公开(公告)号：US06252225B1

公开(公告)日：2001-06-26

申请号：US09492352

申请日：2000-01-27

申请人： Yasuaki Takada ,  Minoru Sakairi ,  Atsumu Hirabayashi ,  Takayuki Nabeshima ,  Hideaki Koizumi

发明人： Yasuaki Takada ,  Minoru Sakairi ,  Atsumu Hirabayashi ,  Takayuki Nabeshima ,  Hideaki Koizumi

IPC分类号： H01J4910

CPC分类号： H01J49/165 ,  G01N30/7266 ,  H01J49/168

摘要： A mass spectrometer including a sprayer for spraying a sample solution, a needle electrode for ionizing the sample contained in the sample solution, an aperture for introducing the ions of the sample into a lower pressure region having a pressure lower than the pressure of a region in which the needle electrode is disposed, and a mass spectrometric apparatus for analyzing the ions introduced from the aperture. A direction of a spray caused by the sprayer is almost perpendicular to a center axis of the aperture and a tip of the needle is disposed facing to an electrode having the aperture.

摘要翻译： 一种质谱仪，包括用于喷射样品溶液的喷雾器，用于使包含在样品溶液中的样品电离的针状电极，用于将样品的离子引入低于区域压力的低压区域的孔 设置针状电极的质谱仪和用于分析从孔径引入的离子的质谱仪。 由喷雾器引起的喷雾方向几乎垂直于孔的中心轴线，并且针的尖端面向具有孔的电极设置。

公开(公告)号：US6011260A

公开(公告)日：2000-01-04

申请号：US114945

申请日：1998-07-14

申请人： Yasuaki Takada ,  Minoru Sakairi ,  Takayuki Nabeshima ,  Yukiko Hirabayashi ,  Hideaki Koizumi

发明人： Yasuaki Takada ,  Minoru Sakairi ,  Takayuki Nabeshima ,  Yukiko Hirabayashi ,  Hideaki Koizumi

IPC分类号： G01N27/62 ,  H01J49/04 ,  H01J49/06 ,  H01J49/34 ,  H01J49/42

CPC分类号： H01J49/067 ,  H01J49/04

摘要： A mass spectrometer comprising an ionization means for ionizing sample compounds to be analyzed mass spectro-scopically in an atmospheric pressure, a sample solution supply means for supplying a solution containing the sample compounds to the ionization means, means for feeding the ions formed by the ionization means through an aperture disposed in an electrode into a vacuum region, and anion trap type mass spectroscopic means for mass spectroscopically analyzing ions entered through the aperture into the vacuum region, in which an ion decelerating electric field forming means is disposed between the electrode disposed with the aperture and an electrode disposed with an ion entrance opening for entering the ions into the ion trap type mass spectroscopic means for forming an electric field for decelerating the ions, and the ions injected to the ion trap mass spectroscopic means is lowered. This facilitates accumulation ions in the ion trap mass spectralyzing means even if a high drift voltage is used thereby enabling high sensitivity analysis for polar compounds such as peptides.

摘要翻译： 一种质谱仪，其特征在于，包括：离子化装置，用于将大气压力分散分析的样品化合物离子化;将含有样品化合物的溶液供给到电离装置的样品溶液供给装置， 意味着通过设置在电极中的孔进入真空区域，以及阴离子阱型质谱分析装置，用于质谱分析通过孔进入真空区域的离子，其中离子减速电场形成装置设置在设置有 所述孔和电极设置有离子入口，用于将离子进入离子阱型质谱分析装置，用于形成用于使离子减速的电场，以及注入离子阱质谱分析装置的离子。 即使使用高漂移电压，这也有助于离子阱质谱分析手段中的积聚离子，从而能够对极性化合物如肽进行高灵敏度分析。

公开(公告)号：US5103093A

公开(公告)日：1992-04-07

申请号：US343363

申请日：1989-04-26

申请人： Minoru Sakairi ,  Hideki Kambara

发明人： Minoru Sakairi ,  Hideki Kambara

IPC分类号： G01N27/62 ,  G01N30/30 ,  G01N30/72 ,  H01J49/04 ,  H01J49/10 ,  H01J49/26

CPC分类号： H01J49/0468 ,  G01N30/7246 ,  G01N30/7253 ,  G01N30/7266 ,  G01N30/7293 ,  H01J49/0445 ,  G01N2030/3038

摘要： A mass spectrometer which comprises an ion source for ionizing a sample and a mass analyzing region for introducing the thus formed ions into a vacuum and mass analyzing the ions, the ion source being provided with a spray ion source comprising a heatable capillary working at least under the atmospheric pressure, the center axis of the capillary being aligned along the center of an aperture for withdrawing the ions and the tip end of the capillary being positioned close to the aperture ionizes a sample from a liquid chromatograph by both atmospheric pressure ionization mode and a thermospray ionization mode and mass analyze the ions, thereby obtaining more exact analytical information on the sample.

摘要翻译： 一种质谱仪，其包括用于离子化样品的离子源和用于将如此形成的离子引入真空并质量分析离子的质量分析区域，所述离子源设置有喷射离子源，所述喷雾离子源包括至少在下面工作的可加热毛细管 大气压力，毛细管的中心轴线沿着用于取出离子的孔的中心对准，并且靠近孔的位置的毛细管的末端将气相色谱仪的样品从大气压电离模式和 热离子电离模式和质量分析离子，从而获得更准确的样品分析信息。

公开(公告)号：US4570068A

公开(公告)日：1986-02-11

申请号：US550973

申请日：1983-11-14

申请人： Minoru Sakairi ,  Hideki Kambara

发明人： Minoru Sakairi ,  Hideki Kambara

IPC分类号： G01N27/62 ,  G01N30/72 ,  H01J49/04 ,  B01D59/44

CPC分类号： H01J49/0454 ,  G01N30/7246

摘要： An interface for liquid chromatograph/mass spectrometer (LC/MS) comprises a liquid chromatograph, an atomizing means for successively atomizing an effluent from the liquid chromatograph, and a mass spectrometer for mass-analyzing samples from the atomizing means, where the atomizing means comprises a conical horn and an ultrasonic vibrator. The conical horn has, along its center line, a perforation for passing the effluent. The ultrasonic vibrator is of a doughnut type and is provided around the conical horn and partly in close contact with the conical horn. Mists generated at the end of the conical horn are carried into the ion source of the mass spectrometer together with a carrier gas.

摘要翻译： 用于液相色谱仪/质谱仪（LC / MS）的界面包括液相色谱仪，用于连续雾化来自液相色谱仪的流出物的雾化装置和用于质量分析来自雾化装置的样品的质谱仪，其中雾化装置包括 锥形喇叭和超声波振子。 锥形喇叭沿其中心线具有用于通过流出物的穿孔。 超声波振动器是环形型，并且设置在圆锥形喇叭周围并且部分地与锥形喇叭紧密接触。 在锥形喇叭末端产生的雾气与载气一起被携带到质谱仪的离子源中。

公开(公告)号：US07455648B2

公开(公告)日：2008-11-25

申请号：US10788377

申请日：2004-03-01

申请人： Akihiko Kandori ,  Tsuyoshi Miyashita ,  Keiji Tsukada ,  Kenko Uchida ,  Hideo Kawaguchi ,  Minoru Sakairi

发明人： Akihiko Kandori ,  Tsuyoshi Miyashita ,  Keiji Tsukada ,  Kenko Uchida ,  Hideo Kawaguchi ,  Minoru Sakairi

IPC分类号： A61B5/103 ,  A61B5/05

CPC分类号： A61B5/1101 ,  A61B5/4082 ,  A61B5/6824 ,  A61B5/6826 ,  A61B5/6828 ,  A61B5/6838 ,  A61B5/7239

摘要： A living body inspection apparatus including an oscillation coil which passes an AC current, a detection coil which detects an AC magnetic field generated from the detection coil, an amplification circuit which amplifies a voltage generated by the magnetic field induced by the detection coil, a detecting unit for detecting the output signal of the amplification circuit, a low pass filter to which the output signal of the detecting unit is input, a unit for setting the oscillation coil and detection coil in first and second regions of the living body, a recording unit for recording the output of the low pass filter while the first region and the second region of the living body are moving and a displaying unit for displaying the data recorded in the recording unit or results of analysis of the recorded data.

摘要翻译： 一种生物体检查装置，包括通过交流电流的振荡线圈，检测由检测线圈产生的交流磁场的检测线圈，放大电路，放大电路，放大由检测线圈感应出的磁场产生的电压， 用于检测放大电路的输出信号的单元，输入检测单元的输出信号的低通滤波器，用于在生物体的第一和第二区域设置振荡线圈和检测线圈的单元，记录单元 用于在活体的第一区域和第二区域移动时记录低通滤波器的输出，以及用于显示记录在记录单元中的数据的显示单元或记录数据的分析结果。

公开(公告)号：US20050065422A1

公开(公告)日：2005-03-24

申请号：US10788377

申请日：2004-03-01

申请人： Akihiko Kandori ,  Tsuyoshi Miyashita ,  Keiji Tsukada ,  Kenko Uchida ,  Hideo Kawaguchi ,  Minoru Sakairi

发明人： Akihiko Kandori ,  Tsuyoshi Miyashita ,  Keiji Tsukada ,  Kenko Uchida ,  Hideo Kawaguchi ,  Minoru Sakairi

IPC分类号： A61B5/05 ,  A61B5/11 ,  A61B5/00

CPC分类号： A61B5/1101 ,  A61B5/4082 ,  A61B5/6824 ,  A61B5/6826 ,  A61B5/6828 ,  A61B5/6838 ,  A61B5/7239

摘要： A living body inspection apparatus including an oscillation coil which passes an AC current, a detection coil which detects an AC magnetic field generated from the detection coil, an amplification circuit which amplifies a voltage generated by the magnetic field induced by the detection coil, a detecting unit for detecting the output signal of the amplification circuit, a low pass filter to which the output signal of the detecting unit is input, a unit for setting the oscillation coil and detection coil in first and second regions of the living body, a recording unit for recording the output of the low pass filter while the first region and the second region of the living body are moving and a displaying unit for displaying the data recorded in the recording unit or results of analysis of the recorded data.

摘要翻译： 一种生物体检查装置，包括通过交流电流的振荡线圈，检测由检测线圈产生的交流磁场的检测线圈，放大电路，放大电路，放大由检测线圈感应出的磁场产生的电压， 用于检测放大电路的输出信号的单元，输入检测单元的输出信号的低通滤波器，用于在生物体的第一和第二区域设置振荡线圈和检测线圈的单元;记录单元 用于在活体的第一区域和第二区域移动时记录低通滤波器的输出，以及用于显示记录在记录单元中的数据的显示单元或记录数据的分析结果。

公开(公告)号：US06649910B2

公开(公告)日：2003-11-18

申请号：US10232718

申请日：2002-09-03

申请人： Minoru Sakairi

发明人： Minoru Sakairi

IPC分类号： H01J4910

CPC分类号： H01J49/168 ,  H01J49/0468

摘要： For measuring dioxins and organic nitro compounds with high sensitivity while reducing complexity, efficiently ionize a sample using negative corona discharge; then, make use of a mass spectrometer to measure negatively charged ions produced.

公开(公告)号：US06483108B1

公开(公告)日：2002-11-19

申请号：US09293886

申请日：1999-04-19

申请人： Minoru Sakairi

发明人： Minoru Sakairi

IPC分类号： H01J4910

CPC分类号： H01J49/168 ,  H01J49/0468

摘要： For measuring dioxins and organic nitro compounds with high sensitivity while reducing complexity, efficiently ionize a sample using negative corona discharge; then, make use of a mass spectrometer to measure negatively charged ions produced.

摘要翻译： 为了在降低复杂性的同时测量高灵敏度的二恶英和有机硝基化合物，可以使用负电晕放电有效地离子化样品; 然后，使用质谱仪来测量产生的带负电荷的离子。

公开(公告)号：US06392226B1

公开(公告)日：2002-05-21

申请号：US09254718

申请日：1999-03-12

申请人： Yasuaki Takada ,  Takayuki Nabeshima ,  Minoru Sakairi ,  Yukiko Hirabayashi

发明人： Yasuaki Takada ,  Takayuki Nabeshima ,  Minoru Sakairi ,  Yukiko Hirabayashi

IPC分类号： B01D5944

CPC分类号： H01J49/424 ,  H01J49/4265

摘要： Disclosed is a mass spectrometer having an ion trap type mass spectrometric unit, characterized in that in each of ion storage periods, ions created in an ion source (7) are allowed to enter in a space surrounded by a ring electrode (21) and end cap electrodes (22a and 22b) and are confined in the space, wherein ions are detected with high sensitivities in a wide range of values of m/z (molecular weight of ion/valence number of ion) of the ions by changing the amplitude of a high-frequency voltage applied to the ring electrode (21) in each of the ion storage periods.

摘要翻译： 公开了一种具有离子阱型质谱仪的质谱仪，其特征在于，在每个离子储存期间，使离子源（7）中产生的离子进入由环形电极（21）包围的空间中，并且结束 盖电极（22a和22b）并且被限制在该空间中，其中通过改变离子的振幅在m / z（离子的分子量/离子的离子数/离子数）离子的宽范围值中以高灵敏度检测离子 在每个离子储存期间施加到环形电极（21）的高频电压。

公开(公告)号：US06188065B1

公开(公告)日：2001-02-13

申请号：US09260552

申请日：1999-03-02

申请人： Yasuaki Takada ,  Minoru Sakairi ,  Atsumu Hirabayashi ,  Hideaki Koizumi

发明人： Yasuaki Takada ,  Minoru Sakairi ,  Atsumu Hirabayashi ,  Hideaki Koizumi

IPC分类号： G01D5944

CPC分类号： H01J49/145 ,  H01J49/0431 ,  H01J49/049 ,  H01J49/165 ,  H01J49/168

摘要： A mass spectrometer includes a sample supplier which supplies a sample solution, the sample solution including a solvent, ions, and a solute, the solute being a sample to be analyzed, an ion converter, disposed after the sample supplier, which converts the ions in the sample solution into gaseous ions, an ion source, disposed after the ion converter, which ionizes the sample in the sample solution, thereby producing sample ions, a mass analyzer which analyzes masses of the sample ions produced by the ion source, and an ion blocking electrode which prevents the gaseous ions produced by the ion converter from reaching the ion source, thereby preventing the mass analyzer from analyzing masses of the gaseous ions produced by the ion converter.

摘要翻译： 质谱仪包括供样品溶液的样品供应商，包含溶剂的样品溶液，离子和溶质，作为待分析样品的溶质，设置在样品供应者之后的离子转化器，其将离子转化为 将样品溶液变成气态离子，离子源，设置在离子转换器之后，将样品溶液中的样品离子化，从而产生样品离子;分析质量分析器，其分析由离子源产生的样品离子的质量;以及离子 阻止由离子转换器产生的气体离子到达离子源的阻挡电极，从而防止质量分析器分析由离子转换器产生的气态离子的质量。