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    Molecular characterization with carbon nanotube control
    41.
    发明申请
    Molecular characterization with carbon nanotube control 有权
    碳纳米管控制的分子表征

    公开(公告)号：US20080257859A1

    公开(公告)日：2008-10-23

    申请号：US12214046

    申请日：2008-06-16

    申请人： Jene A. Golovchenko ,  Daniel Branton

    发明人： Jene A. Golovchenko ,  Daniel Branton

    IPC分类号： H01B13/06

    CPC分类号： G01N27/44791 ,  B82Y15/00 ,  C12Q1/6869 ,  G01N27/44743 ,  G01N33/48721 ,  Y10S977/762 ,  C12Q2565/631

    摘要： In a method for fabricating a molecule characterization device, there is formed an aperture in a support structure, and electrical contact pads are formed on a selected surface of the support structure for connection to molecular analysis circuitry. Then at the aperture is provided at least one carbon nanotube. An electrically insulating layer is deposited on walls of the aperture to reduce an extent of the aperture and form a smaller aperture, while depositing substantially no insulating layer on a region of the nanotube that is at the aperture.

    摘要翻译： 在制造分子表征装置的方法中，在支撑结构中形成孔，并且电连接垫形成在支撑结构的选定表面上，用于连接到分子分析电路。 然后在孔处提供至少一个碳纳米管。 电绝缘层沉积在孔的壁上以减小孔的范围并形成较小的孔，同时在位于孔的纳米管的区域上基本上不沉积绝缘层。

    MOLECULAR CHARACTERIZATION WITH CARBON NANOTUBE CONTROL
    43.
    发明申请
    MOLECULAR CHARACTERIZATION WITH CARBON NANOTUBE CONTROL 有权
    用碳纳米管控制分子表征

    公开(公告)号：US20080171316A1

    公开(公告)日：2008-07-17

    申请号：US11399663

    申请日：2006-04-06

    申请人： Jene A. Golovchenko ,  Daniel Branton

    发明人： Jene A. Golovchenko ,  Daniel Branton

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  C12M1/34

    CPC分类号： G01N27/44791 ,  B82Y15/00 ,  C12Q1/6869 ,  G01N27/44743 ,  G01N33/48721 ,  Y10S977/762 ,  C12Q2565/631

    摘要： There is provided a first reservoir containing a liquid solution including a molecule to be characterized and a second reservoir for containing a liquid solution including a molecule that has been characterized. A solid state support structure is provided including an aperture having a molecular entrance providing a fluidic connection to the first reservoir and a molecular exit providing a fluidic connection to the second reservoir. First and second electron transport probes are each disposed on the support structure with a surface abutting a perimeter of the aperture. At least one of the probes comprises a fullerene structure, e.g., a carbon nanotube. A voltage source is connected between the probes to apply a voltage bias across the aperture. An electrical current monitor is connected between the probes for monitoring changes in electron transport between the probes corresponding to translocation of a molecule through the aperture.

    摘要翻译： 提供了一种包含液态溶液的第一储存器，该液体溶液包括要表征的分子和用于容纳包含已经表征的分子的液体溶液的第二储存器。 提供了一种固态支撑结构，包括具有提供与第一储存器的流体连接的分子入口和提供与第二储存器的流体连接的分子出口的孔。 第一和第二电子传输探针各自设置在支撑结构上，表面邻接孔的周边。 至少一个探针包括富勒烯结构，例如碳纳米管。 探针之间连接一个电压源，以在该孔径上施加电压偏置。 探针之间连接有一个电流监测器，用于监测对应于分子通过孔的易位的探针之间的电子传输变化。

    Molecular characterization with molecular speed control
    45.
    发明授权
    Molecular characterization with molecular speed control 有权
    分子速度控制的分子表征

    公开(公告)号：US09274097B2

    公开(公告)日：2016-03-01

    申请号：US13040537

    申请日：2011-03-04

    申请人： Jene A. Golovchenko ,  Daniel Branton

    发明人： Jene A. Golovchenko ,  Daniel Branton

    IPC分类号： C12M1/34 ,  G01N33/487 ,  C12Q1/68 ,  B82Y15/00

    CPC分类号： G01N27/44791 ,  B82Y15/00 ,  C12Q1/6869 ,  G01N27/44743 ,  G01N33/48721 ,  Y10S977/762 ,  C12Q2565/631

    摘要： Provided is a first reservoir for containing a liquid solution including a molecule to be characterized and a second reservoir for containing a liquid solution. A solid state support includes a nanopore having a molecular inlet providing a fluidic connection to the first reservoir and a molecular outlet providing a fluidic connection to the second reservoir. An electrical connection is disposed between the first and second reservoirs to apply a molecular translocation voltage across the nanopore between the molecular inlet entrance and outlet exit. At least one electrical probe is disposed at the nanopore to apply a first voltage bias with respect to translocation voltage to slow progression of a molecule through the nanopore between the molecular inlet and outlet and to apply a second voltage bias with respect to translocation voltage to cause the molecule to proceed through the nanopore between the molecular inlet and outlet.

    摘要翻译： 提供了一种用于容纳包含要表征的分子的液体溶液的第一储存器和用于容纳液体溶液的第二储存器。 固态载体包括具有提供与第一储存器的流体连接的分子入口和提供与第二储存器的流体连接的分子出口的纳米孔。 电连接设置在第一和第二储存器之间，以在分子入口入口和出口出口之间跨纳米孔施加分子易位电压。 至少一个电探针设置在纳米孔处，以相对于易位电压施加第一电压偏压，以使分子缓慢进入分子入口和出口之间的纳米孔，并且相对于易位电压施加第二电压偏置以引起 分子通过分子入口和出口之间的纳米孔进行。

    Electron beam processing with condensed ice
    46.
    发明授权
    Electron beam processing with condensed ice 有权
    用冷凝冰进行电子束加工

    公开(公告)号：US08790863B2

    公开(公告)日：2014-07-29

    申请号：US13881504

    申请日：2011-10-26

    申请人： Daniel Branton ,  Anpan Han ,  Jene A. Golovchenko

    发明人： Daniel Branton ,  Anpan Han ,  Jene A. Golovchenko

    IPC分类号： G03F7/38 ,  B82B3/00 ,  G03F7/16

    CPC分类号： G03F7/2059 ,  B81C1/00531 ,  B81C2201/0143 ,  B81C2201/0159 ,  B82Y10/00 ,  B82Y40/00 ,  G01N23/2251 ,  H01J37/3174 ,  H01J2237/004 ,  H01J2237/022 ,  H01J2237/2002 ,  H01J2237/2803 ,  H01J2237/2809 ,  H01J2237/31796 ,  H01L21/0331 ,  H01L22/12 ,  H01L51/0014 ,  H01L51/0048

    摘要： In a method for imaging a solid state substrate, a vapor is condensed to an amorphous solid water condensate layer on a surface of a solid state substrate. Then an image of at least a portion of the substrate surface is produced by scanning an electron beam along the substrate surface through the water condensate layer. The water condensate layer integrity is maintained during electron beam scanning to prevent electron-beam contamination from reaching the substrate during electron beam scanning. Then one or more regions of the layer can be locally removed by directing an electron beam at the regions. A material layer can be deposited on top of the water condensate layer and any substrate surface exposed at the one or more regions, and the water condensate layer and regions of the material layer on top of the layer can be removed, leaving a patterned material layer on the substrate.

    摘要翻译： 在固态基板成像方法中，将蒸气冷凝成固态基板表面的无定形固体水凝结物层。 然后通过沿着衬底表面扫描电子束通过水凝结层产生衬底表面的至少一部分的图像。 在电子束扫描期间维持水凝结层的完整性，以防止电子束扫描期间电子束污染到达衬底。 然后可以通过在该区域处引导电子束来局部地去除该层的一个或多个区域。 材料层可以沉积在水冷凝物层的顶部和在一个或多个区域暴露的任何基底表面，并且水凝结物层和该层顶部上的材料层的区域可以被去除，留下图案化的材料层 在基板上。

    Electron Beam Processing With Condensed Ice
    47.
    发明申请
    Electron Beam Processing With Condensed Ice 有权
    冷凝电子束加工

    公开(公告)号：US20130288182A1

    公开(公告)日：2013-10-31

    申请号：US13881504

    申请日：2011-10-26

    申请人： Daniel Branton ,  Anpan Han ,  Jene A. Golovchenko

    发明人： Daniel Branton ,  Anpan Han ,  Jene A. Golovchenko

    IPC分类号： G03F7/20

    CPC分类号： G03F7/2059 ,  B81C1/00531 ,  B81C2201/0143 ,  B81C2201/0159 ,  B82Y10/00 ,  B82Y40/00 ,  G01N23/2251 ,  H01J37/3174 ,  H01J2237/004 ,  H01J2237/022 ,  H01J2237/2002 ,  H01J2237/2803 ,  H01J2237/2809 ,  H01J2237/31796 ,  H01L21/0331 ,  H01L22/12 ,  H01L51/0014 ,  H01L51/0048

    摘要： In a method for imaging a solid state substrate, a vapor is condensed to an amorphous solid water condensate layer on a surface of a solid state substrate. Then an image of at least a portion of the substrate surface is produced by scanning an electron beam along the substrate surface through the water condensate layer. The water condensate layer integrity is maintained during electron beam scanning to prevent electron-beam contamination from reaching the substrate during electron beam scanning. Then one or more regions of the layer can be locally removed by directing an electron beam at the regions. A material layer can be deposited on top of the water condensate layer and any substrate surface exposed at the one or more regions, and the water condensate layer and regions of the material layer on top of the layer can be removed, leaving a patterned material layer on the substrate.

    摘要翻译： 在固态基板成像方法中，将蒸气冷凝成固态基板表面的无定形固体水凝结物层。 然后通过沿着衬底表面扫描电子束通过水凝结层产生衬底表面的至少一部分的图像。 在电子束扫描期间维持水凝结层的完整性，以防止电子束扫描期间电子束污染到达衬底。 然后可以通过在该区域处引导电子束来局部地去除该层的一个或多个区域。 材料层可以沉积在水冷凝物层的顶部和在一个或多个区域暴露的任何基底表面，并且水凝结物层和该层顶部上的材料层的区域可以被去除，留下图案化的材料层 在基板上。

    CHARACTERIZATION OF INDIVIDUAL POLYMER MOLECULES BASED ON MONOMER-INTERFACE INTERACTIONS
    48.
    发明申请
    CHARACTERIZATION OF INDIVIDUAL POLYMER MOLECULES BASED ON MONOMER-INTERFACE INTERACTIONS 审中-公开
    基于单体界面相互作用的个体聚合物分子的表征

    公开(公告)号：US20120160687A1

    公开(公告)日：2012-06-28

    申请号：US13186966

    申请日：2011-07-20

    申请人： Mark Akeson ,  Daniel Branton ,  George Church ,  David W. Deamer

    发明人： Mark Akeson ,  Daniel Branton ,  George Church ,  David W. Deamer

    IPC分类号： C07K1/26

    CPC分类号： C12Q1/6869 ,  G01N27/447 ,  G01N33/48721 ,  C12Q2565/631 ,  C12Q2565/607

    摘要： The invention relates to a method for detecting a double-stranded region in a nucleic acid by (1) providing two separate, adjacent pools of a medium and a interface between the two pools, the interface having a channel so dimensioned as to allow sequential monomer-by-monomer passage of a single-stranded nucleic acid, but not of a double-stranded nucleic acid, from one pool to the other pool; (2) placing a nucleic acid polymer in one of the two pools; and (3) taking measurements as each of the nucleotide monomers of the single-stranded nucleic acid polymer passes through the channel so as to differentiate between nucleotide monomers that are hybridized to another nucleotide monomer before entering the channel and nucleotide monomers that are not hybridized to another nucleotide monomer before entering the channel.

    摘要翻译： 本发明涉及一种用于通过（1）在两个池之间提供两个独立的相邻的介质池和界面来检测核酸中的双链区域的方法，所述界面具有如此尺寸以允许顺序单体 单链核酸但不是双链核酸的单体通过从一个池到另一个池; （2）将核酸聚合物置于两个池中的一个中; 和（3）测量，因为单链核酸聚合物的每个核苷酸单体通过通道，以便在进入通道之前与另一个核苷酸单体杂交的核苷酸单体与未杂交的核苷酸单体区分 进入通道之前的另一种核苷酸单体。

    Molecular Characterization with Molecular Speed Control
    49.
    发明申请
    Molecular Characterization with Molecular Speed Control 有权
    分子速度控制的分子表征

    公开(公告)号：US20110155574A1

    公开(公告)日：2011-06-30

    申请号：US13040537

    申请日：2011-03-04

    申请人： Jene A. Golovchenko ,  Daniel Branton

    发明人： Jene A. Golovchenko ,  Daniel Branton

    IPC分类号： G01N27/447 ,  G01N27/453 ,  B82Y99/00

    CPC分类号： G01N27/44791 ,  B82Y15/00 ,  C12Q1/6869 ,  G01N27/44743 ,  G01N33/48721 ,  Y10S977/762 ,  C12Q2565/631

    摘要： Provided is a first reservoir for containing a liquid solution including a molecule to be characterized and a second reservoir for containing a liquid solution. A solid state support includes a nanopore having a molecular inlet providing a fluidic connection to the first reservoir and a molecular outlet providing a fluidic connection to the second reservoir. An electrical connection is disposed between the first and second reservoirs to apply a molecular translocation voltage across the nanopore between the molecular inlet entrance and outlet exit. At least one electrical probe is disposed at the nanopore to apply a first voltage bias with respect to translocation voltage to slow progression of a molecule through the nanopore between the molecular inlet and outlet and to apply a second voltage bias with respect to translocation voltage to cause the molecule to proceed through the nanopore between the molecular inlet and outlet.

    摘要翻译： 提供了一种用于容纳包含要表征的分子的液体溶液的第一储存器和用于容纳液体溶液的第二储存器。 固态载体包括具有提供与第一储存器的流体连接的分子入口和提供与第二储存器的流体连接的分子出口的纳米孔。 电连接设置在第一和第二储存器之间，以在分子入口入口和出口出口之间跨纳米孔施加分子易位电压。 至少一个电探针设置在纳米孔处，以相对于易位电压施加第一电压偏压，以使分子缓慢进入分子入口和出口之间的纳米孔，并且相对于易位电压施加第二电压偏置以引起 分子通过分子入口和出口之间的纳米孔进行。