利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

73 条记录 (耗时 0.039 秒)

    Fluidic extraction of microdissected samples
    31.
    发明授权
    Fluidic extraction of microdissected samples 有权
    显微解剖样品的流体萃取

    公开(公告)号：US07473401B1

    公开(公告)日：2009-01-06

    申请号：US09357423

    申请日：1999-07-20

    申请人： Thomas M. Baer

    发明人： Thomas M. Baer

    IPC分类号： B01L3/00

    CPC分类号： G01N1/2813 ,  G01N2001/028 ,  G01N2001/2833 ,  G01N2001/284

    摘要： Systems and methods are described for processing of laser capture microdissection (LCM) samples. A biological sample processing system includes a laminated film sample processing device including a reaction chamber mated with a biological sample carrier to form a fluidic circuit. A multiple step fluidic device includes an LCM transfer film and a surface that is spaced apart from the transfer film so as to define a fluid volume. The reaction buffer can be removed through an exit port, or stop junction, in the surface. Advantages of the systems and methods include facilitating subsequent processing reducing the volume of reagents and enhancing economy. For instance, the reaction buffer can be conveniently removed away from the LCM transfer film.

    摘要翻译： 描述了用于处理激光捕获显微解剖（LCM）样品的系统和方法。 生物样品处理系统包括层叠膜样品处理装置，其包括与生物样品载体配合的反应室，以形成流体回路。 多级流体装置包括LCM转移膜和与转移膜间隔开以限定流体体积的表面。 反应缓冲液可以通过表面中的出口或停止连接处去除。 系统和方法的优点包括促进随后的处理减少试剂的体积并增加经济性。 例如，反应缓冲液可以方便地从LCM转移膜上除去。

    Low amplitude noise, intracavity doubled laser
    35.
    发明授权
    Low amplitude noise, intracavity doubled laser 失效
    低振幅噪声，腔内双倍激光

    公开(公告)号：US5627849A

    公开(公告)日：1997-05-06

    申请号：US609186

    申请日：1996-03-01

    申请人： Thomas M. Baer

    发明人： Thomas M. Baer

    IPC分类号： H01S3/081 ,  H01S3/0941 ,  H01S3/109 ,  H01S3/16 ,  H01S3/13

    CPC分类号： H01S3/109 ,  H01S2301/02 ,  H01S3/08022 ,  H01S3/081 ,  H01S3/09415 ,  H01S3/1611 ,  H01S3/1673

    摘要： An amplitude-stable intracavity doubled laser comprises a pair of end mirrors defining a laser cavity having a length L. A laser medium having a gain region substantially smaller than the length L of the laser cavity is positioned within the laser cavity. A doubling crystal having a nonlinear conversion region substantially smaller than, the length L of the laser cavity is positioned within the laser cavity. A pump source is oriented to supply excitation energy to the laser medium. The laser medium and the doubling crystal located at positions within the laser cavity so as to cause the laser to lase in fewer than ten longitudinal modes and to output visible light with an amplitude noise of less than about 3% RMS on visible output from the laser.

    摘要翻译： 幅度稳定的腔内倍增激光器包括限定具有长度L的激光腔的一对端镜。具有基本上小于激光腔的长度L的增益区域的激光介质位于激光腔内。 具有基本上小于激光腔的长度L的非线性转换区域的倍增晶体位于激光腔内。 泵浦源被定向以向激光介质提供激发能量。 激光介质和倍晶体位于激光腔内的位置，以便使激光器以不到十个纵向模式发光，并输出可见光，其振幅噪声小于激光可见光输出的约3％RMS 。

    Apparatus for coupling a multiple emitter laser diode to a multimode optical fiber
    37.
    发明授权
    Apparatus for coupling a multiple emitter laser diode to a multimode optical fiber 失效
    用于将多发射器激光二极管耦合到多模光纤的装置

    公开(公告)号：US5436990A

    公开(公告)日：1995-07-25

    申请号：US841610

    申请日：1992-02-25

    申请人： David F. Head ,  Thomas M. Baer

    发明人： David F. Head ,  Thomas M. Baer

    IPC分类号： G02B6/32 ,  G02B6/42 ,  H01S3/094 ,  H01S3/0941 ,  H01S5/40

    CPC分类号： G02B6/425 ,  G02B6/4206 ,  H01S3/0941 ,  H01S3/094053 ,  H01S5/4012 ,  H01S5/4025

    摘要： A small diameter multimode optical fiber with a low numerical aperture (i.e., 0.1) is used as a microlens to collimate the output emissions of a laser diode before butt coupling the output of the laser diode to an optical fiber. The optical fiber used as the microlens is chosen such that its diameter roughly equals the diameter of the fiber to be coupled to the laser diode. One end of the fiber is mounted in a fixed position and the other end of the fiber is slip fit into the end of a hollow receiving member mounted in a fixed position and running parallel to the axis of the fiber. The collimation is performed in the high NA direction of the output of the laser diode. The output of a bundle of butt coupled optical fibers may be used to pump a laser system.

    摘要翻译： 在将激光二极管的输出与光纤对接之前，使用具有低数值孔径（即，0.1）的小直径多模光纤作为微透镜来校准激光二极管的输出发射。 选择用作微透镜的光纤，使得其直径大致等于要耦合到激光二极管的光纤的直径。 纤维的一端安装在固定位置，纤维的另一端滑入装配在固定位置并平行于纤维轴线延伸的中空接收件的端部。 在激光二极管的输出的高NA方向进行准直。 一对对接光纤的输出可用于泵浦激光系统。

    Solid-state laser Fourier-Transform Raman Spectrometer
    38.
    发明授权
    Solid-state laser Fourier-Transform Raman Spectrometer 失效
    固态激光傅里叶变换拉曼光谱仪

    公开(公告)号：US5351121A

    公开(公告)日：1994-09-27

    申请号：US9454

    申请日：1993-01-27

    申请人： Thomas M. Baer ,  Kelly A. Cox ,  Phillip Gooding ,  John Cole ,  David F. Head ,  Gregory J. Kintz

    发明人： Thomas M. Baer ,  Kelly A. Cox ,  Phillip Gooding ,  John Cole ,  David F. Head ,  Gregory J. Kintz

    IPC分类号： G01J3/12 ,  G01J3/44 ,  G01J3/453 ,  H01S3/082 ,  H01S3/094 ,  H01S3/16 ,  G01N21/65

    CPC分类号： H01S3/082 ,  G01J3/44 ,  G01J3/1256 ,  G01J3/453 ,  G01N2201/06113 ,  H01S3/094038 ,  H01S3/1673

    摘要： A Fourier Transform Raman Spectrometer system includes a folded V laser cavity. A first leg of the folded V laser cavity is defined by a highly reflective end mirror and a dichroic fold mirror and a second leg of the folded V laser cavity is defined by the fold mirror and an output coupler. A solid-state laser gain medium is disposed in the first leg of the folded V laser cavity and is pumped by a pump source aligned with the optical path of the first leg of the laser cavity and radiating through the fold mirror. The fold mirror is highly transmissive at the wavelength of pump radiation from the pump source and highly reflective at the laser output wavelength. An output beam from the laser is passed through a tuneable filter comprising an acousto-optic device and is directed at a sample to be analyzed. Light reflected from the sample is directed to a Raman Spectrometer for analysis.

    摘要翻译： 傅里叶变换拉曼光谱仪系统包括折叠的V激光腔。 折叠的V激光腔的第一段由高反射端镜和二向色折射镜限定，折叠的V激光腔的第二支腿由折叠镜和输出耦合器限定。 固态激光增益介质设置在折叠的V激光腔的第一支腿中，并且通过与激光腔的第一支腿的光路对齐并且通过折叠镜辐射的泵浦源来泵浦。 折射镜在来自泵浦源的泵浦辐射的波长处是高度透射的，并且在激光输出波长处具有高反射性。 来自激光器的输出光束通过包括声光器件的可调谐滤光器，并且被引导到待分析的样品。 从样品反射的光被引导到拉曼光谱仪进行分析。

    High efficiency mode-matched solid-state laser with transverse pumping
    39.
    发明授权
    High efficiency mode-matched solid-state laser with transverse pumping 失效
    具有横向泵浦的高效模式匹配固态激光器

    公开(公告)号：US4894839A

    公开(公告)日：1990-01-16

    申请号：US231192

    申请日：1988-08-11

    申请人： Thomas M. Baer

    发明人： Thomas M. Baer

    IPC分类号： H01S3/094 ,  H01S3/08 ,  H01S3/0941 ,  H01S3/109 ,  H01S5/022

    CPC分类号： H01S3/0941 ,  H01S3/109 ,  H01S5/02252 ,  H01S3/0621 ,  H01S3/0623 ,  H01S3/0625 ,  H01S3/08095 ,  H01S3/09408 ,  H01S5/005 ,  H01S5/4031

    摘要： A high effieciency pumping scheme mode matches the TEMOO laser mode volume with a plurality of spaced apart laser diode pumping sources positioned along a lateral side of a block of laser material. The cavity resonator within the block is configured in tightly folded zig-zag configuration. Pump radiation from the diode pumping sources is collimated by an optical fiber and the fold angle is selected to mode match the pump radiation to the mode volume. Parasitic oscillation across the laser block are prevented.

    摘要翻译： 高效率泵送方案模式将TEM00激光模式体积与沿着激光材料块的侧面定位的多个间隔开的激光二极管泵浦源匹配。 块内的空腔谐振器被配置成紧密折叠的之字形配置。 来自二极管泵浦源的泵浦辐射由光纤校准，并且折叠角被选择为将泵浦辐射与模式体积匹配。 阻止了激光块的寄生振荡。

    Laser diode pumped solid state laser
    40.
    发明授权
    Laser diode pumped solid state laser 失效
    激光二极管泵浦固体激光器

    公开(公告)号：US4872177A

    公开(公告)日：1989-10-03

    申请号：US214020

    申请日：1988-06-30

    申请人： Thomas M. Baer ,  Mark S. Kierstead

    发明人： Thomas M. Baer ,  Mark S. Kierstead

    IPC分类号： H01S3/08 ,  H01S3/0941 ,  H01S3/109

    CPC分类号： H01S3/09415 ,  H01S3/08 ,  H01S3/109 ,  H01S3/025

    摘要： A neodymium or other rare earth doped solid state laser is pumped by a matched high efficiency laser diode, including a diode array and a multi-spatial mode extended emitter diode, resulting in a compact, high efficiency and long lifetime laser assembly. The cavity mode volume is matched to a region of absorption in the pumping volume formed by the focused diode beam. Output is in the near infrared range, but can be converted to the visible spectrum by an intra-cavity frequency doubler. A doubling crystal, e.g., KTP, is placed in an optimum location in the laser cavity. Polarization of the beam for frequency doubling may be achieved by using a birefringent material for the rod or by stressing a non-birefringent rod. An amplitude noise suppression etalon may also be placed at an optimum position in the laser cavity. A folded cavity configuration produces a pair of beam waists in the cavity. Pulsed operation can be produced by means of a Q-switch.

    摘要翻译： 钕或其他稀土掺杂固体激光器由匹配的高效激光二极管泵浦，包括二极管阵列和多空间模式扩展发射二极管，从而产生紧凑，高效率和长寿命的激光器组件。 腔体积体积与由聚焦二极管束形成的泵浦体积中的吸收区域相匹配。 输出处于近红外范围，但可通过腔内倍频器转换为可见光谱。 双重晶体，例如KTP，放置在激光腔中的最佳位置。 用于倍频的光束的极化可以通过使用用于棒的双折射材料或通过应力非双折射棒来实现。 振幅噪声抑制标准具也可以放置在激光腔中的最佳位置。 折叠的腔体构造在空腔中产生一对梁腰。 可以通过Q开关来产生脉冲操作。