利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

90 条记录 (耗时 0.033 秒)

    High performance liquid chromatography with an aqueous mobile phase for analysis of drug and its metabolite
    41.
    发明授权
    High performance liquid chromatography with an aqueous mobile phase for analysis of drug and its metabolite 失效
    用于分析药物及其代谢物的含水流动相的高效液相色谱法

    公开(公告)号：US07632656B2

    公开(公告)日：2009-12-15

    申请号：US10547751

    申请日：2004-03-04

    申请人： Hideko Kanazawa ,  Teruo Okano

    发明人： Hideko Kanazawa ,  Teruo Okano

    IPC分类号： C12Q1/26

    CPC分类号： G01N33/57438 ,  G01N33/573 ,  G01N33/6893

    摘要： The amount of drug consumption caused by a specific drug-metabolizing enzyme and/or the amount of the resulting metabolite(s) is measured by chromatography with an aqueous mobile phase under temperature control using a packing material whose surface is coated with a polymer having a hydration force varying in the temperature range of 0° C. to 80° C. This system enables proper evaluation of drug-metabolizing capacity through simple means without adversely affecting the environment.

    摘要翻译： 由特定药物代谢酶引起的药物消耗量和/或所得代谢物的量通过使用包装材料的水性流动相的色谱法进行测量，所述包装材料的表面涂覆有具有 水合力在0°C至80°C的温度范围内变化。该系统可以通过简单的手段适当评估药物代谢能力，而不会对环境产生不利影响。

    Cultured Periodontal Membrane Cell Sheet, Process for Producing the Same and Method of Use Thereof
    43.
    发明申请
    Cultured Periodontal Membrane Cell Sheet, Process for Producing the Same and Method of Use Thereof 有权
    培养的牙周膜细胞片，其制备方法及其使用方法

    公开(公告)号：US20080118474A1

    公开(公告)日：2008-05-22

    申请号：US11587427

    申请日：2005-04-25

    申请人： Teruo Okano ,  Masateru Hasegawa ,  Masayuki Yamato ,  Akihiko Kikuchi ,  Isao Ishikawa

    发明人： Teruo Okano ,  Masateru Hasegawa ,  Masayuki Yamato ,  Akihiko Kikuchi ,  Isao Ishikawa

    IPC分类号： A01N63/00 ,  A01N1/00 ,  C12N5/06

    CPC分类号： A61L27/3886 ,  A61C8/0006 ,  A61K35/32 ,  A61L27/3804 ,  A61L27/3865 ,  C12N5/066 ,  C12N2502/097 ,  C12N2502/1311 ,  C12N2513/00 ,  C12N2539/10

    摘要： A cultured periodontal ligament cell sheet is produced by a process comprising culturing cells on a cell culture support composed of a base material whose surface is coated with a temperature-responsive polymer having an upper limit or lower limit critical dissolution temperature in water of 0 to 80° C. under specified conditions, (1) regulating the temperature of a culture fluid to the upper limit critical dissolution temperature or higher or to the lower limit critical temperature or lower, (2) allowing a cultured periodontal ligament cell sheet resulting from the culturing to adhere to a carrier and (3) detaching the sheet intact together with the carrier. This cultured periodontal ligament cell sheet has a syndesmotic microstructure, exhibits extremely high bioadherence to the dental root surface and realizes high density transplantation of target cells and positive reconstruction of periodontal tissues. Moreover, through lamination of cell sheets to be transplanted and donation of a three-dimensional polarity, highly efficient reconstruction of an adhesion apparatus can be accomplished and clinical application thereof to moderate periodontitis, severe peridontitis, gingival recession and the like is highly promising.

    摘要翻译： 培养的牙周韧带细胞片通过以下方法制备：将细胞培养在由表面涂覆有在水中的上限或下限临界溶解温度为0〜80的温度敏感性聚合物的基材构成的细胞培养支持体上 ℃，（1）将培养液的温度调节至上限临界溶解温度或更高或下限临界温度或更低，（2）允许培养产生的培养的牙周膜细胞片 粘贴在载体上，（3）与载体一起分离片材。 这种培养的牙周膜细胞片具有相似的微观结构，对牙根表面具有极高的生物相干性，实现了靶细胞的高密度移植和牙周组织的积极重建。 此外，通过层叠待移植的细胞片和三维极性的提供，可以实现粘附装置的高效重建，并且其适度的牙周炎，严重的周围炎，牙龈退缩等的临床应用是非常有希望的。

    Acrylamide derivatives and polymers containing said derivatives
    45.
    发明授权
    Acrylamide derivatives and polymers containing said derivatives 有权
    含有所述衍生物的丙烯酰胺衍生物和聚合物

    公开(公告)号：US06495645B1

    公开(公告)日：2002-12-17

    申请号：US09889953

    申请日：2001-08-30

    申请人： Teruo Okano ,  Takao Aoyagi

    发明人： Teruo Okano ,  Takao Aoyagi

    IPC分类号： C08F12238

    CPC分类号： C07C233/49 ,  C07C233/38 ,  C08F20/54

    摘要： An acrylamide derivative of the following general formula (I) is used to prepare a polymer or copolymer: wherein R1 represents a hydrogen atom, a straight-chain or branched alkyl group containing 1 to 4 carbon atoms or a C3-6 cycloalkyl group, R2 and R3 each independently represent an alkylene group containing 1 to 6 carbon atoms or R2 and R3 may be combined to form a ring, X represents a hydrogen atom, an amino group, a hydroxyl group, a halogen atom, a carboxyl group or a —COOR4 group wherein R4 represents a C1-6 straight-chain or branched alkyl, C3-6 cycloalkyl, phenyl, substituted phenyl, benzyl or substituted benzyl group, and Y represents an amino group, a halogen atom, a carboxyl group or a —COOR4 group wherein R4 represents a C1-6 straight-chain or branched alkyl, C3-6 cycloalkyl, phenyl, substituted phenyl, benzyl or substituted benzyl group. The thus obtained polymer or copolymer is a polymer or hydrogel incorporating many functional groups while maintaining the sensitive temperature response.

    摘要翻译： 使用以下通式（I）的丙烯酰胺衍生物来制备聚合物或共聚物：其中R 1表示氢原子，含有1至4个碳原子的直链或支链烷基或C 3-6环烷基，R 2 R 3各自独立地表示碳原子数1〜6的亚烷基，R 2和R 3可以结合形成环，X表示氢原子，氨基，羟基，卤素原子，羧基或 - COOR 4基团，其中R 4表示C 1-6直链或支链烷基，C 3-6环烷基，苯基，取代的苯基，苄基或取代的苄基，Y表示氨基，卤素原子，羧基或-COOR 4 基团，其中R 4表示C 1-6直链或支链烷基，C 3-6环烷基，苯基，取代的苯基，苄基或取代的苄基。 由此获得的聚合物或共聚物是在保持敏感的温度响应的同时引入许多官能团的聚合物或水凝胶。

    Transdermal delivery system utilizing one way membranes
    46.
    发明授权
    Transdermal delivery system utilizing one way membranes 失效
    使用单向膜的透皮递送系统

    公开(公告)号：US5223262A

    公开(公告)日：1993-06-29

    申请号：US565479

    申请日：1990-08-10

    申请人： Sung W. Kim ,  Teruo Okano ,  Soon H. Yuk

    发明人： Sung W. Kim ,  Teruo Okano ,  Soon H. Yuk

    IPC分类号： A61K9/70

    CPC分类号： A61K9/7084 ,  A61K9/7092 ,  Y10T428/31511 ,  Y10T428/31663

    摘要： A system for transdermally delivering a hydrophobic alkanol soluble active agent to the skin at a constant rate utilizing a lower alkanol penetration enhancer. The system comprises an overlying solvent reservoir containing a lower alkanol solvent and a drug compartment containing an active agent in aqueous alkanol. A one-way membrane is sandwiched between and divides the solvent reservoir from the drum compartment. The one-way membrane is permeable to the alkanol solvent and substantially impermeable to back flux of drug and water into the reservoir. An outer membrane permeable to the alkanol solvent and drug is attached to the outer surface of the drug compartment. Adhesive means is contained on the outer surface of this membrane for attaching the delivery system to the skin of a wearer. Alkanol from the reservoir permeates into the drug compartment and drug and alkanol pass through the outer membrane to the skin of the wearer for transdermal absorption. The rate of alkanol permeation from the reservoir to the drug compartment and from the drug compartment to the skin is substantially constant. The membrane is made up of an epoxidized silicone rubber to which is preferably laminated a layer of a dense hydrophobic copolymer of vinyl-terminated polydimethyl siloxane with methylhydro-dimethyl siloxane. If desired, to prevent any back flux of hydrophobic drugs, and additional layer of cellulose acetate may be sandwiched between the epoxidized silicone rubber and dense hydrophobic membrane.

    摘要翻译： 一种利用低级烷醇渗透增强剂以一定速率将疏水性链烷醇可溶性活性剂透皮递送至皮肤的系统。 该系统包括含有低级链烷醇溶剂的上层溶剂储存器和在链烷醇水溶液中含有活性剂的药物隔室。 单向膜夹在溶剂容器和鼓室之间。 单向膜对于链烷醇溶剂是可渗透的，并且基本上不可渗透地将药物和水的通量回流到储存器中。 可通过链烷醇溶剂和药物的外膜附着到药物隔室的外表面。 粘合剂装在该膜的外表面上，用于将输送系统附着到穿着者的皮肤上。 来自储存器的烷醇渗透到药物隔室中，药物和链烷醇通过外膜到穿着者的皮肤以经皮吸收。 从储存器到药物隔室以及从药物室到皮肤的链烷醇渗透速率基本上是恒定的。 膜由环氧化的硅橡胶组成，其优选层压有乙烯基封端的聚二甲基硅氧烷与甲基氢二甲基硅氧烷的致密疏水性共聚物层。 如果需要，为了防止疏水性药物的任何回流，并且附加的乙酸纤维素层可夹在环氧化硅橡胶和致密疏水膜之间。

    Heterogeneous interpenetrating polymer networks for the controlled release of drugs
    47.
    发明授权
    Heterogeneous interpenetrating polymer networks for the controlled release of drugs 失效
    用于控释药物的非均相互穿聚合物网络

    公开(公告)号：US4931287A

    公开(公告)日：1990-06-05

    申请号：US206593

    申请日：1988-06-14

    申请人： You H. Bae ,  Teruo Okano ,  Sung W. Kim

    发明人： You H. Bae ,  Teruo Okano ,  Sung W. Kim

    IPC分类号： A61K9/20

    CPC分类号： A61K9/2031 ,  A61K9/2027

    摘要： A heterogeneous interpenetrating polymer network is provided for use in the controlled release of drugs. The network is a heterogeneous matrix that is formed from a hydrophilic component such as polyethylene oxide or poly(N,N'-dimethyl acrylamide-co-styrene) and a hydrophobic component such as styrene, an alkyl methacrylate, or polytetramethylene ether glycol. The relative amounts of the two components, or "domains", can be varied, as can the diffusivities and solubilities of the drug combinations to be loaded therein, to control and change as desired the timed release profile of incorporated drug. Prolonged pseudo-zero order release can be obtained where one domain acts as a diffusion barrier layer to the release of drug from the other domain.

    摘要翻译： 提供异构互穿聚合物网络用于药物的控制释放。 该网络是由亲水组分如聚环氧乙烷或聚（N，N'-二甲基丙烯酰胺 - 共 - 苯乙烯）和疏水组分如苯乙烯，甲基丙烯酸烷基酯或聚四亚甲基醚二醇形成的非均相基体。 可以改变两种组分或“结构域”的相对量，以及待加载的药物组合的扩散性和溶解度，以控制并根据需要改变并入药物的定时释放曲线。 可以获得延长的伪零次释放，其中一个结构域充当从另一个域释放药物的扩散阻挡层。

    Cell culture apparatus
    48.
    发明授权
    Cell culture apparatus 有权

    公开(公告)号：US09783773B2

    公开(公告)日：2017-10-10

    申请号：US13432658

    申请日：2012-03-28

    申请人： Mitsuhiro Oura ,  Teruo Okano ,  Tatsuya Shimizu ,  Hirotsugu Kubo ,  Sunao Takeda

    发明人： Mitsuhiro Oura ,  Teruo Okano ,  Tatsuya Shimizu ,  Hirotsugu Kubo ,  Sunao Takeda

    IPC分类号： C12M1/32 ,  C12M1/00

    CPC分类号： C12M33/06 ,  C12M29/26 ,  C12M41/14 ,  C12M41/48

    摘要： A cell culture apparatus includes: an isolator in which a sterile space accommodating a cell incubator filled with a culture solution containing cells to be cultured is disposed; a sampling unit configured to sample the culture solution in the cell incubator; a delivery flow path through which an inside of the sterile space and an outside of the sterile space communicate with each other, the delivery flow path configured to limit a flow in the delivery flow path to a direction that is directed from the inside of the sterile space toward the outside of the sterile space; and a culture solution delivering section configured to deliver the sampled culture solution to the outside of the sterile space via the delivery flow path.