公开(公告)号：US20100121932A1

公开(公告)日：2010-05-13

申请号：US10305823

申请日：2002-11-27

Applicant: Prajakta S. Joshi ,  David Chun Ying Cheung

Inventor： Prajakta S. Joshi ,  David Chun Ying Cheung

IPC: G06F15/173 ,  G06F15/16

CPC classification number: H04L67/1008 ,  H04L67/1002 ,  H04L67/1012 ,  H04L67/1021

Abstract: A global server load-balancing (GSLB) switch serves as a proxy to an authoritative DNS and communicates with numerous site switches that are coupled to host servers serving specific applications. The GSLB switch receives from site switches operational information regarding host servers within the site switches neighborhood. This operational information includes health check information that is remotely obtained in a distributed manner from remote metric agents at the site switches. When a client program requests a resolution of a host name, the GSLB switch, acting as a proxy of an authoritative DNS, returns one or more ordered IP addresses for the host name. The IP addresses are ordered using metrics, including the health check metric that evaluates these IP addresses based on the health check information communicated to the GSLB switch in a distributed manner by the distributed health check site switches. In one instance, the GSLB switch places the address that is deemed “best” at the top of the list.

Abstract translation: 全局服务器负载平衡（GSLB）交换机用作授权DNS的代理，并与多个站点交换机进行通信，这些站点交换机与服务于特定应用程序的主机服务器相连。 GSLB交换机从站点交换机接收关于站点交换机附近的主机服务器的操作信息。 该操作信息包括以现场交换机的远程度量代理以分布式方式远程获取的健康检查信息。 当客户端程序请求解析主机名时，作为权威DNS的代理的GSLB交换机返回主机名的一个或多个有序IP地址。 IP地址使用度量进行排序，包括基于通过分布式健康检查站点交换机以分布式方式传送到GSLB交换机的运行状况检查信息来评估这些IP地址的健康检查指标。 在一个实例中，GSLB开关将地址视为“最佳”位于列表的顶部。

公开(公告)号：US07671214B2

公开(公告)日：2010-03-02

申请号：US11675033

申请日：2007-02-14

Applicant: Wai-Yee Leung ,  Ching-Ying Cheung ,  Stephen Yue

Inventor： Wai-Yee Leung ,  Ching-Ying Cheung ,  Stephen Yue

IPC: C07D215/38

CPC classification number: G01N1/30 ,  A61K41/0057 ,  C07C66/02 ,  C07D209/08 ,  C07D209/12 ,  C07D209/14 ,  C07D209/16 ,  C07D209/18 ,  C07D209/24 ,  C07D209/54 ,  C07D209/60 ,  C07D209/96 ,  C07D401/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D417/06 ,  C07D417/14 ,  C07D471/04 ,  C07D498/04 ,  C07K1/13 ,  C09B23/02 ,  C09B23/06 ,  C09B23/083 ,  C09B23/107 ,  C12Q1/6825 ,  C40B70/00 ,  G01N31/22 ,  G01N33/533 ,  G01N33/535 ,  G01N33/58 ,  G01N33/581 ,  G01N33/582 ,  G01N2001/302 ,  Y10T436/143333

Abstract: Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.

公开(公告)号：US07566790B2

公开(公告)日：2009-07-28

申请号：US11150596

申请日：2005-06-10

Applicant: Wai-Yee Leung ,  Ching-Ying Cheung ,  Stephen Yue

Inventor： Wai-Yee Leung ,  Ching-Ying Cheung ,  Stephen Yue

IPC: C07D209/02 ,  C07D209/04

CPC classification number: G01N1/30 ,  A61K41/0057 ,  C07C66/02 ,  C07D209/08 ,  C07D209/12 ,  C07D209/14 ,  C07D209/16 ,  C07D209/18 ,  C07D209/24 ,  C07D209/54 ,  C07D209/60 ,  C07D209/96 ,  C07D401/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D417/06 ,  C07D417/14 ,  C07D471/04 ,  C07D498/04 ,  C07K1/13 ,  C09B23/02 ,  C09B23/06 ,  C09B23/083 ,  C09B23/107 ,  C12Q1/6825 ,  C40B70/00 ,  G01N31/22 ,  G01N33/533 ,  G01N33/535 ,  G01N33/58 ,  G01N33/581 ,  G01N33/582 ,  G01N2001/302 ,  Y10T436/143333

Abstract: Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.

Abstract translation: 描述了结合通过反应性基团或共轭物质在3位被取代的吲哚环部分的化学活性碳菁染料及其用途。 通过该位置的共轭导致光谱性质均匀地优于光谱相似的染料的缀合物，其中附着在不同的位置。 本发明包括具有一个或多个苯并氮的衍生化合物。

公开(公告)号：US20080254501A1

公开(公告)日：2008-10-16

申请号：US11870238

申请日：2007-10-10

Applicant: Ching-Ying Cheung ,  Diane R. Gray ,  Stephen T. Yue

Inventor： Ching-Ying Cheung ,  Diane R. Gray ,  Stephen T. Yue

IPC: C12Q1/28 ,  G01N21/76 ,  C07D417/06 ,  C07D417/14 ,  C12Q1/02

CPC classification number: G01N33/1806 ,  C07D211/62 ,  C07D295/112 ,  C07D401/14 ,  C07D417/06 ,  C07D417/14 ,  C09B23/04 ,  C12Q1/04 ,  C12Q1/18 ,  G01N21/643 ,  G01N33/52 ,  G01N33/582 ,  G01N2021/6432

Abstract: Chemical stain compounds containing a fluorophore and a reducible quenching unit are disclosed. The reducible quenching unit quenches the fluorophore while in its oxidized state. Upon reduction, the quenching properties of the quenching unit are diminished or eliminated. The chemical compounds can be used in a variety of applications, including the detection of bacterial cells, monitoring the electron transport chain function of bacterial cells, monitoring the oxidation state of non-biological systems, and assaying the effectiveness of antibacterial or antimicrobial agents.

Abstract translation: 公开了含有荧光团和可还原淬火单元的化学染料化合物。 可还原淬火单元在处于氧化状态时淬灭荧光团。 在还原时，淬火单元的淬火特性减弱或消除。 化合物可用于各种应用，包括检测细菌细胞，监测细菌细胞的电子传递链功能，监测非生物系统的氧化状态，以及测定抗菌剂或抗菌剂的有效性。

公开(公告)号：US07271265B2

公开(公告)日：2007-09-18

申请号：US10916822

申请日：2004-08-11

Applicant: Rosaria Haugland ,  Ching-Ying Cheung ,  Stephen Yue

Inventor： Rosaria Haugland ,  Ching-Ying Cheung ,  Stephen Yue

IPC: C07D401/10 ,  C07D417/10 ,  C07D403/10

CPC classification number: C12Q1/6876 ,  C07D209/12 ,  C07D209/14 ,  C07D209/24 ,  C07D401/04 ,  C09B23/12

Abstract: The present invention provides methods and non-fluorescent carbocyanine quencher compounds having the general formula: Wherein the A moiety is a substituted pyridinium, unsubstituted pyridinium, substituted quinolinium, unsubstituted quinolinium, substituted benzazolium, unsubstituted benzazolium, substituted indolinium, or unsubstituted indolinium. The invention further provides luminescent donor molecule-quencher pairs and luminescent donor molecule-quencher-luminescent acceptor molecule conjugates wherein the quencher is a cyanine compound of the present invention. The energy transfer pairs are used to detect an analyte of interest in a sample.

Abstract translation: 本发明提供了具有以下通式的方法和非荧光碳花青猝灭剂化合物：其中A部分是取代的吡啶鎓，未取代的吡啶鎓，取代的喹啉鎓，未取代的喹啉鎓，取代的苯并唑鎓，未取代的苯并咪唑鎓，取代的二氢吲哚鎓或未取代的吲哚啉鎓。 本发明还提供了发光供体分子猝灭剂对和发光供体分子 - 猝灭剂 - 发光受体分子缀合物，其中猝灭剂是本发明的花青化合物。 能量转移对用于检测样品中感兴趣的分析物。

公开(公告)号：US07254626B1

公开(公告)日：2007-08-07

申请号：US10206580

申请日：2002-07-25

Applicant: Sunanda Lakshmi Kommula ,  Ivy Pei-Shan Hsu ,  Rajkumar Jalan ,  David Chun Ying Cheung

Inventor： Sunanda Lakshmi Kommula ,  Ivy Pei-Shan Hsu ,  Rajkumar Jalan ,  David Chun Ying Cheung

IPC: G06F15/173 ,  G06F15/16

CPC classification number: H04L67/1002 ,  H04L67/1008 ,  H04L67/1012 ,  H04L67/1021

Abstract: A global server load-balancing (GSLB) switch serves as a proxy to an authoritative DNS and communicates with numerous site switches that are coupled to host servers serving specific applications. The GSLB switch receives from site switches operational information regarding host servers within the site switches neighborhood. When a client program requests a resolution of a host name, the GSLB switch, acting as a proxy of an authoritative DNS, returns one or more ordered IP addresses for the host name. The IP addresses are ordered using metrics that include the information collected from the site switches. In one instance, the GSLB switch places the address that is deemed “best” at the top of the list.

Abstract translation: 全局服务器负载平衡（GSLB）交换机用作授权DNS的代理，并与多个站点交换机进行通信，这些站点交换机与服务于特定应用程序的主机服务器相连。 GSLB交换机从站点交换机接收关于站点交换机附近的主机服务器的操作信息。 当客户端程序请求解析主机名时，作为权威DNS的代理的GSLB交换机返回主机名的一个或多个有序IP地址。 IP地址使用包含从站点交换机收集的信息的度量来排序。 在一个实例中，GSLB开关将地址视为“最佳”位于列表的顶部。

公开(公告)号：US20070138440A1

公开(公告)日：2007-06-21

申请号：US11624640

申请日：2007-01-18

Applicant: Chi-Ming Chan ,  Kai-Mo NG ,  Catherine Wong ,  Ying Cheung

Inventor： Chi-Ming Chan ,  Kai-Mo NG ,  Catherine Wong ,  Ying Cheung

IPC: H01B1/12

CPC classification number: H01B1/22 ,  H05K1/0257 ,  H05K1/0259 ,  H05K1/167 ,  H05K2201/0738 ,  Y10T428/257 ,  Y10T428/31663

Abstract: The invention provides a process for preparing an overvoltage protection material comprising: (i) preparing a mixture comprising a polymer binder precursor and a conductive material; and (ii) heating the mixture to cause reaction of the polymer binder precursor and generate a polymer matrix having conductive material dispersed therein, wherein the polymer binder precursor is chosen such that substantially no solvent is generated during the reaction.

公开(公告)号：US20070123057A1

公开(公告)日：2007-05-31

申请号：US11622970

申请日：2007-01-12

Applicant: Chi-Ming Chan ,  Kai-Mo Ng ,  Catherine Wong ,  Ying Cheung

Inventor： Chi-Ming Chan ,  Kai-Mo Ng ,  Catherine Wong ,  Ying Cheung

IPC: H01L21/31

CPC classification number: H01B1/22 ,  H05K1/0257 ,  H05K1/0259 ,  H05K1/167 ,  H05K2201/0738 ,  Y10T428/257 ,  Y10T428/31663

Abstract: The invention provides a process for preparing an overvoltage protection material comprising: (i) preparing a mixture comprising a polymer binder precursor and a conductive material; and (ii) heating the mixture to cause reaction of the polymer binder precursor and generate a polymer matrix having conductive material dispersed therein, wherein the polymer binder precursor is chosen such that substantially no solvent is generated during the reaction.

公开(公告)号：US09579402B2

公开(公告)日：2017-02-28

申请号：US12850578

申请日：2010-08-04

Applicant: Fei Mao ,  Wai-Yee Leung ,  Ching-Ying Cheung ,  Hye Eun Hoover

Inventor： Fei Mao ,  Wai-Yee Leung ,  Ching-Ying Cheung ,  Hye Eun Hoover

IPC: C07D233/64 ,  A61K49/00 ,  C07D311/88 ,  C07D405/04 ,  C07D491/147 ,  C07K1/13 ,  C07K16/28 ,  C07K16/32 ,  C07D491/22

CPC classification number: C07H15/26 ,  A61K49/0017 ,  C07D311/88 ,  C07D405/04 ,  C07D405/14 ,  C07D491/147 ,  C07D491/22 ,  C07F9/65586 ,  C07K1/13 ,  C07K16/00 ,  C07K16/2809 ,  C07K16/32 ,  Y10T436/25

Abstract: The present invention relates to fluorescent dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions.

Abstract translation: 本发明一般涉及荧光染料。 本发明提供了广泛的荧光染料和含有该荧光染料的试剂盒，其可用于标记各种生物分子，细胞和微生物。 本发明还提供使用荧光染料进行研究，开发鉴定，环境研究，诊断，预后和/或治疗疾病的各种方法。

公开(公告)号：US09097667B2

公开(公告)日：2015-08-04

申请号：US12334387

申请日：2008-12-12

Applicant: Fei Mao ,  Wai-Yee Leung ,  Ching-Ying Cheung ,  Hye Eun Hoover

Inventor： Fei Mao ,  Wai-Yee Leung ,  Ching-Ying Cheung ,  Hye Eun Hoover

IPC: C09B23/08 ,  C07K2/00 ,  C07K16/00 ,  C07H17/02 ,  C07H21/00 ,  C12N5/07 ,  G01N21/64 ,  C09B11/08 ,  C09B11/24 ,  C09B23/01 ,  C09B23/06 ,  C09B57/00 ,  C09B57/02 ,  C09B69/00 ,  G01N33/58

CPC classification number: G01N33/582 ,  C09B11/08 ,  C09B11/24 ,  C09B23/0066 ,  C09B23/06 ,  C09B23/083 ,  C09B23/086 ,  C09B57/001 ,  C09B57/02 ,  C09B69/00 ,  G01N21/6428 ,  G01N2021/6439

Abstract: The present invention relates to fluorescent dyes. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. In one aspect, the invention provides a compound having a maximal fluorescence excitation wavelength, wherein the compound has a structure of Formula II: F—Y=Ψ  Formula II and wherein Z— is a counterion, Y is a bridge unit permitting electron delocalization between F and Ψ, and F is a moiety having the structure: The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions.

Abstract translation: 本发明涉及荧光染料。 本发明提供了广泛的荧光染料和含有该荧光染料的试剂盒，其可用于标记各种生物分子，细胞和微生物。 一方面，本发明提供具有最大荧光激发波长的化合物，其中该化合物具有式II的结构：F-Y =Ψ式II，其中Z-为抗衡离子，Y为允许电子离域 F和Ψ，F是具有以下结构的部分：本发明还提供使用荧光染料进行研究开发，法医鉴定，环境研究，诊断，预后和/或治疗疾病状况的各种方法。