, which results in a change to the total length of the upper and lower tubes.
摘要:
The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD). In particular, the invention relates to compounds and compositions and the methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the inhibition of malonyl-coenzyme A decarboxylase.
摘要:
A fuel assembly for a pressurized water reactor that includes a bottom nozzle, a plurality of elongated guide thimbles projecting upwardly from the bottom nozzle, an array of fuel rods, a plurality of support grids axially spaced along the guide thimbles, and at least two Intermediate Flow Mixing grids, which may have different configurations of mixing device formations, disposed between pairs of non-uniformly spaced, adjacent support grids at selected locations.
摘要:
A dirty paper precoding (“DPC”) method for broadcasting a signal is disclosed that takes advantage of knowledge of the structure of interference in order to avoid the quantization noise that results in the conventional DPC method. The proposed method modifies the Tomlinson-Harishima precoding (“THP”) scheme by selecting a constellation and mapping scheme that is designed based on the known interference modulation structure of the interference signal, which is typically directed to a second receiver. In a particular embodiment, a source signal and an interference signal are QAM modulated. The modulation structure information of the interference signal is known to the receiver. At the transmitter the source signal is precoded based on the known interference structure, and a common mapping rule is implemented, such that the received signal can be decoded at the receiver without requiring a modulo operation at either the transmitter or receiver.
摘要:
In a communications receiver for quadrature demodulation, a feedback technique for reducing the image response of the receiver. The communications receiver includes an I demodulator and a Q demodulator. A local oscillator (LO) signal is provided by a PLL to a quadrature LO generator that provides an LO_I signal to an I demodulator and an LO_Q signal to a Q demodulator. The LO_I and LO_Q signals are amplitude and phase-controlled versions of the LO signal. An image/signal ratio (I/S) detector detects the relative phase difference and the relative amplitude difference between the respective output terminals of the I demodulator and the Q demodulator and applies an amplitude control signal and a phase control signal to corresponding amplitude control and phase control inputs of the quadrature LO generator. The I/S detector calibrates the quadrature LO generator during the interstitial interval between the reception of data packets. The control signals from the I/S detector adjust the relative amplitude and phase of the LO_I and LO_Q signals in a manner that reduces the image response of the communications receiver.