公开(公告)号：US20170022255A1

公开(公告)日：2017-01-26

申请号：US15098350

申请日：2016-04-14

Applicant: MERIAL, INC.

Inventor： Jean-Christophe Audonnet ,  Xuan Guo ,  Kevin Cox

IPC: C07K14/005 ,  C12N15/82

CPC classification number: C07K14/005 ,  A61K39/12 ,  A61K39/15 ,  A61K2039/517 ,  A61K2039/5252 ,  A61K2039/552 ,  A61K2039/55505 ,  A61K2039/55561 ,  A61K2039/55566 ,  A61K2039/55577 ,  C12N15/8258 ,  C12N2720/12134

Abstract: The present invention encompasses BTV vaccines or compositions. The vaccine or composition may be a vaccine or composition containing BTV antigens. The invention also encompasses recombinant vectors encoding and expressing BTV antigens, epitopes or immunogens which can be used to protect animals, such as ovines, bovines, or caprines, against BTV.

Abstract translation: 本发明包括BTV疫苗或组合物。 疫苗或组合物可以是含有BTV抗原的疫苗或组合物。 本发明还包括编码和表达BTV抗原，表位或免疫原的重组载体，其可用于保护动物，例如绵羊，牛，或者对于BTV的动物。

公开(公告)号：US20170022197A1

公开(公告)日：2017-01-26

申请号：US15191163

申请日：2016-06-23

Applicant: MERIAL, INC.

Inventor： Loic Patrick Le Hir de Fallois ,  Hyoung Ik Lee ,  Douglas Edward Wilkinson ,  Brent Christopher Beck

IPC: C07D471/04 ,  A61K31/437 ,  A61K38/05 ,  C07K5/06 ,  A01N43/90

CPC classification number: C07D471/04 ,  A01N43/80 ,  A01N43/90 ,  A61K31/365 ,  A61K31/437 ,  A61K31/495 ,  A61K38/05 ,  A61K45/06 ,  C07K5/06 ,  A61K2300/00

Abstract: The present invention relates to novel dihydroazole of formula (I) and salts thereof: Wherein R1, A1, A2, G, X and Y are as defined in the description, compositions thereof, processes for their preparation and their uses to prevent or treat parasitic infections or infestations in animals and as pesticides.

Abstract translation: 其中R1，A1，A2，G，X和Y如说明书中所定义，其组合物，其制备方法及其用于预防或治疗动物和农药中的寄生虫感染或侵染的用途。

公开(公告)号：US20160361297A1

公开(公告)日：2016-12-15

申请号：US15248327

申请日：2016-08-26

Applicant: MERIAL, INC.

Inventor： Mark David Soll ,  James Pate ,  Lisa A. Baker

IPC: A61K31/415 ,  A61K9/00 ,  A61K31/4402 ,  A61K31/201 ,  A61K47/44 ,  A01N25/02 ,  A61K47/10 ,  A61K45/06 ,  A01N49/00 ,  A01N43/40 ,  A01N37/38 ,  A01N43/56 ,  A61K31/216 ,  A61K47/22

CPC classification number: A61K31/415 ,  A01N25/02 ,  A01N25/22 ,  A01N37/38 ,  A01N43/40 ,  A01N43/56 ,  A01N47/02 ,  A01N49/00 ,  A01N53/00 ,  A61K9/0017 ,  A61K31/201 ,  A61K31/215 ,  A61K31/216 ,  A61K31/4402 ,  A61K45/06 ,  A61K47/08 ,  A61K47/10 ,  A61K47/14 ,  A61K47/18 ,  A61K47/22 ,  A61K47/44 ,  A61K2300/00 ,  A01N2300/00

Abstract: The subject matter disclosed herein is directed to stable, highly-effective topical formulations comprising permethrin, fipronil and a solvent system that is sufficient to solubilize these two active ingredients and limit degradation of fipronil to its sulfone, and their uses in topical applications on animals and the environment. Useful formulations comprise from about 30% to about 55% (w/w) permethrin and about 2 to 15% (w/w) fipronil and a solvent system that comprises N-methyl pyrrolidone and a glycol, glycol ether, glycol ester, fatty acid ester or neutral oil, wherein the N-methyl pyrrolidone and glycol, glycol ether, glycol ester, fatty acid ester or neutral oil are present in a weight: weight ratio of from about 1:2.0 to about 1:3.5, glycol, glycol ether, glycol ester, fatty acid ester or neutral oil to n-methyl pyrrolidone. These two actives when combined in the described amounts have been found to have unexpected enhanced repellent activity against stable fly. However, it is the formulations described herein that provide solvency and stability that maintain synergistic concentrations after application on an animal.

Abstract translation: 本文公开的主题涉及稳定的，高效的局部制剂，其包含氯菊酯，氟虫腈和溶剂体系，其足以溶解这两种活性成分并限制氟虫腈对其砜的降解，以及它们在局部应用于动物和 环境。 有用的制剂包含约30％至约55％（w / w）苄氯菊酯和约2至15％（w / w）氟虫腈和包含N-甲基吡咯烷酮和二醇，二醇醚，乙二醇酯，脂肪 酸酯或中性油，其中N-甲基吡咯烷酮和二醇，二醇醚，乙二醇酯，脂肪酸酯或中性油以重量比为约1:2.0至约1:3.5存在，乙二醇，乙二醇 醚，乙二醇酯，脂肪酸酯或中性油加到正甲基吡咯烷酮中。 已经发现当以所述量组合时，这两种活性物质具有针对稳定蝇的意想不到的增强的驱避活性。 然而，本文所述的制剂提供了在施用于动物之后保持协同浓度的溶解能力和稳定性。

公开(公告)号：US20160347829A1

公开(公告)日：2016-12-01

申请号：US15162472

申请日：2016-05-23

Applicant: MERIAL INC.

Inventor： Robert Nordgren ,  Monica Dias Figueiredo

IPC: C07K16/12 ,  A61Q11/00 ,  A61K8/04 ,  A61K8/64 ,  A61K8/98

CPC classification number: C07K16/1275 ,  A61K8/042 ,  A61K8/64 ,  A61K8/732 ,  A61K8/982 ,  A61K9/0056 ,  A61K9/2059 ,  A61K9/2063 ,  A61K2039/542 ,  A61K2800/74 ,  A61Q11/00 ,  C07K16/12 ,  C07K16/1203 ,  C07K2317/11 ,  C07K2317/23

Abstract: The present invention encompasses methods and compositions for inhibiting, treating, and preventing dental diseases in human and non-human animals, particularly domesticated companion animals.

Abstract translation: 本发明包括用于抑制，治疗和预防人类和非人类动物，特别是驯养的伴侣动物中的牙齿疾病的方法和组合物。

公开(公告)号：US20160220659A1

公开(公告)日：2016-08-04

申请号：US14863181

申请日：2015-09-23

Applicant: MERIAL, INC.

Inventor： Jean-Christophe Audonnet ,  Zahia Hannas-Djebbara ,  Teshome Mebatsion ,  Yu-Wei Chiang ,  Justin Widener ,  Frédéric Reynard

IPC: A61K39/135 ,  C07K14/005 ,  C12N7/00

CPC classification number: A61K39/135 ,  A61K39/12 ,  A61K2039/5258 ,  A61K2039/545 ,  A61K2039/55577 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/10043 ,  C12N2710/14043 ,  C12N2770/32123 ,  C12N2770/32134

Abstract: The present invention encompasses FMDV vaccines or compositions. The vaccine or composition may be a vaccine or composition containing FMDV antigens. The invention also encompasses recombinant vectors encoding and expressing FMDV antigens, epitopes or immunogens which can be used to protect animals, in particular ovines, bovines, caprines, or swines, against FMDV.

Abstract translation: 本发明包括FMDV疫苗或组合物。 疫苗或组合物可以是含有FMDV抗原的疫苗或组合物。 本发明还包括编码和表达FMDV抗原，表位或免疫原的重组载体，其可用于保护动物，特别是针对FMDV的动物，特别是羊，牛，cap或猪。

公开(公告)号：US20160220566A1

公开(公告)日：2016-08-04

申请号：US14868927

申请日：2015-09-29

Applicant: MERIAL, INC.

Inventor： Joseph K. Rosentel, JR. ,  Monica Tejwani ,  Arima Das-Nandy

IPC: A61K31/4985 ,  A61K31/365 ,  A61K31/231 ,  A61K31/415

CPC classification number: A61K31/4985 ,  A01N31/02 ,  A01N43/56 ,  A01N43/60 ,  A01N43/90 ,  A01N47/02 ,  A01N49/00 ,  A61K31/231 ,  A61K31/365 ,  A61K31/415 ,  A01N25/02 ,  A01N2300/00

Abstract: This invention relates to compositions for combating ectoparasites and endoparasites in animals, comprising at least one 1-arylpyrazole, at least one macrocyclic lactone, at least one insect growth regulator, and at least one anthelmintic compound in combination with a pharmaceutically acceptable carrier. This invention also provides for an improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof.

Abstract translation: 本发明涉及用于对抗动物体内外寄生虫和内寄生虫的组合物，其包含至少一种1-芳基吡唑，至少一种大环内酯，至少一种昆虫生长调节剂和至少一种驱肠药物与药学上可接受的载体的组合。 本发明还提供了用于消除，控制和预防动物中的寄生虫感染和侵染的改进方法，包括将本发明的组合物施用于有需要的动物。

公开(公告)号：US20160199483A1

公开(公告)日：2016-07-14

申请号：US15084108

申请日：2016-03-29

Applicant: MERIAL, INC.

Inventor： Jean-Christophe Audonnet ,  Jules Minke

IPC: A61K39/175 ,  C07K14/535 ,  C12N7/00 ,  C07K14/005

CPC classification number: A61K39/175 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/55522 ,  A61N5/0613 ,  C07K14/005 ,  C07K14/535 ,  C12N7/00 ,  C12N2710/24043 ,  C12N2750/14334 ,  C12N2760/18422 ,  C12N2760/18434 ,  C12N2760/18471 ,  C12N2800/22

Abstract: The present invention provides vectors that contain and express in vivo or in vitro CDV polypeptides or antigens that elicit an immune response in animal against CDV, compositions comprising said vectors and/or CDV polypeptides, and methods of vaccination against CDV. The invention further provides methods for inducing an immunogenic or protective response against CDV and other canine virus, as well as methods for preventing or treating CDV and other canine virus or disease state(s) caused by CDV and other canine virus.

Abstract translation: 本发明提供载体，其含有体内或体外CDV多肽或在动物体内产生针对CDV的免疫应答的抗原，包含所述载体和/或CDV多肽的组合物，以及针对CDV的疫苗接种方法。 本发明还提供了诱导针对CDV和其他犬病毒的免疫原性或保护性应答的方法，以及用于预防或治疗CDV和其他犬病毒或由CDV和其他犬病毒引起的疾病状态的方法。

公开(公告)号：US20160120799A1

公开(公告)日：2016-05-05

申请号：US14930831

申请日：2015-11-03

Applicant: MERIAL, INC. ,  Georgia Tech Research Corporation

Inventor： Yu-Wei Chiang ,  Mark R. Prausnitz ,  Kristopher Daniel DeWitt ,  Jaya Arya

IPC: A61K9/00 ,  C12N7/00 ,  A61K39/205

CPC classification number: A61K9/0021 ,  A61B5/150984 ,  A61B17/20 ,  A61B17/205 ,  A61K39/12 ,  A61K39/205 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/552 ,  A61M37/0015 ,  A61M2037/0046 ,  A61M2037/0061 ,  C12N7/00 ,  C12N2760/20034 ,  C12N2760/20134

Abstract: The present invention relates to microneedle vaccine formulations, as well as methods of use thereof to provide animals, including canines, protective immunity against infection and disease caused by rabies viruses. Once placed onto the skin of the animals, the microneedle formulations dissolve quickly into the surrounding skin, where the antigens then elicit in the animals high and protective levels of rabies virus neutralizing antibodies.

Abstract translation: 本发明涉及微针疫苗制剂，以及其用于提供动物，包括犬科动物的保护性免疫和由狂犬病病毒引起的疾病的方法。 一旦放置在动物的皮肤上，微针制剂迅速溶解到周围的皮肤中，其中抗原然后在动物中引起高的保护水平的狂犬病病毒中和抗体。

公开(公告)号：US20160097753A1

公开(公告)日：2016-04-07

申请号：US14872639

申请日：2015-10-01

Applicant: MERIAL, INC.

Inventor： Abu M. Rustum ,  Satish Kumar ,  Andrew L. McAdoo

IPC: G01N33/15 ,  C09K3/00 ,  G01N30/06

CPC classification number: G01N33/15 ,  C09K3/00 ,  G01N30/06 ,  G01N2013/006

Abstract: This disclosure describes the results of the studies conducted to develop a dissolution method to monitor release profiles of hydrophobic active pharmaceutical ingredients such as ivermectin with or without pyrantel pamoate from a drug product made of complex matrix that includes, but is not limited to beef, tallow, corn cob and soy protein.

Abstract translation: 本公开描述了开发用于开发溶出方法以研究疏水性活性药物成分如伊维菌素的释放曲线的研究结果，所述疏水性活性药物成分具有或不含来自由复合基质制成的药物产品的非特异灵芝，其包括但不限于牛肉，牛脂 玉米芯和大豆蛋白。

公开(公告)号：US09259417B2

公开(公告)日：2016-02-16

申请号：US14627499

申请日：2015-02-20

Applicant: MERIAL INC.

Inventor： Mark David Soll ,  Diane Larsen ,  Susan Mancini Cady ,  Peter Cheifetz ,  Izabela Galeska

IPC: A61K31/42 ,  A61K31/194 ,  A61K9/00 ,  A61K45/06 ,  C07D261/04 ,  A61K31/4985 ,  A61K31/7048 ,  A61K31/365 ,  A61K31/27 ,  A61K31/437 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/32 ,  A61K47/36 ,  A61K47/44

CPC classification number: A61K31/42 ,  A01N43/80 ,  A23K20/00 ,  A61K9/0056 ,  A61K9/0068 ,  A61K31/194 ,  A61K31/27 ,  A61K31/325 ,  A61K31/365 ,  A61K31/437 ,  A61K31/4985 ,  A61K31/7048 ,  A61K45/06 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/32 ,  A61K47/36 ,  A61K47/42 ,  A61K47/44 ,  C07D261/04 ,  A61K2300/00

Abstract: This invention relates to veterinary compositions for treating and/or preventing fleas or ticks infection or infestation in an animal comprising an isoxazoline active agent of Formula (II): or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.

Abstract translation: 本发明涉及用于治疗和/或预防动物中跳蚤或蜱感染或感染的兽用组合物，其包含式（II）的异恶唑啉活性剂：或其药学上可接受的盐; 和药学上可接受的载体。