公开(公告)号：US4182653A

公开(公告)日：1980-01-08

申请号：US843932

申请日：1977-10-20

申请人： Brian J. Bellhouse

发明人： Brian J. Bellhouse

IPC分类号： A61M1/22 ,  A61M1/16 ,  A61M1/36 ,  C12K9/00

CPC分类号： A61M1/1698 ,  A61M1/1631 ,  A61M1/3603 ,  B01D63/08 ,  B01D2313/243

摘要： The oxygenation and removal of carbon dioxide from blood by simultaneous mass transfer through a microporous membrane is improved by pulsing the flow of oxygenating gas over the membrane. This avoids the progressive reduction in carbon dioxide transfer rate which otherwise occurs with steady gas flow and allows such transfer rate to be maintained at an acceptable level.

摘要翻译： 通过脉冲在膜上的含氧气体的流动来改善通过同时通过微孔膜的传质从血液中氧化和去除二氧化碳。 这避免了二氧​​化碳转移速率的逐渐降低，否则在稳定的气体流量下会发生这种变化，并允许将这种转移速率保持在可接受的水平。

公开(公告)号：US3730350A

公开(公告)日：1973-05-01

申请号：US3730350D

申请日：1971-07-12

申请人： BAXTER LABORATORIES INC

发明人： HOELTZENBEIN J

IPC分类号： F28F3/10 ,  A61M1/00 ,  A61M1/22 ,  B01D63/08 ,  B01D31/00

CPC分类号： B01D63/082 ,  A61M1/1631 ,  B01D2313/02

摘要： A plate dialyzer is provided with plates and membranes located therebetween. The membranes extend along the front sides of the plates and are bent around the ends of the plates. The ends of the membranes are tightly clamped between two adjacent plates. The plates have channels used for supplying or removing at least one of the dialysis liquids.

摘要翻译： 板式透析器设有位于其间的板和膜。 膜沿着板的前侧延伸并围绕板的端部弯曲。 膜的端部紧紧夹在两个相邻的板之间。 板具有用于供应或去除至少一种透析液体的通道。

公开(公告)号：US11957824B2

公开(公告)日：2024-04-16

申请号：US17986397

申请日：2022-11-14

申请人： The Regents of the University of California ,  Vanderbilt University

发明人： Shuvo Roy ,  William Fissell ,  Nathan Wright ,  Mark Goodin ,  Steven G. Goebel ,  Amanda Buck ,  Joey Groszek

IPC分类号： A61M1/34 ,  A61M1/16 ,  A61M5/165 ,  B01D63/08 ,  F28F9/02

CPC分类号： A61M1/34 ,  A61M1/1621 ,  A61M1/1631 ,  A61M5/165 ,  B01D63/082 ,  B01D63/085 ,  A61M1/1678 ,  A61M2205/04 ,  A61M2205/3334 ,  A61M2205/75 ,  A61M2206/10 ,  A61M2206/11 ,  B01D2313/105 ,  B01D2313/125 ,  F28F2009/029

摘要： Hemofilters for in vivo filtration of blood are disclosed. The hemofilters disclosed herein provide an optimal flow of blood through the filtration channels while maintaining a pressure gradient across the filtration channel walls to enhance filtration and minimize turbulence and stagnation of blood in the hemofilter.

公开(公告)号：US11712663B2

公开(公告)日：2023-08-01

申请号：US17456344

申请日：2021-11-23

申请人： The Regents of the University of California

发明人： Shuvo Roy

IPC分类号： B01D63/08 ,  B01D61/28 ,  B01D71/02 ,  A61M1/16 ,  A61M1/36 ,  B01D61/24

CPC分类号： B01D63/085 ,  A61M1/1631 ,  A61M1/3655 ,  B01D61/243 ,  B01D61/28 ,  B01D63/084 ,  B01D71/02 ,  A61M2205/04 ,  A61M2205/75 ,  A61M2207/00 ,  B01D2325/04

摘要： Parallel plate devices for hemofiltration or hemodialysis are provided. A parallel plate device includes a parallel plate assembly having an aligned stack of stackable plate subunits, each stackable plate subunit having a through channel for blood, where the blood channels are opened up at opposite ends of the parallel plate assembly. The parallel plate assembly is configured to form filtrate/dialysate channels interleaved with the blood channels, adjacent channels being separated by a silicon nanoporous filtration membrane. A blood conduit adaptor is attached to the parallel plate assembly at each of the ends, and is configured to distribute blood to or collect blood from the blood channels. Also provided are systems and methods for using the parallel plate devices.

公开(公告)号：US20190216996A1

公开(公告)日：2019-07-18

申请号：US15869526

申请日：2018-01-12

申请人： Fresenius Medical Care Holdings, Inc.

发明人： Peter Kotanko ,  Stephan Thijssen

IPC分类号： A61M1/16 ,  A61M1/36

CPC分类号： A61M1/1656 ,  A61M1/1623 ,  A61M1/1631 ,  A61M1/1696 ,  A61M1/3621 ,  A61M1/3639 ,  A61M2205/8275 ,  A61M2205/8293 ,  A61M2250/00

摘要： A system includes a dialyzer having a blood side and a dialysate side, a first extracorporeal circuit including one or more first fluid connectors for connecting the blood side of the dialyzer to the vascular system of a kidney patient, a second extracorporeal circuit including one or more second fluid connectors for connecting the dialysate side of the dialyzer to the vascular system of a healthy animal, a first pump in fluid communication with at least one of the first and second extracorporeal circuits, and a driver mechanically coupled to the first pump, where the driver is configured to drive the first pump using energy from an energy source.

公开(公告)号：US20180256803A1

公开(公告)日：2018-09-13

申请号：US15973648

申请日：2018-05-08

申请人： DEKA Products Limited Partnership

发明人： Simon C. Helmore ,  David W. McGill ,  David J. Hibbard ,  James D. Dale ,  Matthew J. Finch ,  Jesse T. Bodwell ,  Jason A. Demers

IPC分类号： A61M1/28

CPC分类号： A61M1/16 ,  A61M1/14 ,  A61M1/1623 ,  A61M1/1629 ,  A61M1/1631 ,  A61M1/1694 ,  A61M1/28 ,  A61M1/281 ,  A61M1/282 ,  A61M1/288 ,  A61M5/16809 ,  A61M5/16813 ,  A61M5/16827 ,  A61M39/1011 ,  A61M39/105 ,  A61M39/20 ,  A61M39/28 ,  A61M39/281 ,  A61M2039/1066 ,  A61M2205/12 ,  A61M2205/121 ,  A61M2205/122 ,  A61M2205/123 ,  A61M2205/127 ,  A61M2205/128 ,  A61M2205/13 ,  A61M2205/14 ,  A61M2205/3306 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3379 ,  A61M2205/36 ,  A61M2205/502 ,  A61M2209/08 ,  F04B43/02 ,  F04B43/08 ,  F04B43/086 ,  Y02A90/26

摘要： A medical infusion fluid handling system, such as an automated peritoneal dialysis system, may be arranged to de-cap and connect one or more lines (such as solution lines) with one or more spikes or other connection ports on a fluid handling cassette. This feature may reduce a likelihood of contamination since no human interaction is required to de-cap and connect the one or more lines and the one or more spikes. For example, the automated peritoneal dialysis system may include a carriage arranged to receive the one or more lines each having a connector end and a cap. The carriage may move along a first direction so as to move the connector ends of the one or more lines along the first direction, and a cap stripper may be arranged to engage with the caps on the the one or more lines on the carriage. The cap stripper may move in a second direction transverse to the first direction, as well as to move with the carriage along the first direction.

公开(公告)号：US10071193B2

公开(公告)日：2018-09-11

申请号：US15094623

申请日：2016-04-08

申请人： The Charles Stark Draper Laboratory, Inc.

发明人： Christopher DiBiasio ,  Joseph L. Charest ,  Jeffrey T. Borenstein ,  Ernest Kim ,  Daniel I. Harjes

IPC分类号： B01D63/08 ,  B01D63/00 ,  A61M1/34 ,  F17D1/00 ,  A61M1/16 ,  B01D61/24 ,  B01L3/00

CPC分类号： A61M1/34 ,  A61M1/16 ,  A61M1/1631 ,  A61M1/1698 ,  A61M1/3403 ,  A61M1/36 ,  A61M2202/0413 ,  A61M2205/0244 ,  A61M2205/75 ,  B01D61/243 ,  B01D63/005 ,  B01D63/082 ,  B01D63/085 ,  B01D63/088 ,  B01D2313/08 ,  B01D2313/105 ,  B01D2319/04 ,  B01L3/5027 ,  B01L2300/0864 ,  B01L2300/0874 ,  F17D1/00 ,  Y10T137/794

摘要： A compact hydraulic manifold for transporting shear sensitive fluids is provided. A channel network can include a trunk and branch architecture coupled to a bifurcation architecture. Features such as tapered channel walls, curvatures and angles of channels, and zones of low fluid pressure can be used to reduce the size while maintaining wall shear rates within a narrow range. A hydraulic manifold can be coupled to a series of microfluidic layers to construct a compact microfluidic device.

公开(公告)号：US09956531B2

公开(公告)日：2018-05-01

申请号：US14593110

申请日：2015-01-09

申请人： Elwha LLC

发明人： Ralph G. Dacey, Jr. ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Jordin T. Kare ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Dennis J. Rivet ,  Michael A. Smith ,  Clarence T. Tegreene ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood

IPC分类号： B01D69/00 ,  B01D69/06 ,  A61M1/16 ,  A61M1/20 ,  A61M1/26 ,  B01D67/00 ,  A61M1/00 ,  B01D69/12

CPC分类号： B01D67/0088 ,  A61M1/0088 ,  A61M1/1623 ,  A61M1/1631 ,  A61M2205/3334 ,  B01D69/12 ,  B01D2325/26

摘要： A device and methods are disclosed herein for fluid removal during wound treatment or for removal or dialysis of components from blood or tissue. A device is disclosed that includes a multilayer membrane including a plurality of layers; an electroactive polymer within each layer; and a controller operably connected to sequentially activate the electroactive polymer to alter one or more sizes of the plurality of the variably-sized pores within one or more layers of the multilayer membrane. A device is disclosed that includes a multilayer membrane including a plurality of layers; an actuator operably attached to the plurality of layers of the multilayer membrane; and a controller operably activating the actuator to alter a relative lateral position of the two or more layers of the multilayer membrane to align two or more of the plurality of pores within the plurality of layers of the multilayer membrane.

公开(公告)号：US20160339161A1

公开(公告)日：2016-11-24

申请号：US15111843

申请日：2015-01-20

申请人： Toshinari Takahashi ,  Masashi Yokota ,  Hiroshi Fukushima ,  Kimihiko Nakamura

发明人： Toshinari Takahashi ,  Masashi Yokota ,  Hiroshi Fukushima ,  Kimihiko Nakamura

IPC分类号： A61M1/16 ,  A61M39/22 ,  A61M1/36 ,  B01D63/10 ,  B01D65/08

CPC分类号： A61M1/1631 ,  A61M1/3496 ,  A61M1/3633 ,  A61M1/3643 ,  A61M1/3644 ,  A61M1/3652 ,  A61M39/22 ,  A61M2205/3331 ,  A61M2205/7563 ,  B01D29/216 ,  B01D63/10 ,  B01D65/08 ,  B01D2313/083 ,  B01D2313/143 ,  B01D2313/18

摘要： To provide a blood treatment filter device capable of efficiently utilizing a blood treatment filter.A blood treatment filter device 20 has a filter sheet 26 through which a specific component among components forming blood is harder to pass than other components and a spacer sheet 27 through which the specific component is easier to pass than through the filter sheet 26. The filter sheet 26 has filter through-holes 39 disposed at intervals. The filter sheet 26 and the spacer sheet 27 are spirally wound in an overlapped state. The filter device 20 has seals 31 sealing both end portions in the longitudinal direction of a wound body 25 formed by the filter sheet 26 and the spacer sheet 27 which are spirally wound in a fluid-tight manner. The outer peripheral surface of the wound body 25 is formed by the filter sheet 26.

摘要翻译： 血液处理过滤装置20具有过滤片26，其中形成血液的成分中的特定成分比其它成分更难通过，特定成分比通过过滤片26更容易通过的间隔片27.过滤器 片26具有间隔设置的过滤器通孔39。 过滤片26和间隔片27以重叠状态螺旋卷绕。 过滤装置20具有密封件31，该密封件31密封由以流体密封的方式螺旋卷绕的过滤片26和间隔片27形成的卷绕体25的长度方向的两端部。 卷绕体25的外周面由过滤片26形成。

公开(公告)号：US20160220961A1

公开(公告)日：2016-08-04

申请号：US15094623

申请日：2016-04-08

申请人： The Charles Stark Draper Laboratory, Inc.

发明人： Christopher DiBiasio ,  Joseph L. Charest ,  Jeffrey T. Borenstein ,  Ernest Kim ,  Daniel I. Harjes

IPC分类号： B01D63/08 ,  B01D63/00 ,  A61M1/34

CPC分类号： A61M1/34 ,  A61M1/16 ,  A61M1/1631 ,  A61M1/1698 ,  A61M1/3403 ,  A61M1/36 ,  A61M2202/0413 ,  A61M2205/0244 ,  A61M2205/75 ,  B01D61/243 ,  B01D63/005 ,  B01D63/082 ,  B01D63/085 ,  B01D63/088 ,  B01D2313/08 ,  B01D2313/105 ,  B01D2319/04 ,  B01L3/5027 ,  B01L2300/0864 ,  B01L2300/0874 ,  F17D1/00 ,  Y10T137/794

摘要： A compact hydraulic manifold for transporting shear sensitive fluids is provided. A channel network can include a trunk and branch architecture coupled to a bifurcation architecture. Features such as tapered channel walls, curvatures and angles of channels, and zones of low fluid pressure can be used to reduce the size while maintaining wall shear rates within a narrow range. A hydraulic manifold can be coupled to a series of microfluidic layers to construct a compact microfluidic device.

摘要翻译： 提供用于输送剪切敏感流体的紧凑型液压歧管。 信道网络可以包括耦合到分叉架构的中继线和分支架构。 可以使用诸如锥形通道壁，通道的曲率和通道角度以及低流体压力的区域来减小尺寸，同时将壁剪切速率保持在窄范围内。 液压歧管可以连接到一系列微流体层以构造紧凑的微流体装置。