公开(公告)号：US20130270967A1

公开(公告)日：2013-10-17

申请号：US13907046

申请日：2013-05-31

Applicant: Research Triangle Institute

Inventor： David Dausch ,  Scott H. Goodwin

IPC: H01L41/047 ,  H01L41/293

CPC classification number: H01L41/0474 ,  B06B1/0607 ,  G10K11/004 ,  H01L41/0973 ,  H01L41/29 ,  H01L41/293 ,  H01L41/332

Abstract: A method is provided for forming a piezoelectric ultrasonic transducer apparatus having a first electrode deposited on a dielectric layer disposed on a primary substrate. A piezoelectric material is deposited between the first electrode and a second electrode, to form a transducer device. At least the piezoelectric material is patterned such that a portion of the first electrode extends laterally outward therefrom. The primary substrate and the dielectric layer are etched to form a first via extending to the laterally outward portion of the first electrode, and a first conductive material is deposited to substantially fill the first via and form an electrically-conductive engagement with the laterally outward portion of the first electrode. The primary substrate is etched to define a second via extending therethrough, wherein the second via is laterally spaced apart from the first via. An associated method and apparatus are also provided.

Abstract translation: 提供一种用于形成压电超声换能器装置的方法，该装置具有沉积在设置在初级基底上的电介质层上的第一电极。 压电材料沉积在第一电极和第二电极之间，以形成换能器装置。 至少压电材料被图案化，使得第一电极的一部分从其横向向外延伸。 蚀刻初级衬底和电介质层以形成延伸到第一电极的横向向外部分的第一通孔，并且沉积第一导电材料以基本上填充第一通孔并与横向向外部分形成导电接合 的第一电极。 蚀刻初级衬底以限定延伸穿过其中的第二通孔，其中第二通孔与第一通路横向间隔开。 还提供了相关联的方法和装置。

公开(公告)号：US20130150357A1

公开(公告)日：2013-06-13

申请号：US13680710

申请日：2012-11-19

Applicant: Research Triangle Institute ,  Digital Health d/b/a St. Joseph's Hospital and Med ,  Virginia Commonwealth University

Inventor： F. Ivy Carroll ,  Bruce E. Blough ,  Hernan A. Navarro ,  S. Wayne Mascarella ,  Ana Zamfira Muresan ,  M. Imad Damaj ,  Ronald J. Lukas

IPC: C07D265/32

CPC classification number: C07D265/32 ,  A61K31/5375

Abstract: The invention provides hydroxybupropion analogues capable of inhibiting the reuptake of one or more monoamines and/or acting as antagonists at nicotinic acetylcholine receptors. The compounds may selectively bind to one or more monoamine transporters, including those for dopamine, norepinephrine, and serotonin and/or may selectively bind to one or more nicotinic acetylcholine receptor subtypes. Such compounds may be used to treat conditions that are responsive to modification of monoamine levels and/or antagonism of nicotinic acetylcholine receptors, including drug dependency, depression, and obesity.

公开(公告)号：US20040147539A1

公开(公告)日：2004-07-29

申请号：US10350232

申请日：2003-01-24

Applicant: Research Triangle Institute

Inventor： Clarence Edgar Cook ,  Carol Delta Sloan ,  Brian Frazier Thomas ,  Hernan Andres Navarro

IPC: A61K031/473

CPC classification number: A61K31/435 ,  A61K31/473 ,  Y02P20/582

Abstract: Hexahydroindenopyridine compounds are provided which act as spermicides and/or fungicides, spermicidal and/or fungicidal compositions containing the same, and methods for killing motile sperm and/or fungi using the compounds and compositions.

Abstract translation: 提供六氢茚基吡啶化合物，其用作杀精剂和/或杀真菌剂，含有它们的杀精和/或杀真菌组合物，以及使用该化合物和组合物杀死活动精子和/或真菌的方法。

公开(公告)号：US20020188003A1

公开(公告)日：2002-12-12

申请号：US10155012

申请日：2002-05-28

Applicant: Research Triangle Institute

Inventor： Michael J. Kuhar ,  Frank Ivy Carroll ,  John W. Boja ,  Anita H. Lewin ,  Philip Abraham

IPC: C07D413/02 ,  A61K031/46

CPC classification number: C07D451/02 ,  A61K51/0448 ,  A61K2123/00 ,  C07F7/2208

Abstract: Tropane derivatives having a high binding affinity and selectivity for dopamine transporters bear, on the tropane backbone either a carboxylic ester or isoxazole moiety, as well as a substituted phenyl moiety. The compounds have utility both as pharmaceutical and as imaging agents, when one or more atoms are radioactive.

Abstract translation: 对于多巴胺转运蛋白具有高结合亲和性和选择性的托烷衍生物在托烷骨架上具有羧酸酯或异恶唑部分以及取代的苯基部分。 当一个或多个原子是放射性的时，这些化合物既用作药物也可用作成像剂。

公开(公告)号：US20020040889A1

公开(公告)日：2002-04-11

申请号：US09739748

申请日：2000-12-20

Applicant: Research Triangle Institute

Inventor： Robert J. Markunas ,  John B. Posthill ,  Robert C. Hendry ,  Raymond Thomas

IPC: B23K010/00

CPC classification number: H05H1/46 ,  Y10S588/90

Abstract: A method and apparatus for plasma waste disposal of hazardous waste material, where the hazardous material is volatilized under vacuum inside a containment chamber to produce a pre-processed gas as input to a plasma furnace including a plasma-forming region in which a plasma-forming magnetic field is produced. The pre-processed gas is passed at low pressure and without circumvention through the plasma-forming region and is directly energized to an inductively coupled plasma state such that hazardous waste reactants included in the pre-processed gas are completely dissociated in transit through the plasma-forming region. Preferably, the plasma-forming region is shaped as a vacuum annulus and is dimensioned such that there is no bypass by which hazardous waste reactants in the pre-processed gas can circumvent the plasma-forming region. The plasma furnace is powered by a high frequency power supply outputting power at a fundamental frequency. The power supply contains parasitic power dissipation mechanisms to prevent non-fundamental, parasitic frequencies from destabilizing the fundamental frequency output power. These power loss mechanisms use either distributed resistance or frequency-selective power-loss devices to prevent parasitic oscillations from instantaneously turning on the high frequency power oscillator at non-fundamental frequencies.

Abstract translation: 一种用于危险废物等离子体废物处理的方法和装置，其中危险材料在密封室内在真空下挥发，以产生预处理气体作为等离子体炉的输入，其包括等离子体形成区域，其中等离子体形成区域 产生磁场。 预处理气体在低压下通过等离子体形成区域而不规避，并被直接通电到感应耦合的等离子体状态，使得包含在预处理气体中的危险废物反应物在运输过程中完全离解通过等离子体 - 形成区域。 优选地，等离子体形成区域成形为真空环形区域，其尺寸使得不存在预处理气体中的危险废物反应物可绕过等离子体形成区域的旁路。 等离子炉由基频输出功率的高频电源供电。 电源包含寄生功率耗散机制，以防止非基波寄生频率不稳定基频输出功率。 这些功率损耗机制使用分布式电阻或频率选择性功率损耗器件来防止寄生振荡在非基频处瞬时接通高频功率振荡器。

公开(公告)号：US20240400597A1

公开(公告)日：2024-12-05

申请号：US18205314

申请日：2023-06-02

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Daniel O'Nolan ,  Mustapha Soukri

IPC: C07F15/04 ,  B01D53/04 ,  B01D53/047

Abstract: Metal-organic frameworks (MOFs) comprising square arrays of nickel cationic centers linked by N-donor organic ligands and pillared with tungsten oxyfluoride anion are described. In an exemplary MOF, the N-donor organic ligands are pyrazine and the MOF has a pore size of less than about 7 angstroms. Methods of using the MOF to selectively capture carbon dioxide, e.g., from gas compositions comprising nitrogen and/or methane, are also described.

公开(公告)号：US12116286B2

公开(公告)日：2024-10-15

申请号：US17962217

申请日：2022-10-07

Applicant: Research Triangle Institute

Inventor： Ignacio Luz Minguez ,  Mustapha Soukri ,  Marty Lail

IPC: B01J20/10 ,  B01J20/22 ,  B01J20/32 ,  B01J29/06 ,  B01J31/16 ,  C01B39/00 ,  C01B39/02 ,  C01B39/48

CPC classification number: C01B39/026 ,  B01J20/103 ,  B01J20/226 ,  B01J20/3236 ,  B01J20/3265 ,  B01J29/06 ,  B01J31/1691 ,  C01B39/00 ,  C01B39/02 ,  C01B39/48 ,  B01D2253/108 ,  B01D2253/204 ,  B01D2259/4583

Abstract: A method, comprising i) contacting an aqueous solution of an organic ligand salt of the formula Ax(L−x) with a mesoporous material (MPM) to form an impregnated mesoporous salt material of the formula Ax(L−x)/MPM, ii) treating the impregnated mesoporous salt material with an aqueous acidic solution to form an impregnated mesoporous acid material of the formula Hx(L−x)/MPM, iii) contacting an aqueous solution of a metal precursor of the formula M+y(B)y with the impregnated mesoporous acid material to form an impregnated mesoporous metal organic framework precursor of the formula [M+y(B)y][Hx(L−x)]/MPM, and iv) at least one of 1) heating the impregnated mesoporous metal organic framework precursor in the absence of a solvent or 2) exposing the impregnated mesoporous metal organic framework precursor to a volatile vapor in the absence of a solvent such that the heating or the exposing forms a hybrid material of the formula (M+yL−x)/MPM, wherein the hybrid material comprises a nano-crystalline metal organic framework (MOF) embedded within the mesoporous material.

公开(公告)号：US12110451B2

公开(公告)日：2024-10-08

申请号：US17355828

申请日：2021-06-23

Applicant: Research Triangle Institute

Inventor： Leah Marie Johnson ,  Ginger Denison Rothrock ,  Chasity Antoninette Norton ,  Nicolas Daniel Huffman ,  Jeffrey Brent Mecham

IPC: C09K8/588 ,  C09K8/508 ,  C09K8/512 ,  C09K8/516 ,  E21B33/138 ,  E21B43/20

CPC classification number: C09K8/588 ,  C09K8/508 ,  C09K8/512 ,  C09K8/516 ,  E21B33/138 ,  E21B43/20 ,  C09K2208/10

Abstract: The present disclosure relates to delivery and release systems, such as core-shell particles. An exemplary composition according to the disclosure can include a degradable polymeric shell surrounding a core that includes a crosslinker, which can encompass a metal, such as chromium. The core-shell particles can be provided with a gel-forming polymer, such as a polyacrylamide, into a subterranean reservoir having conditions such that the shell of the core-shell polymer degrades, and the so-released metal is effective to at least partially crosslink the gel-forming polymer to form a gel. The so-formed gel can be effective to control water flow through the subterranean reservoir, such as in relation to a waterflood of the reservoir.

公开(公告)号：US20240127954A1

公开(公告)日：2024-04-18

申请号：US18398623

申请日：2023-12-28

Applicant: Research Triangle Institute

Inventor： Kristin Hedgepath Gilchrist ,  Meghan Sarah Hegarty-Craver ,  Dorota Temple ,  Robert Furberg

IPC: G16H50/20 ,  A61B5/00 ,  A61B5/01 ,  A61B5/024 ,  A61B5/11 ,  A61B5/1455 ,  A61B5/28 ,  A61B5/352 ,  G16H10/60

CPC classification number: G16H50/20 ,  A61B5/0022 ,  A61B5/0024 ,  A61B5/01 ,  A61B5/02405 ,  A61B5/1102 ,  A61B5/1118 ,  A61B5/1455 ,  A61B5/28 ,  A61B5/352 ,  A61B5/4266 ,  A61B5/681 ,  A61B5/6823 ,  A61B5/742 ,  G16H10/60 ,  A61B2505/07 ,  A61B2560/045 ,  A61B2560/0462 ,  A61B2562/0219

Abstract: Disclosed herein are systems, methods, and devices of detecting illness in presymptomatic and asymptomatic infected persons using wearable sensor technology. In a first embodiment, a method is implemented on a computing device, the method includes receiving first sensor data associated with the person over a first period of time and applying the first sensor data to a multi-variate detection model. The method further includes receiving second sensor data associated with the person over a second period of time and applying the second sensor data to the multi-variate detection model. Further the method includes determining a probability value of the illness in the person using the multi-variate detection model and transmitting the probability value to a user interface (UI).

公开(公告)号：US11926612B2

公开(公告)日：2024-03-12

申请号：US16341597

申请日：2017-10-11

Applicant: Research Triangle Institute

Inventor： Scott P. Runyon ,  Rangan Maitra ,  Sanju Narayanan ,  Kenneth S. Rehder

IPC: C07D233/90 ,  C07D249/10 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D417/14

CPC classification number: C07D401/12 ,  C07D233/90 ,  C07D249/10 ,  C07D401/04 ,  C07D401/14 ,  C07D403/12 ,  C07D417/14

Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) with heterocyclic cores and uses of such agonists.