ANTIBACTERIAL MACROLACTIN A THAT BACILLUS POLYFERMENTICUS KJS-2 PRODUCED IN
    41.
    发明申请
    ANTIBACTERIAL MACROLACTIN A THAT BACILLUS POLYFERMENTICUS KJS-2 PRODUCED IN 审中-公开
    抗生素大豆蛋白A生产的BACILLUS POLYFERMENKUS KJS-2

    公开(公告)号:US20100087516A1

    公开(公告)日:2010-04-08

    申请号:US12531434

    申请日:2008-03-12

    CPC classification number: C12P17/08 C07D313/00 C12R1/07

    Abstract: The present invention relates to uses of Macrolactin A produced by Bacillus polyfermenticus KJS-2 (KCCM 10769P), which is a new bacillus strain, as an antibiotic. Macrolactin A of the present invention, which is produced by Bacillus polyfermenticus KJS-2, shows a broad spectrum of antibiotic activity against a variety of microorganisms and fungi, and is proved to be very efficient for the inhibition of particularly vancomycin-resistant enterococci (VRE) and methicillin-resistant Staphylococcus Aureus (MRSA) that are multidrug-resistant bacteria. The antibiotic Macrolactin A produced by Bacillus polyfermenticus KJS-2, can be used as an excellent antibiotic against vancomycin-resistant enterococci (VRE) and methicillin-resistant Staphylococcus Aureus (MRSA), and thus the present invention is a very useful invention for medical industry.

    Abstract translation: 本发明涉及作为新型芽孢杆菌菌株的作为抗生素的由Bacillus polyfermenticus KJS-2(KCCM 10769P)生产的Mac lactin A的用途。 由多发芽孢杆菌KJS-2生产的本发明的大肠杆菌素A表现出对多种微生物和真菌的广谱抗生素活性,并被证明对于特别是耐万古霉素耐药性肠球菌(VRE)的抑制是非常有效的 )和耐甲氧西林金黄色葡萄球菌(MRSA)是多重耐药细菌。 通过芽孢杆菌KJS-2生产的抗生素麦脯氨酸A可用作抗万古霉素抗性肠球菌(VRE)和耐甲氧西林金黄色葡萄球菌(MRSA)的优良抗生素,因此本发明是医疗行业非常有用的发明 。

    SALTS OF PYRROLOPYRIMIDINONE DERIVATIVES AND PROCESS FOR PREPARING THE SAME
    42.
    发明申请
    SALTS OF PYRROLOPYRIMIDINONE DERIVATIVES AND PROCESS FOR PREPARING THE SAME 审中-公开
    吡咯烷酮衍生物的制备方法及其制备方法

    公开(公告)号:US20100069632A1

    公开(公告)日:2010-03-18

    申请号:US12307144

    申请日:2007-07-03

    CPC classification number: C07D487/04

    Abstract: The present invention relates to salts of a pyrrolopyrimidinone derivative having superior PDE-5 inhibition activity and a process for preparing the same. More particularly, the present invention relates to a crystalline acid addition salt prepared by reacting a pyrrolopyrimidinone derivative with an acid selected from gentisic acid, maleic acid, citric acid, fumaric acid and tartaric acid. With no hygroscopic property and superior long-term storage stability, photostability and thermal stability, the salts of the pyrrolopyrimidinone derivative are appropriate to be prepared into medications and, with superior PDE-5 inhibition activity, are useful for the treatment and prevention of erectile dysfunction, pulmonary arterial hypertension, chronic obstructive pulmonary disease, benign prostatic hypertrophy and lower urinary tract diseases.

    Abstract translation: 本发明涉及具有优异的PDE-5抑制活性的吡咯并嘧啶酮衍生物的盐及其制备方法。 更具体地,本发明涉及通过使吡咯并嘧啶酮衍生物与选自龙胆酸,马来酸,柠檬酸,富马酸和酒石酸的酸反应制备的结晶酸加成盐。 无吸湿性和优异的长期储存稳定性,光稳定性和热稳定性,吡咯并嘧啶酮衍生物的盐适于制备成药物,并且具有优异的PDE-5抑制活性,可用于治疗和预防勃起功能障碍 肺动脉高压,慢性阻塞性肺疾病,良性前列腺肥大和下尿路疾病。

    Haptic steering wheel switch apparatus
    48.
    发明授权
    Haptic steering wheel switch apparatus 有权
    触觉方向盘开关装置

    公开(公告)号:US08987620B2

    公开(公告)日:2015-03-24

    申请号:US13455496

    申请日:2012-04-25

    CPC classification number: G06F3/016 G06F3/0338 G06F3/0362

    Abstract: The present invention provides haptic steering wheel switch apparatus including: a haptic wheel housing unit disposed on a steering wheel of a vehicle; a circuit board unit disposed in the haptic wheel housing unit; and a haptic wheel device unit including a haptic wheel device actuator establishing an electrical connection with the circuit board unit and including a haptic shaft, a haptic knob connected to the haptic shaft and exposedly disposed on one surface of the haptic wheel housing unit, and a haptic wheel device sensing unit for detecting a rotating state of the haptic shaft, wherein the haptic knob achieves a rotary operation on a plane formed by the steering wheel of the vehicle, the haptic wheel device actuator moves in a longitudinal direction of the haptic shaft, and a button switch unit operating vertically and independently of the haptic knob is provided outside the haptic knob.

    Abstract translation: 本发明提供了一种触觉方向盘开关装置,包括:设置在车辆方向盘上的触觉轮收容单元; 布置在所述触觉轮收纳单元中的电路板单元; 以及触觉轮装置单元,其包括触觉轮装置致动器,其与电路板单元建立电连接并且包括触觉轴,连接到触觉轴并且暴露地设置在触觉轮壳单元的一个表面上的触觉旋钮,以及 触觉轮装置感测单元,用于检测触觉轴的旋转状态,其中所述触觉旋钮在由所述车辆的方向盘形成的平面上实现旋转操作,所述触觉轮装置致动器沿所述触觉轴的纵向方向移动, 并且在触觉旋钮外部设置垂直且独立于触觉旋钮操作的按钮开关单元。

    Composition of skin external application containing ginseng berry extracts
    50.
    发明授权
    Composition of skin external application containing ginseng berry extracts 有权
    含有人参浆果提取物的外用皮肤成分

    公开(公告)号:US08877264B2

    公开(公告)日:2014-11-04

    申请号:US12602421

    申请日:2008-05-30

    Abstract: Disclosed herein is a. skin external composition containing ginseng berry extract. More specifically, disclosed is a skin external composition, which contains, as an active ingredient, ginseng berry extract having the specific components and compositions, among the above-ground parts of ginseng, and thus promotes the production of collagen in the skin, shows an MMP-I inhibitory effect and, at the same time, has skin-aging inhibitory and wrinkle-reducing effects, resulting from antioxidant effects and DNA damage-protecting effects. Also disclosed is a skin external composition, which contains, as an active ingredient, ginseng berry extract, which has a skin whitening effect resulting from the effects of inhibiting melanin production and reducing pigmentation caused by UV radiation, the effects of relieving dry skin symptoms and atopic symptoms by inducing and maintaining the normal differentiation of skin keratinocytes, the effect of relieving acne and skin troubles by the regulation of sebum secretion and an anti-inflammatory effect, and makes complexion ruddy through the improvement of peripheral blood circulation to make the skin clean and clear. Also disclosed is a food composition for reducing and preventing obesity, which contains, as an active ingredient, ginseng berry extract, which increases the expression of a carnitine palmitoyl transterase-1 (CPT-I) gene, serves to transport fatty acids into mitochondria in fatty acid oxidation and promotes fat oxidation.

    Abstract translation: 本文公开的是 皮肤外用组合物含人参浆果提取物。 更具体地,公开了皮肤外用组合物,其含有人参的地上部分中具有特定成分和组成的人参浆果提取物作为活性成分,从而促进皮肤中的胶原蛋白的生成,显示出 MMP-1抑制作用,同时具有由抗氧化作用和DNA损伤保护作用产生的皮肤衰老抑制和皱纹减轻作用。 还公开了一种皮肤外用组合物,其含有作为活性成分的人参浆果提取物,其具有由抑制黑色素产生和减少由紫外线辐射引起的色素沉着的作用而产生的皮肤美白效果,减轻干性皮肤症状的效果和 通过诱导和维持皮肤角质形成细胞的正常分化,减轻痤疮和皮肤麻烦的作用,通过调节皮脂分泌和抗炎作用而产生特应性症状,并通过改善外周血液循环使肤色变红,使皮肤清洁 并清楚 还公开了用于减少和预防肥胖的食物组合物,其包含增加肉碱棕榈酰转铁蛋白-1(CPT-1)基因表达的人参浆果提取物作为活性成分,用于将脂肪酸运输到线粒体中 脂肪酸氧化并促进脂肪氧化。

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