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公开(公告)号：US20170306336A1
公开(公告)日：2017-10-26
申请号：US15497703
申请日：2017-04-26
Applicant: Massachusetts Institute of Technology
Inventor： Timothy Kuan-Ta Lu
CPC classification number: C12N15/635 , A01K67/0275 , A01K2217/05 , C12N9/1241 , C12N9/22 , C12N15/102 , C12N15/63 , C12N15/85 , C12N15/902 , C12N2800/30 , C12N2830/002 , C12Q1/6876 , C12Q2600/158
Abstract: Provided herein are genetic constructs comprising genetic perturbation cassettes and methods of using such to assess the timing and order of gene expression.
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公开(公告)号：US20170058282A1
公开(公告)日：2017-03-02
申请号：US15205625
申请日：2016-07-08
Applicant: Massachusetts Institute of Technology
Inventor： Timothy Kuan-Ta Lu , Mark K. Mimee
CPC classification number: C12N15/70 , A61K35/74 , A61K49/0013 , A61K49/0017 , A61K49/0069 , C07K14/245 , C07K14/31 , C07K14/335 , C12N15/635 , C12N15/746 , C12Q1/02 , C12Q1/6897 , G01N2800/22
Abstract: Provided herein are microorganisms engineered with heme-responsive transcription factors and genetic circuits. Also provided are methods for using engineered microorganisms to sense bleeding events and treat bleeding in vivo.
Abstract translation: 本文提供了用血红素反应转录因子和遗传回路工程化的微生物。 还提供了使用工程微生物感测出血事件和治疗体内出血的方法。
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33.发明申请BIOPOLYMER-MEDIATED ASSEMBLY OF NANOPARTICLES USING GENETICALLY ENCODED PROTEINS 审中-公开使用基因编码蛋白的纳米颗粒的生物聚合物介导的组装公开(公告)号：US20160238591A1
公开(公告)日：2016-08-18
申请号：US14597575
申请日：2015-01-15
Applicant: Massachusetts Institute of Technology
Inventor： ZHENGTAO DENG , Timothy Kuan-Ta Lu
IPC: G01N33/52
CPC classification number: G01N33/521 , A61K49/0093
Abstract: Various aspects and embodiments provided herein are directed to compositions that include at least one nanoparticle linked to a first polypeptide, and a biologically synthesizable polymer linked to at least one second polypeptide that binds covalently to the first polypeptide. Other aspects and embodiments provided herein are directed to methods of producing the foregoing compositions and components therein.
Abstract translation: 本文提供的各个方面和实施方案涉及包含连接至第一多肽的至少一个纳米颗粒的组合物，以及与至少一种与第一多肽共价结合的第二多肽连接的生物可合成聚合物。 本文提供的其它方面和实施例涉及在其中生产前述组合物和组分的方法。
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公开(公告)号：US20150064770A1
公开(公告)日：2015-03-05
申请号：US14478657
申请日：2014-09-05
Applicant: Massachusetts Institute of Technology
Inventor： Timothy Kuan-Ta Lu , Hiroki Ando , Sebastien Lemire
IPC: C12N7/00
CPC classification number: C12N7/00 , C12N7/02 , C12N15/81 , C12N2795/00011 , C12N2795/00021
Abstract: Various aspects and embodiments of the invention are directed to high-throughput phage-engineering methods and recombinant bacteriophages with tunable host ranges for controlling phage specificity.
Abstract translation: 本发明的各个方面和实施方案涉及高通量噬菌体工程方法和具有可控的宿主范围的用于控制噬菌体特异性的重组噬菌体。
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公开(公告)号：US20150004705A1
公开(公告)日：2015-01-01
申请号：US14320965
申请日：2014-07-01
Inventor： Timothy Kuan-Ta Lu , Robert James Citorik , James Collins , Russell-John Krom
IPC: C12N15/74
CPC classification number: C12N15/74 , C12N7/00 , C12N15/70 , C12N2795/14132 , C12N2795/14143 , C12N2795/14171 , C12N2830/55
Abstract: Various aspects and embodiments of the present disclosure are directed to methods and compositions for functionalizing endogenous bacteria in vivo. The methods include delivering to endogenous bacterial cells a recombinant bacteriophage or phagemid that is engineered to contain at least one genetic circuit.
Abstract translation: 本公开的各个方面和实施方案涉及在体内功能化内源性细菌的方法和组合物。 所述方法包括向内源细菌细胞递送重组噬菌体或被设计成含有至少一个遗传回路的噬菌粒。
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Patent Agency Ranking
公开(公告)号：US20200277605A1
公开(公告)日：2020-09-03
申请号：US16815072
申请日：2020-03-11
Applicant: Massachusetts Institute of Technology
Inventor： Timothy Kuan-Ta Lu , Sebastien Lemire , Andrew C. Yang , Kevin M. Yehl
IPC: C12N15/113 , G01N33/569 , A61P31/04 , C07K14/005
Abstract: Disclosed herein are novel synthetic bacteriophages and bacteriophage compositions, methods of production thereof, and therapeutic uses thereof.
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公开(公告)号：US10760065B2
公开(公告)日：2020-09-01
申请号：US14475785
申请日：2014-09-03
Applicant: Massachusetts Institute of Technology
Inventor： Timothy Kuan-Ta Lu , Robert James Citorik , Mark Kyle Mimee
Abstract: Various aspects and embodiments of the invention are directed to methods and compositions for reversing antibiotic resistance or virulence in and/or destroying pathogenic microbial cells such as, for example, pathogenic bacterial cells. The methods include exposing microbial cells to a delivery vehicle with at least one nucleic acid encoding an engineered autonomously distributed circuit that contains a programmable nuclease targeted to one or multiple genes of interest.
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38.发明申请公开(公告)号：US20190279741A1
公开(公告)日：2019-09-12
申请号：US16299641
申请日：2019-03-12
Inventor： Timothy Kuan-Ta Lu , Cesar De la Fuente Nunez , William Porto , Octavio Franco
Abstract: Disclosed herein are methods of designing peptides having at least one property of interest, such as α-helical propensity, higher net charge, hydrophobicity, and/or hydrophobic moment. Also disclosed herein are novel artificially evolved peptides (e.g., antimicrobial peptides), which may be designed according to the methods described herein, and methods of use thereof.
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公开(公告)号：US20190240356A1
公开(公告)日：2019-08-08
申请号：US16318958
申请日：2017-07-20
Applicant: Massachusetts Institute of Technology
Inventor： Timothy Kuan-Ta Lu , Xinyue Liu , Tzu-Chieh Tang , Eléonore Claire Tham , Xuanhe Zhao
IPC: A61K49/00 , C12Q1/6897 , C12N15/70 , A61B5/00
CPC classification number: A61K49/0097 , A61B5/6806 , A61B5/6833 , A61K49/0073 , C12N11/04 , C12N11/10 , C12N15/63 , C12N15/70 , C12Q1/6897
Abstract: Provided herein, in some embodiments, are hydrogel-elastomer and hydrogel-alginate devices, compositions and associated methods to encapsulate living cells.
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公开(公告)号：US20190106683A1
公开(公告)日：2019-04-11
申请号：US16166523
申请日：2018-10-22
Applicant: Massachusetts Institute of Technology
Inventor： Timothy Kuan-Ta Lu , Hiroki Ando , Sebastien Lemire
IPC: C12N7/00
Abstract: Various aspects and embodiments of the invention are directed to high-throughput phage-engineering methods and recombinant bacteriophages with tunable host ranges for controlling phage specificity.
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