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公开(公告)号：US20050281811A1
公开(公告)日：2005-12-22
申请号：US11185373
申请日：2005-07-19
IPC分类号： A61K38/00 , A61K38/19 , A61K39/395 , C07K14/525 , C07K14/715 , C07K16/24 , C07K16/28
CPC分类号： A61K38/191 , A61K39/395 , A61K2039/505 , C07K14/525 , C07K14/715 , C07K16/2866 , C07K2317/24 , C07K2317/52 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/30 , Y10S424/809 , A61K2300/00
摘要： This invention relates to compositions and methods useful for activating LT-β receptor signaling, which in turn elicits potent anti-proliferative effects on tumor cells. More particularly, this invention relates to lymphotoxin heteromeric complexes formed between lymphotoxin-α and multiple subunits of lymphotoxin-β, which induce cytotoxic effects on tumor cells in the presence of lymphotoxin-β receptor activating agents. Also within the scope of this invention are antibodies directed against the lymphotoxin-β receptor which act as lymphotoxin-β receptor activating agents alone or in combination with other lymphotoxin-β receptor activating agents either in the presence or absence of lymphotoxin-α/β complexes. A screening method for selecting such antibodies is provided. This invention also relates to compositions and methods using cross-linked anti-lymphotoxin-β receptor antibodies either alone or in the presence of other lymphotoxin-β receptor activating agents to potentiate tumor cell cytotoxicity.
摘要翻译： 本发明涉及用于激活LT-β受体信号传导的组合物和方法，其又引起对肿瘤细胞的有效的抗增殖作用。 更具体地，本发明涉及在淋巴毒素-α与淋巴毒素-β的多个亚基之间形成的淋巴毒素异聚体复合物，其在淋巴毒素-β受体活化剂存在下诱导对肿瘤细胞的细胞毒性作用。 也在本发明范围内的是针对淋巴毒素-β受体的抗体，其单独或与其它淋巴毒素-β受体活化剂组合起作用，即在存在或不存在淋巴毒素-α/β复合物的情况下作为淋巴毒素-β受体活化剂 。 提供了选择这种抗体的筛选方法。 本发明还涉及使用交联的抗淋巴毒素-β受体抗体单独或在其它淋巴毒素-β受体活化剂存在下增强肿瘤细胞毒性的组合物和方法。
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32.发明授权Method and eddy current test probe for the inspection of screws for nuclear reactor pressure vessels 失效用于检查核反应堆压力容器螺钉的方法和涡流试验探头
公开(公告)号：US4788499A
公开(公告)日：1988-11-29
申请号：US795340
申请日：1985-11-06
申请人： Werner Meier , Edgar Friedrich , Erich Modlich
发明人： Werner Meier , Edgar Friedrich , Erich Modlich
CPC分类号： G01N27/902 , G01N27/9033
摘要： A method for the inspection of screws with an eddy current test probe including an insulating material body having a linear contact surface and at least one coil disposed in the body, includes orienting the coil transverse to threads of a reactor pressure vessel setscrew to be inspected, feeding high-frequency alternative current through the at least one coil, generating a coil field covering at least two threads, and guiding the linear contact surface along the threads, and a device for carrying out the method.
摘要翻译： 一种用涡流检测探头检查螺丝的方法，该探针包括具有线性接触表面的绝缘材料主体和设置在本体中的至少一个线圈，包括将线圈横向定向到待检查的反应堆压力容器固定螺丝的螺纹， 通过所述至少一个线圈馈送高频替代电流，产生覆盖至少两个线的线圈场，以及沿所述线引导所述线性接触表面，以及用于执行所述方法的装置。
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33.发明授权Device for gravimetric distribution of liquid for mass and heat transfer columns 失效用于质量和传热柱的液体重量分配装置
公开(公告)号：US4565216A
公开(公告)日：1986-01-21
申请号：US584509
申请日：1984-02-28
申请人： Werner Meier
发明人： Werner Meier
CPC分类号： F28F25/04 , B01D3/008 , B01D53/185 , B01F15/0264 , B01J4/008 , B01F5/0601 , Y10T137/85938
摘要： The liquid distributing device provides for a gravimetric distribution of liquids to mass and heat transfer columns. The device employs a container with pipe outlets, a plurality of individual distributors in the form of manifolds and metering devices between the container and individual distributors for metering the partial flows of liquid to the individual distributors. The device is particularly suitable for columns having a large cross-section and insures a uniform distribution of liquid even where the column or device is inclined.
摘要翻译： 液体分配装置提供液体到质量传热柱和热传递柱的重量分配。 该装置采用具有管道出口的容器，多个单独的分配器，其形式为容器和各个分配器之间的歧管和计量装置，用于计量液体到各个分配器的部分流动。 该装置特别适合于具有大横截面的柱，并且即使在柱或装置倾斜的情况下也确保均匀的液体分布。
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公开(公告)号：US4305881A
公开(公告)日：1981-12-15
申请号：US93209
申请日：1979-11-13
申请人： Andor Furst , Ludwig Labler , Werner Meier
发明人： Andor Furst , Ludwig Labler , Werner Meier
IPC分类号： C07J1/00 , A61K31/59 , A61P3/02 , C07C67/00 , C07C401/00 , C07J7/00 , C07J9/00 , C07J17/00 , C07J21/00 , C07J71/00 , C07J75/00
CPC分类号： C07J17/00 , C07J21/008 , C07J7/007 , C07J71/001 , C07J9/00
摘要： A process for the synthesis of 1.alpha.,3.beta.-dihydroxy-.DELTA..sup.5 -steroids from steroids such as 1.alpha.,2.alpha.-epoxy-cholesta-4,6-dien-3-one, which is reacted with lithium in liquid ammonia in the absence of a proton donator and subsequently reduced by repeated alternative additions of a proton donator, said additions being followed in each case by an equivalent amount of lithium. The final product, a 1.alpha.,3.beta.-dihydorxy-.DELTA..sup.5 -steroid, is useful in the synthesis of derivatives of cholecalciferol.
摘要翻译： 从类固醇如1α，2α-环氧 - 胆甾烯-4,6-二烯-3-酮合成1α，3β-二羟基-TATA5-类固醇的方法，其与液体氨中的锂反应 在不存在质子供体的情况下，随后通过反复添加质子给体而减少，所述添加物在每种情况下都遵循等量的锂。 最终产物1α，3β-二羟基-D-DELTA5-类固醇可用于合成胆钙化甾醇的衍生物。
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公开(公告)号：US4160238A
公开(公告)日：1979-07-03
申请号：US836979
申请日：1977-09-26
CPC分类号： G08C15/12 , B60R16/0315
摘要： A plurality of receivers which can be respectively addressed by addressing pulses provide reply pulses on a separate reply signal bus indicative of a single digit, or multi-digit binary response condition. To permit extended indication, the central station includes a holding stage which holds the output received from the reply receivers for the duration of a selection cycle during which the plurality of loads can be addressed, for example during a predetermined counted number of such cycles or during a predetermined counted number of pulses to permit averaging-type instruments to respond to said number of pulses --if present--or to permit extended indication of single digit binary output--if present.
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公开(公告)号：US4045490A
公开(公告)日：1977-08-30
申请号：US651764
申请日：1976-01-23
申请人： Jean-Marie Cassal , Andor Furst , Werner Meier
发明人： Jean-Marie Cassal , Andor Furst , Werner Meier
IPC分类号： C07C401/00 , C07C49/76 , C07C49/82 , C07C49/84
CPC分类号： C07C201/12 , C07C49/753 , C07C2102/24
摘要： A process for the preparation of 9,10-seco-steroids of the formula ##STR1## wherein R.sup.1 and R.sup.2 independently are hydrogen, amino, OR.sup.5, OCOR.sup.6 or NHCOR.sup.5 wherein R.sup.5 is hydrogen or lower alkyl and R.sup.6 is lower alkyl or phenyl; R.sup.3 is lower alkyl; R.sup.4 is oxo, ##STR2## wherein R.sup.13 is lower alkyl, lower alkoxy - lower alkylene, tetrahydropyranyl or tetrahydrofuryl, R.sup.14 is lower alkyl or aryl and R.sup.15 and R.sup.16 are lower alkyl or taken together form lower alkylene or arylene, and n is 1 or 2 is disclosed. The 9,10-seco-steroids of this invention are useful intermediates for the preparation of steroids.
摘要翻译： 其中R1和R2独立地是氢，氨基，OR5，OCOR6或NHCOR5，其中R5是氢或低级烷基，R6是低级烷基或苯基; R3是低级烷基; R4是氧代，其中R13是低级烷基，低级烷氧基 - 低级亚烷基，四氢吡喃基或四氢呋喃基，R14是低级烷基或芳基，R15和R16是低级烷基或一起形成低级亚烷基或亚芳基，n是1或 2。 本发明的9,10-秒类固醇是制备类固醇的有用中间体。
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37.发明授权
公开(公告)号：US3963015A
公开(公告)日：1976-06-15
申请号：US421539
申请日：1973-12-04
申请人： Georg Haubner , Walter Hofer , Werner Meier
发明人： Georg Haubner , Walter Hofer , Werner Meier
CPC分类号： F02P1/083
摘要： In an ignition system in which the spark coil is wound right on the magneto armature and the spark is produced by electronic interruption of a short circuit across the primary winding, the first of a succession of rectified half waves applied to the electronic circuit unit has its amplitude reduced either by insertion of a circuit component in one half wave path of the rectifier to provide damping, or by the configuration of the armature core, or both. The magneto rotor has a U-shaped permanent magnet, the pole faces on the end of the legs of which are rotated past opposed pole faces of the armature core, which has the desired effect if the latter is of asymmetric U-shape or of symmetrical E-shape.
摘要翻译： 在点火系统中，其中火花线圈正好卷绕在磁电枢上，并且火花是通过在初级绕组上短路的电子中断而产生的，施加到电子电路单元的一连串整流半波中的第一个具有其 通过在整流器的一个半波通路中插入电路元件以提供阻尼，或者通过电枢铁芯的构造，或两者都减小振幅。 磁转子具有U形永磁体，其极端在电极芯的相对的极面上旋转，如果后者为不对称的U形或对称的，则它们具有期望的效果 E形。
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公开(公告)号：US09443619B2
公开(公告)日：2016-09-13
申请号：US13822567
申请日：2012-05-14
申请人： Michael Liebler , Werner Meier
发明人： Michael Liebler , Werner Meier
CPC分类号： G21C3/352 , G21C3/322 , G21C3/356 , G21C3/3563 , Y02E30/38
摘要： The strip is of the type comprising a wall portion for delimiting a cell for receiving a fuel rod and allowing flow of a coolant upwardly through the spacer grid, a spring provided on the wall portion for biasing a fuel rod extending through the cell away from the wall portion, the spring being cut out in the strip and delimited by a slot and a motion limiter formed in the strip on the wall portion to limit motion of a fuel rod received in the cell towards the wall portion against action of the spring. According to one aspect of the invention, the motion limiter is located on an edge of the slot opposite the spring and defines a risen portion on the edge.
摘要翻译： 该条带是包括用于限定用于容纳燃料棒的电池单元的壁部分的类型，并允许冷却剂向上流动通过间隔栅格，弹簧设置在壁部分上，用于偏置延伸穿过电池的燃料棒远离 弹簧被切出并且由狭槽和运动限制器限定，该狭缝形成在壁部分上的条带中，以限制容纳在电池单元中的燃料棒抵抗弹簧的动作朝向壁部的运动。 根据本发明的一个方面，运动限制器位于与弹簧相对的槽的边缘上，并且限定了边缘上的上升部分。
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39.发明授权Method for increasing expression of active tumor necrosis factor receptor family member-Ig fusion proteins 有权增加活性肿瘤坏死因子受体家族成员-Ig融合蛋白表达的方法公开(公告)号：US08709759B2
公开(公告)日：2014-04-29
申请号：US13553604
申请日：2012-07-19
CPC分类号： C12P21/00 , A61K38/00 , C07K14/70578 , C07K14/7151 , C07K2319/00 , C12P21/02
摘要： Methods for high level expression of active lymphotoxin-β receptor immunoglobulin chimeric proteins and their purification.
摘要翻译： 高水平表达活性淋巴毒素的方法 受体免疫球蛋白嵌合蛋白及其纯化。
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公开(公告)号：US08338376B2
公开(公告)日：2012-12-25
申请号：US12560257
申请日：2009-09-15
IPC分类号： A61K38/00 , A61K38/16 , A61K45/00 , C12P21/06 , C12P21/04 , C12N15/00 , C12N5/00 , C07H21/04 , C07K1/00 , C07K14/00
CPC分类号： C07K14/70578 , A61K38/00 , C07K2319/30
摘要： This invention relates to methods of treating disease with soluble inhibitors of the lymphotoxin pathway having improved properties. This invention also relates to improved LTBR-Ig fusion proteins, and pharmaceutical compositions thereof.
摘要翻译： 本发明涉及用具有改进性质的淋巴毒素途径的可溶性抑制剂治疗疾病的方法。 本发明还涉及改良的LTBR-Ig融合蛋白及其药物组合物。
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