摘要:
The invention provides a catheter for ice mapping and ablation and a method of ablation using the catheter. The catheter includes at least two lumens for circulating a refrigerating fluid adjacent an ablation device located at the end of a catheter. The refrigerated ablation device is used to chill a localized region of myocardial tissue, thereby permitting the resulting change in electrical activity to be determined. In response to the test results, the ablation device may be used to make a lesion in the myocardial tissue to correct a cardiac arrhythmia. In one embodiment, the ablation device is an electrode which uses radio frequency energy to ablate the myocardial tissue. Alternatively, the ablation device is an electrode adapted for direct current ablation. In another embodiment, the electrode is replaced with an optical fiber in communication with a laser which uses the laser's light energy to ablate tissue. Yet another embodiment is a cryogenic catheter, useful for cooling tissue for other applications, for use as combined or separate mapping and ablation devices, or for use with the ice mapping and ablation means of the present invention. The embodiments may include provisions for steering the catheter and for stabilizing the ablation device at the proposed lesion site.
摘要:
Cryogenic apparatus for surgery operating with liquid cryogenic medium in a closed circuit, provided with an applicator and porous heat exchanger particularly adapted for tumor surgery, operating at an overpressure of the order of 10 kPa, with the possibility of adjustment of the cooling effect, quick response and possibility of selection of the position of the surgical instrument.
摘要:
A method of preparing a cryo-surgical system for treatment includes accessing a container containing a refrigerant, a delivery tube having a first end configured to be in flow communication with the container and a second end opposite the first end. The system further includes a plurality of flexible finger portions disposed proximate the second end of the delivery tube opposite the first end. A porous applicator bud is disposed proximate the second end of the delivery tube. The porous applicator bud includes a body portion disposed between the plurality of flexible finger portions and a contact surface extending from the plurality of flexible finger portions. An adjustment ring disposed along the delivery tube adjacent to the plurality of flexible finger portions can be used to adjust the size of the contact surface of the porous applicator bud.
摘要:
Provided herein are recombinant virion arrays comprising human membrane bound proteins that retain their native conformations and/or interactions, recombinant HSV-1 virions, and methods of use including high-content, high-throughput assays for screening for ligands and/or drugs that bind human membrane bound proteins, diagnostic assays, proteomic assays, and bio-sensor assays. Also provided are recombinant HSV-1 virions comprising an envelope comprising a plurality of heterologous membrane bound proteins that retain their native conformations and/or interactions as well as recombinant HSV-1 bacterial artificial chromosome (BAC) clones encoding heterologous membrane polypeptides.
摘要:
A device, system, and method for enhancing cooling uniformity and efficiency of cryogenic fluids and providing a treatment element the shape of which can be adjusted for multiple purposes. The device may include a balloon catheter and fluid dispersion element, the fluid dispersion element directing the flow of coolant from a fluid injection element the interior wall of the balloon. The method of changing the shape of the treatment element may include retracting and extending a shaft to which the distal neck of a balloon is coupled, so that the balloon goes from a first shape to a second shape.
摘要:
A device for providing a cryotherapy ablation treatment includes a piping assembly and a snow horn adapted to create a spray of snow from a pressurized source of a low-temperature liquid, a tubular applicator for collecting a mass of snow at a prescribed density that is sufficient to allow the mass to serve as the needed, low temperature, thermal reservoir for the device after the applicator's distal end has been disconnected from the snow horn end so that it can to be used during the treatment process, and an applicator tip adapted to allow it to connect to the applicator's distal end and be used to treat those specific locations which are to receive this treatment.
摘要:
The present invention relates to a treatment device utilized in the freezing treatment method and its treatment planning device, and has an object to settle a freezing period·defrosting period according to a size of a treatment portion.A cryotherapy device comprises a gas supply-exhaust system 100, a control system 200 therefore and a freezing probe system 300. The gas supply-exhaust system 100 supplies a freezing gas and a defrosting gas to a probe 60 of the freezing probe system 300 to freeze and defrost the treatment portion surrounding the tip of the probe 60 by the Joule·Thomson effect. The control system 200 controls the gas supply-exhaust system 100 and makes treatment planning data for this control. The treatment planning data includes a freezing·defrosting sequence to determine the freezing period and the defrosting period. The determination of this sequence is performed by the computer in the control system 200. Further, this sequence is determined corresponding to the focus treatment size according to the freezing·defrosting characteristics of the tissue.
摘要:
Self-contained disposable cryosurgical devices dispense a cryogenic fluid, such as a stream of liquid nitrous oxide, carbon dioxide or argon. The cryosurgical devices include a container, including a reservoir containing a cryogenic fluid, a flow passage configured to receive the cryogenic fluid from the reservoir, a valve assembly configured in an ergonomic housing, and a dispensing head. The device further includes at least one filter disposed in the flow passage configured to facilitate the flow of the cryogenic fluid. The valve assembly includes a valve body and valve slide that is actuated to effect the flow of the cryogenic fluid through the flow passage to patient target. The housing includes an activation lever with an eccentric hub that primes the device for use when a container is loaded into the housing and the activation lever is closed.
摘要:
A cryoablation catheter assembly includes an expansion element coupled to a distal portion of a catheter that is configured and arranged for insertion into patient vasculature. The catheter includes a guide tube, a coolant transfer tube, and at least one coolant outtake region that each extend along the catheter. The guide tube and the coolant transfer tube extend beyond the distal portion of the catheter. The coolant transfer tube includes a coiled distal that wraps around a portion of the guide tube and defines a plurality of spaced-apart spray apertures. The coolant transfer tube defines a lumen configured and arranged to receive and transfer coolant from a coolant source to the spray apertures. The expansion element is in fluid communication with the at least one coolant outtake region and the plurality of spray apertures.
摘要:
The present invention relates to devices and methods delivering a plurality of thermal ablation probes to an organic target in a body, the probes being delivered in a configuration and orientation enabling efficient and thorough ablation of a large target of complex shape. Preferred embodiments include introducers having individual probe channels shaped to direct inserted probes to diverge upon exiting the introducer, probes designed and constructed to bend in selected manner when exiting the introducer, and apparatus for stabilizing an introducer with respect to a target during insertion of treatment probes from introducer to target.