摘要:
A method is provided for targeting a diagnostic agent for delivery to a folate receptor-bearing cell of an animal. The method comprises the step of administering to an animal a composition comprising a diagnostic agent complexed with a targeting ligand selected from the group consisting of folate, folate receptor-binding analogs of folate, or other folate receptor-binding ligands.
摘要:
A method and apparatus for a pellet fuel burning heating unit for burning corn or wood pellets having a balanced pressure system having a four-way split combustion intake airstream. The invention includes a combustion air blower system for providing combustion air into a firebox containing a burner under positive pressure and at the same time providing a negative pressure to remove the combustion gases from the firebox. A pressure regulator and air splitter maintains a balance between the positive and negative pressure and adjusts the air flow into the firebox and out the exhaust. The exhaust is provided through a bank of exhaust tubes running from the top of the firebox to an exhaust manifold. The blower air moves into the pressure regulator and air splitter dividing the air flow such that a portion enters the heating unit exhaust manifold to produce a negative pressure and the remaining portion enters the heating unit burner under positive pressure. Such remaining positive pressure portion is split three ways, with a flow stream directed at the fuel bed in the burner, a flow stream directed concentrically with a fuel pellet feed toward the region directly above the burner and a flow stream directed along the firebox door window. This flow split results in improved combustion efficiency of the fuel pellets and is self-regulating as between the relative amounts of air between the burner fuel bed and the region above the burner. The flow directed above the burner is concentric with the fuel feed line and hence reduces the likelihood of flame or smoke entering the fuel feed lines. The combination of air flow through the burner and directly above the burner results in a turbulence which ensures each corn kernel or pellet of fuel is sufficiently surrounded by combustion air to efficiently burn each kernel or pellet. The flow along the firebox door window prevents buildup of soot or discoloration of the glass in the door. A second, room air blower system is provided which directs ambient air around the exhaust tube bank and through vents in the heating unit housing into the room or space to be heated.
摘要:
The present invention relates to labelled resiniferatoxin and congeners thereof. Preferably, the labelled compounds of the invention are radio or fluorescently labelled. The invention is further directed to compositions comprising these labelled compounds, as well as to methods of using these compounds.
摘要:
A method is provided for enhancing transmembrane transport of exogenous molecules. The method comprises contacting a membrane of a living cell with a complex formed between said molecules and ligands selected from biotin, biotin analogs and other biotin receptor-binding ligands, and/or folic acid, folate analogs and other folate receptor-binding ligands to initiate receptor mediated transmembrane transport of the ligand complex. The method is used for the efficient delivery of peptides, proteins, nucleic acids and other compounds capable of modifying cell function into plant, animal, yeast, and bacterial cells.
摘要:
A substance-conjugated complement component Clq is provided. A substance such as signal emitting substances or cell function regulating substances is conjugated via a sulfur atom to at least one site of the component. The site is not involved in binding immunoglobulins. A marker-labelled complement component Clq is used for measuring a complement-binding antibody, an antigen, a neutralizing antibody or a substance produced internally of and at the surface of a cell or a microorganism by measuring the marker.
摘要:
Systems and methods are provided for locating anatomical features in the skin based on analysis of reflected light, and treating the located anatomical features using high-energy light. A labeling agent can be administered to optically differentiate the anatomical feature.
摘要:
Provided herein are an exogenous antibody that binds selectively to a misfolded form of human FasR, and methods and uses for said antibody. Specifically disclosed is the antibody designated AMF 3a-118 which selectively binds the peptide represented by LHHDGQFCH (SEQ ID NO:2) and the antibody designated AMF 3d-19 which selectively binds the peptide represented by NSTVCEH (SEQ ID NO:5).
摘要:
Provided are methods and agents for depleting senescent cells endogenous to a subject, involving administering to the subject a binding agent that is selectively toxic to senescent cells in an amount effective to reduce the number of such cells, wherein the binding agent binds selectively to a senescent cell surface protein having a misfolded conformation, relative to said protein in a native conformation.
摘要:
Provided herein are an exogenous antibody that binds selectively to a misfolded form of human FasR, and methods and uses for said antibody. Specifically disclosed is the antibody designated AMF 3a-118 which selectively binds the peptide represented by LHHDGQFCH (SEQ ID NO:2) and the antibody designated AMF 3d-19 which selectively binds the peptide represented by NSTVCEH (SEQ ID NO:5).
摘要翻译:本文提供了选择性结合人FasR的错误折叠形式的外源性抗体,以及所述抗体的方法和用途。 具体公开的是称为AMF 3a-118的抗体,其选择性地结合由LHHDGQFCH(SEQ ID NO:2)表示的肽和命名为AMF 3d-19的抗体,其选择性地结合由NSTVCEH(SEQ ID NO:5)表示的肽。