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公开(公告)号：US20130004479A1
公开(公告)日：2013-01-03
申请号：US13609504
申请日：2012-09-11
申请人： Robert Dicosimo , Arie Ben-Bassat , William R. Cahill , David George Dipietro , Eugenia Costa Hann , Mark S. Payne , Richard Alan Reynolds , Raymond Richard Zolandz
发明人： Robert Dicosimo , Arie Ben-Bassat , William R. Cahill , David George Dipietro , Eugenia Costa Hann , Mark S. Payne , Richard Alan Reynolds , Raymond Richard Zolandz
CPC分类号： C12N9/18 , A61L2/183 , A61L2/186 , A61L2/22 , A61L2202/24 , C11D3/06 , C11D3/10 , C11D3/201 , C11D3/2017 , C11D3/2044 , C11D3/2048 , C11D3/2068 , C11D3/2079 , C11D3/2082 , C11D3/2086 , C11D3/2093 , C11D3/221 , C11D3/226 , C11D3/32 , C11D3/361 , C11D3/38636 , C11D3/3947 , C11D17/041 , C12P7/40 , C12Y301/01001 , Y02E50/16
摘要： Disclosed herein are multi-component formulations for enzymatically producing aqueous solutions of peroxycarboxylic acids suitable for use in, e.g., disinfectant and/or bleaching applications. The multi-component peroxycarboxylic acid formulations comprise at least one carbohydrate esterase family 7 enzyme having perhydrolytic activity.
摘要翻译： 本文公开了用于酶促生产适用于例如消毒剂和/或漂白应用的过氧羧酸的水溶液的多组分制剂。 多组分过氧羧酸制剂包含至少一种具有过水解活性的碳水化合物酯酶家族7酶。
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公开(公告)号：US08334120B2
公开(公告)日：2012-12-18
申请号：US13248260
申请日：2011-09-29
申请人： Robert Dicosimo , Mark S. Payne , Tyler Yin
发明人： Robert Dicosimo , Mark S. Payne , Tyler Yin
CPC分类号： C12N9/18 , A61L2/183 , A61L2/186 , A61L2/22 , A61L2202/24 , C11D3/06 , C11D3/10 , C11D3/201 , C11D3/2017 , C11D3/2044 , C11D3/2048 , C11D3/2068 , C11D3/2079 , C11D3/2082 , C11D3/2086 , C11D3/2093 , C11D3/221 , C11D3/226 , C11D3/32 , C11D3/361 , C11D3/38636 , C11D3/3947 , C11D17/041 , C12P7/40 , C12Y301/01001 , Y02E50/16
摘要： Disclosed herein are variants enzymes that are structurally classified as CE-7 enzymes and have perhydrolysis activity. Also disclosed herein is a process for producing peroxycarboxylic acids from carboxylic acid esters using the aforementioned variant enzymes as well as methods and compositions comprising the variant enzymes. Further, disinfectant formulations comprising the peroxycarboxylic acids produced by the processes described herein are provided.
摘要翻译： 本文公开了在结构上分类为CE-7酶并具有过水解活性的变体酶。 本文还公开了使用上述变体酶从羧酸酯生产过氧羧酸的方法以及包含变体酶的方法和组合物。 此外，提供包含通过本文所述方法产生的过氧羧酸的消毒剂制剂。
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公开(公告)号：US08293792B2
公开(公告)日：2012-10-23
申请号：US12722302
申请日：2010-03-11
CPC分类号： A01N37/02 , A01N37/16 , A01N37/36 , A01N59/00 , A61L2/186 , C12P7/40 , C12P7/62 , A01N63/02 , A01N2300/00
摘要： A process is provided for producing peroxycarboxylic acids from carboxylic acid esters. More specifically, carboxylic acid esters are reacted with an inorganic peroxide, such as hydrogen peroxide, in the presence of an enzyme catalyst having perhydrolysis activity. The present perhydrolase catalysts are classified as members of the carbohydrate esterase family 7 (CE-7) based on the conserved structural features. Further, disinfectant formulations comprising the peracids produced by the processes described herein are provided.
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公开(公告)号：US08148314B2
公开(公告)日：2012-04-03
申请号：US13213642
申请日：2011-08-19
CPC分类号： C12N9/18 , A61L2/183 , A61L2/186 , A61L2/22 , A61L2202/24 , C11D3/06 , C11D3/10 , C11D3/201 , C11D3/2017 , C11D3/2044 , C11D3/2048 , C11D3/2068 , C11D3/2079 , C11D3/2082 , C11D3/2086 , C11D3/2093 , C11D3/221 , C11D3/226 , C11D3/32 , C11D3/361 , C11D3/38636 , C11D3/3947 , C11D17/041 , C12P7/40 , C12Y301/01001 , Y02E50/16
摘要： Disclosed herein is a method for stabilization of the perhydrolase activity of the CE-7 esterase in a formulation with a carboxylic acid ester that employs the addition of a buffering agent, substantially undissolved, to the mixture of the CE-7 esterase and the carboxylic acid ester. Further, disinfectant and laundry care formulations comprising the peracids produced by the processes described herein are provided.
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公开(公告)号：US20110312053A1
公开(公告)日：2011-12-22
申请号：US13162631
申请日：2011-06-17
CPC分类号： C12P7/16 , A23K10/38 , B01D3/002 , B01D11/0492 , B01D21/26 , B01D21/262 , C07C29/86 , C11B1/025 , C11B13/00 , C12F3/10 , C12M1/00 , C12M21/12 , C12M45/04 , C12M45/09 , C12N1/14 , C12N15/00 , C12P7/18 , C12P7/6418 , Y02E50/10 , Y02E50/16 , Y02E50/17 , Y02W30/74
摘要： Fatty acids derived from biomass at a step in a fermentation process can be added to a fermentation medium comprising a recombinant microorganism that produces a product alcohol. At least one of growth rate and fermentable carbon consumption of the microorganism is greater in the presence of the fatty acids than the growth rate and the fermentable carbon consumption of the microorganism in the absence of the fatty acids. The addition of the fatty acids can increase glucose consumption, and can improve microorganism biomass production (cell growth/density) and growth rate, thereby reducing production time and increasing productivity of the fermentation process.
摘要翻译： 在发酵过程中的步骤中衍生自生物质的脂肪酸可以加入到包含产生产物醇的重组微生物的发酵培养基中。 在存在脂肪酸的情况下，微生物的生长速率和可发酵碳消耗量中的至少一种比在不存在脂肪酸时微生物的生长速率和可发酵碳消耗量更大。 脂肪酸的添加可以增加葡萄糖消耗，并且可以改善微生物生物量的生产（细胞生长/密度）和生长速率，从而减少生产时间并提高发酵过程的生产率。
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公开(公告)号：US20110236335A1
公开(公告)日：2011-09-29
申请号：US13070123
申请日：2011-03-23
IPC分类号： C12P7/40 , C12N15/63 , C12N1/00 , C12N9/18 , C07H21/04 , C12M1/40 , A01N37/16 , D21C9/16 , A61L2/16 , D06L3/02 , A01P1/00
CPC分类号： C12N9/18 , C11D3/38636 , C11D3/3945 , C12P7/40 , D21C5/005 , D21C9/1036
摘要： An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.
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公开(公告)号：US20110150857A1
公开(公告)日：2011-06-23
申请号：US13036763
申请日：2011-02-28
IPC分类号： A01N63/02 , A01N37/16 , A01P1/00 , C11D7/54 , C11D7/60 , C12N9/18 , C12P7/40 , C12M1/00 , D21H21/32 , C09K3/00
摘要： An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in the ratio of peracetic acid formation to peracetic acid hydrolysis specific activities (PAAF/PAAH ratio). The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.
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38.发明申请公开(公告)号：US20080032371A1
公开(公告)日：2008-02-07
申请号：US11485575
申请日：2006-07-12
申请人： Robert Dicosimo , Sharon L. Haynie , Lixuan Lisa Huang , Fateme Sima Sariaslani , Robert J. Trotman , Tina K. Van Dyk
发明人： Robert Dicosimo , Sharon L. Haynie , Lixuan Lisa Huang , Fateme Sima Sariaslani , Robert J. Trotman , Tina K. Van Dyk
摘要： TAL cell biocatalyst was immobilized in alginate cross-linked beads using low concentrations of glutaraldehyde. The biocatalyst beads have highly stable TAL activity and mechanical strength such that they withstand prolonged recycling in production of pHCA.
摘要翻译： 使用低浓度戊二醛将TAL细胞生物催化剂固定在藻酸盐交联珠粒中。 生物催化剂珠具有高度稳定的TAL活性和机械强度，使得它们在pHCA的生产中经受长时间的再循环。
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公开(公告)号：US20070004017A1
公开(公告)日：2007-01-04
申请号：US11516408
申请日：2006-09-05
申请人： Michael Bramucci , Robert Dicosimo , Robert Fallon , John Gavagan , Frank Herkes , Lech Wilczek
发明人： Michael Bramucci , Robert Dicosimo , Robert Fallon , John Gavagan , Frank Herkes , Lech Wilczek
摘要： This invention relates to a process for the preparation of a 3-hydroxycarboxylic acid from a 3-hydroxynitrile. More specifically, 3-hydroxyvaleronitrile is converted to 3-hydroxyvaleric acid in high yield at up to 100% conversion, using as an enzyme catalyst 1) nitrile hydratase activity and amidase activity or 2) nitrilase activity of a microbial cell. 3-Hydroxyvaleric acid is used as a substitute for ε-caprolactone in the preparation of highly branched copolyester.
摘要翻译： 本发明涉及一种由3-羟基腈制备3-羟基羧酸的方法。 更具体地，使用酶催化剂1）腈水合酶活性和酰胺酶活性或2）微生物细胞的腈水解酶活性，将3-羟基戊腈以高产率转化为3-羟基戊酸。 3-羟基戊酸用于制备高支化共聚酯中的ε-己内酯的替代物。
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40.发明授权Process for the enzymatic resolution of N-(alkoxycarbonyl)-4-ketoproline alkyl esters or N-(alkoxycarbonyl)-4-hydroxyproline alkyl esters using Candida antarctica lipase B 失效使用南极假丝酵母脂肪酶B酶解拆分N-（烷氧基羰基）-4-酮脯氨酸烷基酯或N-（烷氧基羰基）-4-羟基脯氨酸烷基酯的方法
公开(公告)号：US5928933A
公开(公告)日：1999-07-27
申请号：US105713
申请日：1998-06-26
申请人： Robert Dicosimo , Wonpyo Hong
发明人： Robert Dicosimo , Wonpyo Hong
CPC分类号： C12P41/005 , C12P13/04 , C12P13/24 , Y10S435/921
摘要： The present invention relates to a process for the enzymatic resolution of racemic mixtures of N-(alkoxycarbonyl)-4-keto-D,L-proline alkyl esters, using Candida antarctica lipase fraction B (CALB) as enzyme catalyst to enantioselectively hydrolyze the alkyl ester of one of the two enantiomers present. Separating the unreacted N-(alkoxycarbonyl)-4-keto-D-proline alkyl ester from the N-(alkoxycarbonyl)-4-keto-L-proline, followed by hydrogenation of the keto group of the D-isomer and subsequent hydrolysis of the ester and N-(alkoxy-carbonyl) groups produces cis-4-hydroxy-D-proline in high yield. Diastereomeric mixtures of N-(alkoxycarbonyl)-4-hydroxyproline alkyl esters can also be resolved using CALB to ultimately produce cis-4-hydroxy-D-proline or trans-4-hydroxy-L-proline.
摘要翻译： 本发明涉及使用南极假丝酵母脂肪酶B（CALB）作为酶催化剂来解离N-（烷氧基羰基）-4-酮基-D-脯氨酸烷基酯的外消旋混合物的方法，以对映体水解烷基 存在两种对映体之一的酯。 从N-（烷氧基羰基）-4-酮-L-脯氨酸分离未反应的N-（烷氧基羰基）-4-酮基-D-脯氨酸烷基酯，然后氢化D-异构体的酮基，随后水解 酯和N-（烷氧基 - 羰基）基团以高产率产生顺式-4-羟基-D-脯氨酸。 N-（烷氧基羰基）-4-羟基脯氨酸烷基酯的非对映异构体混合物也可以使用CALB来分解，以最终产生顺式-4-羟基-D-脯氨酸或反式-4-羟基-L-脯氨酸。
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