公开(公告)号：US5604225A

公开(公告)日：1997-02-18

申请号：US449174

申请日：1995-05-24

Applicant: Manfred Reiffen ,  Rudolf Hurnaus ,  Robert Sauter ,  Wolfgang Grell ,  Eckhard Rupprecht

Inventor： Manfred Reiffen ,  Rudolf Hurnaus ,  Robert Sauter ,  Wolfgang Grell ,  Eckhard Rupprecht

IPC: A61K31/42 ,  A61K31/421 ,  A61K31/425 ,  A61K31/426 ,  A61K31/445 ,  A61K31/495 ,  A61K31/496 ,  A61K31/535 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/55 ,  A61P3/06 ,  A61P3/08 ,  A61P3/10 ,  A61P7/02 ,  C07D263/32 ,  C07D263/34 ,  C07D263/48 ,  C07D265/30 ,  C07D265/32 ,  C07D277/20 ,  C07D277/22 ,  C07D277/24 ,  C07D277/28 ,  C07D277/32 ,  C07D277/38 ,  C07D277/40 ,  C07D277/42 ,  C07D277/44 ,  C07D277/46 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14 ,  C07D413/06

CPC classification number: C07D277/22 ,  C07D263/32 ,  C07D265/32 ,  C07D277/24 ,  C07D277/32 ,  C07D277/40 ,  C07D277/42 ,  C07D277/46 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14

Abstract: Substituted thiazoles, oxazoles and 2-hydroxy morpholine compounds useful in the treatment of diabetes mellitus and obesity are described.

Abstract translation: 描述了可用于治疗糖尿病和肥胖症的取代的噻唑，恶唑和2-羟基吗啉化合物。

公开(公告)号：US5534644A

公开(公告)日：1996-07-09

申请号：US464308

申请日：1995-06-05

Applicant: Endre Palosi ,  Dezso Korbonits ,  Erzsebet Molnar nee Bako ,  Ida Szvoboda nee Kanzel ,  Gergely Heja ,  Pal Kiss ,  Csaba Gonczi ,  Ferenc Sperber ,  Csaba Huszar ,  Gyorgy Mihalovics ,  Attila Nemeth ,  Mihaly Su ,  Karol Gyure ,  Istvan Bone ,  Ferenc Morasz ,  Laszlo Ledniczky ,  Erzsebet Szabo nee Kardos ,  Peter Gy ri ,  Erzsebet Szalay ,  Karoly Ban ,  Iidiko Buttkai ,  Arpad K vari ,  Sandor Garaczy

Inventor： Endre Palosi ,  Dezso Korbonits ,  Erzsebet Molnar nee Bako ,  Ida Szvoboda nee Kanzel ,  Gergely Heja ,  Pal Kiss ,  Csaba Gonczi ,  Ferenc Sperber ,  Csaba Huszar ,  Gyorgy Mihalovics ,  Attila Nemeth ,  Mihaly Su ,  Karol Gyure ,  Istvan Bone ,  Ferenc Morasz ,  Laszlo Ledniczky ,  Erzsebet Szabo nee Kardos ,  Peter Gy ri ,  Erzsebet Szalay ,  Karoly Ban ,  Iidiko Buttkai ,  Arpad K vari ,  Sandor Garaczy

IPC: C07D277/20 ,  A61K31/00 ,  C07C331/02 ,  C07C331/04 ,  C07D277/22 ,  C07D277/32 ,  C07D277/34

CPC classification number: C07D277/22 ,  C07C331/04 ,  C07D277/32 ,  C07D277/34

Abstract: The present invention relates to a process for the preparation of compounds of general formula (I), wherein R stands for a straight chained C.sub.1-5 alkyl group substituted by a chlorine atom in the 2-position, and acid addition salts thereof, characterized by reacting a 3,5-dichloro-2-alkanone of general formula (V), wherein R is a defined above, with an inorganic thiocyamate, and a) converting the 3-thiocyanato-5-chloro-2-alkanone of general formula (IV), thus obtained, wherein R is as defined above, into 2-chloro-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (II), wherein R is as defined above, by gaseous hydrochloric acid in an organic solvent, hydrogenating the said compound in the presence of a metal catalyst in an organic solvent, or b) reacting said compound of general formula (IV) with an aqueous mineral acid and treating the 2-hydroxy-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (III), thus obtained with a halogenating agent, and hydrogenating the 2-chloro-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (II) thus obtained, wherein R is as defined above, in an organic solvent in presence of a metal catalyst, and optionally converting the 4-methyl-5-(2-chloroalkyl)-thiazole of general formula (I), wherein R is as defined above, thus obtained or a hydrochloride salt thereof, in a manner known per into another acid addition salt or setting free a compound of general formula (I), wherein R is a defined above, from its acid addition salt.

Abstract translation: 本发明涉及制备通式（I）化合物的方法，其中R代表2-位被氯原子取代的直链C 1-5烷基及其酸加成盐，其特征在于使 通式（Ⅴ）的3,5-二氯-2-烷酮（其中R为上述定义）与无机硫氰酸酯反应，和a）将通式（IV）的3-氰硫基-5-氯-2-烷酮 ），其中R如上所定义，通过气态盐酸在通式（II）的2-氯-4-甲基-5-（2-氯烷基） - 噻唑中，其中R如上所定义， 有机溶剂，在金属催化剂存在下，在有机溶剂中氢化所述化合物，或b）使所述通式（Ⅳ）化合物与无机酸水溶液反应，并处理2-羟基-4-甲基-5-（ 2-氯烷基） - 噻唑，由卤化剂得到，并氢化2-氯-4-甲基 在金属催化剂的存在下，在有机溶剂中，如此获得的通式（II）的5-（5-氯-2-（2-氯烷基） - 噻唑），其中R如上定义，并且任选地将4-甲基-5- - 氯代烷基） - 噻唑，其中R如上所定义，如此获得，或其盐酸盐，以与另一种酸加成盐相同的方式或不含通式（I）的化合物，其中 R是上述定义的酸加成盐。

公开(公告)号：US5384324A

公开(公告)日：1995-01-24

申请号：US55402

申请日：1993-04-30

Applicant: Kozo Shiokawa ,  Shinichi Tsuboi ,  Koichi Moriya ,  Ikuro Honda ,  Yumi Hattori ,  Katsuhiko Shibuya

Inventor： Kozo Shiokawa ,  Shinichi Tsuboi ,  Koichi Moriya ,  Ikuro Honda ,  Yumi Hattori ,  Katsuhiko Shibuya

IPC: C07D237/08 ,  A01N47/40 ,  C07D213/38 ,  C07D213/40 ,  C07D213/61 ,  C07D213/74 ,  C07D231/12 ,  C07D239/26 ,  C07D239/30 ,  C07D241/12 ,  C07D261/08 ,  C07D263/34 ,  C07D271/10 ,  C07D277/20 ,  C07D277/28 ,  C07D277/32 ,  C07D333/28 ,  C07D521/00 ,  A01N43/78

CPC classification number: C07D213/40 ,  C07D213/61 ,  C07D239/26 ,  C07D241/12 ,  C07D277/32

Abstract: A cyano compound useful as an insecticide, of the formula (I) ##STR1## wherein the radicals are defined in the claims.

Abstract translation: 用作杀虫剂的氰基化合物，式（I）其中基团在权利要求中定义。

公开(公告)号：US5304564A

公开(公告)日：1994-04-19

申请号：US987510

申请日：1992-12-07

Applicant: Shin-ichi Tsuboi ,  Koichi Moriya ,  Yumi Hattori ,  Shinzaburo Sone ,  Katsuhiko Shibuya

Inventor： Shin-ichi Tsuboi ,  Koichi Moriya ,  Yumi Hattori ,  Shinzaburo Sone ,  Katsuhiko Shibuya

IPC: A01N47/44 ,  A01N51/00 ,  C07D213/61 ,  C07D261/08 ,  C07D261/10 ,  C07D277/20 ,  C07D277/32 ,  A01N43/40

CPC classification number: C07D261/10 ,  A01N47/44 ,  A01N51/00 ,  C07D213/61 ,  C07D277/32

Abstract: Novel guanidine derivatives of the formula (I) ##STR1## wherein Z is 2-chloro-5-pyridyl, 2-chloro-5-thiazolyl, or 3-chloro-5-isoxazolyl,R.sup.1 is hydrogen or C.sub.1-4 alkyl,R.sup.2 is hydrogen, C.sub.1-4 alkyl, C.sub.3-4 alkynyl, C.sub.3-4 alkenyl or 2-chloro-5-pyridylmethyl,R.sup.3 and R.sup.4 each represent hydrogen, halogen, C.sub.1-4 alkyl, C.sub.3-1 alkynyl, C.sub.3-4 alkenyl, benzyl which may be substituted, or Z--C(R.sup.1)H--,n is 2 or 3, andY is nitro or cyano,and pesticidal compositions comprising the compound of the formula (I) as active components.

Abstract translation: 式（I）的新型胍衍生物（*化学结构*）（I）其中Z是2-氯-5-吡啶基，2-氯-5-噻唑基或3-氯-5-异恶唑基，R 1是氢或 C 1-4烷基，R 2是氢，C 1-4烷基，C 3-4炔基，C 3-4链烯基或2-氯-5-吡啶基甲基，R 3和R 4各自代表氢，卤素，C 1-4烷基，C 3-8炔基 ，可以被取代的C 3-4链烯基，可以被取代的苄基或ZC（R 1）H - ，n是2或3，Y是硝基或氰基，以及包含式（I）化合物作为活性组分的杀虫组合物。

公开(公告)号：US5283363A

公开(公告)日：1994-02-01

申请号：US821202

申请日：1992-01-16

Applicant: Dietmar Kuhnt ,  Thomas Himmler ,  Heinz Ziemann

Inventor： Dietmar Kuhnt ,  Thomas Himmler ,  Heinz Ziemann

IPC: B01J31/30 ,  C07B61/00 ,  C07C209/68 ,  C07C209/70 ,  C07C209/74 ,  C07C211/28 ,  C07C211/29 ,  C07C211/49 ,  C07C215/54 ,  C07C229/38 ,  C07C255/58 ,  C07C323/32 ,  C07D213/38 ,  C07D239/26 ,  C07D249/12 ,  C07D277/20 ,  C07D277/28 ,  C07D277/32 ,  C07D319/20 ,  C07D333/20 ,  C07C211/08 ,  C07D211/00 ,  C07D251/14

CPC classification number: C07D333/20 ,  C07C209/68 ,  C07C209/70 ,  C07C211/28 ,  C07C211/29 ,  C07C211/49 ,  C07C215/54 ,  C07C229/38 ,  C07C255/58 ,  C07C323/32 ,  C07D213/38 ,  C07D277/28 ,  C07D319/20

Abstract: The invention relates to a new process for the preparation of (hetero)arylalk(en/in)ylamines of the formula (I) ##STR1## in which A represents ethane-1,2-diyl (ethylene, dimethylene, --CH.sub.2 --CH.sub.2 --) or represents ethene-1,2-diyl (ethenylene, vinylene, --CH.dbd.CH--) or represents ethine-1,2-diyl (ethinylene, --C.ident.C--),characterized in that(a) in the event that, in formula (I), A represents ethine-1,2-diyl, halogeno(hetero)aryl compounds of the general formula (II)Ar--X (II)are reacted with aminoalkinyl compounds of the general formula (III) ##STR2## and, if appropriate, (b) in the event that, in formula (I), A represents ethane-1,2-diyl or ethene-1,2-diyl, the new (hetero)aralkinylamines which are obtained by the process step described under (a), of the general formula (Ia), ##STR3## are reacted with a hydrogenating agent, if appropriate in the presence of a catalyst and if appropriate in the presence of a diluent, the definitions applying to Ar, R.sup.1, R.sup.2 and X being those mentioned in the description, and their use as intermediates for medicoments and plant protection agents, in this case in particular herbicides.

Abstract translation: 本发明涉及一种制备式（I）（*化学结构*）（I）的（杂）芳基烯（烯/茚）基胺的新方法，其中A代表乙烷-1,2-二基（乙烯， 二亚乙基，-CH 2 -CH 2 - ）或代表乙烯-1,2-二基（亚乙烯基，亚乙烯基，-CH = CH-）或代表乙炔-1,2-二基（亚乙烯基，-C + 5 C-），其特征在于 （a）在式（I）中A表示乙炔-1,2-二基的情况下，通式（Ⅱ）Ar-X（Ⅱ）的卤代（杂）芳基化合物与 通式（III）（*化学结构*）（III），如果合适，（b）在式（I）中，A表示乙烷-1,2-二基或乙烯-1,2-二基 通过通式（Ia）中描述的方法步骤（Ia），（*化学结构*）（Ia）获得的新的（杂）芳炔基胺与氢化剂反应，如果合适，在存在下 的催化剂，如果在稀释剂存在下适当，定义a 适用于Ar，R1，R2和X是说明书中提及的那些，它们用作药物和植物保护剂的中间体，在这种情况下特别是除草剂。

公开(公告)号：US5225423A

公开(公告)日：1993-07-06

申请号：US591767

申请日：1990-10-02

Applicant: Antonio Mete ,  Lai C. Chan

Inventor： Antonio Mete ,  Lai C. Chan

IPC: C07D277/28 ,  A01N43/40 ,  A01N43/78 ,  C07C323/22 ,  C07C323/27 ,  C07D213/36 ,  C07D213/60 ,  C07D213/61 ,  C07D277/20 ,  C07D277/32 ,  C07D277/42

CPC classification number: C07D277/32 ,  A01N43/40 ,  A01N43/78 ,  C07C323/22 ,  C07C323/27 ,  C07D213/61

Abstract: A butenone compound having the general formula I: ##STR1## wherein R.sup.1 represents a pyridyl or thiazolyl group bearing one or more substituents independantly selected from halogen atoms, alkyl, alkoxy, alkylthio, haloalkyl, cyano, alkoxycarbonyl, alkylamino and dialkylamino; R.sup.2 represents a hydrogen atom, an alkyl group or an alkylcarbonyl group; R.sup.3 represents an alkyl group; R.sup.4 represents a haloalkyl group; X represents a sulphur atom or a group of formula N--R.sup.5, wherein R.sup.5 represents a hydrogen atom, an alkyl group or an alkylcarbonyl group; and n is 0 or 1, methods for their preparation and their use in combating pests.

公开(公告)号：US5175301A

公开(公告)日：1992-12-29

申请号：US406515

申请日：1989-09-13

Applicant: Isao Minamida ,  Koichi Iwanaga ,  Tetsuo Okauchi

Inventor： Isao Minamida ,  Koichi Iwanaga ,  Tetsuo Okauchi

IPC: C07D213/61 ,  A01N33/18 ,  A01N35/08 ,  A01N43/40 ,  A01N43/42 ,  A01N43/60 ,  A01N43/78 ,  A01N47/24 ,  A01N55/00 ,  C07C211/22 ,  C07C211/29 ,  C07C229/34 ,  C07C243/10 ,  C07C311/50 ,  C07D20060101 ,  C07D213/24 ,  C07D213/38 ,  C07D213/40 ,  C07D213/42 ,  C07D213/64 ,  C07D213/70 ,  C07D213/74 ,  C07D213/77 ,  C07D215/12 ,  C07D215/38 ,  C07D239/26 ,  C07D241/12 ,  C07D277/20 ,  C07D277/22 ,  C07D277/28 ,  C07D277/32 ,  C07D277/38 ,  C07D277/42 ,  C07D295/13 ,  C07D295/30 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07F7/08

CPC classification number: C07D213/40 ,  A01N35/08 ,  A01N43/40 ,  A01N43/42 ,  A01N43/60 ,  A01N43/78 ,  A01N47/24 ,  A01N55/00 ,  C07C211/29 ,  C07D213/38 ,  C07D213/42 ,  C07D213/61 ,  C07D213/64 ,  C07D213/70 ,  C07D213/74 ,  C07D215/12 ,  C07D241/12 ,  C07D277/28 ,  C07D277/32 ,  C07D277/42 ,  C07D401/06 ,  C07F7/0812

Abstract: .alpha.-Unsaturated amines of the formula: ##STR1## wherein X.sup.1 and X.sup.2 are such that one is an electron-attracting group with the other being a hydrogen atom or an electron-attracting group; R.sup.1 is a group attached through a nitrogen atom; R.sup.2 is a hydrogen atom or a group attached through a carbon, nitrogen or oxygen atom; n is an integer equal to 0, 1 or 2; A is a heterocyclic group or a cyclic hydrocarbon group, and salts thereof and their agrochemical use as insecticidal and/or miticidal agents are described.

Abstract translation: 具有下式的α-不饱和胺：其中X1和X2使得一个是吸电子基团，另一个是吸电子基团或吸电子基团; R1是通过氮原子连接的基团; R2是氢原子或通过碳，氮或氧原子连接的基团; n是等于0,1或2的整数; A是杂环基或环状烃基，其盐及其作为杀虫剂和/或杀螨剂的农药用途被描述。

公开(公告)号：US5166167A

公开(公告)日：1992-11-24

申请号：US851922

申请日：1992-03-16

Applicant: Jean-Louis Brayer ,  Jean-Pierre Demoute ,  Gilles Mourioux

Inventor： Jean-Louis Brayer ,  Jean-Pierre Demoute ,  Gilles Mourioux

IPC: A01N43/78 ,  A61K31/425 ,  A61K31/426 ,  A61P31/04 ,  C07C69/716 ,  C07D277/20 ,  C07D277/24 ,  C07D277/30 ,  C07D277/32 ,  C07D277/34 ,  C07D277/36

CPC classification number: C07D277/20 ,  A01N43/78 ,  C07C69/716 ,  C07D277/30 ,  C07D277/32 ,  C07D277/34 ,  C07D277/36

Abstract: A compound of the formula ##STR1## wherein Ar is phenyl optionally substituted with at least one member of the group consisting of halogen, methylenedioxy, phenoxy, phenyl, --CF.sub.3 and alkyl, alkoxy and alkylthio of 1 to 6 carbon atoms, Z is selected from the group consisting of hydrogen, chlorine, --CF.sub.3 and alkyl, alkoxy and alkylthio of 1 to 6 carbon atoms, R.sub.1 and R.sub.2 are individually alkyl of 1 to 6 carbon atoms and the exocyclic double bond has (Z) or (E) configuration having fungicidal activity.

Abstract translation: 式（I）的化合物，其中Ar为任选被至少一个选自卤素，亚甲二氧基，苯氧基，苯基，-CF 3和1-6个碳原子的烷氧基和烷硫基的成员取代的苯基， Z选自氢，氯，-CF 3和1至6个碳原子的烷基，烷氧基和烷硫基，R 1和R 2分别是1至6个碳原子的烷基，并且环外双键具有（Z）或（ E）配置具有杀菌活性。

公开(公告)号：US5114959A

公开(公告)日：1992-05-19

申请号：US478119

申请日：1990-02-09

Applicant: Alexander Klausener ,  Gerd Kleefeld ,  Wilhelm Brandes ,  Stefan Dutzmann ,  Gerd Hanssler

Inventor： Alexander Klausener ,  Gerd Kleefeld ,  Wilhelm Brandes ,  Stefan Dutzmann ,  Gerd Hanssler

IPC: C07D277/20 ,  A01N43/74 ,  A01N43/76 ,  A01N43/78 ,  C07D263/34 ,  C07D263/38 ,  C07D263/46 ,  C07D263/48 ,  C07D277/32 ,  C07D277/34 ,  C07D277/36 ,  C07D277/38 ,  C07D277/42 ,  C07D277/56 ,  C07D413/04 ,  C07D417/04

CPC classification number: C07D277/56 ,  A01N43/74 ,  C07D277/42

Abstract: Fungicidal substituted acrylic esters of the formula ##STR1## in which R.sup.1 represents hydrogen, alkyl or alkenyl, or represents in each case optionally substitued aralkyl, aralkenyl, aryl or heteroaryl,R.sup.2 represents halogen, cyano, nitro, formyl, halogenoalkyl, alkoxyalkyl or alkylthioalkyl, or represents hydroximinoalkyl, alkoximinoalkyl, N-alkyliminoalkyl, N-aryliminoalkyl or N,N-dialkylhydrazonoalkyl, or represents alkoxy, alkylthio, halogenoalkoxy or halogenoalkylthio, or represents aryloxy or arylthio, or represents alkanoyl, alkoxycarbonyl, N,N-dialkylcarbamoyl or heterocyclylcarbonyl,R.sup.3 represents alkyl, or represents optionally substituted aralkyl,R.sup.4 represents dialkylamino or represents a radical --Z--R.sup.5,X represents oxygen or sulphur andY represents oxygen or sulphur or represents a radical ##STR2## where R.sup.5 represents alkyl or represents optionally substituted aralkyl,R.sup.6 represents hydrogen, alkyl or alkanoyl, or represents in each case optionally substituted aralkyl or aryl, andZ represents oxygen or sulphur.

Abstract translation: 式（I）的杀真菌取代的丙烯酸酯，其中R 1表示氢，烷基或烯基，或在每种情况下表示任选取代的芳烷基，芳烯基，芳基或杂芳基，R 2表示卤素，氰基，硝基，甲酰基，卤代烷基， 烷氧基烷基或烷硫基烷基，或代表肟基烷基，烷肟基烷基，N-烷基亚氨基烷基，N-芳基亚氨基烷基或N，N-二烷基肼基烷基，或代表烷氧基，烷硫基，卤代烷氧基或卤代烷硫基，或代表芳氧基或芳硫基，或代表烷酰基，烷氧羰基，N， 二烷基氨基甲酰基或杂环基羰基，R3代表烷基，或代表任意取代的芳烷基，R4代表二烷基氨基或代表基团-Z-R5，X代表氧或硫，Y代表氧或硫，或代表基团，其中R5代表烷基或代表 任选取代的芳烷基，R 6表示氢，烷基或烷酰基，或在各种情况下表示任选取代的芳烷基或 芳基，Z表示氧或硫。

公开(公告)号：US5054194A

公开(公告)日：1991-10-08

申请号：US649261

申请日：1991-01-30

Applicant: Randy Pollock

Inventor： Randy Pollock

IPC: A01N43/40 ,  A01N47/42 ,  A01N47/44 ,  C07D213/38 ,  C07D213/61 ,  C07D277/32

CPC classification number: C07D277/32 ,  A01N43/40 ,  A01N47/42 ,  A01N47/44 ,  C07D213/38 ,  C07D213/61 ,  H01L2224/48091 ,  H01L2224/48137 ,  H01L2224/49175 ,  H01L2924/19107 ,  Y10T29/49004 ,  Y10T29/49144 ,  Y10T29/49162

Abstract: A method for controlling the wire loop height of wires installed during the manufacture of an electronic module with a wire bond machine provides for making adjustments based on the wire loop height adjustment resolution of the wire bond machine itself, rather than on an electrical performance specification tolerance for the module.