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120 条记录 (耗时 0.03 秒)

    Intradermal delivery of substances
    41.
    发明申请
    Intradermal delivery of substances 审中-公开
    物质的皮内递送

    公开(公告)号：US20050096632A1

    公开(公告)日：2005-05-05

    申请号：US11004780

    申请日：2004-12-03

    申请人： Ronald Pettis ,  James Down ,  Noel Harvey

    发明人： Ronald Pettis ,  James Down ,  Noel Harvey

    IPC分类号： A61K38/22 ,  A61D7/00 ,  A61K38/28 ,  A61M5/158 ,  A61M5/30 ,  A61M5/32 ,  A61M5/46 ,  A61M37/00 ,  A61P3/10 ,  A61M31/00

    CPC分类号： A61M5/46 ,  A61K38/28 ,  A61K38/29 ,  A61M5/158 ,  A61M5/32 ,  A61M5/3286 ,  A61M5/3291 ,  A61M5/3295 ,  A61M37/0015 ,  A61M2037/0038 ,  A61M2037/0061

    摘要： The present invention provides improved methods for ID delivery of drugs and other substances to humans or animals. The methods employ small gauge needles, especially microneedles, placed in the intradermal space to deliver the substance to the intradermal space as a bolus or by infusion. It has been discovered that the placement of the needle outlet within the skin and the exposed height of the needle outlet are critical for efficacious delivery of active substances via small gauge needles to prevent leakage of the substance out of the skin and to improve absorption within the intradermal space. The pharmacokinetics of hormone drugs delivered according to the methods of the invention have been found to be very similar to the pharmacokinetics of conventional SC delivery, indicating that ID administration according to the methods of the invention is likely to produce a similar clinical result (i.e., similar efficacy) with the advantage of reduction or elimination of pain for the patient. Delivery devices which place the needle outlet at an appropriate depth in the intradermal space and control the volume and rate of fluid delivery provide accurate delivery of the substance to the desired location without leakage.

    摘要翻译： 本发明提供了将药物和其它物质的ID递送给人或动物的改进方法。 该方法使用放置在皮内空间中的小规格针，特别是微针，以将物质作为推注或通过输注递送至皮内空间。 已经发现，针出口在皮肤内的放置和针出口的暴露高度对于通过小规格针有效递送活性物质是至关重要的，以防止物质从皮肤泄漏并改善吸收在 皮内空间。 已经发现根据本发明的方法递送的激素药物的药代动力学与常规SC递送的药代动力学非常相似，表明根据本发明的方法的ID给药可能产生类似的临床结果（即， 具有类似功效），具有减少或消除患者疼痛的优点。 将针头出口放置在皮内空间内的适当深度并控制流体输送的体积和速率的输送装置能够将物质精确地输送到期望的位置而不泄漏。

    PUNCTURE INJECTION INSTRUMENT
    48.
    发明申请
    PUNCTURE INJECTION INSTRUMENT 审中-公开
    冲压注射器

    公开(公告)号：US20170021112A1

    公开(公告)日：2017-01-26

    申请号：US15283563

    申请日：2016-10-03

    申请人： TOPPAN PRINTING CO., LTD.

    发明人： Yoshihiro KODAMA ,  Tomoya Sumida

    IPC分类号： A61M5/32 ,  A61B8/08 ,  A61M5/315 ,  A61B8/00 ,  A61B5/00

    CPC分类号： A61M5/3295 ,  A61B5/0066 ,  A61B5/441 ,  A61B8/0858 ,  A61B8/4444 ,  A61B8/4477 ,  A61B8/461 ,  A61M5/3158 ,  A61M5/31581 ,  A61M5/46 ,  A61M2005/31588 ,  A61M2037/0061

    摘要： A puncture injection instrument including a hollow needle body including a substrate having a first surface and a second surface opposite to the first surface, the hollow needle body having one or more projections which are formed on the first surface and each have a through hole penetrating from a distal end of the projection to the second surface of the substrate, and one or more probes positioned outside a region where the one or more projections are formed. The one or more probes include an ultrasound probe or an optical coherence tomography probe.

    摘要翻译： 1.一种穿刺注射器械，其特征在于，包括具有第一面和与该第一面相对的第二面的基材的中空针体，所述中空针体具有形成在所述第一面上的一个以上突起， 所述突起的远端到所述基板的第二表面，以及位于形成所述一个或多个突起的区域外的一个或多个探针。 一个或多个探针包括超声波探头或光学相干断层摄影探针。

    Apparatus and method for transdermal delivery of bioactive solution
    49.
    发明授权
    Apparatus and method for transdermal delivery of bioactive solution 有权
    用于经皮递送生物活性溶液的装置和方法

    公开(公告)号：US09517297B2

    公开(公告)日：2016-12-13

    申请号：US13668813

    申请日：2012-11-05

    申请人： King Saud University

    发明人： Saad Ibrahim Almohizea

    IPC分类号： A61M31/00 ,  A61M5/00 ,  A61M5/178 ,  A61M5/32 ,  A61M37/00

    CPC分类号： A61M5/00 ,  A61M5/178 ,  A61M5/3295 ,  A61M5/3298 ,  A61M37/00

    摘要： Apparatus for transdermal or subcutaneous delivery of a bioactive solution, including a plurality of needles fixed on a needle carrier in a spaced apart relationship and projecting from the needle carrier, each needle having a tip zone adapted to receive an amount of bioactive solution from a reservoir coupled to the needle carrier and to deliver the bioactive solution upon penetrating a skin.

    摘要翻译： 用于经皮或皮下递送生物活性溶液的装置，包括以间隔开的关系固定在针架上的多个针并从针架延伸出来，每个针头具有适于从贮存器接收一定数量的生物活性溶液的尖端区域 耦合到针架上并在穿透皮肤时递送生物活性溶液。

    INTRADERMAL DELIVERY OF SUBSTANCES
    50.
    发明申请
    INTRADERMAL DELIVERY OF SUBSTANCES 审中-公开
    物质输送

    公开(公告)号：US20160331911A1

    公开(公告)日：2016-11-17

    申请号：US15155921

    申请日：2016-05-16

    申请人： Becton, Dickinson and Company

    发明人： Ronald J. Pettis ,  James A. Down ,  Noel J. Harvey

    IPC分类号： A61M5/46 ,  A61M5/158 ,  A61M5/32

    CPC分类号： A61M5/46 ,  A61K38/28 ,  A61K38/29 ,  A61M5/158 ,  A61M5/32 ,  A61M5/3286 ,  A61M5/3291 ,  A61M5/3295 ,  A61M37/0015 ,  A61M2037/0038 ,  A61M2037/0061

    摘要： Methods for ID delivery of drugs and other substances to humans or animals are provided. The methods employ small gauge needles, especially microneedles, placed in the intradermal space to deliver the substance to the intradermal space as a bolus or by infusion. It has been discovered that the placement of the needle outlet within the skin and the exposed height of the needle outlet are critical for efficacious delivery of active substances via small gauge needles to prevent leakage of the substance out of the skin and to improve absorption within the intradermal space. Delivery devices which place the needle outlet at an appropriate depth in the intradermal space and control the volume and rate of fluid delivery to provide accurate delivery of the substance to the desired location without leakage are also provided herein.

    摘要翻译： 提供了将药物和其他物质的ID递送给人或动物的方法。 该方法使用放置在皮内空间中的小规格针，特别是微针，以将物质作为推注或通过输注递送至皮内空间。 已经发现，针出口在皮肤内的放置和针出口的暴露高度对于通过小规格针有效递送活性物质是至关重要的，以防止物质从皮肤泄漏并改善吸收在 皮内空间。 在这里还提供了将针头出口放置在皮内空间内适当深度并且控制流体输送的体积和速率以提供物质到所需位置而没有泄漏的精确输送的输送装置。