公开(公告)号：US10299477B2

公开(公告)日：2019-05-28

申请号：US15765809

申请日：2016-10-06

Applicant: MITSUI CHEMICALS AGRO, INC.

Inventor： Hideki Umetani ,  Hideaki Ikishima ,  Ryohei Naito ,  Toshiyuki Kouno ,  Takeshi Fukumoto ,  Satoshi Yutani ,  Toshiaki Ohara ,  Akihiro Nishida

IPC: C07F7/12 ,  A01N43/40 ,  A01N47/02 ,  A01N47/40 ,  A01N55/00 ,  C07D211/84 ,  C07D211/86 ,  C07D213/64 ,  C07D213/70 ,  C07D401/04 ,  C07D405/12

Abstract: A compound represented by Formula (1) or a salt thereof is provided. R1 represents a C1-C6 alkyl group optionally substituted, a C1-C6 haloalkyl group or the like, R2 represents a halogen atom, a C1-C6 alkyl group optionally substituted, a C1-C6 alkyloxy group optionally substituted or the like, R3 represents a hydrogen atom, a halgenatom, C1-C6 alkyl group optionally substituted or the like, n represents an integer of 0 to 5, X represents an oxygen atom or a sulfur atom, Y represents a phenyl group or a pyridyl group that is substituted with substituent at an ortho position, and the bond with a broken line indicates a double bond or a single bond.

公开(公告)号：US09701636B2

公开(公告)日：2017-07-11

申请号：US14541284

申请日：2014-11-14

Applicant: Akebia Therapeutics, Inc.

Inventor： James Densmore Copp ,  Ann W. Newman ,  Anne Luong

IPC: A61K31/44 ,  C07D211/72 ,  C07D211/84 ,  C07D213/62 ,  C07D213/78 ,  C07D213/81

CPC classification number: A61K31/444 ,  A61K9/14 ,  A61K9/48 ,  C07D213/803 ,  C07D213/81 ,  C07D221/00

Abstract: Provided herein are solid forms comprising {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions comprising the solid forms, methods of making the solid forms and methods of their use for the treatment of various diseases and/or disorders.

公开(公告)号：US09487474B2

公开(公告)日：2016-11-08

申请号：US14405757

申请日：2013-05-31

Applicant: Elkimia, Inc.

Inventor： Elie Abou-Khalil ,  Stephane Raeppel ,  Franck Raeppel

IPC: C07D279/16 ,  C07D241/38 ,  C07C251/20 ,  A61K8/44 ,  A61K8/49 ,  A61Q17/04 ,  C07D309/32 ,  C07D241/44 ,  C07D471/04 ,  C07D491/052 ,  C07D265/36 ,  C07D498/04 ,  C07D513/04 ,  C07D211/84 ,  A61K8/69 ,  C08K3/22 ,  C08K3/34 ,  C08K5/01 ,  C08K5/06 ,  C08K5/17 ,  C08K5/3432 ,  C08K5/5419 ,  C09D101/00 ,  C09D103/00 ,  C09D105/00 ,  C09D177/00 ,  C09D191/06 ,  C09J101/00 ,  C09J103/00 ,  C09J105/00 ,  C09J177/00 ,  C09J191/06

CPC classification number: C07C251/20 ,  A61K8/44 ,  A61K8/49 ,  A61K8/494 ,  A61K8/69 ,  A61Q17/04 ,  C07C2601/14 ,  C07C2601/16 ,  C07D211/84 ,  C07D241/38 ,  C07D241/44 ,  C07D265/36 ,  C07D279/16 ,  C07D309/32 ,  C07D471/04 ,  C07D491/052 ,  C07D498/04 ,  C07D513/04 ,  C08K3/22 ,  C08K3/34 ,  C08K3/346 ,  C08K5/01 ,  C08K5/06 ,  C08K5/175 ,  C08K5/3432 ,  C08K5/5419 ,  C08K2003/2296 ,  C09D101/00 ,  C09D103/00 ,  C09D105/00 ,  C09D177/00 ,  C09D191/06 ,  C09J101/00 ,  C09J103/00 ,  C09J105/00 ,  C09J177/00 ,  C09J191/06

Abstract: The present invention relates to compounds having the general Formula I: which absorb UV radiations and protect biological materials as well as non-biological materials from damaging exposure to UV radiations. The present invention also relates to formulations and compositions comprising such compounds for use in absorbing UV radiations and in protecting biological materials as well as non-biological materials against UV radiations.

公开(公告)号：US08921391B2

公开(公告)日：2014-12-30

申请号：US13265216

申请日：2010-04-22

Applicant: Yukinori Take ,  Shinichi Koizumi ,  Takako Okumura ,  Kazuhiko Nonomura

Inventor： Yukinori Take ,  Shinichi Koizumi ,  Takako Okumura ,  Kazuhiko Nonomura

IPC: A01N43/42 ,  A61K31/44 ,  A01N43/40 ,  A01N37/12 ,  A01N37/44 ,  A61K31/195 ,  A01N47/28 ,  A61K31/17 ,  C07D513/02 ,  C07D515/02 ,  C07D211/72 ,  C07D211/84 ,  C07D213/56 ,  C07C273/00 ,  C07C275/00 ,  C07C239/00 ,  A61K31/192 ,  A61K31/437 ,  A61K31/4412

CPC classification number: C07D471/04 ,  A61K31/192 ,  A61K31/437 ,  A61K31/44 ,  A61K31/4412 ,  A61K45/06 ,  C07C235/60 ,  C07D213/82

Abstract: This invention provides a medicament for the treatment of cancer, which cause a reduction of cancer. This invention relates to use of a compound which has inhibitory activities against prostaglandin E2 receptor (EP4 receptor) and is represented by the following general formula (I), (II), (III), or (IV), or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising the compound or the salt for the manufacture of a medicament for the treatment of cancer. The invention relates to a method for treatment of cancer comprising administering the compound or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising the compound or the salt to humans or animals. The compound or a pharmaceutically acceptable salt thereof, or the pharmaceutical composition may be used in combination with one or more second active agents.

Abstract translation: 本发明提供了用于治疗导致癌症减少的癌症的药物。 本发明涉及对前列腺素E2受体（EP4受体）具有抑制活性且由以下通式（I），（II），（III）或（IV）表示的化合物或其药学上可接受的盐 或包含该化合物或盐的药物组合物，用于制备用于治疗癌症的药物。 本发明涉及一种治疗癌症的方法，其包括将化合物或其药学上可接受的盐或包含该化合物或盐的药物组合物给予人或动物。 化合物或其药学上可接受的盐或药物组合物可以与一种或多种第二活性剂组合使用。

公开(公告)号：US08741936B2

公开(公告)日：2014-06-03

申请号：US13528624

申请日：2012-06-20

Applicant: Lawrence M. Blatt ,  Scott D. Seiwert ,  Leonid Beigelman ,  Ramachandran Radhakrishnan ,  Karl Kossen ,  Vladimir Serebryany

Inventor： Lawrence M. Blatt ,  Scott D. Seiwert ,  Leonid Beigelman ,  Ramachandran Radhakrishnan ,  Karl Kossen ,  Vladimir Serebryany

IPC: A01N43/40 ,  A61K31/44 ,  C07D213/62 ,  C07D213/78 ,  C07D211/72 ,  C07D211/84 ,  C07D213/63 ,  C07D213/70 ,  A61K31/45 ,  C07D213/16 ,  C07D213/64

CPC classification number: A61K31/4412 ,  A61K31/44 ,  A61K31/444 ,  A61K31/45 ,  A61K31/4704 ,  A61K31/7052 ,  A61K47/56 ,  A61K47/58 ,  C07D213/16 ,  C07D213/26 ,  C07D213/63 ,  C07D213/64 ,  C07D213/69 ,  C07D215/227 ,  C07H15/26 ,  C07K1/1077 ,  C08F289/00 ,  Y02A50/401 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/475

Abstract: Disclosed are methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of at least one p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the at least one p38 MAPK by the compound. Also disclosed are derivatives of pirfenidone. These derivatives can modulate a stress activated protein kinase (SAPK) system.

Abstract translation: 公开了用活性化合物调节应激活化蛋白激酶（SAPK）系统的方法，其中活性化合物表现出低的抑制至少一种p38MAPK的能力; 并且其中所述接触以对所述化合物抑制至少一种p38MAPK的低百分比抑制浓度的SAPK-调节浓度进行。 还公开了吡非尼酮的衍生物。 这些衍生物可以调节应激活化蛋白激酶（SAPK）系统。

公开(公告)号：US08653110B2

公开(公告)日：2014-02-18

申请号：US13020960

申请日：2011-02-04

Applicant: Michael Kilian ,  Margit Doth

Inventor： Michael Kilian ,  Margit Doth

IPC: A01N25/00 ,  A01N43/40 ,  A61K31/44 ,  A01N43/08 ,  A61K31/34 ,  C07D405/00 ,  C07D211/72 ,  C07D211/84

CPC classification number: A01N43/40 ,  A01N43/90 ,  A01N65/00 ,  A01N65/26 ,  A01N2300/00

Abstract: Disclosed are novel active compound combinations comprising at least one substituted enaminocarbonyl compound and azadirachtin, which combinations are highly suitable for controlling animal pests such as insects and unwanted acarids. Methods of controlling insects and acarids are also disclosed.

Abstract translation: 公开了包含至少一种取代的烯氨基羰基化合物和印苦楝子素的新型活性化合物组合，其组合非常适合于控制动物害虫如昆虫和不需要的螨。 还公开了控制昆虫和螨虫的方法。

公开(公告)号：US08367666B2

公开(公告)日：2013-02-05

申请号：US13407520

申请日：2012-02-28

Applicant: Takashi Sasatani ,  Yoshiharu Hiramatsu ,  Susumu Mitsumori

Inventor： Takashi Sasatani ,  Yoshiharu Hiramatsu ,  Susumu Mitsumori

IPC: A61K31/5377 ,  A61K31/435 ,  A61K31/4412 ,  A61K31/496 ,  A61K31/506 ,  A61P17/00 ,  C07D211/84 ,  C07D221/04 ,  C07D401/12 ,  C07D413/12

CPC classification number: C07D213/82

Abstract: The present invention provides compounds having an agonistic activity to the cannabinoid receptor, which is represented by the formula (I): wherein R1, R2, R3, R4, and G are defined as herein, a pharmaceutically acceptable salt or a solvate thereof, and pharmaceutical compositions, atopic dermatitis treating agents, and anti-pruritus agents, especially anti-pruritus agents for oral used and for external application, which each contains the said compound as an active ingredient.

Abstract translation: 本发明提供对大麻素受体具有激动作用的化合物，其由式（I）表示：其中R 1，R 2，R 3，R 4和G如本文所定义，其药学上可接受的盐或溶剂合物，以及 药物组合物，特应性皮炎治疗剂和抗瘙痒剂，特别是用于口服和外用的抗瘙痒剂，其各自含有所述化合物作为活性成分。

公开(公告)号：US08211513B2

公开(公告)日：2012-07-03

申请号：US13053479

申请日：2011-03-22

Applicant: Axel Jansen ,  Helmut Haensel ,  Philipp Krattiger ,  Andreas Taugerbeck ,  Malgorzata Rillich

Inventor： Axel Jansen ,  Helmut Haensel ,  Philipp Krattiger ,  Andreas Taugerbeck ,  Malgorzata Rillich

IPC: C09K19/34 ,  C09K19/12 ,  C07C25/13 ,  C07C43/225 ,  C07D239/02 ,  C07D309/02 ,  C07D319/06 ,  C07D211/84

CPC classification number: C09K19/20 ,  C09K19/0275 ,  C09K19/42 ,  C09K19/46 ,  C09K2019/0466 ,  Y10T428/10

Abstract: The present invention relates to liquid-crystalline compounds having at least three fluorine-substituted benzene rings, a terminal trifluoromethyl group and at least one —CF2O— bridge. The invention also relates to liquid-crystalline media prepared therewith and to liquid-crystal display devices (LC displays) containing these media.

Abstract translation: 本发明涉及具有至少三个氟取代的苯环，末端三氟甲基和至少一个-CF 2 O-桥的液晶化合物。 本发明还涉及制备的液晶介质和含有这些介质的液晶显示装置（LC显示器）。

公开(公告)号：US20110059981A9

公开(公告)日：2011-03-10

申请号：US12307279

申请日：2007-07-02

Applicant: Kay Brickmann ,  Fabrizio Giordanetto ,  Johan Johansson ,  Fredrik Zetterberg

Inventor： Kay Brickmann ,  Fabrizio Giordanetto ,  Johan Johansson ,  Fredrik Zetterberg

IPC: A61K31/497 ,  C07D409/14 ,  C07D211/84 ,  A61K31/4545 ,  A61P7/04

CPC classification number: C07D401/12 ,  C07D401/14 ,  C07D413/04 ,  C07D413/14

Abstract: The present invention relates to certain new pyridin analogues of Formula (I) to processes for preparing such compounds, to their utility as P2Y12 inhibitors and as anti-trombotic agents etc, their use as medicaments in cardiovascular diseases as well as pharmaceutical compositions containing them.

Abstract translation: 本发明涉及式（I）的某些新的吡啶类似物，用于制备这些化合物的方法，其用作P2Y12抑制剂和抗血栓形成剂等，它们作为心血管疾病中的药物的用途以及含有它们的药物组合物。

公开(公告)号：US20100004284A1

公开(公告)日：2010-01-07

申请号：US11920597

申请日：2006-05-17

Applicant: Marco Farina ,  Stefania Gagliardi ,  Emmanuel Le Poul ,  Giovanni Palombi ,  Jean-Philippe Rocher

Inventor： Marco Farina ,  Stefania Gagliardi ,  Emmanuel Le Poul ,  Giovanni Palombi ,  Jean-Philippe Rocher

IPC: A61K31/4545 ,  C07D401/04 ,  C07D211/84 ,  A61K31/454 ,  A61P25/18

CPC classification number: C07D401/04 ,  C07D413/04 ,  C07D413/14

Abstract: The present invention relates to new compounds which are Heterocyclic derivatives of formula (I) wherein A, B, P, X, Y, Q, W, R1 and R2 are defined in the description. Invention compounds are useful for treating central or peripheral nervous system disorders and other disorders which are affected by the neuromodulatory effect of mGluR5 positive allosteric modulators such as cognitive decline and also to treat both positive and negative symptoms in schizophrenia.

Abstract translation: 本发明涉及作为其中A，B，P，X，Y，Q，W，R 1和R 2在本说明书中定义的式（I）的杂环衍生物的新化合物。 本发明化合物可用于治疗受到mGluR5阳性变构调节剂如认知衰退的神经调节作用影响的中枢性或周围神经系统疾病和其它疾病，并且还可用于治疗精神分裂症中的阳性和阴性症状。