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    Catalyst ligands, catalytic metal complexes and processes using same
    42.
    发明申请
    Catalyst ligands, catalytic metal complexes and processes using same 审中-公开
    催化剂配体，催化金属络合物和使用它们的方法

    公开(公告)号：US20040249157A1

    公开(公告)日：2004-12-09

    申请号：US10881573

    申请日：2004-06-29

    Applicant: Symyx Technologies, Inc.

    Inventor： Anil Guram ,  Cheryl Lund ,  Howard W. Turner ,  Tetsuo Uno

    IPC: C07F005/02

    CPC classification number: C08F10/00 ,  C07C211/49 ,  C07C223/06 ,  C07C251/24 ,  C08F4/60013 ,  C08F4/7006

    Abstract: A new ligands that include a benzene ring in the backbone can be combined with a metal or metal precursor compound or formed into a metal-ligand complex catalyze a number of different chemical transformations, including olefin polymerization reactions. The ligands, complexes formed with the ligands and compositions including the ligands are useful catalysts, depending on the reaction.

    Abstract translation: 在骨架中包括苯环的新配体可以与金属或金属前体化合物组合或形成金属 - 配体配合物催化许多不同的化学转化，包括烯烃聚合反应。 根据反应，配体与配体和包含配体的组合物形成的配合物是有用的催化剂。

    Evaluating effects of exposure conditions on drug samples over time
    44.
    发明申请
    Evaluating effects of exposure conditions on drug samples over time 审中-公开
    评估暴露条件对药物样品随时间的影响

    公开(公告)号：US20040219602A1

    公开(公告)日：2004-11-04

    申请号：US10790956

    申请日：2004-03-01

    Applicant: Symyx Technologies, Inc.

    Inventor： Eric D. Carlson ,  Peter J. Desrosiers ,  Li Song

    IPC: G01N033/53 ,  G01N033/543

    CPC classification number: G01N33/15 ,  B01J2219/00599 ,  B01J2219/00686 ,  B01J2219/00702 ,  B01J2219/00756 ,  C40B60/12

    Abstract: The present invention relates to the field of research for drug formulations. More particularly, this invention is directed toward an apparatus and method of performing parallel synthesis and screening of multiple drug compositions for stability and compatibility when exposed to various conditions over time, including various environmental and/or chemical conditions. In one aspect, the invention includes a method of testing for effects of a condition on a drug sample. The method includes providing an array of drug samples, simultaneously exposing a first plurality of the drug samples in the array to a first controlled condition for a period of time within an exposure period, and evaluating a plurality of the exposed drug samples at a first time and a second time using a non-destructive test in order to determine whether the condition has an affect on one or more of the drug samples over time. At least a portion of the exposure period between said first and second time, and the non-destructive test is the same each time.

    Abstract translation: 本发明涉及药物制剂的研究领域。 更具体地说，本发明涉及当暴露于包括各种环境和/或化学条件在内的各种条件时，在稳定性和相容性方面进行多种药物组合物的平行合成和筛选的装置和方法。 一方面，本发明包括测试病症对药物样品的影响的方法。 该方法包括提供药物样品阵列，同时将阵列内的第一组多个药物样品暴露于暴露期内的第一受控状态一段时间，以及在第一次评估多个暴露的药物样品 并且第二次使用非破坏性测试来确定条件对一种或多种药物样品随时间的影响。 所述第一次和第二次之间的曝光期间的至少一部分与无损检测每次相同。

    Parallel gas chromatograph with microdetector array
    45.
    发明申请
    Parallel gas chromatograph with microdetector array 失效
    具有微量检测器阵列的平行气相色谱仪

    公开(公告)号：US20040139784A1

    公开(公告)日：2004-07-22

    申请号：US10718196

    申请日：2003-11-20

    Applicant: Symyx Technologies, Inc.

    Inventor： Ravi Srinivasan ,  Daniel Meron Pinkas ,  Shenheng Guan ,  Michael Myslovaty ,  Mikhail Spitkovsy ,  James R. Engstrom ,  H. Sam Bergh

    IPC: G01N030/04

    CPC classification number: G01N30/18 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00306 ,  B01J2219/00704 ,  G01N30/466 ,  G01N30/6004 ,  G01N30/6095 ,  G01N30/66 ,  G01N30/8631 ,  G01N2030/185 ,  G01N2030/208 ,  G01N2030/3084 ,  G01N2030/8881

    Abstract: Gas chromatographs of the invention generally comprise four or more analysis channels. Specifically, four or more gas chromatography columns are configured for parallel analysis of four or more gaseous samples with detection being effected using a microdetector array comprising four or more microdetectors. In one embodiment, the four or more microdetectors 510 are microfabricated detectors, and are integrally formed with a substrate or with one or more microchip bodies mounted on a substrate. In a preferred embodiment, a microdetector array comprises four or more thermal conductivity detectors having one or more thin-film detection filaments. A preferred heated environment for highly parallel gas chromatographs is also disclosed.

    Abstract translation: 本发明的气相色谱通常包含四个或更多个分析通道。 具体地说，四个或更多个气相色谱柱被配置用于并行分析四种或更多种气态样品，其中使用包含四个或更多微量检测器的微量检测器阵列进行检测。 在一个实施例中，四个或更多个微检测器510是微制造的检测器，并且与基板或与安装在基板上的一个或多个微芯片体整体形成。 在优选实施例中，微检测器阵列包括具有一个或多个薄膜检测丝的四个或更多个热导检测器。 还公开了用于高度平行的气相色谱仪的优选的加热环境。

    Application specific integrated circuitry for controlling analysis of a fluid
    47.
    发明申请
    Application specific integrated circuitry for controlling analysis of a fluid 有权
    用于控制流体分析的专用集成电路

    公开(公告)号：US20040107055A1

    公开(公告)日：2004-06-03

    申请号：US10394543

    申请日：2003-03-21

    Applicant: Symyx Technologies, Inc.

    Inventor： Oleg V. Kolosov ,  Leonid Matsiev ,  Mikhail B. Spitkovsky ,  Vladimir Gammer

    IPC: G06F019/00

    CPC classification number: G01N29/036 ,  G01N29/34 ,  G01N29/36 ,  G01N2291/02818 ,  G01N2291/0427

    Abstract: A circuit for determining characteristics of a fluid under-test is provided. The circuit includes analog-to-digital processing circuitry for interfacing with a sensor and host electronics. The analog-to-digital processing circuitry includes a frequency generator for providing stimulus to the sensor and receiving a response signal from the sensor. Conditioning circuitry for reducing analog signal offsets in the response signal and signal detection circuitry for identifying amplitude data of the response signal are provided. Further provided is analog-to-digital conversion circuitry for converting the detected amplitude data into digital form. Memory for holding calibration data and approximated fluid characteristics of the fluid under-test is included in the circuitry. The digital form of the response signal is processed in conjunction with the calibration data and approximated fluid characteristics to generate fluid characteristics of the actual fluid under-test.

    Abstract translation: 提供了一种用于确定待测流体特性的电路。 该电路包括用于与传感器和主机电子设备连接的模数转换处理电路。 模数处理电路包括用于向传感器提供刺激并从传感器接收响应信号的频率发生器。 提供了用于减少响应信号中的模拟信号偏移的调节电路和用于识别响应信号的幅度数据的信号检测电路。 还提供了用于将检测到的幅度数据转换成数字形式的模数转换电路。 用于保持校准数据的存储器和被测流体的近似流体特性包括在电路中。 响应信号的数字形式结合校准数据和近似流体特性进行处理，以产生实际待测液体的流体特性。

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