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    Anti-lymphotoxin-beta receptor antibodies as anti-tumor agents
    1.
    发明申请
    Anti-lymphotoxin-beta receptor antibodies as anti-tumor agents 失效
    抗淋巴毒素-β受体抗体作为抗肿瘤剂

    公开(公告)号：US20050281811A1

    公开(公告)日：2005-12-22

    申请号：US11185373

    申请日：2005-07-19

    申请人： Jeffrey Browning ,  Werner Meier ,  Christopher Benjamin

    发明人： Jeffrey Browning ,  Werner Meier ,  Christopher Benjamin

    IPC分类号： A61K38/00 ,  A61K38/19 ,  A61K39/395 ,  C07K14/525 ,  C07K14/715 ,  C07K16/24 ,  C07K16/28

    CPC分类号： A61K38/191 ,  A61K39/395 ,  A61K2039/505 ,  C07K14/525 ,  C07K14/715 ,  C07K16/2866 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30 ,  Y10S424/809 ,  A61K2300/00

    摘要： This invention relates to compositions and methods useful for activating LT-β receptor signaling, which in turn elicits potent anti-proliferative effects on tumor cells. More particularly, this invention relates to lymphotoxin heteromeric complexes formed between lymphotoxin-α and multiple subunits of lymphotoxin-β, which induce cytotoxic effects on tumor cells in the presence of lymphotoxin-β receptor activating agents. Also within the scope of this invention are antibodies directed against the lymphotoxin-β receptor which act as lymphotoxin-β receptor activating agents alone or in combination with other lymphotoxin-β receptor activating agents either in the presence or absence of lymphotoxin-α/β complexes. A screening method for selecting such antibodies is provided. This invention also relates to compositions and methods using cross-linked anti-lymphotoxin-β receptor antibodies either alone or in the presence of other lymphotoxin-β receptor activating agents to potentiate tumor cell cytotoxicity.

    摘要翻译： 本发明涉及用于激活LT-β受体信号传导的组合物和方法，其又引起对肿瘤细胞的有效的抗增殖作用。 更具体地，本发明涉及在淋巴毒素-α与淋巴毒素-β的多个亚基之间形成的淋巴毒素异聚体复合物，其在淋巴毒素-β受体活化剂存在下诱导对肿瘤细胞的细胞毒性作用。 也在本发明范围内的是针对淋巴毒素-β受体的抗体，其单独或与其它淋巴毒素-β受体活化剂组合起作用，即在存在或不存在淋巴毒素-α/β复合物的情况下作为淋巴毒素-β受体活化剂 。 提供了选择这种抗体的筛选方法。 本发明还涉及使用交联的抗淋巴毒素-β受体抗体单独或在其它淋巴毒素-β受体活化剂存在下增强肿瘤细胞毒性的组合物和方法。

    LOWER NOZZLE FOR USE IN NUCLEAR FUEL ASSEMBLY
    5.
    发明申请
    LOWER NOZZLE FOR USE IN NUCLEAR FUEL ASSEMBLY 有权
    用于核燃料组件的低喷嘴

    公开(公告)号：US20140064428A1

    公开(公告)日：2014-03-06

    申请号：US13822516

    申请日：2012-05-11

    申请人： Dirk Blavius ,  Erhard Friedrich ,  Werner Meier

    发明人： Dirk Blavius ,  Erhard Friedrich ,  Werner Meier

    IPC分类号： G21C3/32

    CPC分类号： G21C3/3206 ,  G21C3/322 ,  G21C3/3305 ,  Y02E30/40

    摘要： A lower nozzle for use in a nuclear fuel assembly provided. The lower nozzle is of the type having an axis and comprising a transverse lower tie plate for channelling the coolant through the lower tie plate and a tubular skirt extending axially from the periphery of the lower tie plate, the skirt delimiting an axial housing closed at one end by the lower tie plate and open at the opposite end, a debris filter configured for axial insertion in the housing and snap-fit springs for retaining the debris filter in the housing after insertion. The springs are configured to shift the debris filter axially towards the lower tie plate.

    摘要翻译： 用于核燃料组件的下喷嘴。 下喷嘴是具有轴线的类型，并且包括用于将冷却剂引导通过下连接板的横向下连接板和从下连接板的周边轴向延伸的管状裙部，裙部限定在一个闭合的轴向壳体 通过下连接板结束并在相对端开口，构造成用于轴向插入壳体中的碎屑过滤器和用于在插入之后将碎屑过滤器保持在壳体中的卡合弹簧。 弹簧构造成将碎屑过滤器轴向移向下连接板。

    Fuel assembly
    7.
    发明授权
    Fuel assembly 失效
    燃油组件

    公开(公告)号：US06912264B2

    公开(公告)日：2005-06-28

    申请号：US10642548

    申请日：2003-08-15

    申请人： Werner Meier ,  Peter Rau

    发明人： Werner Meier ,  Peter Rau

    IPC分类号： G21C3/322 ,  G21C3/34 ,  G21C3/332

    CPC分类号： G21C3/322 ,  G21C3/34 ,  G21Y2004/302 ,  Y02E30/38

    摘要： A fuel element for a nuclear reactor has fuel rods with nuclear fuel guided through spacers. The spacers are equipped with devices that exert a swirling impulse upon a coolant flowing along the fuel rods. In order to present as little flow resistance as possible for the coolant, these swirl-introducing devices have the form of a vane with a spoonlike or bladelike shape and they extend into the coolant flow. Owing to the shape—here the vane is curved in the longitudinal and in the transverse directions—practically all cross sections of the vane have such a high geometrical moment of inertia that even a vane made of a thin sheet metal is sufficiently rigid. Fuel elements configured according to the invention are particularly suitable for use in boiling water nuclear reactors.

    摘要翻译： 用于核反应堆的燃料元件具有通过间隔物引导的具有核燃料的燃料棒。 间隔件配备有对沿着燃料棒流动的冷却剂施加旋转脉冲的装置。 为了对冷却剂呈现尽可能小的流动阻力，这些涡流引入装置具有勺状或扁平形状的叶片的形式，并且它们延伸到冷却剂流中。 由于形状，这里叶片在纵向和横向方向上是弯曲的，实际上叶片的所有横截面都具有如此高的几何惯性矩，即使由薄金属板制成的叶片也足够刚性。 根据本发明配置的燃料元件特别适用于沸水核反应堆。

    Nuclear reactor fuel assembly with a supporting coolant tube
    8.
    发明授权
    Nuclear reactor fuel assembly with a supporting coolant tube 失效
    核反应堆燃料组件带有支撑冷却剂管

    公开(公告)号：US5327471A

    公开(公告)日：1994-07-05

    申请号：US924056

    申请日：1992-08-28

    申请人： Werner Meier ,  Hans-Joachim Lippert ,  Hans Lettau ,  Kurt Kraus

    发明人： Werner Meier ,  Hans-Joachim Lippert ,  Hans Lettau ,  Kurt Kraus

    IPC分类号： G21C3/30 ,  G21C3/32 ,  G21C3/322 ,  G21C3/33 ,  G21C3/34

    CPC分类号： G21C3/32 ,  G21C3/322 ,  Y02E30/38

    摘要： In order to obviate the use of supporting rods, an upper end piece of a coolant tube penetrates a fuel assembly head of a nuclear reactor fuel assembly and is supported on the fuel assembly head. A lower end piece of the coolant tube is fastened to and supported by a fuel assembly foot, in particular with rods of partial lengths. A supporting skeleton therefore includes the foot and the coolant tube with spacers. The fuel assembly head and a handle are placed on the skeleton and screwed onto the coolant tube after fuel rods are pushed into meshes of the spacer.

    摘要翻译： 为了避免使用支撑杆，冷却剂管的上端件穿过核反应堆燃料组件的燃料组件头并被支撑在燃料组件头上。 冷却剂管的下端部件被紧固到燃料组件脚并由其支撑，特别是具有部分长度的杆。 因此，支撑骨架包括脚和具有间隔件的冷却剂管。 燃料组件头和把手被放置在骨架上并且在将燃料棒推入间隔件的网格之后拧到冷却剂管上。

    Hydraulic control rod drive for a nuclear reactor
    10.
    发明授权
    Hydraulic control rod drive for a nuclear reactor 失效
    用于核反应堆的液压控制杆驱动

    公开(公告)号：US5276719A

    公开(公告)日：1994-01-04

    申请号：US929980

    申请日：1992-08-14

    申请人： Pramod Batheja ,  Werner Meier ,  Peter Rau

    发明人： Pramod Batheja ,  Werner Meier ,  Peter Rau

    IPC分类号： G21C7/16 ,  G21C17/12 ,  G21C7/06

    CPC分类号： G21C17/12 ,  G21C7/16 ,  Y02E30/39

    摘要： A hydraulic control rod drive for a nuclear reactor, with a a reactor plenum enclosing the drive, comprises first and second hollow bodies together forming a cylinder and a hollow piston. Working fluid is supplied through one of the hollow bodies. The first hollow body is stationary and the second hollow body is disposed coaxially around the first hollow body. The two hollow bodies define an annular gap therebetween so as to allow axial reciprocating movement of the second hollow body, which forms a carrier body for control elements of the control rod. The second hollow body can be lifted, lowered or suspended by feeding working fluid. A portion of the fluid is removed from the inner space via a throttle passage. A positional measurement system determines the relative displacement of the second hollow body by measuring an ultrasonic measurement path. The system includes an ultrasound reflector and an ultrasonic transducer rigidly mounted remote from the ultrasound reflector. Provisions are made for venting the inner space through venting channels which open into the reactor plenum at a security distance from the measurement path so as not to adversely affect the ultrasonic measurement.

    摘要翻译： 用于核反应堆的液压控制杆驱动器，其中包围驱动器的反应器集气室包括一起形成气缸和中空活塞的第一和第二空心体。 工作流体通过一个空心体供给。 第一中空体是静止的，第二中空体同轴地设置在第一中空体周围。 两个中空体在它们之间限定一个环形间隙，从而允许第二中空体的轴向往复运动，该第二空心体形成用于控制棒的控制元件的载体。 第二中空体可以通过供给工作流体而被提升，降低或悬挂。 流体的一部分经由节流通道从内部空间移除。 位置测量系统通过测量超声波测量路径来确定第二中空体的相对位移。 该系统包括超声波反射器和刚性地安装在超声波反射器上的超声波换能器。 规定了通过在与测量路径保持距离的开放进入反应堆的排气通道排出内部空间，以免对超声波测量产生不利影响。