摘要:
Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.
摘要:
One method includes forming a sacrificial gate structure above a substrate, forming a first sidewall spacer adjacent a sacrificial gate electrode, removing a portion of the first sidewall spacer to expose a portion of the sidewalls of the sacrificial gate electrode, and forming a liner layer on the exposed sidewalls of the sacrificial gate electrode and above a residual portion of the first sidewall spacer. The method further includes forming a first layer of insulating material above the liner layer, forming a second sidewall spacer above the first layer of insulating material and adjacent the liner layer, performing an etching process to remove the second sidewall spacer and sacrificial gate cap layer to expose an upper surface of the sacrificial gate electrode, removing the sacrificial gate electrode to define a gate cavity at least partially defined laterally by the liner layer, and forming a replacement gate structure in the cavity.
摘要:
Disclosed herein is a structural sheet includes an energy storage density that is greater than 10-mWh/ft2 and is capable of withstanding greater than 5-KPa stress under at least 5% strain.
摘要翻译:本文公开了一种结构片,其包括大于10-mWh / ft 2的能量存储密度,并且能够在至少5%应变下耐受大于5KPa的应力。
摘要:
A gas turbine engine (10) having a pressure-rise combustor (30) and the pressure-rise combustor (30) is positioned upstream of a stage of turbine nozzle guide vanes (32). The vanes (33) of the stage of turbine nozzle guide vanes (32) forms an ejector and each of the vanes (33) has an upstream portion (34) and a downstream portion (36). The upstream portions (34) of the vanes (33) have leading edges (38) and the upstream portions (34) are arranged substantially straight and parallel to define constant area mixing passages (40) for a flow of gases there-through. The downstream portions (36) of the vanes (33) are arranged at an angle to the upstream portions (34) of the vanes (33) to turn the flow of gases there-through.
摘要:
A modular tile assembly having a substantially rigid substrate, at least one sealant layer, and at least one stone, ceramic, or porcelain tile. A bottom surface of a first sealant layer being bonded to an upper surface of the substrate and a top surface of a second sealant layer being bonded to a lower surface of the substrate. The tile being bonded to at least a portion of the top surface of the first sealant layer. In one example, the substrate is provided with a tongue or a groove defined in any one, combination, or each of the respective side edges of the substrate, as desired.
摘要:
The present invention is directed to baking apparatuses that are adapted for use in baking cakes, custards and other dishes that involve the use of a water bath. In a disclosed embodiment of the invention a baking apparatus is disclosed that includes an inner and outer pan, which may be formed as an integral unit. The outer pan is preferably adapted to receive and hold water and the inner pan is adapted to receive a springform containing a cheesecake batter or other mixture. The side or sides of the inner pan are preferably watertight and prevent leakage of water into the inner pan. The present invention offers the advantage of water bath baking without the problem of water from the bath leaking into the springform that contains the cake batter.
摘要:
An embodiment includes a radio frequency (RF) sensor system having a plurality of magnetoresistive (MR) sensors, where each MR sensor includes a configuration of MR elements and is adapted to produce a time-varying output voltage in response to a time-varying, external magnetic field. The RF sensor system also includes combiner circuitry, electrically coupled to the plurality of MR sensors, and adapted to receive and combine a plurality of time-varying output voltages from the plurality of MR sensors to generate a sensor output voltage. Another embodiment includes an electromagnetic sensor array having a plurality of MR sensors arranged in an array configuration, where each MR sensor includes a plurality of MR elements forming a Wheatstone bridge circuit, and where each MR sensor is adapted to produce a time-varying output voltage in response to a time-varying, external magnetic field. Still another embodiment includes a method for manufacturing an electromagnetic sensor array.
摘要:
A transition duct for a gas turbine engine typically contains one or more non-turning fairings. These fairings disturb the air flow through the duct, leading to flow separation and aerodynamic inefficiency. The invention proposes non-axisymmetric perturbations in the duct end walls to minimise these undesirable aerodynamic effects. This permits the construction of shorter and lighter transition ducts, with more pronounced curvature.
摘要:
A decorated floor panel having a core with a top surface and an opposite bottom surface; a decorative layer coupled to the top surface of the core, the decorative layer having a desired aesthetic appearance; and a wear layer coupled to and substantially covering the decorative layer for protecting the decorative layer. The wear layer has an exposed wear surface with depressions therein of a variable depth below the wear surface, the depressions being arranged to display a desired texture pattern. It is noted that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to ascertain quickly the subject matter of the technical disclosure. The abstract is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims pursuant to 37 C.F.R. § 1.72(b).