Abstract:
The present invention relates to novel tacrolimus analogs, a composition for the prevention or treatment of neurological diseases or immune hypersensitivity disorders comprising the same, a method for preventing or treating neurological diseases or immune hypersensitivity disorders comprising administering the analogs to a subject, a method for preparing the analogs using an isolated modified Streptomyces sp. strain wherein the activity of one or more enzymes selected from the group consisting of TcsA, TcsB, TcsC and TcsD is reduced; and the isolated modified Streptomyces sp. strain for prepare the analogs.
Abstract:
An integrated nonvolatile memory control subsystem and method are disclosed. The integrated nonvolatile memory control subsystem includes a nonvolatile buffer cache, a nonvolatile journal area, nonvolatile storage, and an integrated memory control unit. The integrated memory control unit performs a read operation, a write operation, a commit operation and a checkpoint operation on the cache blocks of the nonvolatile buffer cache and the journal blocks of the nonvolatile journal area. The integrated memory control unit sets each of data blocks of the nonvolatile storage as one among valid state, erasable state and invalid state, depending on being cached or not, being journaled or not, and being a clean cache or not, so as to maintain an authentic original up-to-date consistent data within any one of the nonvolatile buffer cache, the nonvolatile journal area and the nonvolatile storage.
Abstract:
A magnetic random access memory includes multiple gate lines that are divided into a first gate line group and a second gate line group and arranged to be parallel to one another; multiple magnetic random access memory cells that are bonded to the gate lines in a direction intersected with the gate lines, respectively; multiple source lines that are bonded to one ends of switching devices included in the magnetic random access memory cells and arranged to be parallel to one another; and multiple bit lines that are bonded to one ends of magnetic tunnel junction devices included in the magnetic random access memory cells and arranged to be parallel to one another.
Abstract:
The present invention provides a composition for preventing or treating kidney disease, the composition comprising a pyrazole derivative compound or a pharmaceutically acceptable salt thereof; and the composition of the present invention is effective in reducing proteinuria, reducing cell formation between glomerular blood vessels and suppressing kidney fibrosis.
Abstract:
The present invention provides pyrazole derivative compounds and pharmaceutically acceptable salts thereof. The compounds of the present invention have an excellent effect of preventing and treating osteoporosis.
Abstract:
The present invention relates to a novel cyanne derivative having a meso-reaction functional group in a polymethine chain, and a preparation method thereof, and the cyanine derivative having the reaction functional group substituted at the meso site may be suitable for mass production thanks to a very simple synthesis method, have a very fast reaction rate because while a related art reagent for detection of nerve agents undergoes two steps of reactions, the cyanine derivative of the present invention undergoes only one step of reaction, have very excellent sensitivity, and be useful as an acid pH-activated ratiometric NIR probe because it is able to be activated in an acidic pH and is usable in an aqueous environment.
Abstract:
The present invention relates to a brain-metastatic lung cancer cell line and a use of Noggin as a marker for brain metastasis of lung cancer. In the present invention, a brain metastatic lung cancer cell line with optimized characteristics for brain metastasis was established by repeatedly transplanting the lung cancer cell line through the carotid artery. In addition, in the brain metastatic lung cancer cell line, the expressions of Noggin protein and its mRNA are reduced, confirming that the motility and invasiveness of cells are reduced and adhesion increased. Therefore, the Noggin protein or its gene is expected to be useful as a biomarker for diagnosis of brain metastasis of lung cancer and its target therapy.
Abstract:
The present disclosure relates to a pharmaceutical composition comprising chiral nanozyme and method of preventing or treating proliferative diseases using the same. A first nanozyme and/or a second nanozyme according to embodiments of the present disclosure has a chiral structure, and their enzymatic activity is maximized when circularly polarized light with the same directionality as the first nanozyme and/or the second nanozyme is irradiated.
Abstract:
A frame packing method in an MPEG immersive video format is provided. A frame packing method in association with an immersive-video encoding and decoding method efficiently arranges, on a single screen, texture information and depth information of a basic view and an additional view to increase the coding efficiency.
Abstract:
Disclosed is a method for video encoding and decoding using adaptive color transform on a residual signal. In particular, the maximum memory size required for adaptive color transform is limited by: controlling whether to allow color space conversion on a sequence level according to a syntax element indicating the maximum conversion size allowed for a sequence of pictures; or controlling whether to apply color space conversion on a block level according to the size of a coding block.