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169 条记录 (耗时 0.045 秒)

    Supported highly-polar liquid phase chiral sulfonated binap catalyst for asymmetric synthesis of optically active compounds
    31.
    发明授权
    Supported highly-polar liquid phase chiral sulfonated binap catalyst for asymmetric synthesis of optically active compounds 失效
    用于不对称合成光学活性化合物的载体高极性液相手性磺化二元催化剂

    公开(公告)号：US5827794A

    公开(公告)日：1998-10-27

    申请号：US535784

    申请日：1995-09-28

    申请人： Mark E. Davis ,  Kam To Wan

    发明人： Mark E. Davis ,  Kam To Wan

    IPC分类号： B01J31/02 ,  B01J31/16 ,  B01J31/24 ,  C07B53/00 ,  C07C45/50 ,  C07C51/353 ,  C07C51/36 ,  C07C51/487 ,  C07C67/31

    CPC分类号： B01J31/0202 ,  B01J31/1616 ,  B01J31/2452 ,  C07B53/00 ,  C07C45/505 ,  C07C51/353 ,  C07C51/36 ,  C07C51/487 ,  C07C67/31 ,  B01J2231/323 ,  B01J2531/0266 ,  B01J2531/42 ,  B01J2531/44 ,  B01J2531/56 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/827 ,  B01J2531/828 ,  B01J2531/847 ,  B01J2531/96 ,  B01J2540/32 ,  Y02P20/588

    摘要： The present invention relates to water soluble chiral sulfonated 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl and its use as organometallic catalysts for asymmetric synthesis of optically active compounds. Asymmetric reactions of the present invention include those reactions in which organometallic catalysts are commonly used. Such reactions include, but are not limited to, reduction and isomerization reactions on unsaturated substrates and carbon--carbon bond forming reactions. Examples of such reactions include, but are not limited to, hydrogenation, hydroboration, hydrosilylation, hydride reduction, hydroformylation, alkylation, allylic alkylation, arylation, alkenylation, epoxidation, hydrocyanation, disilylation, cyclization and isomerization reactions. The catalysts of the present invention provide the advantage of functioning in the presence of water without loss in enantioselectivity relative to the nonsulfonated BINAP catalyst in an organic solvent. As a result, the catalysts of the present invention may be employed in water, water miscible solvents, in aqueous--organic two phase solvent systems and in supported aqueous phase catalysts in organic solvents without loss in enantioselectivity. Further, the catalysts of the present invention may also be effectively employed in highly polar solvents such as primary alcohols and ethylene glycol. The present invention also relates to a method for conducting asymmetric reactions on prochiral unsaturated bonds contained within a compound using the water soluble chiral sulfonated 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl organometallic catalysts of the present invention.

    摘要翻译： 本发明涉及水溶性手性磺化2,2'-双（二苯基膦基）-1,1'-联萘及其作为用于不对称合成光学活性化合物的有机金属催化剂的用途。 本发明的不对称反应包括通常使用有机金属催化剂的那些反应。 这样的反应包括但不限于在不饱和基材上的还原和异构化反应和碳 - 碳键形成反应。 这些反应的实例包括但不限于氢化，氢化，氢化硅烷化，氢化物还原，加氢甲酰化，烷基化，烯丙基烷基化，芳基化，链烯基化，环氧化，氢氰化，二甲硅烷基化，环化和异构化反应。 本发明的催化剂提供了在有机溶剂中相对于非磺化的BINAP催化剂在不存在对映体选择性的情况下在水存在下的作用。 结果，本发明的催化剂可以用于水，水混溶性溶剂，水 - 有机两相溶剂体系中，并且在有机溶剂中的负载型水相催化剂中使用，而不会降低对映体选择性。 此外，本发明的催化剂也可以有效地用于高极性溶剂如伯醇和乙二醇。 本发明还涉及使用本发明的水溶性手性磺化2,2'-双（二苯基膦基）-1,1'-联萘有机金属催化剂对化合物中所含的前手性不饱和键进行不对称反应的方法。

    System for providing locale dependent user interface for presenting control graphic which has different contents or same contents displayed in a predetermined order
    32.
    发明授权
    System for providing locale dependent user interface for presenting control graphic which has different contents or same contents displayed in a predetermined order 失效
    用于提供具有区域设置的用户界面的系统，用于呈现具有以预定顺序显示的不同内容或相同内容的控制图形

    公开(公告)号：US5551055A

    公开(公告)日：1996-08-27

    申请号：US996781

    申请日：1992-12-23

    申请人： John R. Matheny ,  Christopher White ,  Mark E. Davis

    发明人： John R. Matheny ,  Christopher White ,  Mark E. Davis

    IPC分类号： G06F9/06 ,  B82B1/00 ,  G06F3/048 ,  G06F3/14 ,  G06F9/44 ,  G06F3/00 ,  G06F3/03

    CPC分类号： G06F8/24 ,  G06F9/4448

    摘要： A method and apparatus for updating an application to conform to unique requirements of a specific locale. The update involves language translation, graphic substitution, and interface element reorientation. For example, the text used in labels, titles, and messages depends upon the selected language. Its direction and orientation may affect the placement and orientation of a menu, menubar, title, scrollbar, or toolbar. Similarly, the selection of icons and other graphical symbols may be culturally dependent. Once localized, user interface elements are stored in a disk dictionary. A disk dictionary is an object that, when given a key, returns a value after reading it in from disk. This disk dictionary is managed by an object called an archive. An archive is responsible for putting together the individual user interface elements that make up a particular presentation.

    摘要翻译： 一种用于更新应用以符合特定区域的独特需求的方法和装置。 更新涉及语言翻译，图形替换和界面元素重定向。 例如，标签，标题和消息中使用的文本取决于所选择的语言。 其方向和方向可能会影响菜单，菜单栏，标题，滚动条或工具栏的位置和方向。 类似地，图标和其他图形符号的选择可以在文化上依赖。 一旦本地化，用户界面元素被存储在磁盘字典中。 磁盘字典是一个对象，当给定一个键时，从磁盘读取它后返回一个值。 该磁盘字典由称为存档的对象管理。 归档文件负责组合构成特定演示文稿的各个用户界面元素。

    Zeolite CIT-1
    33.
    发明授权
    Zeolite CIT-1 失效
    沸石CIT-1

    公开(公告)号：US5512267A

    公开(公告)日：1996-04-30

    申请号：US306177

    申请日：1994-09-14

    申请人： Mark E. Davis ,  Raul F. Lobo

    发明人： Mark E. Davis ,  Raul F. Lobo

    IPC分类号： C01B39/12 ,  C01B39/48 ,  C07C4/06 ,  C10G11/05 ,  C01B39/04 ,  C01B39/46

    CPC分类号： C10G11/05 ,  C01B39/12 ,  C01B39/48 ,  C07C4/06 ,  C07C2529/87

    摘要： A zeolite composition CIT-1 is provided, the composition having a mole ratio greater than about 20:1 of a first oxide selected from silicon oxide, germanium oxide, or mixtures thereof to a second oxide comprising boron oxide; which zeolite composition has a specific X-ray powder diffraction pattern in accordance with Table 1 of the disclosure. In one embodiment, the second oxide may comprise mixtures of boron oxide with one or more of aluminum oxide, gallium oxide, iron oxide, titanium oxide and vanadium oxide. Also disclosed is a method for making CIT-1 zeolites comprising the preparation of an aqueous mixture containing sources of a N,N,N-trimethyl cis-myrtanyl ammonium ion, boron oxide or mixtures of boron oxide with one or more of aluminum oxide, gallium oxide, iron oxide, titanium oxide and vanadium oxide, and an oxide selected from silicon oxide, germanium oxide, and mixtures thereof. The mixture is maintained under sufficient crystallization conditions, preferably at a temperature of at least 100.degree. C., in an autoclave and under autogenous pressure until the crystals of the zeolite are formed.

    摘要翻译： 提供沸石组合物CIT-1，该组合物的摩尔比大于约20:1，选自氧化硅，氧化锗或其混合物的第一氧化物与包含氧化硼的第二氧化物; 该沸石组合物具有根据本公开的表1的特定X射线粉末衍射图。 在一个实施方案中，第二氧化物可以包括氧化硼与氧化铝，氧化镓，氧化铁，氧化钛和氧化钒中的一种或多种的混合物。 还公开了一种制备CIT-1沸石的方法，其包括制备含有N，N，N-三甲基顺式 - 甲硅烷基铵离子，氧化硼或氧化硼与氧化铝中的一种或多种的混合物的含水混合物， 氧化镓，氧化铁，氧化钛和氧化钒，以及选自氧化硅，氧化锗及其混合物的氧化物。 将混合物在高压釜中并在自生压力下保持在足够的结晶条件下，优选在至少100℃的温度下，直到形成沸石的晶体。

    System for displaying insertion text based on preexisting text display characteristics
    34.
    发明授权
    System for displaying insertion text based on preexisting text display characteristics 失效
    基于预先存在的文本显示特征显示插入文本的系统

    公开(公告)号：US5495577A

    公开(公告)日：1996-02-27

    申请号：US500022

    申请日：1995-07-10

    申请人： Mark E. Davis ,  Russell Sonnenschein

    发明人： Mark E. Davis ,  Russell Sonnenschein

    IPC分类号： G09G5/24 ,  G06F17/21

    CPC分类号： G06F17/214

    摘要： A method and system for automatically selecting a font so that a user sees the characters and fonts expected to appear in a document. The preferred embodiment of the invention employs a first process when a character, or string of characters, is entered into a text stream. If the character is missing from the font specified in the current typing style, the process selects a font that can display the character. For example, if the code for a ".SIGMA." is inserted before "n/2" the process would automatically style the code with a font that could display the ".SIGMA.". Styling a character means that the character will always have a font style associated with the character.

    摘要翻译： 用于自动选择字体的方法和系统，以便用户看到预期出现在文档中的字符和字体。 当字符或字符串被输入到文本流中时，本发明的优选实施例采用第一处理。 如果当前打字风格中指定的字体缺少字符，则该进程将选择一个可显示该字符的字体。 例如，如果在“n / 2”之前插入“SIGMA”的代码，则该过程将自动使用可能显示“SIGMA”的字体对代码进行样式化。 对字符进行样式意味着字符将始终具有与字符相关联的字体样式。

    Layered drug delivery polymer monofilament fibers
    36.
    发明授权
    Layered drug delivery polymer monofilament fibers 有权
    层状药物递送聚合物单丝纤维

    公开(公告)号：US08974814B2

    公开(公告)日：2015-03-10

    申请号：US12269838

    申请日：2008-11-12

    申请人： Brendan C. Mack ,  Mark E. Davis ,  Kenneth W. Wright

    发明人： Brendan C. Mack ,  Mark E. Davis ,  Kenneth W. Wright

    IPC分类号： A61K9/70 ,  A01N25/34 ,  A61K31/155 ,  A61K9/00 ,  A61K31/4164 ,  A61K31/496 ,  A61K31/505 ,  A61K31/5365 ,  A61K31/56 ,  A61K31/65 ,  A61K31/7008 ,  A61K31/7052 ,  A61K38/00

    CPC分类号： A61K31/155 ,  A61K9/0051 ,  A61K9/70 ,  A61K31/4164 ,  A61K31/496 ,  A61K31/505 ,  A61K31/5365 ,  A61K31/56 ,  A61K31/65 ,  A61K31/7008 ,  A61K31/7052 ,  A61K38/00

    摘要： The present invention is directed generally to a layered polymeric monofilament fiber drug delivery device, where each layer of the device can contain a different polymer, drug, additive, or any combination or mixture thereof. The layered nature of the current monofilament polymeric monofilament device provides the capability to modulate the release of one or more drugs and/or the mechanical properties of the fiber so that drug release and device failure can be separately tuned to provide for the tailored introduction of therapeutically effective drugs or agents to a target tissue. Moreover, the fiber may comprise more than one distinct segments along its length, each segment itself having different combinations and/or numbers of layers thereby providing even greater freedom in the design of the therapeutic delivery device. The invention is also directed to a method of manufacturing such a layered polymeric monofilament fiber drug delivery device, and methods of treatment using such devices.

    摘要翻译： 本发明一般涉及层状聚合物单丝纤维药物递送装置，其中该装置的各层可包含不同的聚合物，药物，添加剂或其任何组合或混合物。 当前单丝聚合单丝装置的分层性质提供了调节纤维的一种或多种药物释放和/或机械性能的能力，使得药物释放和装置故障可以被单独调节以提供定制的治疗引入 有效的药物或药剂到目标组织。 此外，纤维可以沿其长度包括多于一个不同的片段，每个片段本身具有不同的组合和/或层数，从而在治疗递送装置的设计中提供更大的自由度。 本发明还涉及制造这种层状聚合物单丝纤维药物递送装置的方法，以及使用这种装置的处理方法。

    Molecular sieves and related methods and structure directing agents
    38.
    发明授权
    Molecular sieves and related methods and structure directing agents 有权
    分子筛及相关方法和结构指导剂

    公开(公告)号：US08562942B2

    公开(公告)日：2013-10-22

    申请号：US12757894

    申请日：2010-04-09

    申请人： Raymond Archer ,  Mark E. Davis

    发明人： Raymond Archer ,  Mark E. Davis

    IPC分类号： C01B39/04

    CPC分类号： C01B39/48 ,  B01J20/18 ,  B01J20/3057 ,  B01J29/047 ,  B01J29/70 ,  B01J29/7007 ,  B01J29/86 ,  B01J29/87 ,  B01J29/88 ,  B01J29/89 ,  B01J37/0018 ,  C01B37/005 ,  C01B37/007 ,  C01B37/02 ,  C01B39/04 ,  C01B39/08 ,  C01B39/12

    摘要： Method for preparing molecular sieves and molecular sieves obtained thereby are described. The method includes preparing a reaction mixture, comprising a structure directing agent, at least one source of at least one oxide of a tetravalent element, optionally, one or more sources of one or more oxides selected from the group consisting of oxides of trivalent elements, pentavalent elements, and mixtures thereof, optionally, at least one source of an element selected from Groups 1 and 2 of the Periodic Table; and optionally, hydroxide ions or fluoride ions, and maintaining the reaction mixture under conditions sufficient to form crystals of the molecular sieve. In the method, various imidazolium cations are used as the structure directing element.

    摘要翻译： 对由此得到的分子筛和分子筛的制备方法进行了说明。 该方法包括制备反应混合物，其包含结构导向剂，至少一种四价元素氧化物的源，任选的一种或多种一种或多种氧化物源，所述氧化物选自三价元素的氧化物， 五价元素及其混合物，任选地，至少一种选自元素周期表第1和2组元素的源; 和任选的氢氧根离子或氟离子，并将反应混合物保持在足以形成分子筛结晶的条件下。 在该方法中，使用各种咪唑阳离子作为结构导向元件。

    Complexing agents for compositions containing inclusion complexes
    40.
    发明授权
    Complexing agents for compositions containing inclusion complexes 有权
    含有复合物的组合物的络合剂

    公开(公告)号：US08277846B2

    公开(公告)日：2012-10-02

    申请号：US13107024

    申请日：2011-05-13

    申请人： Suzie Hwang Pun ,  Hector Gonzalez ,  Mark E. Davis ,  Nathalie C. Bellocq ,  Jianjun Cheng

    发明人： Suzie Hwang Pun ,  Hector Gonzalez ,  Mark E. Davis ,  Nathalie C. Bellocq ,  Jianjun Cheng

    IPC分类号： A61K31/74 ,  A61K9/14 ,  C12P19/30 ,  C12N15/63

    CPC分类号： A61K47/48215 ,  A61K38/44 ,  A61K47/60 ,  A61K47/6949 ,  A61K47/6951 ,  A61K48/0041 ,  B82Y5/00 ,  C08B37/0012 ,  C08G65/33396 ,  C08G65/48 ,  C08G2650/04 ,  C08G2650/38 ,  C12Y113/12007

    摘要： The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent. According to the method, a therapeutically effective amount of a therapeutic composition of the invention is administered to a mammal (e.g. person or animal) in recognized need of the therapeutic. Also disclosed are compounds having the formula:

    摘要翻译： 本发明提供了含有聚合物和治疗剂的颗粒复合物的组合物。 该组合物还含有络合剂。 聚合物与宿主客体或客体 - 宿主相互作用中的络合剂相互作用以形成包合物。 本发明的治疗组合物可用于递送治疗剂并治疗各种疾病。 颗粒复合材料的聚合物和络合剂都可用于将功能性引入治疗组合物中。 本发明还涉及制备组合物的方法。 该方法结合治疗剂，具有宿主或客体功能的聚合物和具有客体或宿主功能的络合剂以形成治疗组合物。 络合剂与聚合物形成包合络合物。 本发明还涉及递送治疗剂的方法。 根据该方法，将治疗有效量的本发明的治疗组合物在公认的治疗需要中给予哺乳动物（例如人或动物）。 还公开了具有下式的化合物：