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192 条记录 (耗时 0.053 秒)

    NOVEL TRIFLUOROMETHYLSULFONAMIDE GAMMA SECRETASE INHIBITOR
    42.
    发明申请
    NOVEL TRIFLUOROMETHYLSULFONAMIDE GAMMA SECRETASE INHIBITOR 有权
    新型三氟甲磺酰胺游离氨基酸抑制剂

    公开(公告)号：US20110275719A1

    公开(公告)日：2011-11-10

    申请号：US13145190

    申请日：2010-01-29

    申请人： Matthew Daniels ,  Jed Hubbs ,  Thomas Miller

    发明人： Matthew Daniels ,  Jed Hubbs ,  Thomas Miller

    IPC分类号： A61K31/18 ,  A61P25/28 ,  C07C305/18

    CPC分类号： C07D233/42 ,  C07C317/30 ,  C07C2601/14 ,  C07D295/185

    摘要： The present invention is directed to a novel trifluoromethylsulfonamide derivative which inhibits the processing of APP by the putative γ-secretase and thus is useful in the treatment or prevention of Alzheimer's disease. This compound possesses favorable pharmacokinetic properties in higher species (rhesus) and thus can be dosed on an intermittent dosing regiment (e.g., once weekly). When dosed on such a regiment the compound exhibits significant and continuous Aβ lowering without the manifestation of Notch associated gastrointestinal toxicity for extended periods, e.g., 7 days. Pharmaceutical compositions and methods of use are also included.

    摘要翻译： 本发明涉及一种新的三氟甲基磺酰胺衍生物，其抑制通过推定的γ-分泌酶处理APP，因此可用于治疗或预防阿尔茨海默氏病。 该化合物在较高种类（恒河猴）中具有有利的药代动力学性质，因此可以间歇给药剂量（例如每周一次）给药。 当这样一个团体配合时，该化合物显示出显着和连续的A＆Bgr; 降低Notch相关胃肠道毒性长期持续的表现，例如7天。 还包括药物组合物和使用方法。

    Delay locked loop
    44.
    发明授权
    Delay locked loop 失效
    延迟锁定环路

    公开(公告)号：US07457392B2

    公开(公告)日：2008-11-25

    申请号：US10266296

    申请日：2002-10-08

    申请人： Christian Weis ,  Thomas Miller ,  Patrick Heyne

    发明人： Christian Weis ,  Thomas Miller ,  Patrick Heyne

    IPC分类号： H03D3/24

    CPC分类号： G11C7/1066 ,  G11C7/1072 ,  G11C7/22 ,  G11C7/222 ,  G11C11/4076 ,  H03K5/131 ,  H03K2005/00058 ,  H03K2005/00156 ,  H03L7/0814 ,  H03L7/0818

    摘要： A delay locked loop includes a first delay device for obtaining a fine setting and a downstream-connected second delay device for obtaining a coarse setting of the delay time. The control signals for controlling the respective delay devices are provided by synchronization latches, which receive a clock obtained by the output signal of the first delay device for obtaining the fine setting. The delay locked loop enables a linear operating behavior at a high operating frequency and is particularly suitable when a differential embodiment of the two delay devices is used.

    摘要翻译： 延迟锁定环包括用于获得精细设置的第一延迟装置和用于获得延迟时间的粗略设置的下游连接的第二延迟装置。 用于控制各个延迟装置的控制信号由同步锁存器提供，同步锁存器接收由第一延迟装置的输出信号获得的时钟，以获得精细设置。 延迟锁定环使得能够在高工作频率下的线性操作特性，并且当使用两个延迟装置的差分实施例时特别合适。

    Robotic Trajectory Guide
    46.
    发明申请
    Robotic Trajectory Guide 有权
    机器人轨迹指南

    公开(公告)号：US20080039869A1

    公开(公告)日：2008-02-14

    申请号：US11873154

    申请日：2007-10-16

    申请人： Gerald Mills ,  Martin Brady ,  Raghu Raghavan ,  John David ,  Thomas Miller ,  Matthew Solar

    发明人： Gerald Mills ,  Martin Brady ,  Raghu Raghavan ,  John David ,  Thomas Miller ,  Matthew Solar

    IPC分类号： A61B19/00

    CPC分类号： A61B90/11 ,  A61B34/20 ,  A61B34/30 ,  A61B34/70 ,  A61B2034/107 ,  A61B2034/2055 ,  A61B2034/301 ,  A61B2090/374

    摘要： A surgical alignment device is disclosed that is controlled remotely through the use of an actuator, where the actuator in turn controls at least one local adjustment device. The alignment device is suited for neurosurgery, although it is not exclusively limited to neurosurgery. The alignment device includes an insertion guide that is coupled to the local adjustment device, the insertion guide being used to guide a device such as a catheter into a patient. The alignment device may also be coupled to a control module such as a microcomputer that controls the orientation of the insertion guide in response to inputs from the surgeon as to a location of interest within the patient.

    摘要翻译： 公开了通过使用致动器远程控制的外科对准装置，其中致动器依次控制至少一个局部调节装置。 对准装置适用于神经外科手术，但并不限于神经外科手术。 对准装置包括联接到局部调节装置的插入引导件，插入引导件用于将诸如导管的装置引导到患者体内。 对准装置还可以耦合到诸如微型计算机的控制模块，微型计算机响应于来自外科医生的输入以及患者内感兴趣的位置来控制插入引导件的取向。

    Hydroxamic acid compounds and methods of use thereof
    49.
    发明申请
    Hydroxamic acid compounds and methods of use thereof 失效
    羟肟酸化合物及其使用方法

    公开(公告)号：US20070155785A1

    公开(公告)日：2007-07-05

    申请号：US11710036

    申请日：2007-02-22

    申请人： Ronald Breslow ,  Thomas Miller ,  Sandro Belvedere ,  Paul Marks ,  Victoria Richon ,  Richard Rifkind

    发明人： Ronald Breslow ,  Thomas Miller ,  Sandro Belvedere ,  Paul Marks ,  Victoria Richon ,  Richard Rifkind

    IPC分类号： A61K31/4709 ,  C07D401/02

    CPC分类号： C07D211/02 ,  C07D215/38 ,  C07D401/12

    摘要： The present invention relates to a novel class of hydroxamic acid derivatives having at least two aryl containing groups, at least one of which is a quinolinyl, isoquinolinyl or benzyl moiety, linked to the hydroxamic acid group through a methylene chain. The hydroxamic acid compounds can be used to treat cancer, for example, brain cancer. The hydroxamic acid compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention are also useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases.

    摘要翻译： 本发明涉及一类具有至少两个含芳基基团的异羟肟酸衍生物，其中至少一个是喹啉基，异喹啉基或苄基部分，通过亚甲基链与异羟肟酸基团连接。 异羟肟酸化合物可用于治疗癌症，例如脑癌。 异羟肟酸化合物也可以抑制组蛋白脱乙酰酶，适用于选择性诱导终末分化，阻止肿瘤细胞的细胞生长和/或凋亡，从而抑制这些细胞的增殖。 因此，本发明的化合物可用于治疗具有以肿瘤细胞增殖为特征的肿瘤的患者。 本发明的化合物还可用于预防和治疗TRX介导的疾病，例如自身免疫性，过敏性和炎性疾病，以及预防和/或治疗中枢神经系统（CNS）的疾病，例如神经变性 疾病

    Mobile-device directed conference calling
    50.
    发明申请
    Mobile-device directed conference calling 审中-公开
    移动设备定向会议呼叫

    公开(公告)号：US20070111716A1

    公开(公告)日：2007-05-17

    申请号：US11273163

    申请日：2005-11-14

    申请人： Randolph Leigh ,  Thomas Miller ,  David Guthrie ,  J. Tapp

    发明人： Randolph Leigh ,  Thomas Miller ,  David Guthrie ,  J. Tapp

    IPC分类号： H04M3/42

    CPC分类号： H04M3/56 ,  H04L12/1818 ,  H04L12/189 ,  H04M3/563 ,  H04M2203/5054 ,  H04M2207/18

    摘要： A method for mobile-device directed conference calling comprises receiving information from a subscriber of a mobile-communication service, communicating an access number and providing executable instructions to the mobile-communication device that expose a conference service to the subscriber, wherein when the subscriber selects an option from the mobile-communication device, the mobile-communication device initiates a call to a conference service that uses automatic number identification to authenticate the subscriber and connect the call with a teleconference bridge. A system comprises a processor, interfaces in communication with the public telephone network and a data network, respectively, and a memory. The system receives information from a subscriber of a mobile-communication service, communicates an access number to the subscriber and configures the mobile-communication device to expose a conference service to the subscriber. When the subscriber selects an option, the subscriber is authenticated and connected to a teleconference bridge.

    摘要翻译： 一种用于移动设备定向会议呼叫的方法，包括从移动通信服务的用户接收信息，传送接入号码并向向用户公开会议业务的移动通信设备提供可执行指令，其中，当用户选择 来自移动通信设备的选项，移动通信设备发起对使用自动号码识别的会议服务的呼叫以认证用户并将呼叫与电话会议桥连接。 系统包括处理器，分别与公共电话网络和数据网络通信的接口以及存储器。 该系统从移动通信服务的用户接收信息，向用户传送接入号码，并配置移动通信设备向用户公开会议服务。 当用户选择选项时，用户被认证并连接到电话会议桥。