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公开(公告)号：US11262571B2
公开(公告)日：2022-03-01
申请号：US16851686
申请日：2020-04-17
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yochay Shlomo Eshel , Natalie Lezmy , Dan Gluck , Arnon Houri Yafin , Joseph Joel Pollak
Abstract: Apparatus and methods are described including staining a blood sample with one or more stains. A plurality of microscopic images of the stained blood sample are acquired, using a microscope. Staining-quality parameters for respective microscopic images are determined, using a computer processor, the staining-quality parameters being indicative of a quality of the staining within each of the respective microscopic images. An action is performed by the computer processor, based upon the staining-quality parameters of the respective microscopic images. Other applications are also described.
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公开(公告)号：US10831013B2
公开(公告)日：2020-11-10
申请号：US14914329
申请日：2014-08-26
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Noam Yorav Raphael , Yuval Greenfield , Joseph Joel Pollak , Yonatan Bilu
Abstract: Methods, systems and computer program products relating to digital microscopy are disclosed. A digital microscopy method may comprise capturing a plurality of overlapping images of a sample, wherein the capturing of at least one of the plurality of images is performed while the sample and a focal plane are in relative motion along an optical axis at a speed greater than zero; and processing the plurality of images using a reference criterion to determine a reference relative arrangement of the focal plane and the sample along the optical axis.
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公开(公告)号：US10663712B2
公开(公告)日：2020-05-26
申请号：US16657473
申请日：2019-10-18
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yochay Shlomo Eshel , Natalie Lezmy , Dan Gluck , Arnon Houri Yafin , Joseph Joel Pollak
Abstract: Apparatus and methods for analyzing a bodily sample are described. A microscope system acquires one or more microscope images of the bodily sample. A computer processor identifies, in the one or more images, at least one element as being a candidate of a given entity. The computer processor extracts, from the one or more images, at least one candidate-informative feature associated with the candidate of the given entity, and at least one sample-informative feature that is indicative of a characteristic of the bodily sample as a whole. The computer processor processes the candidate-informative feature in combination with the sample-informative feature, and generates an output upon the output device, in response thereto. Other applications are also described.
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公开(公告)号：US10093957B2
公开(公告)日：2018-10-09
申请号：US15083610
申请日：2016-03-29
Applicant: S.D. SIGHT DIAGNOSTICS LTD.
Inventor： Joseph Joel Pollak , Arnon Houri Yafin , Seth J. Salpeter
Abstract: Provided is a method for imaging a blood sample and a kit and system for executing the method. The method includes introducing a cell suspension including red blood cells onto a base surface of a carrier having a vertical height (H) being greater than or equal to a vertical depth (h) of the cell suspension when on the base carrier, the cell suspension including a cell concentration (C) being determined by a defined function; allowing the cells in the cell suspension to settle on the base surface of the carrier to form a monolayer of cells thereon; and acquiring at least one microscope image of at least a portion of the monolayer of cells; wherein the at least one microscope image is obtained by a microscope set to Depth Of Field that is not more than 20% of the vertical height of the cell suspension settled on the base surface.
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公开(公告)号：US20160279633A1
公开(公告)日：2016-09-29
申请号：US15174490
申请日：2016-06-06
Applicant: S.D. Sight Diagnostics Ltd
Inventor： Ido Bachelet , Joseph Joel Pollak , Daniel Levner , Yonatan Bilu , Noam Yorav-Raphael
Abstract: Apparatus and methods are described for use with a digital camera that is configured to acquire images of a bodily sample. Two or more stains are configured to stain the bodily sample. A computer processor drives the digital camera to acquire, for each of a plurality of imaging fields of the bodily sample, two or more digital images, at least one of the images being acquired under brightfield lighting conditions, and at least one of the images being acquired under fluorescent lighting conditions. The computer processor performs image processing on the digital images, by extracting visual classification features from the digital images and analyzing the extracted visual classification features. The computer processor outputs a result of the image processing that includes an indication of one or more entities that are contained within the sample. Other applications are also described.
Abstract translation: 描述了与被配置为获取身体样本的图像的数字照相机一起使用的装置和方法。 两个或多个污渍被配置为染色身体样品。 计算机处理器驱动数字照相机以对于身体样本的多个成像场域中的每一个采集两个或更多个数字图像，在明场照明条件下获取至少一个图像，并且至少一个图像是 在荧光照明条件下获得。 计算机处理器通过从数字图像提取视觉分类特征并分析提取的视觉分类特征，对数字图像执行图像处理。 计算机处理器输出包括样本中包含的一个或多个实体的指示的图像处理的结果。 还描述了其它应用。
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Patent Agency Ranking
公开(公告)号：US20150316477A1
公开(公告)日：2015-11-05
申请号：US14440864
申请日：2014-06-30
Applicant: S.D. SIGHT DIAGNOSTICS LTD.
Inventor： Joseph Joel Pollak , Arnon Houri Yafin , Seth J. Salpeter
CPC classification number: C12Q1/04 , G01N1/2813 , G01N1/38 , G01N15/1463 , G01N15/1475 , G01N21/6428 , G01N21/6486 , G01N33/49 , G01N2015/0065 , G01N2021/6439 , G02B21/361
Abstract: Provided is a method for imaging a blood sample and a kit and system for executing the method. The method includes introducing a cell suspension including red blood cells onto a base surface of a carrier having a vertical height (H) being greater than or equal to a vertical depth (h) of the cell suspension when on the base carrier, the cell suspension including a cell concentration (C) being determined by a defined function; allowing the cells in the cell suspension to settle on the base surface of the carrier to form a monolayer of cells thereon; and acquiring at least one microscope image of at least a portion of the monolayer of cells; wherein the at least one microscope image is obtained by a microscope set to Depth Of Field that is not more than 20% of the vertical height of the cell suspension settled on the base surface.
Abstract translation: 提供了一种用于对血液样本进行成像的方法以及用于执行该方法的套件和系统。 该方法包括在载体的基底表面上引入包含红细胞的细胞悬浮液，所述载体的垂直高度（H）大于或等于细胞悬液的垂直深度（h） 包括由定义的功能确定的细胞浓度（C）; 允许细胞悬浮液中的细胞沉淀在载体的基底表面上以在其上形成单层细胞; 以及获取细胞单层的至少一部分的至少一个显微镜图像; 其中所述至少一个显微镜图像是通过设置在深度不到所述细胞悬液沉降在所述基面上的垂直高度的20％的显微镜得到的。
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公开(公告)号：US12181463B2
公开(公告)日：2024-12-31
申请号：US17360503
申请日：2021-06-28
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Amir Zait , Arnon Houri Yafin , Dan Gluck , Sharon Pecker , Yochay Shlomo Eshel , Sarah Levy Schreier , Joseph Joel Pollak
Abstract: Apparatus and methods are described including measuring hematocrit within a blood sample, by performing a first measurement on a first portion of the blood sample. Mean corpuscular volume in the blood sample is measured, by performing a second measurement on a second portion of the blood sample, the second portion being diluted with respect to the first portion. A red blood cell count per unit volume within the blood sample is determined by dividing the hematocrit measured within the first portion by the mean corpuscular volume measured within the second portion. Other applications are also described.
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公开(公告)号：US11921272B2
公开(公告)日：2024-03-05
申请号：US16763810
申请日：2018-11-12
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Noam Yorav-Raphael , Joseph Joel Pollak , Sarah Levy Schreier , Yochay Shlomo Eshel
CPC classification number: G02B21/0076 , G01N21/6456 , G02B21/36
Abstract: Apparatus and methods are described including a sample carrier (22) configured to carry a portion of a bodily sample, at least a portion of the sample carrier being configured to fluoresce, at least under certain conditions. An optical measurement device (24) performs optical measurements upon the portion of the bodily sample that is housed within the sample carrier (22), and at least partially photobleaches an area within the portion of the sample carrier (22) by causing the area to fluoresce. By detecting that the area within the portion of the sample carrier (22) has been photobleached, an output is generated indicating that at least a portion of the sample carrier (22) is contaminated or that optical measurements cannot be performed on the portion of the sample carrier (22), or the optical measurement device (24) is prevented from performing optical measurements upon a sample portion housed within the given portion of the sample carrier (22).
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公开(公告)号：US20230342925A1
公开(公告)日：2023-10-26
申请号：US18214568
申请日：2023-06-27
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Noam YORAV-RAPHAEL , Uri Wolfovitz , Joseph Joel Pollak
CPC classification number: G06T7/0012 , G02B21/244 , G06T7/0002 , G06T7/90 , G06T2207/10056 , G06T2207/10061 , G06T2207/30072 , G06T2207/30168
Abstract: Apparatus and methods are described for use with a digital microscope unit that includes a digital microscope. A biological cell sample that is disposed within a sample carrier is received into the digital microscope unit. It is determined that there is a variation in the focal depth of the biological sample with respect to the microscope due to curvature in the sample carrier and/or due to tolerance in setup of the microscope. In response to determining that there is the variation in the focal depth of the biological sample with respect to the microscope, the variation in the focal depth of the biological sample with respect to the microscope is accounted for. Other applications are also described.
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公开(公告)号：US20230296495A1
公开(公告)日：2023-09-21
申请号：US18203109
申请日：2023-05-30
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yochay Shlomo ESHEL , Arnon Houri Yafin , Joseph Joel Pollak , Neta Bachar , Annael Marciano , Sarah Levy Schreier
CPC classification number: G01N15/1475 , G01N1/30 , G01N33/49 , G02B21/367 , G01N2015/1006
Abstract: Apparatus and methods are described for use with an output device, and a blood sample that was drawn from a subject. A microscope system acquires first and second images of the blood sample at respective times. A computer processor determines whether, between acquisitions of the first and second images, there was relative motion between at least one erythrocyte within the sample and at least one entity within the sample, by comparing the first and second images to one another. At least partially in response thereto, the computer processor determines whether the entity is an extra-erythrocytic or an intra-erythrocytic entity, and generates an output on the output device, at least partially in response thereto. Other applications are also described.
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