公开(公告)号：US11754431B2

公开(公告)日：2023-09-12

申请号：US17660966

申请日：2022-04-27

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christopher Espy

IPC: G01F23/292 ,  G01N15/04 ,  G01N15/05 ,  G01N35/04

CPC classification number: G01F23/2921 ,  G01N15/042 ,  G01N15/05 ,  G01N35/04 ,  G01N2015/045 ,  G01N2035/0493

Abstract: An apparatus for determining a vertical position of at least one interface between a first component and at least one second component, the components comprised as different layers in a sample container. The apparatus comprises a first sensing unit and a first light detector configured to generate a first sensing signal, a second sensing unit comprising a second light detector configured to generate a second sensing signal, a driving unit configured to move the sample container, a position sensing unit configured to output a position sensing signal indicative of a vertical position of the sample container, a vertical position determining unit configured to match the first and the second sensing signal such that first and the second sensing signal correspond to identical vertical positions, and to determine the vertical position of the at least one interface in response to the matched sensing signals and the position sensing signal.

公开(公告)号：US11747377B2

公开(公告)日：2023-09-05

申请号：US17075303

申请日：2020-10-20

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Michael Lambertson

IPC: G01R27/14 ,  G01R31/36

CPC classification number: G01R27/14 ,  G01R31/3648

Abstract: A method for determining system resistance of at least one power supply of a handheld medical device, the method including: a) generating at least one excitation voltage signal, wherein the excitation voltage signal comprises at least one direct current (DC) voltage signal, wherein the excitation voltage signal has a fast transition DC flank of 20 ns or less; b) applying the excitation voltage signal to at least one reference resistor having a predetermined or pre-defined resistance value, wherein the reference resistor is arranged in series with the power supply; c) measuring a response signal of the power supply; d) determining a signal flank from the response signal and determining an ohmic signal portion from one or both of shape and height of the signal flank; and e) determining the system resistance of the power supply from the ohmic signal portion.

公开(公告)号：US11747354B2

公开(公告)日：2023-09-05

申请号：US17211113

申请日：2021-03-24

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Goran Savatic

IPC: G01N35/00

CPC classification number: G01N35/00732 ,  G01N35/00623 ,  G01N2035/00752

Abstract: The present disclosure relates to a method to re-identify a carrier on a laboratory transport system after a system failure. The carrier is associated with an identity and is configured to move over a transport plane of the laboratory transport system. The laboratory transport system comprises a monitoring system configured to monitor motion positions of the carrier on the transport plane when the laboratory transport system is activated. After a system failure, the identity dissociates from the carrier and the carrier keeps moving on the transport plane. After reactivation of the laboratory transport system, a predicted position of the identity is compared to an actual position of the carrier by a control unit of the laboratory transport system. The control unit assigns the identity to the carrier if the predicted position of the identity matches with the actual position of the carrier.

公开(公告)号：US11743239B2

公开(公告)日：2023-08-29

申请号：US17151950

申请日：2021-01-19

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Urs Suter ,  Alejandro Morcillo Montejo ,  Antonio Tienda Fernandez ,  Stephen Martin

IPC: H04L9/40 ,  H04W12/033 ,  H04L67/561 ,  H04L67/565 ,  G06F21/62 ,  G16H10/60 ,  G16H40/67 ,  A61B5/00 ,  G16H40/20 ,  H04L9/08 ,  H04L9/14 ,  H04L9/30 ,  H04L69/08

CPC classification number: H04L63/0442 ,  A61B5/0022 ,  G16H10/60 ,  G16H40/20 ,  G16H40/67 ,  H04L9/0825 ,  H04L9/0866 ,  H04L9/14 ,  H04L9/30 ,  H04L63/0478 ,  H04L67/561 ,  H04L67/565 ,  H04W12/033 ,  A61B5/00 ,  G06F21/6245 ,  H04L63/0471 ,  H04L69/08

Abstract: A method for processing data of an analytical instrument for analyzing biological samples is presented. The method comprises receiving instrument data from the analytical instrument at a data processing module communicatively connected with the analytical instrument, generating metadata from the received instrument data at the data processing module, applying a first encryption to the instrument data at the data processing module, applying a second encryption to the generated metadata at the data processing module, and transmitting the encrypted metadata and encrypted instrument data to a remote server. The remote server and the data processing module are communicatively connected. The method also comprises removing the second encryption from the metadata at the remote server and forwarding the instrument data encrypted by the first encryption from the remote server to a management system of the analytical instrument.

公开(公告)号：US11740254B2

公开(公告)日：2023-08-29

申请号：US16646622

申请日：2018-11-29

Applicant: Hitachi High-Tech Corporation ,  Roche Diagnostics Operations, Inc.

Inventor： Yuichiro Ota ,  Takaaki Hagiwara ,  Yoshihiro Yamashita ,  Koshin Hamasaki ,  Michaela Windfuhr ,  Heike Guggemos ,  Johannes Stoeckel ,  Guenter Ziegler ,  Michael Kuehnl

IPC: G01N35/10

CPC classification number: G01N35/1011 ,  G01N35/1016 ,  G01N2035/1025

Abstract: The object of the invention is to provide an automatic analysis apparatus capable of setting a dispensing mechanism for measuring dispensing accuracy and a dispensing volume, and capable of performing dispensing accuracy measurement without absorbance measurement. Regarding a dispensing accuracy, a dispensing mechanism to be measured is designated. Parameters including a dispensing volume and the like are input. A dispensing operation of the input dispensing volume is automatically performed for each designated dispensing mechanism. A reaction vessel contains, for example, a reagent of the input dispensing volume which has been dispensed by the designated dispensing mechanism. By measuring a weight of the reagent in the reaction vessel, or the like, it is possible to measure the dispensing accuracy of the designated dispensing mechanism.

公开(公告)号：US11726044B2

公开(公告)日：2023-08-15

申请号：US16739236

申请日：2020-01-10

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Reinhold Kraemer ,  Michael Kuehnl ,  Uwe Mertsch ,  Marion Borchers

IPC: G01N21/69 ,  G01N21/47 ,  G01N21/76 ,  G01N27/416 ,  G01N33/543 ,  G01N21/84

CPC classification number: G01N21/69 ,  G01N21/47 ,  G01N21/76 ,  G01N27/416 ,  G01N33/543 ,  G01N2021/4726 ,  G01N2021/8411 ,  G01N2458/30

Abstract: A method of monitoring detection of an analyte in a liquid sample using a measuring cell, the measuring cell comprising a working electrode for excitation of electrochemiluminescence in the liquid sample, an optical detector for detecting the excited electrochemiluminescence, the excitation and detection being performed in an measurement cycle, the measurement cycle comprising transporting the liquid sample via a transport path to the working electrode using a support liquid, the method comprising: coupling light of a light source into the transport path during part of the measurement cycle, the transport path forming a light guide between the light source and the optical detector, detecting the coupled light by the optical detector, analyzing the detected light for a gas bubble in the transport path, providing a measurement state if the result of the analysis deviates from a target state regarding the presence of a gas bubble in the transport path.

公开(公告)号：US20230251277A1

公开(公告)日：2023-08-10

申请号：US18125708

申请日：2023-03-23

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Silvia Baecher ,  Andrea Geistanger ,  Dominik Gruber ,  Hans-Peter Josel

IPC: G01N33/82

CPC classification number: G01N33/82

Abstract: The present invention relates to a method and the use thereof for for determining the level of Vitamin D and metabolites thereof. Further, it is an object of the present invention to provide a kit and the use thereof for determining the level of Vitamin D and metabolites thereof.

公开(公告)号：US11719710B2

公开(公告)日：2023-08-08

申请号：US16695713

申请日：2019-11-26

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Andrea Horsch ,  Dietmar Zdunek ,  Georg Hess

IPC: G01N33/74 ,  G01N33/68 ,  A61P13/12 ,  C07K14/47

CPC classification number: G01N33/74 ,  C07K14/4716 ,  G01N33/6863 ,  G01N33/6893 ,  G01N2333/4712 ,  G01N2333/495 ,  G01N2333/52 ,  G01N2800/347 ,  G01N2800/50 ,  G01N2800/52

Abstract: The present disclosure relates to the field of laboratory diagnostics. Specifically, means and methods are disclosed for determining a patient's risk of suffering from acute kidney injury after a surgical procedure based on the detection of GDF-15, troponin T and/or a natriuretic peptide.

公开(公告)号：US20230203460A1

公开(公告)日：2023-06-29

申请号：US18068739

申请日：2022-12-20

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christian Helmut Bell ,  Harald Sobek ,  Heiko Walch ,  Kiyoshi Yasukawa ,  Misato Baba

IPC: C12N9/12 ,  C12Q1/68 ,  C12P19/34

CPC classification number: C12N9/1276 ,  C12Q1/68 ,  C12Y207/07049 ,  C12P19/34

Abstract: The present invention relates to a mutant reverse transcriptase (RT) with increased thermal stability relative to the wildtype, a nucleic acid encoding the mutant RT, a cell comprising the mutant RT or the nucleic acid, a kit comprising the mutant RT, the use of the mutant RT for cDNA synthesis, method for reverse transcription of RNA comprising synthesizing cDNA with the use of the mutant RT and a method for detecting an RNA marker in a sample with the use of the mutant RT.

公开(公告)号：US20230184796A1

公开(公告)日：2023-06-15

申请号：US18061717

申请日：2022-12-05

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Avinash Addihalli Narayana ,  Michael Rein

IPC: G01N35/02

CPC classification number: G01N35/025

Abstract: A laboratory sample container carrier handling apparatus is provided comprising a revolving device, a guiding surface, and a force-applying device, wherein the force-applying device is adapted to apply a force to a laboratory sample container carrier supplied to the revolving device to such an extent that the laboratory sample container carrier is forced against the guiding surface to such an extent that the laboratory sample container carrier rolls off at the guiding surface pushed by the revolving device. A laboratory automation system is also provided comprising such a laboratory sample container carrier handling apparatus and to a use of such a laboratory sample container carrier handling apparatus for handling a laboratory sample container carrier in, in particular such, a laboratory automation system.