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    Medical system for monitoring a measured value of a patient relating to blood-clotting
    32.
    发明授权
    Medical system for monitoring a measured value of a patient relating to blood-clotting 有权
    用于监测与血液凝固有关的患者的测量值的医疗系统

    公开(公告)号：US06730026B2

    公开(公告)日：2004-05-04

    申请号：US10056409

    申请日：2002-01-25

    申请人： Tilo Christ ,  Arne Hengerer ,  Volker Schmidt ,  Werner Striebel

    发明人： Tilo Christ ,  Arne Hengerer ,  Volker Schmidt ,  Werner Striebel

    IPC分类号： A61B500

    CPC分类号： A61B5/0002 ,  G06F19/00 ,  G06F19/3418 ,  G06F19/3456 ,  G16H10/60 ,  G16H40/63 ,  G16H50/20 ,  Y10S128/92

    摘要： A medical system for monitoring a measured value of a patient characterizing blood clotting and/or for setting a medication that influences blood clotting for a patient in a home environment, has a device for acquiring measured values of the patient relating to blood clotting, a device for transmitting the measured values to a system central, a device for interrogating the measured values, and a reception device at a monitoring person. The system central has a memory for the measured values, an analysis device for the measured values by comparing the measured values to stored reference values, an alarm generator which generates an alarm signal upon a recognition of predetermined conditions, and a routing device for forwarding the alarm signal to a reception device of a person to be alerted in a process chain.

    摘要翻译： 用于监测表征血液凝固的患者的测量值和/或用于设定在家庭环境中影响患者的血液凝固的药物的医疗系统具有用于获取与血液凝结有关的患者的测量值的装置， 用于将测量值发送到系统中心，用于询问测量值的设备，以及监视人员处的接收设备。 系统中心具有用于测量值的存储器，通过将测量值与存储的参考值进行比较来测量值的分析装置，在识别预定条件时产生报警信号的报警发生器，以及用于转发 向处理链中要通知的人的接收装置发出警报信号。

    Network for evaluating data obtained in a biochip measurement device
    33.
    发明授权
    Network for evaluating data obtained in a biochip measurement device 失效
    用于评估在生物芯片测量装置中获得的数据的网络

    公开(公告)号：US06484104B2

    公开(公告)日：2002-11-19

    申请号：US09784571

    申请日：2001-02-15

    申请人： Klaus Abraham-Fuchs ,  Arne Hengerer ,  Norbert Windhab ,  Kieran Gallahue ,  James P. O'Conell ,  Greg Gosch

    发明人： Klaus Abraham-Fuchs ,  Arne Hengerer ,  Norbert Windhab ,  Kieran Gallahue ,  James P. O'Conell ,  Greg Gosch

    IPC分类号： G06F300

    CPC分类号： G16H10/40 ,  G06F19/00 ,  G06F19/20 ,  G16H50/20

    摘要： In a network and a method for evaluating medical data, a disposable biochip is provided which contains a patient sample with multiple biomolecular markers, as well as a biochip identifier which characterizes the biochip. The biochip is inserted into a point of care test device, which reads the biochip identifier. The point of care test device transmits the data characterizing the biochip to a remote server having access to a data bank in which a large number of measurement protocols are stored, and which selects one of the measurement protocols for testing the sample based on the transmitted data characterizing the biochip. The measurement protocol is transmitted back to the point of care test device via the data link, where the sample is tested using the measurement protocol. The test results are evaluated in an expert system, and a diagnostic result is displayed at the point of care test device.

    摘要翻译： 在网络和用于评估医疗数据的方法中，提供了包含具有多个生物分子标记的患者样本以及表征生物芯片的生物芯片标识符的一次性生物芯片。 将生物芯片插入护理测试装置，读取生物芯片标识符。 护理测试设备的点将表征生物芯片的数据发送到具有访问其中存储大量测量协议的数据库的远程服务器，并且基于所发送的数据选择用于测试样本的测量协议之一 表征生物芯片。 测量协议通过数据链路传输回到护理测试设备的位置，其中使用测量协议对样本进行测试。 测试结果在专家系统中进行评估，诊断结果显示在护理测试设备的位置。

    Apparatus and method for determining the position of a medical instrument
    35.
    发明申请
    Apparatus and method for determining the position of a medical instrument 审中-公开
    用于确定医疗器械位置的装置和方法

    公开(公告)号：US20160073926A1

    公开(公告)日：2016-03-17

    申请号：US14854649

    申请日：2015-09-15

    申请人： David Grodzki ,  Annemarie Hausotte ,  Björn Heismann ,  Arne Hengerer ,  Mark-Aleksi Keller-Reichenbecher ,  Sebastian Schmidt

    发明人： David Grodzki ,  Annemarie Hausotte ,  Björn Heismann ,  Arne Hengerer ,  Mark-Aleksi Keller-Reichenbecher ,  Sebastian Schmidt

    IPC分类号： A61B5/06 ,  A61B5/00 ,  A61B5/055

    CPC分类号： A61B5/062 ,  A61B5/055 ,  A61B5/7425

    摘要： An apparatus for determining a position of a medical instrument within a patient receiving zone of a magnetic resonance tomography device is provided. The apparatus includes a sensor and a computing and control device. The sensor is arranged on or in the medical instrument, includes at least one magnetic field sensor for obtaining measured values of a magnetic flux density, and may be connected to the computing and control device for data transfer purposes. The computing and control device is embodied to control magnetic fields of the magnetic resonance tomography device and to determine the position of the medical instrument. The measured values of the at least one magnetic field sensor and control signals for controlling the magnetic fields of the magnetic resonance tomography device are included in the determination of the position of the medical instrument.

    摘要翻译： 提供了一种用于确定医疗器械在磁共振断层摄影装置的患者接收区域内的位置的装置。 该装置包括传感器和计算和控制装置。 传感器布置在医疗器械上或其中，包括用于获得磁通密度的测量值的至少一个磁场传感器，并且可以连接到计算和控制装置用于数据传输目的。 计算和控制装置被实现为控制磁共振断层摄影装置的磁场并确定医疗器械的位置。 用于控制磁共振断层摄影装置的磁场的至少一个磁场传感器的测量值和控制信号被包括在医疗仪器的位置的确定中。

    Tracking of bone marrow cells for metastasis screening
    36.
    发明授权
    Tracking of bone marrow cells for metastasis screening 失效
    跟踪骨髓细胞进行转移筛选

    公开(公告)号：US08747839B2

    公开(公告)日：2014-06-10

    申请号：US12974214

    申请日：2010-12-21

    申请人： Christian Geppert ,  Arne Hengerer ,  Sven Meyburg ,  Sebastian Schmidt ,  Susanne Schmolke ,  Ralph Markus Wirtz

    发明人： Christian Geppert ,  Arne Hengerer ,  Sven Meyburg ,  Sebastian Schmidt ,  Susanne Schmolke ,  Ralph Markus Wirtz

    IPC分类号： A01N63/02 ,  A61K35/32 ,  A61K51/02 ,  A61B5/055

    CPC分类号： G01N33/574 ,  A61K49/1896 ,  A61K51/1203 ,  C12N5/0669 ,  C12N2503/00

    摘要： At least one embodiment of the invention relates to bone marrow precursor cells or bone marrow cells of a patient, the cells labeled with at least one contrast agent suitable for an imaging method, for use in an imaging method for diagnosing a metastasizing cancer, wherein the local accumulation of the labeled precursor cells or bone marrow cells indicates the presence of a metastasizing tumor growth. At least one embodiment also relates to a method for imaging a metastasizing tumor tissue in a patient, wherein a) bone marrow precursor cells or bone marrow cells are extracted from a patient, b) these precursor cells or bone marrow cells are labeled with at least one contrast agent suitable for an imaging method, c) the precursor cells or bone marrow cells thus labeled are retransplanted or reinjected into the patient, and d) the presence of metastasizing tumor cells is depicted with an imaging method. At least one embodiment also relates a method for imaging a metastasizing tumor tissue, wherein a suitable imaging method is used to image bone marrow precursor cells and/or bone marrow cells that are accumulated in a metastasizing tumor tissue and labeled with at least one contrast agent suitable for an imaging method.

    摘要翻译： 本发明的至少一个实施方案涉及患者的骨髓前体细胞或骨髓细胞，所述细胞用适于成像方法的至少一种造影剂标记，用于诊断转移性癌症的成像方法，其中 标记的前体细胞或骨髓细胞的局部积累表明存在转移性肿瘤生长。 至少一个实施方案还涉及用于对患者的转移性肿瘤组织进行成像的方法，其中a）从患者中提取骨髓前体细胞或骨髓细胞，b）至少标记这些前体细胞或骨髓细胞 一种适用于成像方法的造影剂，c）将如此标记的前体细胞或骨髓细胞重新移植或重新注入患者体内，d）用成像方法描绘转移肿瘤细胞的存在。 至少一个实施方案还涉及用于成像转移肿瘤组织的方法，其中使用合适的成像方法来成像骨髓前体细胞和/或骨髓细胞，所述骨髓前体细胞和/或骨髓细胞积聚在转移肿瘤组织中并用至少一种造影剂 适合成像方法。

    Vessel size imaging for antiangiogenic therapy
    37.
    发明授权
    Vessel size imaging for antiangiogenic therapy 有权
    抗血管生成治疗的血管尺寸成像

    公开(公告)号：US08195275B2

    公开(公告)日：2012-06-05

    申请号：US12124681

    申请日：2008-05-21

    申请人： Stefan Zwick ,  Ralph Strecker ,  Fabian Kiessling ,  Arne Hengerer ,  Sebastian Schmidt

    发明人： Stefan Zwick ,  Ralph Strecker ,  Fabian Kiessling ,  Arne Hengerer ,  Sebastian Schmidt

    IPC分类号： A61B5/055 ,  G06K9/00

    CPC分类号： A61B5/055 ,  A61B5/0515 ,  G06T7/60

    摘要： A system and method of evaluating the effectiveness of antiangionetic therapy is described. A patient or test animal is treated with an antiangionetic substance. Magnetic resonance imaging data is obtained prior to and subsequent to the treatment. The parameters of the imaging process are configured so that, by administering a intravascular contrast agent, the relative size of the microvascular and the total vascular volumes in a region of interest may be obtained, so as to form a vascular size index. The value of the vascular size index and other pharmacokinetic data obtained by the administration of a diffusible contrast agent are used to assess the efficacy of the treatment or the antiangionetic substance being studied.

    摘要翻译： 描述了评估抗血管治疗疗效的系统和方法。 患者或测试动物用抗血友病药物治疗。 在治疗之前和之后获得磁共振成像数据。 成像过程的参数被配置为使得通过施用血管内造影剂可以获得感兴趣区域中的微血管的相对大小和总血管体积，从而形成血管尺寸指数。 使用通过施用可扩散造影剂获得的血管尺寸指数和其他药代动力学数据的值来评估所研究的治疗或抗血小球药物的功效。

    Contrast Agents For Detecting Protease Activity By Means Of Hyperpolarization And For Stratifying Patients
    38.
    发明申请
    Contrast Agents For Detecting Protease Activity By Means Of Hyperpolarization And For Stratifying Patients 审中-公开
    用于通过超极化和分层患者检测蛋白酶活性的对比剂

    公开(公告)号：US20110229414A1

    公开(公告)日：2011-09-22

    申请号：US13013127

    申请日：2011-01-25

    申请人： Christian Geppert ,  Arne Hengerer ,  Sven Meyburg ,  Sebastian Schmidt ,  Susanne Schmolke ,  Ralph Markus Wirtz

    发明人： Christian Geppert ,  Arne Hengerer ,  Sven Meyburg ,  Sebastian Schmidt ,  Susanne Schmolke ,  Ralph Markus Wirtz

    IPC分类号： A61K49/08 ,  C07K2/00 ,  A61K49/00 ,  C07K7/06 ,  A61P43/00

    CPC分类号： A61K49/06

    摘要： A contrast agent is disclosed for imaging methods. In at least one embodiment the contrast agent includes a construct including i) at least two copies of a substrate for at least one tumor-specific protease, and ii) at least one linker having at least one recognition site for at least one tumor-specific protease, wherein a hyperpolarization site is located at the N and/or C terminus of the substrate, and wherein the linker is configured such that the hydrophobic ends of the substrate interact and form a central core by means of noncovalent interactions with the lipophilic residues, and the contrast agent together with a parahydrogen metal template for use in an imaging method for diagnosing a tumor. At least one embodiment of the invention further relates to a method for imaging a tumor tissue, wherein the above-described contrast agent accumulated in a tumor tissue is imaged using a suitable imaging method after hyperpolarization by way of contact with a parahydrogen metal template, and also to a method for imaging a tumor tissue in a patient, wherein a) a contrast agent as described above is administered to a patient, b) a parahydrogen metal template is administered to the patient, and c) the presence of a tumor is depicted using an imaging method.

    摘要翻译： 公开了用于成像方法的造影剂。 在至少一个实施方案中，造影剂包括构建体，其包括i）用于至少一种肿瘤特异性蛋白酶的底物的至少两个拷贝，和ii）至少一个具有至少一个肿瘤特异性的识别位点的接头 蛋白酶，其中超极化位点位于底物的N和/或C末端，并且其中接头被配置为使得底物的疏水末端通过与亲脂性残基的非共价相互作用相互作用并形成中心核心， 和造影剂以及用于诊断肿瘤的成像方法中的副氢金属模板。 本发明的至少一个实施方案还涉及一种用于对肿瘤组织进行成像的方法，其中通过与超临界金属模板的接触在超极化之后，使用合适的成像方法将累积在肿瘤组织中的上述造影剂成像，并且 还涉及对患者的肿瘤组织进行成像的方法，其中a）对患者施用如上所述的造影剂，b）向患者施用副氢金属模板，和c）描绘肿瘤的存在 使用成像方法。

    TRACKING OF BONE MARROW CELLS FOR METASTASIS SCREENING
    39.
    发明申请
    TRACKING OF BONE MARROW CELLS FOR METASTASIS SCREENING 失效
    跟踪用于METASTASIS筛选的骨髓细胞

    公开(公告)号：US20110150758A1

    公开(公告)日：2011-06-23

    申请号：US12974214

    申请日：2010-12-21

    申请人： Christian Geppert ,  Arne Hengerer ,  Sven Meyburg ,  Sebastian Schmidt ,  Susanne Schmolke ,  Ralph Markus Wirtz

    发明人： Christian Geppert ,  Arne Hengerer ,  Sven Meyburg ,  Sebastian Schmidt ,  Susanne Schmolke ,  Ralph Markus Wirtz

    IPC分类号： A61K51/02 ,  C12N5/071 ,  A61K49/08 ,  C12Q1/02 ,  B82Y15/00

    CPC分类号： G01N33/574 ,  A61K49/1896 ,  A61K51/1203 ,  C12N5/0669 ,  C12N2503/00

    摘要： At least one embodiment of the invention relates to bone marrow precursor cells or bone marrow cells of a patient, the cells labeled with at least one contrast agent suitable for an imaging method, for use in an imaging method for diagnosing a metastasizing cancer, wherein the local accumulation of the labeled precursor cells or bone marrow cells indicates the presence of a metastasizing tumor growth. At least one embodiment also relates to a method for imaging a metastasizing tumor tissue in a patient, wherein a) bone marrow precursor cells or bone marrow cells are extracted from a patient, b) these precursor cells or bone marrow cells are labeled with at least one contrast agent suitable for an imaging method, c) the precursor cells or bone marrow cells thus labeled are retransplanted or reinjected into the patient, and d) the presence of metastasizing tumor cells is depicted with an imaging method. At least one embodiment also relates a method for imaging a metastasizing tumor tissue, wherein a suitable imaging method is used to image bone marrow precursor cells and/or bone marrow cells that are accumulated in a metastasizing tumor tissue and labeled with at least one contrast agent suitable for an imaging method.

    摘要翻译： 本发明的至少一个实施方案涉及患者的骨髓前体细胞或骨髓细胞，所述细胞用适于成像方法的至少一种造影剂标记，用于诊断转移性癌症的成像方法，其中 标记的前体细胞或骨髓细胞的局部积累表明存在转移性肿瘤生长。 至少一个实施方案还涉及用于对患者的转移性肿瘤组织进行成像的方法，其中a）从患者中提取骨髓前体细胞或骨髓细胞，b）至少标记这些前体细胞或骨髓细胞 一种适用于成像方法的造影剂，c）将如此标记的前体细胞或骨髓细胞重新移植或重新注入患者体内，d）用成像方法描绘转移肿瘤细胞的存在。 至少一个实施方案还涉及用于成像转移肿瘤组织的方法，其中使用合适的成像方法来成像骨髓前体细胞和/或骨髓细胞，所述骨髓前体细胞和/或骨髓细胞积聚在转移肿瘤组织中并用至少一种造影剂 适合成像方法。