公开(公告)号：US08758602B2

公开(公告)日：2014-06-24

申请号：US12995010

申请日：2009-05-11

申请人： Seiichi Yamamoto ,  Takuo Shigehisa ,  Yutaka Mitou ,  Shigeru Kinoshita ,  Yuko Sugita

发明人： Seiichi Yamamoto ,  Takuo Shigehisa ,  Satoru Sugita ,  Yutaka Mitou ,  Shigeru Kinoshita

IPC分类号： C10G1/00 ,  C10G1/04

CPC分类号： C10G1/045 ,  C10G1/00 ,  C10G1/04 ,  C10L9/08 ,  C10L9/10

摘要： A method of upgrading coal which comprises: pulverizing low-grade coal; mixing the pulverized low-grade coal with an oil to form a slurry; heating the slurry to or above the boiling point of water to vaporize the water contained in the low-grade coal and dehydrate the coal; compressing a vapor mixture of the steam resulting from the slurry heating and that part of the oil which has vaporized simultaneously and thereby elevating the temperature and pressure of the vapor mixture; and supplying the vapor mixture increased in temperature and pressure by the compression and utilizing this vapor mixture as a high-temperature heat source to heat the slurry. In the method, the vapor mixture before being compressed is brought into contact with an oil in a liquid state. This method is a process in which low-grade coal containing water in a large proportion and hence having a low calorific value is dewatered in an oil to thereby upgrade the coal to a high-calorie fuel for thermal power generation, wherein the vapor mixture to be supplied to a compressor can be purified.

摘要翻译： 一种提炼煤的方法，包括：粉碎低档煤; 将粉碎的低品位煤与油混合以形成浆料; 将浆料加热至或高于水的沸点，蒸发低级煤中所含的水分，使煤脱水; 压缩由浆料加热产生​​的蒸汽的蒸汽混合物和同时蒸发的部分油，从而提高蒸汽混合物的温度和压力; 并通过压缩将蒸汽混合物的温度和压力提高，并利用该蒸气混合物作为高温热源来加热浆料。 在该方法中，压缩前的蒸气混合物与液态的油接触。 这种方法是一种方法，其中大部分含量低，因此具有低热值的低含量煤在油中脱水，从而将煤升级为用于热发电的高热量燃料，其中蒸汽混合物 供应给压缩机可以净化。

公开(公告)号：US20130275349A1

公开(公告)日：2013-10-17

申请号：US13976967

申请日：2011-12-28

申请人： Kei Tashiro ,  Shigeru Kinoshita ,  Tomohito Yagi ,  Masakazu Nakano ,  Kazuhiko Mori ,  Yoko Ikeda ,  Morio Ueno ,  Yuichi Tokuda ,  Katsumi Yagi ,  Kengo Yoshii ,  Masahiro Fuwa

发明人： Kei Tashiro ,  Shigeru Kinoshita ,  Tomohito Yagi ,  Masakazu Nakano ,  Kazuhiko Mori ,  Yoko Ikeda ,  Morio Ueno ,  Yuichi Tokuda ,  Katsumi Yagi ,  Kengo Yoshii ,  Masahiro Fuwa

IPC分类号： G06N99/00

CPC分类号： G06N20/00 ,  C12Q1/6886 ,  G16B20/00 ,  G16B25/00 ,  G16B40/00

摘要： Provided is a technique for determining a physiological attribute in a mammal, including the onset or progression of human glaucoma, with high accuracy. The results of the determination of genotype date and the results of the determination of cytokine date are consolidated by a consolidated determination unit (114); comparison is made for determining as to which is larger, the number of Case determination procedures or the number of control determination procedures (S330); and it is determined as Case (glaucoma) when the number of Case determination procedures is larger and it is determined as Control (normal person) when the number of Control determination procedures is larger.

摘要翻译： 提供了一种用于以高精度确定哺乳动物的生理属性，包括人类青光眼的发病或进展的技术。 确定基因型日期的结果和细胞因子日期的确定结果由综合确定单位（114）合并; 比较确定哪个更大，判定程序的数量或控制确定程序的数量（S330）; 当判定判定过程的数量较多并且当控制确定过程的数量较大时被确定为控制（普通人）时被确定为病例（青光眼）。

公开(公告)号：US08431345B2

公开(公告)日：2013-04-30

申请号：US12596462

申请日：2008-04-17

申请人： Shigeru Kinoshita ,  Kei Tashiro ,  Masakazu Nakano ,  Tomohito Yagi ,  Kazuhiko Mori ,  Yoko Ikeda ,  Takazumi Taniguchi ,  Masaaki Kageyama

发明人： Shigeru Kinoshita ,  Kei Tashiro ,  Masakazu Nakano ,  Tomohito Yagi ,  Kazuhiko Mori ,  Yoko Ikeda ,  Takazumi Taniguchi ,  Masaaki Kageyama

IPC分类号： C12Q1/68 ,  C07H21/02 ,  C07H21/04

CPC分类号： C12Q1/6886 ,  C12Q1/6883 ,  C12Q2600/156

摘要： A method of determining the presence or the absence of a glaucoma risk, including the steps of detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism which is located on a 31st base of a base sequence, in a sample from a subject, wherein the base sequence is at least one base sequence selected from the group consisting of base sequences shown in SEQ ID NOs: 203 to 752 or a complementary sequence thereto (step A), and comparing the allele and/or the genotype detected in the step A with at least one of an allele and/or a genotype, containing a high-risk allele, in the base sequences shown in SEQ ID NOs: 203 to 752 (step B). According to the method of the present invention, the level of a progressive risk of glaucoma in a sample donor can be determined by analyzing an allele or a genotype of a single nucleotide polymorphism in the present invention in the sample, so that the sample donor can take a preventive measure of glaucoma, or can receive appropriate treatments, on the basis of this risk.

摘要翻译： 一种确定青光眼风险的存在或不存在的方法，包括以下步骤：在位于碱基序列的第31位的单核苷酸多态性的体外检测等位基因和/或基因型， 其中所述碱基序列是选自SEQ ID NO：203至752所示的碱基序列或其互补序列的至少一种碱基序列（步骤A），并比较检测到的等位基因和/或基因型 在SEQ ID NO：203〜752（步骤B）所示的碱基序列中具有含有高风险等位基因的等位基因和/或基因型中的至少一种的步骤A。 根据本发明的方法，可以通过分析样品中本发明的单核苷酸多态性的等位基因或基因型来确定样品供体中青光眼进行性风险的水平，使得样品供体可以 采取预防措施的青光眼，或者可以根据这种风险接受适当的治疗。

公开(公告)号：US20120291342A1

公开(公告)日：2012-11-22

申请号：US13124133

申请日：2009-10-09

申请人： Satoru Sugita ,  Yuko Sugita ,  Yutaka Mitou ,  Seiichi Yamamoto ,  Takuo Shigehisa ,  Shigeru Kinoshita ,  Takahiro Shimizu

发明人： Satoru Sugita ,  Yuko Sugita ,  Yutaka Mitou ,  Seiichi Yamamoto ,  Takuo Shigehisa ,  Shigeru Kinoshita ,  Takahiro Shimizu

IPC分类号： C10L5/08

CPC分类号： C10L5/22 ,  C10L5/08 ,  C10L5/16 ,  C10L5/361 ,  C10L5/363

摘要： Provided is a manufacturing method for a briquetted solid fuel that can reduce the briquetting cost while maintaining the strength of the briquetted product. A mixed oil that includes a heavy oil and a solvent oil, and a porous coal are mixed to obtain a slurry. The slurry is dewatered by heating to obtain a dewatered slurry. Solvent oil is separated from the dewatered slurry to obtain a cake, the cake is heated, and solvent oil is further separated from the cake to obtain a modified coal. Moisture is added to the modified coal to obtain a moist modified coal with a moisture content of 3 wt % to 10 wt %, and then the moist modified coal is briquetted under pressure.

摘要翻译： 提供一种压块固体燃料的制造方法，其能够在保持压块产品的强度的同时降低压块成本。 将包含重油和溶剂油的混合油和多孔煤混合以获得浆料。 通过加热使浆料脱水得到脱水浆料。 将溶剂油与脱水的浆料分离，得到滤饼，加热滤饼，将溶剂油从滤饼中进一步分离，得到改性煤。 向改性煤中加入水分，得到水分含量为3重量％〜10重量％的湿的改性煤，然后在压力下压块。

公开(公告)号：US20120190621A1

公开(公告)日：2012-07-26

申请号：US13386844

申请日：2009-07-24

申请人： Yasuhiko Tabata ,  Shigeru Kinoshita ,  Noriko Koizumi ,  Yuji Sakamoto ,  Naoki Okumura ,  Hiroaki Takahashi

发明人： Yasuhiko Tabata ,  Shigeru Kinoshita ,  Noriko Koizumi ,  Yuji Sakamoto ,  Naoki Okumura ,  Hiroaki Takahashi

IPC分类号： A61K38/18 ,  A61P27/02

CPC分类号： A61K38/1825 ,  A61K9/0048 ,  A61K9/06 ,  A61K47/42

摘要： The present invention aims to provide a corneal endothelium cell proliferation accelerator and a therapeutic agent for a disease relating to corneal endothelium damage, which are administered into the anterior chamber. bFGF is released in a sustained manner by forming bFGF sustained-release gelatin hydrogel particles wherein bFGF is carried on gelatin hydrogel. Therefore, the proliferation of corneal endothelium cells can be accelerated persistently by administration of a preparation containing the bFGF sustained-release gelatin hydrogel particles into the anterior chamber, and diseases relating to corneal endothelium damage can be treated.

摘要翻译： 本发明的目的在于提供角膜内皮细胞增殖促进剂和与角膜内皮损伤相关的疾病的治疗剂，其被施用于前房。 通过形成bFGF缓释明胶水凝胶颗粒，其中bFGF携带在明胶水凝胶上，以持续的方式释放bFGF。 因此，可以通过将含有bFGF缓释明胶水凝胶颗粒的制剂给予前房来持续加速角膜内皮细胞的增殖，并且可以治疗与角膜内皮损伤有关的疾病。

公开(公告)号：US07955876B2

公开(公告)日：2011-06-07

申请号：US11859152

申请日：2007-09-21

申请人： Shigeru Kinoshita

发明人： Shigeru Kinoshita

IPC分类号： H01L21/66

CPC分类号： H01L22/20 ,  H01L22/12

摘要： A deposition film shape simulation method for calculating a thickness of a thin-film formed by supplying deposition species on a substrate surface, includes: changing a parameter to be used in the calculation depending on the thickness of the deposited thin-film.

摘要翻译： 用于计算通过在基板表面上提供沉积物质而形成的薄膜的厚度的沉积膜形状模拟方法包括：根据沉积的薄膜的厚度改变要用于计算的参数。

公开(公告)号：US20100233240A1

公开(公告)日：2010-09-16

申请号：US12161433

申请日：2007-01-18

申请人： Noriko Koizumi ,  Shigeru Kinoshita ,  Yuji Sakamoto

发明人： Noriko Koizumi ,  Shigeru Kinoshita ,  Yuji Sakamoto

IPC分类号： A61F2/14 ,  A61K35/44 ,  A61P27/02

CPC分类号： A61L27/3839 ,  A61L27/24 ,  A61L27/3808 ,  A61L2430/16

摘要： The present invention provides a graft more suitable for the transplantation of corneal endothelial cells and an application method thereof. Specifically, the present invention provides a corneal endothelial preparation capable of cell proliferation in vivo, which contains a substrate and a corneal endothelial cell layer cultured on the substrate, and a treatment method of a disease selected from the group consisting of bullous keratopathy, corneal edema, corneal leukoma and corneal endothelial inflammation, which includes a step of transplanting the preparation to patients. As the substrate, collagen is used.

摘要翻译： 本发明提供了更适合于角膜内皮细胞移植的移植物及其应用方法。 具体地说，本发明提供能够在体内进行细胞增殖的角膜内皮制剂，该角膜内皮制剂含有在底物上培养的底物和角膜内皮细胞层，以及选自下组的疾病的治疗方法：大疱性角膜病，角膜水肿 ，角膜白血病和角膜内皮炎症，其中包括将制剂移植到患者中的步骤。 作为底物，使用胶原。

公开(公告)号：US07681155B2

公开(公告)日：2010-03-16

申请号：US11858551

申请日：2007-09-20

申请人： Shigeyuki Takagi ,  Shigeru Kinoshita ,  Hiroshi Watanabe ,  Toshitake Yaegashi

发明人： Shigeyuki Takagi ,  Shigeru Kinoshita ,  Hiroshi Watanabe ,  Toshitake Yaegashi

IPC分类号： G06F17/50

CPC分类号： G06F17/5036

摘要： A semiconductor device designing method includes calculating capacitance. The semiconductor device has a semiconductor substrate, an insulator formed on the semiconductor substrate, and an electrode formed on the insulator. The capacitance is calculated under an approximation assuming a portion of the semiconductor substrate, the insulator and a portion of the electrode to be one of a conductor and a dielectric depending on electric characteristics thereof, respectively.

摘要翻译： 半导体器件设计方法包括计算电容。 半导体器件具有半导体衬底，形成在半导体衬底上的绝缘体和形成在绝缘体上的电极。 假设半导体衬底的一部分，绝缘体和电极的一部分分别根据其电特性分别为导体和电介质之一，在近似值下计算电容。

公开(公告)号：US20080220546A1

公开(公告)日：2008-09-11

申请号：US11859152

申请日：2007-09-21

申请人： Shigeru Kinoshita

发明人： Shigeru Kinoshita

IPC分类号： H01L21/66

CPC分类号： H01L22/20 ,  H01L22/12

摘要： A deposition film shape simulation method for calculating a thickness of a thin-film formed by supplying deposition species on a substrate surface, includes: changing a parameter to be used in the calculation depending on the thickness of the deposited thin-film.

摘要翻译： 用于计算通过在基板表面上提供沉积物质形成的薄膜的厚度的沉积膜形状模拟方法包括：根据沉积的薄膜的厚度改变要用于计算的参数。

公开(公告)号：US20060153928A1

公开(公告)日：2006-07-13

申请号：US10546774

申请日：2004-02-17

申请人： Shigeru Kinoshita ,  Takahiro Nakamura

发明人： Shigeru Kinoshita ,  Takahiro Nakamura

IPC分类号： A61K35/54

CPC分类号： A61L27/3813 ,  A61L15/40 ,  A61L27/3604 ,  A61L27/3641 ,  A61L27/3683 ,  A61L27/3808 ,  A61L27/3839 ,  A61L2430/40

摘要： It is intended to provide an amnion-origin medical material which can be easily handled and fully sterilized and, moreover, favorably acts as a base material for forming a cell layer thereon. This material is prepared by: (i) removing the epithelial layer from the amnion while remaining at at leaset a part of the base membrane thereof; and (ii) drying it under such conditions that the remaining base membrane can sustain a structure allowing the adhesion and proliferation of cells thereon in using.

摘要翻译： 旨在提供一种易于处理和完全消毒的羊膜源医疗材料，此外，还有利地用作在其上形成细胞层的基材。 该材料通过以下步骤制备：（i）从羊膜中除去上皮层，同时在其一部分基膜上留下; 和（ii）在这样的条件下干燥，使得剩余的基膜可以维持使用中其上的细胞粘附和增殖的结构。