-
31.发明申请公开(公告)号：US20170274059A1
公开(公告)日：2017-09-28
申请号：US15505148
申请日：2015-08-20
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Liangfang Zhang , Che-Ming Jack Hu , Jonathan Copp , Ronnie H. Fang , Brian T. Luk
CPC classification number: A61K39/0008 , A61K9/0014 , A61K9/0019 , A61K9/5146 , A61K9/5184 , A61K35/12 , A61K39/385 , A61K45/06 , A61K47/34 , A61K2039/55555 , A61K2039/6006
Abstract: The invention provides a composition, and method of use thereof, comprising self-antigen displaying nanoparticles to target auto-reactive immune components for treating and/or preventing the autoimmune diseases associated therewith. The nanoparticles can also be loaded with cytotoxic drugs for targeted cell killing or with immune-tolerizing compounds to normalize the immune regulation.
-
公开(公告)号：US20170143830A1
公开(公告)日：2017-05-25
申请号：US15356977
申请日：2016-11-21
Applicant: The Regents of the University of California
Inventor： Joseph Wang , Liangfang Zhang
CPC classification number: A61K49/0097 , A61K9/0009 , A61K9/5094 , A61K9/5115 , A61K35/18 , A61K41/00 , A61K47/6901 , A61K49/0067 , A61K2035/124
Abstract: Living cells, such as red blood cells (RBCs) modified with functional micromotors with the aid of ultrasound propulsion and magnetic guidance. Iron oxide nanoparticles are loaded into the RBCs, where their asymmetric distribution within the cells results in a net magnetization, thus enabling magnetic alignment and guidance under acoustic propulsion. The RBC motors display efficient guided and prolonged propulsion in various biological fluids, including undiluted whole blood.
-
公开(公告)号：US20240358630A1
公开(公告)日：2024-10-31
申请号：US18737848
申请日：2024-06-07
Applicant: The Regents of the University of California
Inventor： Joseph Wang , Liangfang Zhang
CPC classification number: A61K9/0007 , A61K9/0053 , A61K9/2009 , A61K9/2027 , A61K9/204 , A61K9/205 , A61K9/2086 , A61K9/4808 , A61K9/4866 , A61K9/501 , A61K9/5026 , A61K9/5031 , A61K9/5036 , A61B5/4222
Abstract: Disclosed are nano/micromotor devices, systems, and methods for providing payloads in the gastrointestinal system. In one aspect, a micromotor for a gastrointestinal tract includes a micromotor body including a one or more material layers to provide a structure that surrounds a hollow interior region and has an opening to an exterior of the micromotor body; one or more particles including a biocompatible metal element, the one or more particles contained in the interior region of the micromotor body; a coating coupled to the structure of the micromotor body; and a payload material, in which the micromotor is structured to move in a fluid of a gastrointestinal system based on a reaction between the one or more particles and a constituent or a condition of the fluid, such that the reaction generates bubbles that accelerate out of the opening of the micromotor body to propel the micromotor in the fluid.
-
公开(公告)号：US20240316211A1
公开(公告)日：2024-09-26
申请号：US18614193
申请日：2024-03-22
Applicant: The Regents of the University of California
Inventor： Joseph Wang , Liangfang Zhang , Fangyu Zhang , Jia Zhuang
IPC: A61K47/69 , A61K9/00 , A61K31/496 , A61K31/704 , A61K47/54 , A61P31/04 , A61P35/00
CPC classification number: A61K47/6901 , A61K9/007 , A61K31/496 , A61K31/704 , A61K47/545 , A61K47/6937 , A61P31/04 , A61P35/00
Abstract: Microalgae combined with antibiotic-loaded neutrophil membrane-coated polymeric nanoparticles provide a hybrid microrobot having robust locomotion in the lungs in vivo toward effective treatment of pulmonary and gastrointestinal tract infections. The algae-nanoparticle hybrid microrobots are provided in methods of treatment of disease or conditions by administration for active in vivo delivery of therapeutics to the lungs or gastrointestinal tract. The microrobot system can be applied to treat a wide range of diseases, including viral pneumonia.
-
35.发明公开公开(公告)号：US20230225964A1
公开(公告)日：2023-07-20
申请号：US18156328
申请日：2023-01-18
Applicant: The Regents of the University of California
Inventor： Joseph Wang , Rodolfo Andres Mundaca Uribe , Berta Esteban-Fernandez de Avila , Ronnie Fang , Liangfang Zhang
CPC classification number: A61K9/0053 , A61J3/06 , A61K9/0007 , A61K9/1611 , A61K9/2018
Abstract: Disclosed are methods, materials and devices that pertain to a microstirring pill technology with built-in mixing capability for oral drug delivery that greatly enhances bioavailability of its therapeutic payload. In some aspects, a drug delivery device includes a pill matrix dissolvable in a fluid medium and loaded with a plurality of drug payloads; and a plurality of micro stirrers embedded in the pill matrix and configured to create a local fluid transport upon interacting with a biological fluid surrounding the microstirring pill.
-
Patent Agency Ranking
公开(公告)号：US11007281B2
公开(公告)日：2021-05-18
申请号：US15939104
申请日：2018-03-28
Applicant: The regents of the University of California
Inventor： Joseph Wang , Berta Esteban-Fernández de Ávila , Yi Chen , Chava Angell , Fernando Soto , Liangfang Zhang , Malthe Hansen-Bruhn
IPC: A61K48/00 , A61K38/48 , A61K41/00 , A61M31/00 , A61M37/00 , C12N15/11 , C12N15/113 , C12N9/22 , C12N9/64 , C12N15/87 , B82Y15/00
Abstract: Methods, systems, and devices are disclosed for intracellular payload delivery by nanomotor structures. In some aspects, a nanomotor for intracellular payload delivery includes an asymmetric body having a concave cavity at one end of the nanowire body; a functionalization layer on an outer surface of the nanowire body; and a payload substance coupled to the nanomotor by the functionalization layer in a biologically active conformation, wherein the payload substance is attached to a portion of the functionalization layer or at least partially encapsulated within the functionalization layer, in which the nanomotor is operable to propel in a biological medium and into an intracellular region of a living cell to initiate an interaction of the biologically active payload substance with an intracellular constituent of the living cell.
-
公开(公告)号：US20200276122A1
公开(公告)日：2020-09-03
申请号：US16811515
申请日：2020-03-06
Applicant: The Regents of the University of California
Inventor： Liangfang Zhang , Che-Ming Jack Hu , Weiwei Gao , Jonathan Copp
IPC: A61K9/06 , A61K9/16 , A61K9/51 , A61K38/17 , A61K35/17 , A61K35/18 , A61K35/19 , A61K35/58 , A61K35/63 , A61K45/06 , A61K31/49 , A61L26/00 , A61K9/00 , A61L27/52 , A61L27/54
Abstract: The present invention provides for compositions comprising a polymeric hydrogel impregnated with a toxin-absorbing or binding nanoparticle. The present invention also provides for the use of the above compositions for decreasing or neutralizing the effect of a toxin, or for treating or preventing an infection by a microbe that produces a toxin, in a subject. The exemplary toxin is a biological toxin such as a viral, bacterial, fungal, plant or animal toxin.
-
公开(公告)号：US10653803B2
公开(公告)日：2020-05-19
申请号：US15356977
申请日：2016-11-21
Applicant: The Regents of the University of California
Inventor： Joseph Wang , Liangfang Zhang
Abstract: Living cells, such as red blood cells (RBCs) modified with functional micromotors with the aid of ultrasound propulsion and magnetic guidance. Iron oxide nanoparticles are loaded into the RBCs, where their asymmetric distribution within the cells results in a net magnetization, thus enabling magnetic alignment and guidance under acoustic propulsion. The RBC motors display efficient guided and prolonged propulsion in various biological fluids, including undiluted whole blood.
-
公开(公告)号：US10588867B2
公开(公告)日：2020-03-17
申请号：US16515906
申请日：2019-07-18
Applicant: The Regents of the University of California
Inventor： Liangfang Zhang , Weiwei Gao , Ronnie H. Fang , Che-Ming Jack Hu
IPC: A61K39/00 , A61K9/51 , A61K39/02 , A61K9/50 , A61K31/427 , A61K31/43 , A61K31/49 , A61K31/545 , A61K45/06 , B82Y5/00
Abstract: Nanoparticles are provided comprising an inner core comprising a non-cellular material, and an outer surface comprising a bacterial membrane, e.g., a bacterial membrane derived from a bacteria outer membrane vesicle. Also provided are compositions, e.g., medicament delivery systems and pharmaceutical compositions, comprising the present nanoparticles. Also provided are uses of the present nanoparticles, pharmaceutical compositions and medicament delivery systems for treating and/or preventing a disease or condition, e.g., bacterial infection, in a subject.
-
公开(公告)号：US20190142746A1
公开(公告)日：2019-05-16
申请号：US16139612
申请日：2018-09-24
Applicant: The Regents of the University of California
Inventor： Liangfang Zhang , Che-Ming Jack Hu , Weiwei Gao , Jonathan Coop
IPC: A61K9/06 , A61L27/54 , A61L27/52 , A61K9/16 , A61K38/17 , A61K35/17 , A61K9/00 , A61K9/51 , A61L26/00 , A61K31/49 , A61K45/06 , A61K35/63 , A61K35/58 , A61K35/19 , A61K35/18
Abstract: The present invention provides for compositions comprising a polymeric hydrogel impregnated with a toxin-absorbing or binding nanoparticle. The present invention also provides for the use of the above compositions for decreasing or neutralizing the effect of a toxin, or for treating or preventing an infection by a microbe that produces a toxin, in a subject. The exemplary toxin is a biological toxin such as a viral, bacterial, fungal, plant or animal toxin.
-
-
-
-
-
-
-
-
-
Search Results
42
records
(took 0.031 seconds)
