-
41.Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors 失效
标题翻译: 氨基酸羟乙基氨基磺酰胺逆转录病毒蛋白酶抑制剂公开(公告)号:US5968970A
公开(公告)日:1999-10-19
申请号:US894900
申请日:1998-01-02
申请人: Daniel P. Getman , Gary A. DeCrescenzo , John N. Freskos , Michael L. Vazquez , James A. Sikorski , Balekudru Devadas , Srinivasan R. Nagarajan , David L. Brown , Joseph J. McDonald
发明人: Daniel P. Getman , Gary A. DeCrescenzo , John N. Freskos , Michael L. Vazquez , James A. Sikorski , Balekudru Devadas , Srinivasan R. Nagarajan , David L. Brown , Joseph J. McDonald
IPC分类号: C07D317/46 , A61K31/357 , A61K31/36 , A61K31/4025 , A61K31/4035 , A61K31/4184 , A61K31/423 , A61K31/426 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K38/00 , A61P31/12 , A61P31/18 , A61P43/00 , C07D235/30 , C07D263/56 , C07D277/62 , C07D277/82 , C07D307/79 , C07D311/58 , C07D317/58 , C07D317/62 , C07D319/18 , C07D339/06 , C07K5/06 , C07K5/08 , A61K31/40 , C07D207/06
CPC分类号: C07D307/79 , C07D311/58 , C07D317/62 , C07D319/18 , C07D339/06 , C07K5/06026 , C07K5/06034 , C07K5/0606 , C07K5/06069 , A61K38/00
摘要: Described herein is a retroviral protease inhibiting compound of the formula: ##STR1## or a pharmaceutically acceptable salt, prodrug or ester thereof.
摘要翻译: PCT No.PCT / US96 / 02684第 371日期:1998年1月12日 102(e)日期1998年1月12日PCT 1996年3月7日PCT公布。 WO96 / 28463 PCT出版物 日期1996年9月19日描述了下式的逆转录病毒蛋白酶抑制化合物:或其药学上可接受的盐,前药或酯。
-
公开(公告)号:US06667307B2
公开(公告)日:2003-12-23
申请号:US10082123
申请日:2002-02-26
申请人: Daniel P. Getman , Gary A. DeCrescenzo , John N. Freskos , Michael L. Vazquez , James A. Sikorski , Balekudru Devadas , Srinivasan Nagarajan , Joseph J. McDonald
发明人: Daniel P. Getman , Gary A. DeCrescenzo , John N. Freskos , Michael L. Vazquez , James A. Sikorski , Balekudru Devadas , Srinivasan Nagarajan , Joseph J. McDonald
IPC分类号: A61K31343
CPC分类号: C07D263/56 , C07C317/44 , C07D215/36 , C07D217/02 , C07D217/04 , C07D235/30 , C07D235/32 , C07D249/20 , C07D277/62 , C07D277/82 , C07D307/79 , C07D307/82 , C07D311/58 , C07D317/62 , C07D319/18
摘要: Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
-
43.
公开(公告)号:US5776971A
公开(公告)日:1998-07-07
申请号:US474117
申请日:1995-06-07
申请人: Daniel P. Getman , Gary A. DeCrescenzo , John N. Freskos , Michael L. Vazquez , James A. Sikorski , Balekudru Devadas , Srinivasan Nagarajan , David L. Brown , Joseph J. McDonald
发明人: Daniel P. Getman , Gary A. DeCrescenzo , John N. Freskos , Michael L. Vazquez , James A. Sikorski , Balekudru Devadas , Srinivasan Nagarajan , David L. Brown , Joseph J. McDonald
IPC分类号: A61K38/00 , C07K5/078 , A61K31/40 , C07D207/48
CPC分类号: C07K5/06165 , C07K5/06139 , A61K38/00
摘要: Selected heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
-
公开(公告)号:US5475027A
公开(公告)日:1995-12-12
申请号:US148817
申请日:1993-11-08
申请人: John J. Talley , Daniel P. Getman , Ko-Chung Lin , Gary A. DeCrescenzo , Donald J. Rogier, Jr. , John N. Freskos
发明人: John J. Talley , Daniel P. Getman , Ko-Chung Lin , Gary A. DeCrescenzo , Donald J. Rogier, Jr. , John N. Freskos
IPC分类号: A61K31/17 , A61K31/195 , A61K31/197 , A61K31/27 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K38/00 , C07C213/02 , C07C271/20 , C07C271/22 , C07C275/14 , C07C275/18 , C07C275/22 , C07C275/24 , C07C275/28 , C07C311/47 , C07C317/44 , C07C317/50 , C07C323/60 , C07C329/06 , C07C335/08 , C07C335/12 , C07D213/81 , C07D215/48 , C07D215/50 , C07D215/54 , C07D215/56 , C07D217/26 , C07D235/06 , C07D235/24 , C07D239/38 , C07D241/44 , C07D295/13 , C07D295/15 , C07D307/85 , C07D401/12 , C07K5/02 , C07K5/06 , C07K5/078
CPC分类号: C07K5/06191 , A61K31/17 , A61K31/195 , A61K31/197 , A61K31/27 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , C07C213/02 , C07C271/20 , C07C271/22 , C07C275/14 , C07C275/18 , C07C275/22 , C07C275/24 , C07C275/28 , C07C311/47 , C07C317/44 , C07C317/50 , C07C323/60 , C07C329/06 , C07C335/08 , C07C335/12 , C07D213/81 , C07D215/48 , C07D215/50 , C07D215/54 , C07D215/56 , C07D217/26 , C07D235/06 , C07D235/24 , C07D239/38 , C07D241/44 , C07D295/13 , C07D295/15 , C07D307/85 , C07D401/12 , C07K5/0207 , C07K5/021 , C07K5/06026 , C07K5/06139 , A61K38/00 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14
摘要: Urea-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
摘要翻译: 含尿素的羟胺化合物作为逆转录病毒蛋白酶抑制剂是有效的,特别是作为HIV蛋白酶的抑制剂。
-
公开(公告)号:US5703076A
公开(公告)日:1997-12-30
申请号:US449966
申请日:1995-05-25
申请人: John J. Talley , Daniel P. Getman , Ko-Chung Lin , Gary A. DeCrescenzo , Donald J. Rogier, Jr. , John N. Freskos
发明人: John J. Talley , Daniel P. Getman , Ko-Chung Lin , Gary A. DeCrescenzo , Donald J. Rogier, Jr. , John N. Freskos
IPC分类号: A61K31/17 , A61K31/195 , A61K31/197 , A61K31/27 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K38/00 , C07C213/02 , C07C271/20 , C07C271/22 , C07C275/14 , C07C275/18 , C07C275/22 , C07C275/24 , C07C275/28 , C07C311/47 , C07C317/44 , C07C317/50 , C07C323/60 , C07C329/06 , C07C335/08 , C07C335/12 , C07D213/81 , C07D215/48 , C07D215/50 , C07D215/54 , C07D215/56 , C07D217/26 , C07D235/06 , C07D235/24 , C07D239/38 , C07D241/44 , C07D295/13 , C07D295/15 , C07D307/85 , C07D401/12 , C07K5/02 , C07K5/06 , C07K5/078
CPC分类号: C07K5/06191 , A61K31/17 , A61K31/195 , A61K31/197 , A61K31/27 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , C07C213/02 , C07C271/20 , C07C271/22 , C07C275/14 , C07C275/18 , C07C275/22 , C07C275/24 , C07C275/28 , C07C311/47 , C07C317/44 , C07C317/50 , C07C323/60 , C07C329/06 , C07C335/08 , C07C335/12 , C07D213/81 , C07D215/48 , C07D215/50 , C07D215/54 , C07D215/56 , C07D217/26 , C07D235/06 , C07D235/24 , C07D239/38 , C07D241/44 , C07D295/13 , C07D295/15 , C07D307/85 , C07D401/12 , C07K5/0207 , C07K5/021 , C07K5/06026 , C07K5/06139 , A61K38/00 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14
摘要: Urea-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
摘要翻译: 含尿素的羟胺化合物作为逆转录病毒蛋白酶抑制剂是有效的,特别是作为HIV蛋白酶的抑制剂。
-
公开(公告)号:US07026485B2
公开(公告)日:2006-04-11
申请号:US10793672
申请日:2004-03-05
申请人: John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Kathryn L. Reed , Ko-Chung Lin , John Nicholas Freskos , Michael Clare , Donald Joseph Rogier, Jr. , Robert M. Heintz , Michael L. Vazquez , Richard A. Mueller
发明人: John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Kathryn L. Reed , Ko-Chung Lin , John Nicholas Freskos , Michael Clare , Donald Joseph Rogier, Jr. , Robert M. Heintz , Michael L. Vazquez , Richard A. Mueller
IPC分类号: C07D471/00
CPC分类号: C07D401/12 , C07D207/16 , C07D211/60 , C07D217/26
摘要: N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
-
47.Method for making intermediates useful in the synthesis of retroviral protease inhibitors 失效
标题翻译: 制备可用于合成逆转录病毒蛋白酶抑制剂的中间体的方法公开(公告)号:US5648511A
公开(公告)日:1997-07-15
申请号:US452187
申请日:1995-05-25
申请人: John S. Ng , Claire A. Przybyla , Richard A. Mueller , Michael L. Vazquez , Daniel P. Getman , John J. Freskos , Gary A. DeCrescenzo , Deborah E. Bertenshaw , Robert M. Heintz , Suhong Zhang , Chin Liu , Scott A. Laneman
发明人: John S. Ng , Claire A. Przybyla , Richard A. Mueller , Michael L. Vazquez , Daniel P. Getman , John J. Freskos , Gary A. DeCrescenzo , Deborah E. Bertenshaw , Robert M. Heintz , Suhong Zhang , Chin Liu , Scott A. Laneman
IPC分类号: A61K31/17 , A61K31/195 , A61K31/197 , A61K31/27 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K38/00 , C07C213/00 , C07C213/02 , C07C213/08 , C07C215/28 , C07C269/04 , C07C269/06 , C07C271/16 , C07F7/18 , C07K5/078 , C07D253/00
CPC分类号: C07C269/06 , A61K31/17 , A61K31/195 , A61K31/197 , A61K31/27 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , C07C213/00 , C07C213/02 , C07C213/08 , C07C269/04 , C07F7/188 , C07K5/06139 , A61K38/00 , C07B2200/07
摘要: A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide or cyanohydrin from a chiral alpha amino aldehyde.
摘要翻译: 对于易于大规模制备基于羟基脲的手性HIV蛋白酶抑制剂的中间体描述了合成。 该方法包括由手性α氨基醛形成非对映选择性环氧化物或羟腈。
-
公开(公告)号:US5643924A
公开(公告)日:1997-07-01
申请号:US455237
申请日:1995-05-31
申请人: John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Kathryn L. Reed , Ko-Chung Lin , John Nicholas Freskos , Michael Clare , Donald Joseph Rogier, Jr. , Robert M. Heintz , Michael L. Vazquez , Richard A. Mueller
发明人: John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Kathryn L. Reed , Ko-Chung Lin , John Nicholas Freskos , Michael Clare , Donald Joseph Rogier, Jr. , Robert M. Heintz , Michael L. Vazquez , Richard A. Mueller
IPC分类号: A61K31/40 , A61K31/4427 , A61K31/445 , A61K31/4468 , A61K31/47 , A61K31/472 , A61K38/55 , A61P31/12 , C07D207/16 , C07D211/60 , C07D217/26 , C07D241/04 , C07D401/12 , C07K5/06 , C07K14/81 , A61K31/44
CPC分类号: C07D401/12 , C07D207/16 , C07D211/60 , C07D217/26
摘要: N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
-
公开(公告)号:US5698569A
公开(公告)日:1997-12-16
申请号:US487664
申请日:1995-06-07
申请人: John J. Talley , Daniel P. Getman , John N. Freskos , Ko-Chung Lin , Robert M. Heintz , Donald J. Rogier, Jr. , Deborah E. Bertenshaw
发明人: John J. Talley , Daniel P. Getman , John N. Freskos , Ko-Chung Lin , Robert M. Heintz , Donald J. Rogier, Jr. , Deborah E. Bertenshaw
IPC分类号: A61K31/17 , A61K31/195 , A61K31/197 , A61K31/27 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K38/00 , C07C213/02 , C07C271/20 , C07C271/22 , C07C275/14 , C07C275/18 , C07C275/22 , C07C275/24 , C07C275/28 , C07C311/47 , C07C317/44 , C07C317/50 , C07C323/60 , C07C329/06 , C07C335/08 , C07C335/12 , C07D213/81 , C07D215/48 , C07D215/50 , C07D215/54 , C07D217/26 , C07D235/06 , C07D235/24 , C07D239/38 , C07D241/44 , C07D295/13 , C07D295/15 , C07D307/85 , C07D401/12 , C07K5/02 , C07K5/06 , C07K5/078
CPC分类号: C07K5/06191 , A61K31/17 , A61K31/195 , A61K31/197 , A61K31/27 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , C07C213/02 , C07C271/20 , C07C271/22 , C07C275/14 , C07C275/18 , C07C275/22 , C07C275/24 , C07C275/28 , C07C311/47 , C07C317/44 , C07C317/50 , C07C323/60 , C07C329/06 , C07C335/08 , C07C335/12 , C07D213/81 , C07D215/48 , C07D215/50 , C07D215/54 , C07D217/26 , C07D235/06 , C07D235/24 , C07D239/38 , C07D241/44 , C07D295/13 , C07D295/15 , C07D307/85 , C07D401/12 , C07K5/0207 , C07K5/021 , C07K5/06026 , C07K5/06139 , A61K38/00 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14
摘要: Urea-containing hydroxyethylamine peptide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
摘要翻译: 含尿素的羟胺胺化合物作为逆转录病毒蛋白酶抑制剂是有效的,特别是作为HIV蛋白酶的抑制剂。
-
公开(公告)号:US5475013A
公开(公告)日:1995-12-12
申请号:US886531
申请日:1992-05-20
申请人: John J. Talley , Daniel P. Getman , John N. Freskos , Ko-Chung Lin , Robert M. Heintz , Donald J. Rogier, Jr. , Deborah E. Bertenshaw
发明人: John J. Talley , Daniel P. Getman , John N. Freskos , Ko-Chung Lin , Robert M. Heintz , Donald J. Rogier, Jr. , Deborah E. Bertenshaw
IPC分类号: A61K31/17 , A61K31/195 , A61K31/197 , A61K31/27 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K38/00 , C07C213/02 , C07C271/20 , C07C271/22 , C07C275/14 , C07C275/18 , C07C275/22 , C07C275/24 , C07C275/28 , C07C311/47 , C07C317/44 , C07C317/50 , C07C323/60 , C07C329/06 , C07C335/08 , C07C335/12 , C07D213/81 , C07D215/48 , C07D215/50 , C07D215/54 , C07D217/26 , C07D235/06 , C07D235/24 , C07D239/38 , C07D241/44 , C07D295/13 , C07D295/15 , C07D307/85 , C07D401/12 , C07K5/02 , C07K5/06 , C07K5/078
CPC分类号: C07K5/06191 , A61K31/17 , A61K31/195 , A61K31/197 , A61K31/27 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , C07C213/02 , C07C271/20 , C07C271/22 , C07C275/14 , C07C275/18 , C07C275/22 , C07C275/24 , C07C275/28 , C07C311/47 , C07C317/44 , C07C317/50 , C07C323/60 , C07C329/06 , C07C335/08 , C07C335/12 , C07D213/81 , C07D215/48 , C07D215/50 , C07D215/54 , C07D217/26 , C07D235/06 , C07D235/24 , C07D239/38 , C07D241/44 , C07D295/13 , C07D295/15 , C07D307/85 , C07D401/12 , C07K5/0207 , C07K5/021 , C07K5/06026 , C07K5/06139 , A61K38/00 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14
摘要: Urea-containing hydroxyethylamine peptide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
摘要翻译: 含尿素的羟胺胺化合物作为逆转录病毒蛋白酶抑制剂是有效的,特别是作为HIV蛋白酶的抑制剂。
-
-
-
-
-
-
-
-
-