公开(公告)号：US09067066B2

公开(公告)日：2015-06-30

申请号：US14356629

申请日：2012-03-27

申请人： Yukiko Yamada ,  Hisashi Harada ,  Taizo Honda ,  Masahiro Ikeda ,  Kazushi Hanakawa ,  Toshihiro Otani ,  Tadashi Katayose

发明人： Yukiko Yamada ,  Hisashi Harada ,  Taizo Honda ,  Masahiro Ikeda ,  Kazushi Hanakawa ,  Toshihiro Otani ,  Tadashi Katayose

IPC分类号： G21K5/04 ,  A61N5/10

CPC分类号： A61N5/1048 ,  A61N5/1043 ,  A61N5/1077 ,  A61N2005/1074 ,  A61N2005/1087 ,  H05H13/04 ,  H05H2277/11

摘要： A control unit is provided with, a retaining section that retains a plurality of operation patterns each being a pattern of operation to be periodically repeated by an accelerator, the operation patterns having respective operation conditions adjusted for different emission times of an particle beam, to cause a deflection electromagnet in the accelerator to have an intended magnetic field intensity even under a presence of a hysteresis; a reading section for a plurality of slices of an irradiation target in a depth direction, which reads an irradiation condition for each of the slices; a selection section that selects the operation pattern suitable for each of the slices, on the basis of the read irradiation condition; and a main control section that controls, for each of the slices, the accelerator on the basis of the selected operation pattern and an irradiation device on the basis of the irradiation condition.

摘要翻译： 控制单元设置有保持部，其保持多个操作模式，每个操作模式是由加速器周期性重复的操作模式，所述操作模式具有针对粒子束的不同发射次数调整的各自的操作条件，以使得 加速器中的偏转电磁体即使在滞后的情况下也具有预期的磁场强度; 用于读取每个切片的照射条件的用于在深度方向上的照射目标的多个切片的读取部分; 选择部，其基于读取的照射条件选择适合于每个切片的操作模式; 以及主控制部，其基于所述照射条件，基于所选择的操作模式和照射装置对每个切片进行加速器的控制。

公开(公告)号：US20150038766A1

公开(公告)日：2015-02-05

申请号：US14386626

申请日：2012-03-21

申请人： Yuehu PU ,  Masahiro Ikeda ,  Taizo Honda

发明人： Yuehu PU ,  Masahiro Ikeda ,  Taizo Honda

IPC分类号： A61N5/10

CPC分类号： A61N5/1071 ,  A61N5/103 ,  A61N5/1031 ,  A61N5/1043 ,  A61N2005/1087

摘要： A particle beam scanning irradiation method includes the steps of calculating a planned irradiating particle count of a particle beam for each of irradiation spots, on the basis of a relative amount of particle beam irradiation and a prescription particle-beam dose determined from a particle-beam therapy plan; simulating an irradiation process of the particle beam at each irradiation spot, on the basis of the planned irradiating particle count and a beam current waveform of the particle beam, and calculating a particle count of the particle beam irradiating the diseased portion during a scan shift of the particle beam; correcting the planned irradiating particle count for each irradiation spot by using the irradiating particle count during the scan shift; converting the corrected planned-irradiation particle count into a count value used in a dose monitor; and irradiating the irradiation spot with the particle beam, on the basis of the converted count value.

摘要翻译： 粒子束扫描照射方法包括以下步骤：基于粒子束照射的相对量和从粒子束确定的处方粒子束剂量来计算每个照射点的粒子束的计划照射粒子数 治疗方案; 基于所计划的照射粒子数和粒子束的束电流波形，模拟在各照射点处的粒子束的照射过程，计算在扫描位移期间照射患病部位的粒子束的粒子数 粒子束; 通过使用扫描偏移期间的照射粒子数来校正每个照射点的计划照射粒子数; 将校正的计划照射粒子数转换为剂量监视器中使用的计数值; 并且基于转换后的计数值，用粒子束照射照射点。

公开(公告)号：US08933420B2

公开(公告)日：2015-01-13

申请号：US14240197

申请日：2011-11-02

申请人： Masahiro Ikeda ,  Hisashi Harada ,  Kazushi Hanakawa ,  Toshihiro Otani ,  Tadashi Katayose ,  Taizo Honda ,  Yukiko Yamada ,  Yuehu Pu

发明人： Masahiro Ikeda ,  Hisashi Harada ,  Kazushi Hanakawa ,  Toshihiro Otani ,  Tadashi Katayose ,  Taizo Honda ,  Yukiko Yamada ,  Yuehu Pu

IPC分类号： A61N5/10

CPC分类号： A61N5/1077 ,  A61N5/1049 ,  A61N5/1069 ,  A61N2005/1087

摘要： A particle beam therapy system comprising a treatment table, a treatment table control unit and an irradiation control unit configured to output an instruction for controlling the treatment table control unit, an accelerator and a scanning electromagnet, wherein after the treatment table control unit controls the treatment table so as for a patient isocenter which is reference position of an affected area of a patient to move to a position of an irradiation isocenter which is set at a position which is closer to an irradiation nozzle than an equipment isocenter which is reference of positional relation of the irradiation nozzle and the treatment table, the irradiation control unit outputs an instruction for irradiating the patient with a particle beam.

摘要翻译： 一种粒子束治疗系统，包括治疗台，治疗台控制单元和照射控制单元，其被配置为输出用于控制治疗台控制单元的指令，加速器和扫描电磁体，其中在治疗台控制单元控制治疗 将患者的中心位置作为患者的受影响区域的基准位置移动到被设定在比作为位置关系的参照的设备等角点更靠近照射喷嘴的位置的照射等角点的位置 的照射喷嘴和处理台，照射控制单元输出用于对粒子束照射患者的指示。

公开(公告)号：US20130068921A1

公开(公告)日：2013-03-21

申请号：US13613557

申请日：2012-09-13

申请人： Masahiro IKEDA

发明人： Masahiro IKEDA

IPC分类号： F16C35/04 ,  F16M13/02

CPC分类号： F16C35/04 ,  F16C19/06 ,  F16C27/066 ,  F16C33/80 ,  F16C33/805 ,  F16C2326/00 ,  F16C2326/30

摘要： The invention provides a center bearing support which can effectively suppress an inflow of a muddy water or the like into a center bearing side even at a time when a rotating shaft stops, without using a contact type seal such as an oil seal or the like. In a center bearing support in which an inner ring retaining a center bearing is provided in an inner periphery of an outer ring fixed to a vehicle body side via an elastic body made of a rubber-like elastic material, a rib guiding a flow of a muddy water or the like in a circumferential direction is formed on a convex surface constructed by a bellow-like bent portion of the elastic body.

摘要翻译： 本发明提供一种即使在旋转轴停止时也能够有效地抑制泥水等进入中心轴承侧的中心轴承座，而不使用诸如油封等的接触型密封。 在通过橡胶状弹性材料制成的弹性体将保持中心轴承的内圈设置在固定于车体侧的外圈的内周的中心轴承座中， 在由弹性体的波纹状弯曲部构成的凸面上形成有圆周方向的泥水等。

公开(公告)号：US20120313002A1

公开(公告)日：2012-12-13

申请号：US13318866

申请日：2011-03-08

申请人： Masahiro Ikeda ,  Hisashi Harada ,  Osamu Takahashi

发明人： Masahiro Ikeda ,  Hisashi Harada ,  Osamu Takahashi

IPC分类号： A61N5/10

CPC分类号： A61N5/1036 ,  A61N5/1043 ,  A61N2005/1087

摘要： A particle beam treatment device includes an irradiation nozzle which moves a particle beam in a direction which is perpendicular to an advancing direction; a dose monitor which measures the dose of the particle beam; a planning part which sets the irradiation dose applied to a target volume; and a controlling part which controls the irradiation dose applied to a target volume based on irradiation dose set value which is set by a value measured by the dose monitor and the planning part, wherein the planning part stores the absorbed dose distribution data in the depth direction which is prepared in advance using the absorbed dose at the reference depth which is a predetermined position nearer to an incident side of the particle beam than the position of Bragg peak as the reference and calculates the irradiation dose set value using the absorbed dose at the reference depth.

摘要翻译： 粒子束处理装置包括使粒子束沿与前进方向正交的方向移动的照射喷嘴; 测量粒子束剂量的剂量监测器; 将照射剂量设定在目标体积上的规划部分; 以及控制部，其基于由所述剂量监视器和所述规划部测量的值设定的照射剂量设定值来控制施加于目标体积的照射剂量，其中，所述规划部将所述吸收剂量分布数据存储在所述深度方向 其预先使用在比布拉格峰位置作为基准更靠近粒子束的入射侧的预定位置处的参考深度处的吸收剂量来计算，并且使用参考的吸收剂量来计算照射剂量设定值 深度。

公开(公告)号：US08323118B2

公开(公告)日：2012-12-04

申请号：US12968574

申请日：2010-12-15

申请人： Masahiro Ikeda

发明人： Masahiro Ikeda

IPC分类号： F16F7/108

CPC分类号： F16F15/1442 ,  F16C3/02 ,  Y10T464/50

摘要： In order to achieve downsizing, and to prevent a cleaning fluid from staying inside, a dynamic damper for a hollow rotating shaft is provided with a mass body floatingly inserted to an inner periphery of the hollow rotating shaft, of which a vibration is to be reduced, and an elastic body structured such that an inner diameter portion is fitly attached to an outer periphery of the mass body and an outer diameter portion is brought into pressure contact with an inner peripheral surface of the hollow rotating shaft, and made of a rubber-like elastic material, wherein grooves having both ends open to spaces at both sides in an axial direction of the elastic body are formed in one of fitted surfaces to each other of the mass body and the elastic body.

摘要翻译： 为了实现小型化，并且为了防止清洗液停留在内部，中空旋转轴的动力阻尼器设置有浮动地插入中空旋转轴的内周的质量体，其中振动将被减小 以及弹性体，其构造成使得内径部分适配地附接到所述质量体的外周，并且外径部与所述中空旋转轴的内周面压力接触，并且由橡胶 - 其特征在于，在所述弹性体的轴向的两侧的空间的两端开口的槽形成在所述质量体和所述弹性体的彼此嵌合的一个表面上。

公开(公告)号：US20120228521A1

公开(公告)日：2012-09-13

申请号：US13258772

申请日：2011-03-10

申请人： Taizo Honda ,  Masahiro Ikeda ,  Yuehu Pu ,  Kazushi Hanakawa

发明人： Taizo Honda ,  Masahiro Ikeda ,  Yuehu Pu ,  Kazushi Hanakawa

IPC分类号： A61N5/00

CPC分类号： A61N5/1043 ,  A61N5/1048 ,  A61N5/1077 ,  A61N2005/1074 ,  A61N2005/1087

摘要： The objective is to obtain a particle beam therapy system that can suppress the effect of a leakage dose. There are provided a scanning nozzle that irradiates in a predetermined direction a particle beam emitted from an accelerator; an irradiation control unit that controls operation of the irradiation nozzle in such a way that the particle beam of a predetermined dose is sequentially irradiated onto each of a plurality of spots set in a planar direction in an irradiation subject; and a control unit that on/off-controls emission of the particle beam from the accelerator. The irradiation control unit makes the irradiation nozzle scan in a diluting manner the particle beam onto a predetermined area in the irradiation subject, in a predetermined period after a time point when emission is switched from ON to OFF, or in a period from the time point when emission is switched from ON to OFF to a time point when the particle beam is cut off.

摘要翻译： 目的是获得能够抑制泄漏剂量影响的粒子束治疗系统。 提供了沿预定方向照射从加速器发射的粒子束的扫描喷嘴; 照射控制单元，其以照射对象的平面方向上设置的多个点顺序地照射预定剂量的粒子束的方式控制照射喷嘴的动作; 以及控制单元，其控制来自加速器的粒子束的发射。 照射控制单元使得照射喷嘴在发射从ON切换到OFF之后的预定时间内或在从时间点开始的时间段内，将粒子束以稀释的方式扫描到照射对象的预定区域上 当发射从ON切换到截止到粒子束的时间点时。

公开(公告)号：US20110176098A1

公开(公告)日：2011-07-21

申请号：US13074805

申请日：2011-03-29

申请人： Arihiro Takeda ,  Katsufumi Ohmuro ,  Yoshio Koike ,  Shingo Kataoka ,  Takahiro Sasaki ,  Takashi Sasabayashi ,  Hideaki Tsuda ,  Hideo Chida ,  Makoto Ohashi ,  Kenji Okamoto ,  Hisashi Yamaguchi ,  Minoru Otani ,  Makoto Morishige ,  Noriaki Furukawa ,  Tsuyoshi Kamada ,  Yoshinori Tanaka ,  Atuyuki Hoshino ,  Shougo Hayashi ,  Hideaki Takizawa ,  Takeshi Kinjou ,  Makoto Tachibanaki ,  Keiji Imoto ,  Tadashi Hasegawa ,  Hidefumi Yoshida ,  Hiroyasu Inoue ,  Yoji Taniguchi ,  Tetsuya Fujikawa ,  Satoshi Murata ,  Manabu Sawasaki ,  Tomonori Tanose ,  Siro Hirota ,  Masahiro Ikeda ,  Kunihiro Tashiro ,  Kouji Tsukao ,  Yasutoshi Tasaka ,  Takatoshi Mayama ,  Seiji Tanuma ,  Yohei Nakanishi

发明人： Arihiro Takeda ,  Katsufumi Ohmuro ,  Yoshio Koike ,  Shingo Kataoka ,  Takahiro Sasaki ,  Takashi Sasabayashi ,  Hideaki Tsuda ,  Hideo Chida ,  Makoto Ohashi ,  Kenji Okamoto ,  Hisashi Yamaguchi ,  Minoru Otani ,  Makoto Morishige ,  Noriaki Furukawa ,  Tsuyoshi Kamada ,  Yoshinori Tanaka ,  Atuyuki Hoshino ,  Shougo Hayashi ,  Hideaki Takizawa ,  Takeshi Kinjou ,  Makoto Tachibanaki ,  Keiji Imoto ,  Tadashi Hasegawa ,  Hidefumi Yoshida ,  Hiroyasu Inoue ,  Yoji Taniguchi ,  Tetsuya Fujikawa ,  Satoshi Murata ,  Manabu Sawasaki ,  Tomonori Tanose ,  Siro Hirota ,  Masahiro Ikeda ,  Kunihiro Tashiro ,  Kouji Tsukao ,  Yasutoshi Tasaka ,  Takatoshi Mayama ,  Seiji Tanuma ,  Yohei Nakanishi

IPC分类号： G02F1/1337

CPC分类号： G02F1/133753 ,  G02F1/133512 ,  G02F1/133514 ,  G02F1/133707 ,  G02F1/134309 ,  G02F1/134336 ,  G02F1/1393 ,  G02F2001/133388 ,  G02F2413/10

摘要： A vertically alignment mode liquid crystal display device having an improved viewing angle characteristic is disclosed. The disclosed liquid crystal display device uses a liquid crystal having a negative anisotropic dielectric constant, and orientations of the liquid crystal are vertical to substrates when no voltage being applied, almost horizontal when a predetermined voltage is applied, and oblique when an intermediate voltage is applied. At least one of the substrates includes a structure as domain regulating means, and inclined surfaces of the structure operate as a trigger to regulate azimuths of the oblique orientations of the liquid crystal when the intermediate voltage is applied.

摘要翻译： 公开了具有改进的视角特性的垂直取向模式液晶显示装置。 所公开的液晶显示装置使用具有负的各向异性介电常数的液晶，并且当施加电压时，液晶的取向垂直于基板，当施加预定电压时几乎水平，并且当施加中间电压时，倾斜 。 至少一个基板包括作为畴调节装置的结构，并且当施加中间电压时，该结构的倾斜表面用作触发器以调节液晶的倾斜取向的方位角。

公开(公告)号：US20110159972A1

公开(公告)日：2011-06-30

申请号：US12968574

申请日：2010-12-15

申请人： Masahiro IKEDA

发明人： Masahiro IKEDA

IPC分类号： F16F15/14 ,  F16C3/02

CPC分类号： F16F15/1442 ,  F16C3/02 ,  Y10T464/50

摘要： In order to achieve downsizing, and to prevent a cleaning fluid from staying inside, a dynamic damper for a hollow rotating shaft is provided with a mass body floatingly inserted to an inner periphery of the hollow rotating shaft, of which a vibration is to be reduced, and an elastic body structured such that an inner diameter portion is fitly attached to an outer periphery of the mass body and an outer diameter portion is brought into pressure contact with an inner peripheral surface of the hollow rotating shaft, and made of a rubber-like elastic material, wherein grooves having both ends open to spaces at both sides in an axial direction of the elastic body are formed in one of fitted surfaces to each other of the mass body and the elastic body.

摘要翻译： 为了实现小型化，并且为了防止清洗液停留在内部，中空旋转轴的动力阻尼器设置有浮动地插入中空旋转轴的内周的质量体，其中振动将被减小 以及弹性体，其构造成使得内径部分适配地附接到所述质量体的外周，并且外径部与所述中空旋转轴的内周面压力接触，并且由橡胶 - 其特征在于，在所述弹性体的轴向的两侧的空间的两端开口的槽形成在所述质量体和所述弹性体的彼此嵌合的一个表面上。

公开(公告)号：US20110071170A1

公开(公告)日：2011-03-24

申请号：US12915982

申请日：2010-10-29

申请人： Hitoshi Ohki ,  Tooru Okayama ,  Masahiro Ikeda ,  Masahiro Ota ,  Yoshihiro Shibata ,  Toshiyuki Nakanishi ,  Yasusi Ueda ,  Nobuyuki Suzuki ,  Shinji Matuura

发明人： Hitoshi Ohki ,  Tooru Okayama ,  Masahiro Ikeda ,  Masahiro Ota ,  Yoshihiro Shibata ,  Toshiyuki Nakanishi ,  Yasusi Ueda ,  Nobuyuki Suzuki ,  Shinji Matuura

IPC分类号： A61K31/519 ,  C07D495/16 ,  A61P35/00

CPC分类号： A61K31/519 ,  C07D495/16

摘要： A pyrazolopyrimidine compound represented by formula (1) that inhibits the function of HSP90 as a chaperone protein and that has antitumor activity, a medicament comprising a compound represented by formula (1), a pharmaceutical composition comprising a compound represented by formula (1), and a method for treating cancer using a compound represented by formula (1).

摘要翻译： 由式（1）表示的吡唑并嘧啶化合物，其抑制HSP90作为伴侣蛋白的功能并具有抗肿瘤活性，包含式（1）表示的化合物的药物，包含式（1）表示的化合物的药物组合物， 和使用式（1）表示的化合物治疗癌症的方法。