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公开(公告)号：US5252296A
公开(公告)日：1993-10-12
申请号：US652194
申请日：1991-02-06
IPC分类号： B01J19/00 , C07H21/00 , C07K1/04 , C07K7/08 , C07K14/575 , C07K16/00 , C40B40/06 , C40B40/10 , C40B60/14 , G05D7/00
CPC分类号： C07H21/00 , B01J19/0046 , C07K1/045 , C07K1/047 , B01J2219/00283 , B01J2219/00286 , B01J2219/00308 , B01J2219/00416 , B01J2219/00418 , B01J2219/00423 , B01J2219/00466 , B01J2219/00493 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00691 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B60/14
摘要： Method and apparatus for synthesizing biopolymers, such as polypeptides and polynucleotides. The apparatus includes plural reaction vessels in which subunit coupling to biopolymers in a particle suspension is carried out. The vessels are connected to common valving structure for use in mixing the suspension and removing suspension liquid. In one embodiment, a robotic arm in the apparatus is operable to transfer reaction solution to the reaction vessels, and to transfer particle suspensions from the reaction vessels to a mixing vessel and back to the reaction vessels. The method can be used to produce preferably equi-molar amounts of different-sequence biopolymers, such as polypeptides and polynucleotides.
摘要翻译： 用于合成生物聚合物的方法和装置，例如多肽和多核苷酸。 该装置包括多个反应容器，其中进行与颗粒悬浮液中的生物聚合物偶合的亚基。 容器连接到公共阀结构，用于混合悬浮液并除去悬浮液。 在一个实施例中，设备中的机器人手臂可操作以将反应溶液转移到反应容器中，并将颗粒悬浮液从反应容器转移到混合容器并返回到反应容器中。 该方法可用于产生优选等摩尔量的不同序列生物聚合物，例如多肽和多核苷酸。
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公开(公告)号：US5240680A
公开(公告)日：1993-08-31
申请号：US811162
申请日：1991-12-19
CPC分类号： C07K1/045 , B01J19/0046 , G01N35/0099 , B01J2219/00286 , B01J2219/00389 , B01J2219/00423 , B01J2219/00454 , B01J2219/00466 , B01J2219/005 , B01J2219/00691 , B01J2219/00725 , C40B40/10 , C40B50/14 , C40B60/14 , Y10T436/11
摘要： An automated apparatus for use in cleaving, deprotecting and purifying synthesized polypeptides immobilized on solid phase particles. The apparatus includes cleavage and extraction vessels where peptide cleavage from solid-phase particles, and extraction of scavenger reagents occurs, respectively, and structure for automated transfer of (i) reaction solutions into and out of the cleavage vessel, (ii) peptide solution from the cleavage vessel to the extraction vessel, and (iii) extraction solvent into the extraction vessel, in dispersed form. Excess extraction solvent is removed from a side arm in the extraction vessel.
摘要翻译： 用于切割，去保护和纯化固相在固相颗粒上的合成多肽的自动化装置。 该装置包括裂解和提取容器，其中分别从固相颗粒中切割肽和清除剂试剂的提取，以及自动转移（i）反应溶液进入和离开裂解容器的结构，（ii）肽溶液 将切割容器提取到提取容器中，和（iii）以分散形式将萃取溶剂萃取到萃取容器中。 从提取容器中的侧臂除去过量的提取溶剂。
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33.发明授权Cell transfecting formulations of small interfering RNA related compositions and methods of making and use 有权小干扰RNA相关组合物的细胞转染制剂及制备和使用方法公开(公告)号：US08772255B2
公开(公告)日：2014-07-08
申请号：US12053486
申请日：2008-03-21
IPC分类号： C12N15/113 , A61K47/48
CPC分类号： A61K47/44 , A61K31/7088 , A61K47/6909 , A61K48/00 , C07H21/04 , C12N15/111 , C12N15/113 , C12N15/1137 , C12N15/87 , C12N15/88 , C12N2310/14 , C12N2310/321 , C12N2320/32 , C12Y207/01037 , C12N2310/3521
摘要： Compositions incorporating small interfering ribonucleic acid (siRNA) and certain lipid-conjugated polyamide compound-based delivery vehicles that are particularly useful in the delivery siRNA and other polynucleotides to cells. Also, methods of making and using the compositions.
摘要翻译： 包含小干扰核糖核酸（siRNA）和某些基于脂质偶联的聚酰胺化合物的递送载体的组合物，其特别可用于递送siRNA和其它多核苷酸至细胞。 而且，制备和使用组合物的方法。
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公开(公告)号：US08673842B2
公开(公告)日：2014-03-18
申请号：US13385310
申请日：2012-02-13
IPC分类号： A61K38/00 , C07K5/00 , C07K14/785
CPC分类号： C07K14/785 , A61K38/1709 , Y10S930/32 , A61K31/74 , A61K31/685 , A61K31/66 , A61K31/20 , A61K31/195 , A61K2300/00
摘要： The present invention provides spreading agents based on sequence-specific oligomers comprising a peptoid, a peptide-peptoid chimera, a retropeptoid or a retro(peptoid-peptide) chimera, and methods for using the same, including for the treatment of respiratory distress of the lungs. The spreading agents are sequence-specific oligomers, including retrosequence-specific oligomers, based on a peptide backbone, that are designed as analogs of surfactant protein-B or surfactant protein-C.
摘要翻译： 本发明提供了基于包含拟肽，肽 - 拟肽嵌合体，retropeptoid或复古（peptoid-peptide）嵌合体的序列特异性寡聚体的铺展剂及其使用方法，包括用于治疗呼吸窘迫 肺。 扩散剂是序列特异性寡聚体，包括基于肽骨架的逆序列特异性寡聚体，其被设计为表面活性蛋白B或表面活性蛋白C的类似物。
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公开(公告)号：US20140031523A1
公开(公告)日：2014-01-30
申请号：US13898181
申请日：2013-05-20
申请人： Annelise E. Barron , Ronald N. Zuckermann , Ann M. Czyzewski , Michelle T. Dohm , Tyler M. Miller , James A. Patch , Nathaniel P. Chongsiriwatana
发明人： Annelise E. Barron , Ronald N. Zuckermann , Ann M. Czyzewski , Michelle T. Dohm , Tyler M. Miller , James A. Patch , Nathaniel P. Chongsiriwatana
IPC分类号： C07K7/06
CPC分类号： C07K7/06 , A61K38/00 , B01D71/06 , C07K5/0815 , C07K7/08 , Y02A50/473
摘要： Antimicrobial peptoid compounds and related compositions as can be used against bacteria effectively and selectively.
摘要翻译： 可以有效和有选择地使用抗菌类化合物和相关组合物。
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公开(公告)号：US20110300053A1
公开(公告)日：2011-12-08
申请号：US13153141
申请日：2011-06-03
CPC分类号： C01F11/183 , C01P2004/03 , C01P2004/30 , C01P2004/32 , C01P2004/39 , C01P2004/61 , C08G69/10 , Y10S930/03
摘要： The present invention provides for a bio-mimetic polymer capable of catalyzing CO2 into a carbonate.
摘要翻译： 本发明提供了能够将CO 2催化成碳酸盐的生物模拟聚合物。
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公开(公告)号：US20100036088A1
公开(公告)日：2010-02-11
申请号：US12378034
申请日：2009-02-09
申请人： Annelise E. Barron , Ann M. Czyzewski , Michelle T. Dohm , Tyler M. Miller , Ronald N. Zuckermann , James A. Patch , Nathaniel P. Chongsiriwatana
发明人： Annelise E. Barron , Ann M. Czyzewski , Michelle T. Dohm , Tyler M. Miller , Ronald N. Zuckermann , James A. Patch , Nathaniel P. Chongsiriwatana
IPC分类号： C07K2/00
CPC分类号： C07K7/06 , A61K38/00 , C07K5/0815 , C07K7/08
摘要： Antimicrobial peptoid compounds and related compositions as can be used against bacteria effectively and selectively.
摘要翻译： 可以有效和有选择地使用抗菌类化合物和相关组合物。
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38.发明申请CELL TRANSFECTING FORMULATIONS OF SMALL INTERFERING RNA RELATED COMPOSITIONS AND METHODS OF MAKING AND USE 有权小干扰RNA相关组合物的细胞转染制剂及其制备和使用方法公开(公告)号：US20090143322A1
公开(公告)日：2009-06-04
申请号：US12053486
申请日：2008-03-21
CPC分类号： A61K47/44 , A61K31/7088 , A61K47/6909 , A61K48/00 , C07H21/04 , C12N15/111 , C12N15/113 , C12N15/1137 , C12N15/87 , C12N15/88 , C12N2310/14 , C12N2310/321 , C12N2320/32 , C12Y207/01037 , C12N2310/3521
摘要： Compositions incorporating small interfering ribonucleic acid (siRNA) and certain lipid-conjugated polyamide compound-based delivery vehicles that are particularly useful in the delivery siRNA and other polynucleotides to cells. Also, methods of making and using the compositions.
摘要翻译： 包含小干扰核糖核酸（siRNA）和某些基于脂质偶联的聚酰胺化合物的递送载体的组合物，其特别可用于递送siRNA和其它多核苷酸至细胞。 而且，制备和使用组合物的方法。
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公开(公告)号：US07148058B2
公开(公告)日：2006-12-12
申请号：US10190433
申请日：2002-07-03
CPC分类号： B01J19/0046 , B01J2219/00387 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00725 , B01J2219/0074 , B82Y30/00 , C40B30/04 , G01N33/543 , G01N33/54386 , G01N33/545 , G01N33/552 , G01N33/553 , G01N33/6842 , G01N33/6845 , G01N2500/00
摘要： Provided are protein microarrays, their manufacture, use, and application. Protein microarrays in accordance with the present invention are useful in a variety preoteomic analyses. Various protein arrays in accordance with the present invention may immobilize large arrays of proteins that may be useful for studying protein-protein interactions to improve understanding of disease processes, facilitating drug discovery, or for identifying potential antigens for vaccine development. The protein array elements of the invention are native or modified proteins (e.g., antibodies or fusion proteins). The protein array elements may be attached directly to a organic functionalized mirrored substrate by a binding reaction between functional groups on the substrate (e.g., amine) and protein (e.g., activated carboxylic acid). Techniques for chemical blocking of the arrays are also provided. The invention contemplates spotting of array elements onto solid planar substrates, labeling of complex protein mixtures, and the analysis of protein binding to the array. The invention also enables the enrichment or purification, and subsequent sequencing or structural analysis of proteins that are identified as differential by the array screen. Kits including protein-binding microarrays for proteomic analysis in accordance with the present invention are also provided.
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公开(公告)号：US07030216B2
公开(公告)日：2006-04-18
申请号：US10117841
申请日：2002-04-05
申请人： Thomas Horn , Ronald N. Zuckermann
发明人： Thomas Horn , Ronald N. Zuckermann
IPC分类号： C07K1/00
摘要： Molecules having potential biological activity, particularly peptoids, that are conjugated to solid phase supports, spacer groups, and/or ligation moieties, and methods of their preparation, are described. In some instances, the molecules of the invention are made entirely by solid phase synthesis. In other instances, the spacer groups are hydrophilic and compositions containing them, and to solid phase synthesis of varied structure peptoids using chemoselective ligation moieties.
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