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公开(公告)号:US07632834B2
公开(公告)日:2009-12-15
申请号:US12101462
申请日:2008-04-11
申请人: Thierry Bouyssou , Ingo Konetzki , Philipp Lustenberger , Juergen Mack , Andreas Schnapp , Dieter Wiedenmayer , Christoph Hoenke , Klaus Rudolf
发明人: Thierry Bouyssou , Ingo Konetzki , Philipp Lustenberger , Juergen Mack , Andreas Schnapp , Dieter Wiedenmayer , Christoph Hoenke , Klaus Rudolf
IPC分类号: A61K31/538 , A61K31/536 , C07D413/12 , C07D413/14
CPC分类号: C07D265/36 , C07D413/12
摘要: A compound of formula 1′″ wherein: V is —CH2—, —NH—, or —O—; Ra and Rb are each independently hydrogen, C1-4-alkyl, or halogen-C1-4-alkyl, or Ra and Rb together are a C2-5-alkylene bridge wherein one or more hydrogen atoms are optionally replaced by halogen; R1 and R1′ are each independently hydrogen, C1-6-alkyl, C3-6-cycloalkyl, halogen-C1-6-alkyl, halogen-C3-6-cycloalkyl, or C1-6-alkylene-C3-6-cycloalkyl, or R1 and R1′ together are a C2-5-alkylene bridge wherein one or more hydrogen atoms are optionally replaced by halogen; R2, R2′, R2″, and R2′″ are each independently hydrogen, C1-6-alkyl, halogen-C1-6-alkylene, OH, HO—C1-6-alkylene, —O—C1-6-alkyl, C6-10-aryl, C6-10-aryl-C1-4-alkylene, C6-10-aryl-C1-6-alkylene-O, COOH, COOC1-6-alkyl, O—C1-6-alkylene-COOH, O—C1-6-alkylene-COOC1-6-alkyl, NHSO2—C1-6-alkyl, CN, NH2, NH—C1-6-alkyl, N(C1-6-alkyl)2, NO2, S—C1-6-alkyl, SO2—C1-6-alkyl, SO—C1-6-alkyl, O(CO)C1-6-alkyl, COC1-6-alkyl, NHCOC1-6-alkyl, or halogen; and n is 0, 1, or 2, or an optical isomer thereof, or a corresponding acid addition salt thereof with a pharmacologically acceptable acid, and the use thereof as pharmaceutical compositions, particularly for the treatment of inflammatory and obstructive respiratory complaints.
摘要翻译: 式1“'的化合物,其中:V是-CH 2 - , - NH-或-O-; R a和R b各自独立地为氢,C 1-4 - 烷基或卤素-C 1-4 - 烷基,或者R a和R b一起是C 2-5亚烷基桥,其中一个或多个氢原子任选被卤素取代; R 1和R 1'各自独立地为氢,C 1-6 - 烷基,C 3-6 - 环烷基,卤素-C 1-6 - 烷基,卤素-C 3-6环烷基或C 1-6亚烷基-C 3-6环烷基, 或者R1和R1'一起是C2-5亚烷基桥,其中一个或多个氢原子任选地被卤素取代; R 2,R 2',R 2“和R 2”各自独立地为氢,C 1-6 - 烷基,卤素-C 1-6亚烷基,OH,HO-C 1-6 - 亚烷基,-O-C 1-6 - 烷基,C 6-10 - 芳基,C 6-10 - 芳基-C 1-4 - 亚烷基,C 6-10 - 芳基-C 1-6 - 亚烷基-O,COOH,COOC 1-6 - 烷基,O-C 1-6亚烷基 - COOH,O-C 1-6亚烷基-COOC 1-6 - 烷基,NHSO 2 -C 1-6 - 烷基,CN,NH 2,NH-C 1-6 - 烷基,N(C 1-6 - 烷基)2,NO 2, C 1-6 - 烷基,SO 2 -C 1-6 - 烷基,SO-C 1-6 - 烷基,O(CO)C 1-6 - 烷基,CO C 1-6 - 烷基,NHCOC 1-6 - 烷基或卤素; 和n为0,1或2,或其光学异构体或其与药理学上可接受的酸的相应的酸加成盐,以及其作为药物组合物的用途,特别是用于治疗炎性和阻塞性呼吸道疾病。
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公开(公告)号:US07375104B2
公开(公告)日:2008-05-20
申请号:US11600417
申请日:2006-11-15
申请人: Thierry Bouyssou , Ingo Konetzki , Philipp Lustenberger , Juergen Mack , Andreas Schnapp , Dieter Wiedenmayer , Christoph Hoenke , Klaus Rudolf
发明人: Thierry Bouyssou , Ingo Konetzki , Philipp Lustenberger , Juergen Mack , Andreas Schnapp , Dieter Wiedenmayer , Christoph Hoenke , Klaus Rudolf
IPC分类号: C07D413/12 , C07D413/14 , A61K31/538 , A61K31/536
CPC分类号: C07D265/36 , C07D413/12
摘要: A compound of formula 1′ wherein: V is —CH2—, —NH—, or —O—; Ra and Rb are each independently hydrogen, C1-4-alkyl, or halogen-C1-4-alkyl, or Ra and Rb together are a C2-5-alkylene bridge wherein one or more hydrogen atoms are optionally replaced by halogen; R1 and R1′ are each independently hydrogen, C1-6-alkyl, C3-6-cycloalkyl, halogen-C1-6-alkyl, halogen-C3-6-cycloalkyl, or C1-6-alkylene-C3-6-cycloalkyl, or R1 and R1′ together are a C2-5-alkylene bridge wherein one or more hydrogen atoms are optionally replaced by halogen; R2, R2′, R2″, and R′″ are each independently hydrogen, C1-6-alkyl, halogen-C1-6-alkylene, OH, HO—C1-6-alkylene, —O—C1-6-alkyl, C6-10-aryl, C6-10-aryl-C1-4-alkylene, C6-10-aryl-C1-6-alkylene-O, COOH, COOC1-6-alkyl, O—C1-6-alkylene-COOH, O—C1-6-alkylene-COOC1-6-alkyl, NHSO2—C1-6-alkyl, CN, NH2, NH—C1-6-alkyl, N(C1-6-alkyl)2, NO2, S—C1-6-alkyl, SO2—C1-6-alkyl, SO—C1-6-alkyl, O(CO)C1-6-alkyl, COC1-6-alkyl, NHCOC1-6-alkyl, or halogen; and n is 0, 1, or 2, or an optical isomer thereof, or a corresponding acid addition salt thereof with a pharmacologically acceptable acid, and the use thereof as pharmaceutical compositions, particularly for the treatment of inflammatory and obstructive respiratory complaints.
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公开(公告)号:US20070287704A1
公开(公告)日:2007-12-13
申请号:US11751917
申请日:2007-05-22
申请人: Horst Dollinger , Domnic Martyres , Juergen Mack , Rolf Goeggel , Birgit Jung , Peter Nickolaus
发明人: Horst Dollinger , Domnic Martyres , Juergen Mack , Rolf Goeggel , Birgit Jung , Peter Nickolaus
IPC分类号: A61K31/541 , A61K31/5377 , A61K31/525 , C07D475/02
CPC分类号: C07D475/08 , C07D519/00
摘要: The invention relates to new pteridines which are suitable for treating respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin or eyes, diseases of the peripheral or central nervous system and cancers. This invention also relates to pharmaceutical compositions containing these compounds.
摘要翻译: 本发明涉及适用于治疗呼吸道或胃肠道疾病,关节,皮肤或眼睛的炎性疾病,外周或中枢神经系统疾病和癌症的新型蝶啶。 本发明还涉及含有这些化合物的药物组合物。
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公开(公告)号:US20060116372A1
公开(公告)日:2006-06-01
申请号:US11282535
申请日:2005-11-18
申请人: Horst Dollinger , Juergen Mack , Domnic Martyres , Birgit Jung , Peter Nickolaus
发明人: Horst Dollinger , Juergen Mack , Domnic Martyres , Birgit Jung , Peter Nickolaus
IPC分类号: A61K31/541 , A61K31/5377 , C07D475/02 , A61K31/525
CPC分类号: C07D475/08
摘要: The invention relates to new pteridines which are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin or eyes, diseases of the peripheral or central nervous system or cancers, as well as pharmaceutical compositions which contain these compounds.
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公开(公告)号:US09553459B2
公开(公告)日:2017-01-24
申请号:US14130206
申请日:2012-05-25
申请人: Juergen Mack
发明人: Juergen Mack
CPC分类号: H02J7/0004 , G08C19/00 , G08C23/04 , H01M10/482 , H01M2010/4278 , H02J7/0045 , H02J7/025 , H02J50/10 , H02J50/30 , H02J50/60 , H02J2007/0096 , H02J2007/0098
摘要: A system for supplying an electric load, in particular for charging a battery device, including a charging station with an accommodation unit for the battery device and a detection unit for the battery device. The detection unit includes a first optical transmitting device for transmitting a first optical signal and an optical receiving device for receiving the first optical signal. The battery device includes a second optical transmitting device for transmitting a second and third optical signal, the second optical transmitting device functioning as a transmitter of a discretely configured optocoupler for transmitting information from the battery device to the charging station. The optical receiving device of the charging station is configured as a receiver of the discretely configured optocoupler for receiving the second and third optical signals.
摘要翻译: 一种用于提供电负载的系统,特别是用于对电池装置进行充电,包括具有用于电池装置的容纳单元的充电站和用于电池装置的检测单元。 检测单元包括用于发送第一光信号的第一光发送装置和用于接收第一光信号的光接收装置。 电池装置包括用于发送第二和第三光信号的第二光发送装置,第二光发射装置用作离散配置的光耦合器的发射器,用于将信息从电池装置传送到充电站。 充电站的光接收装置被配置为用于接收第二和第三光信号的离散配置的光耦合器的接收器。
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公开(公告)号:US20150002089A1
公开(公告)日:2015-01-01
申请号:US14359541
申请日:2012-11-07
申请人: Marcin Rejman , Volker Amann , Juergen Mack , Freiderike Dietzel , Guenter Lohr
发明人: Marcin Rejman , Volker Amann , Juergen Mack , Freiderike Dietzel , Guenter Lohr
CPC分类号: H02J7/0045 , B25H3/02 , H02J5/005 , H02J7/0021 , H02J7/0042 , H02J7/0047 , H02J7/0052 , H02J7/025 , H02J50/10 , H02J50/40 , H02J50/90 , H02J2007/0096
摘要: A system includes: a hand-held tool battery, a hand-held tool battery charging device which has a battery accommodating area for accommodating the hand-held tool battery during an inductive charging operation, and a user interface which outputs an item of information about the charging operation.
摘要翻译: 一种系统,包括:手持式工具电池,手持式工具电池充电装置,其具有用于在感应充电操作期间容纳手持式工具电池的电池容纳区域;以及用户界面,其输出关于 充电操作。
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公开(公告)号:US08916589B2
公开(公告)日:2014-12-23
申请号:US12675224
申请日:2008-08-28
申请人: Norbert Hauel , Angelo Ceci , Enzo Cereda , Henri Doods , Ingo Konetzki , Juergen Mack , Henning Priepke , Annette Schuler-Metz , Rainer Walter
发明人: Norbert Hauel , Angelo Ceci , Enzo Cereda , Henri Doods , Ingo Konetzki , Juergen Mack , Henning Priepke , Annette Schuler-Metz , Rainer Walter
IPC分类号: A61K31/44 , A61K31/41 , C07D239/28 , C07C237/24 , C07C317/44 , C07D209/42 , C07D213/64 , C07D213/82 , C07D233/90 , C07D237/24 , C07D239/34 , C07D239/36 , C07D239/42 , C07D261/18 , C07D263/34 , C07D277/56 , C07D307/68 , C07K5/062 , C07K5/078
CPC分类号: C07D239/28 , C07C237/24 , C07C317/44 , C07C2601/02 , C07D209/42 , C07D213/64 , C07D213/82 , C07D233/90 , C07D237/24 , C07D239/34 , C07D239/36 , C07D239/42 , C07D261/18 , C07D263/34 , C07D277/56 , C07D307/68 , C07K5/06026 , C07K5/06139
摘要: The present invention relates to compounds of general formula I wherein n, R1, R2, R3, R4, R5, R6, R7 and R8 are defined as stated hereinafter, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with organic or inorganic acids or bases, which have valuable properties, the preparation thereof, the pharmaceutical compositions containing the pharmacologically effective compounds, the preparation thereof and the use thereof.
摘要翻译: 本发明涉及通式I的化合物,其中n,R 1,R 2,R 3,R 4,R 5,R 6,R 7和R 8如下文所定义,对映异构体,非对映体,其混合物及其盐, 其有机或无机酸或碱的生理上可接受的盐,其具有有价值的性质,其制备,含有药理学有效化合物的药物组合物,其制备及其用途。
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公开(公告)号:US07750009B2
公开(公告)日:2010-07-06
申请号:US11282548
申请日:2005-11-18
申请人: Horst Dollinger , Juergen Mack , Domnic Martyres , Birgit Jung , Peter Nickolaus
发明人: Horst Dollinger , Juergen Mack , Domnic Martyres , Birgit Jung , Peter Nickolaus
IPC分类号: C07D487/00 , C07D491/00 , A61K31/495
CPC分类号: C07D475/08
摘要: The invention relates to new pteridines which are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin or eyes, diseases of the peripheral or central nervous system or cancers, as well as pharmaceutical compositions which contain these compounds.
摘要翻译: 本发明涉及适用于治疗呼吸道或胃肠道疾病,关节,皮肤或眼睛的炎性疾病,外周或中枢神经系统或癌症的疾病以及含有这些化合物的药物组合物的新型蝶啶 。
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公开(公告)号:US07648988B2
公开(公告)日:2010-01-19
申请号:US12031396
申请日:2008-02-14
申请人: Horst Dollinger , Domnic Martyres , Juergen Mack , Peter Nickolaus , Birgit Jung
发明人: Horst Dollinger , Domnic Martyres , Juergen Mack , Peter Nickolaus , Birgit Jung
IPC分类号: C07D475/08 , A61K31/4985 , A61K31/541 , A61K31/5355 , A61P1/00 , A61P11/00 , A61P35/00 , A61P29/00 , A61P25/00 , A61P25/02
CPC分类号: C07D475/08
摘要: Described are new pteridine compounds of the formula 1, where the variables are as described herein. The compounds are useful for the treatment of: respiratory or gastrointestinal complaints or diseases; inflammatory diseases of the joints, skin or eyes; diseases of the peripheral or central nervous system; and cancers. Also described are pharmaceutical compositions which contain these compounds.
摘要翻译: 描述了式1的新的蝶啶化合物,其中变量如本文所述。 该化合物可用于治疗:呼吸道或胃肠道疾病或疾病; 关节,皮肤或眼睛的炎症性疾病; 外周或中枢神经系统疾病; 和癌症。 还描述了含有这些化合物的药物组合物。
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公开(公告)号:US07550472B2
公开(公告)日:2009-06-23
申请号:US11282535
申请日:2005-11-18
申请人: Horst Dollinger , Juergen Mack , Domnic Martyres , Birgit Jung , Peter Nickolaus
发明人: Horst Dollinger , Juergen Mack , Domnic Martyres , Birgit Jung , Peter Nickolaus
IPC分类号: A01N43/90 , A61K31/519
CPC分类号: C07D475/08
摘要: The invention relates to new pteridines which are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin or eyes, diseases of the peripheral or central nervous system or cancers, as well as pharmaceutical compositions which contain these compounds.
摘要翻译: 本发明涉及适用于治疗呼吸道或胃肠道疾病,关节,皮肤或眼睛的炎性疾病,外周或中枢神经系统或癌症的疾病以及含有这些化合物的药物组合物的新型蝶啶 。
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