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41.发明申请公开(公告)号：US20050079571A1
公开(公告)日：2005-04-14
申请号：US10483842
申请日：2002-07-26
申请人： Katherine Collier , Edwin Lee , Nicholas Leiva , Thomas Morrison , Volker Schellenberger , Olga Selifonova , Adam Kean
发明人： Katherine Collier , Edwin Lee , Nicholas Leiva , Thomas Morrison , Volker Schellenberger , Olga Selifonova , Adam Kean
IPC分类号： C07K14/32 , C12N15/75 , C12P21/02 , C12P21/04 , C12N9/56 , C07H21/04 , C11D3/386 , C12N15/74
摘要： An evolvable production strain of B. subtilis exhibiting continuous or high level expression during protein evolution is described. An evolved Bacillus subtilis pstS promoter facilitates screening and production of secreted proteins.
摘要翻译： 描述了在蛋白质进化期间表现出连续或高水平表达的枯草芽孢杆菌的可进化生产菌株。 一种进化的枯草芽孢杆菌pstS启动子有助于分泌蛋白的筛选和产生。
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公开(公告)号：US06248541B1
公开(公告)日：2001-06-19
申请号：US09556921
申请日：2000-04-21
IPC分类号： C12Q102
CPC分类号： C12Q1/04
摘要： Described herein are methods for obtaining from an initial population of cells a plurality of subpopulations of cells having a similar density by growing samples from the initial population in medium having a limiting nutrient. Also provided are methods for using such subpopulation of cells to identify members of an initial population, either spontaneously occurring or induced by mutagenesis, having altered and/or preferred phenotypes.
摘要翻译： 本文描述的是通过在具有限制性营养物的培养基中培养来自初始群体的样品，从初始种群获得具有相似密度的多个细胞亚群的方法。 还提供了使用这种细胞亚群来鉴定自发发生或通过诱变诱导的具有改变和/或优选表型的初始群体的成员的方法。
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公开(公告)号：US6027873A
公开(公告)日：2000-02-22
申请号：US272122
申请日：1999-03-19
CPC分类号： B01L3/50857 , B01J19/0046 , B01L3/5085 , B01J2219/00286 , B01J2219/00317 , B01J2219/00319 , B01J2219/0052 , B01J2219/00524 , B01J2219/00659 , B01J2219/00662 , B01J2219/00707 , C40B60/14 , G01N2035/00237 , G01N35/1065
摘要： A method for holding samples for analysis and an apparatus thereof includes a testing plate with a pair of opposing surfaces and a plurality of holes. Each of the holes extends from one of the opposing surfaces to the other one of the opposing surfaces. The holes are arranged in groups, where each group has at least two rows and two columns of holes. The groups are arranged in sets, where each set has at least two rows and two columns of groups. To analyze samples, at least one of the opposing surfaces of the testing plate is immersed in a solution to be analyzed. A portion of the solution enters openings for each of the holes in the immersed opposing surface. Once the holes are filled with solution, the testing plate is removed and is held above a supporting surface. Surface tension holds the solution in each of the holes. The solution in one or more of the holes is then analyzed and the solution in one of these holes is identified for further study. The location of the identified solution is marked based upon its location within a particular set and group of holes.
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公开(公告)号：US20160137711A1
公开(公告)日：2016-05-19
申请号：US14343111
申请日：2012-09-12
申请人： Volker Schellenberger , Joshua Silverman , Willem P. Stemmer , Chia-Wei Wang , Nathan Geething , Benjamin Spink
发明人： Volker Schellenberger , Joshua Silverman , Willem P. Stemmer , Chia-Wei Wang , Nathan Geething , Benjamin Spink
IPC分类号： C07K14/605
CPC分类号： C07K14/605 , A61K38/00 , C07K2319/31
摘要： The present invention relates to compositions comprising GLP-2 protein or variants thereof linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in the treatment of GLP-2-related conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的GLP-2蛋白或其变体的组合物，编码组合物的分离的核酸和含有该组合物的载体和宿主细胞，以及制备和使用该组合物治疗 GLP-2相关条件。
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公开(公告)号：US08492530B2
公开(公告)日：2013-07-23
申请号：US12939120
申请日：2010-11-03
申请人： Volker Schellenberger , Willem P. Stemmer , Chia-Wei Wang , Michael D. Scholle , Mikhail Popkov , Nathaniel C. Gordon , Andreas Crameri
发明人： Volker Schellenberger , Willem P. Stemmer , Chia-Wei Wang , Michael D. Scholle , Mikhail Popkov , Nathaniel C. Gordon , Andreas Crameri
CPC分类号： C07K14/56 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/001 , C07K14/415 , C07K14/47 , C07K14/53 , C07K14/535 , C07K14/61 , C07K2319/31 , C07K2319/35 , C12N15/1044 , G01N33/6845
摘要： The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
摘要翻译： 本发明提供非结构化重组聚合物（URP）和含有一种或多种URP的蛋白质。 本发明还提供微蛋白，毒素和其它相关的蛋白质实体，以及显示这些实体的遗传包。 本发明还提供重组多肽，包括编码受试蛋白质实体的载体，以及包含载体的宿主细胞。 主题组合物具有各种实用性，包括一系列药物应用。
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公开(公告)号：US08088609B2
公开(公告)日：2012-01-03
申请号：US10590870
申请日：2005-04-12
IPC分类号： C07K16/00
CPC分类号： C07K16/3007 , A61K2039/505 , C07K2317/622 , C07K2319/00
摘要： The present invention relates to CAB molecules, ADEPT constructs directed against CEA, and their use in therapy.
摘要翻译： 本发明涉及CAB分子，针对CEA的ADEPT构建体及其在治疗中的用途。
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47.发明授权Mutant E. coli appa phytase enzymes and natural variants thereof, nucleic acids encoding such phytase enzymes, vectors and host cells incorporating same and methods of making and using same 有权突变大肠杆菌植酸酶及其天然变体，编码这种植酸酶的核酸，与其结合的载体和宿主细胞以及制备和使用它们的方法公开(公告)号：US07968342B2
公开(公告)日：2011-06-28
申请号：US10524234
申请日：2003-08-11
申请人： Beat O Blattmann , Aldis Darzins , John M. Davis , Lance P. Encell , Thomas B. Morrison , Gregory T. Mrachko , Volker Schellenberger
发明人： Beat O Blattmann , Aldis Darzins , John M. Davis , Lance P. Encell , Thomas B. Morrison , Gregory T. Mrachko , Volker Schellenberger
CPC分类号： C12N15/8243 , C12N9/16 , C12N15/8245
摘要： Cells producing mutant phytases having modified activity are provided, as well as the phytases so produced. Also provided are methods of making and producing such phytases and the use of the expressed phytase protein in feed as a supplement.
摘要翻译： 提供具有改变活性的产生突变体植酸酶的细胞，以及如此制备的植酸酶。 还提供了制备和生产这种植酸酶的方法以及在饲料中使用表达的植酸酶蛋白作为补充物。
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48.发明申请METHODS FOR PRODUCTION OF UNSTRUCTURED RECOMBINANT POLYMERS AND USES THEREOF 审中-公开生产未经改造的重组聚合物的方法及其用途公开(公告)号：US20110151433A1
公开(公告)日：2011-06-23
申请号：US12939129
申请日：2010-11-03
申请人： Volker Schellenberger , Willem P. Stemmer , Chia-Wei Wang , Michael D. Scholle , Mikhail Popkov , Nathaniel C. Gordon , Andreas Crameri
发明人： Volker Schellenberger , Willem P. Stemmer , Chia-Wei Wang , Michael D. Scholle , Mikhail Popkov , Nathaniel C. Gordon , Andreas Crameri
CPC分类号： C07K14/415 , A61K38/00 , C07K14/001 , C07K14/475 , C07K2319/21 , C07K2319/43 , C12N15/1044 , C12N2795/14011 , G01N33/68 , G01N33/6845
摘要： The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
摘要翻译： 本发明提供非结构化重组聚合物（URP）和含有一种或多种URP的蛋白质。 本发明还提供微蛋白，毒素和其它相关的蛋白质实体，以及显示这些实体的遗传包。 本发明还提供重组多肽，包括编码受试蛋白质实体的载体，以及包含载体的宿主细胞。 主题组合物具有各种实用性，包括一系列药物应用。
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49.发明申请公开(公告)号：US20110046060A1
公开(公告)日：2011-02-24
申请号：US12806004
申请日：2010-08-02
申请人： Volker Schellenberger , Joshua Silverman , Willem Stemmer , Chia-wei Wang , Benjamin Spink , Nathan Geething , Wayne To
发明人： Volker Schellenberger , Joshua Silverman , Willem Stemmer , Chia-wei Wang , Benjamin Spink , Nathan Geething , Wayne To
IPC分类号： A61K38/36 , C07K14/745 , A61P7/04
CPC分类号： C12N9/644 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/31 , C07K2319/50 , C12N9/6437 , C12N15/70 , C12Y304/21022
摘要： The present invention relates to compositions comprising factor IX coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子IX凝血因子的组合物，编码组合物的分离的核酸和载体以及含有它们的宿主细胞，以及制备和使用这些组合物治疗凝血因子相关的方法 疾病，病症和状况。
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公开(公告)号：US07125695B2
公开(公告)日：2006-10-24
申请号：US10719571
申请日：2003-11-20
CPC分类号： C12N9/0006 , C07K14/245 , C12N15/102 , C12P7/18 , C12R1/01 , C12R1/19
摘要： The present invention provides methods for directing the evolution of microorganisms comprising the use of mutator genes and growth under conditions of selective pressure. The method discloses mutator genes which can be used in the methods of the present invention and provides ATCC deposits which exemplify the evolved microorganisms produced by the methods.
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