Human anti-epidermal growth factor receptor antibody
    38.
    发明授权
    Human anti-epidermal growth factor receptor antibody 有权
    人类抗表皮生长因子受体抗体

    公开(公告)号:US07598350B2

    公开(公告)日:2009-10-06

    申请号:US10593804

    申请日:2005-03-21

    IPC分类号: C07K16/28

    摘要: The present invention provides a fully human antibody that binds human EGFR with affinity comparable to or higher than IMC-C225, and that neutralizes activation of EGFR. Antibodies include whole immunoglobulins, monovalent Fabs and single chain antibodies, multivalent single chains antibodies, diabodies, triabodies, and single domain antibodies. The invention further provides nucleic acids and host cells and animals that encode and express these antibodies. The invention further provides a method for neutralizing activation of EGFR, treating in a mammal with neoplastic growth and non-cancerous hyperproliferative diseases using the antibodies alone or in combination with other agents.

    摘要翻译: 本发明提供了与IMC-C225相当或更高的亲和力结合人EGFR的完全人抗体,并且中和EGFR的活化。 抗体包括整个免疫球蛋白,单价Fab和单链抗体,多价单链抗体,双抗体,三抗体和单结构域抗体。 本发明还提供编码和表达这些抗体的核酸和宿主细胞和动物。 本发明还提供中和EGFR活化的方法,用哺乳动物用单独的或与其它试剂组合的抗肿瘤生长和非癌性过度增殖性疾病进行治疗。

    Human Anti-Epidermal Growth Factor Receptor Antibody
    39.
    发明申请
    Human Anti-Epidermal Growth Factor Receptor Antibody 有权
    人类抗表皮生长因子受体抗体

    公开(公告)号:US20070264253A1

    公开(公告)日:2007-11-15

    申请号:US10593804

    申请日:2005-03-21

    摘要: A condenser coil for a refrigerated beverage and food service merchandiser includes a plurality of parallel fins be-tween adjacent tubes. In order to reduce the likelihood of fouling by the bridging of fibers therebetween, the spacing of the fins is maintained at a distance of 0.4 to 0.8 inches apart. In one embodiment, the tubes comprise microchannel tubes, with no fins there-between, and the spacing between the microchannel tubes is maintained in the range of 0.75 inches to optimize the heat transfer performance while minimizing the occurrence of fouling. A supporting structure is provided between microchannel tubes when no fins are included. Also, plural rows of microchannel tubes are provided with separate inlet headings and with the rows being stag-gered in transverse relationship to enhance the heat transfer characteristic while minimizing the likelihood of fouling.

    摘要翻译: 用于冷藏饮料和食品服务商品的冷凝器盘管包括相邻管之间的多个平行翅片。 为了减少纤维之间的桥接造成结垢的可能性,散热片的间距保持在0.4至0.8英寸的距离。 在一个实施例中,管包括在其间没有翅片的微通道管,并且微通道管之间的间隔保持在0.75英寸的范围内,以优化传热性能,同时最小化污染的发生。 当不包括翅片时,在微通道管之间提供支撑结构。 而且,多排微通道管设置有独立的入口标题,并且这些行以横向关系延伸,以增强传热特性,同时最小化结垢的可能性。