公开(公告)号：US06316223B1

公开(公告)日：2001-11-13

申请号：US09359081

申请日：1999-07-22

Applicant: Donald Payan ,  Ying Luo ,  Betty Huang

Inventor： Donald Payan ,  Ying Luo ,  Betty Huang

IPC: C12P2106

CPC classification number: C12N15/1055 ,  C12Q2565/201

Abstract: The present invention is directed to compositions and methods for a genetic system of detecting protein-protein interactions in a mammalian host cell. Two fusion proteins are made in the host cell. The first fusion protein contains a DNA binding domain which is fused to a so-called bait protein. The second fusion protein consists of a transcriptional activation domain fused to a so-called test protein. The DNA binding domain binds to an operator sequence which controls expression of one or more reporter genes. The transcriptional activation domain is recruited to the promoter through the functional interaction between the bait protein and the test protein. Subsequently the transcriptional activation domain interacts with the basal transcription machinery to activate expression of one or more reporter genes which can be identified and characterized. The individual compositions are useful for analyzing protein-protein interactions between known proteins and to isolate, clone and characterize unknown proteins. The individual compositions can be used to express the fusion proteins either transiently or stably. In addition, the present invention is directed to methods for screening for candidate bioactive agents that modulate the protein-protein interaction between a bait protein and a test protein and thus are useful for the identification of novel therapeutic drugs and the like.

Abstract translation: 本发明涉及用于在哺乳动物宿主细胞中检测蛋白质 - 蛋白质相互作用的遗传系统的组合物和方法。 在宿主细胞中制备两种融合蛋白。 第一个融合蛋白含有与所谓诱饵蛋白融合的DNA结合结构域。 第二种融合蛋白由与所谓的测试蛋白融合的转录激活结构域组成。 DNA结合域与控制一个或多个报道基因表达的操纵子序列结合。 通过诱饵蛋白质和测试蛋白质之间的功能相互作用将转录激活结构域引入启动子。 随后，转录激活结构域与基础转录机制相互作用以激活一种或多种可鉴定和表征的报告基因的表达。 单独的组合物可用于分析已知蛋白质之间的蛋白质 - 蛋白质相互作用并分离，克隆和表征未知蛋白质。 单独的组合物可用于瞬时或稳定地表达融合蛋白。 此外，本发明涉及筛选调节诱饵蛋白质和测试蛋白质之间的蛋白质 - 蛋白质相互作用的候选生物活性剂的方法，因此可用于鉴定新的治疗药物等。

公开(公告)号：US08737846B2

公开(公告)日：2014-05-27

申请号：US13361873

申请日：2012-01-30

Applicant: Xuezhe Zheng ,  Ying Luo ,  Guoliang Li ,  Ashok V. Krishnamoorthy

Inventor： Xuezhe Zheng ,  Ying Luo ,  Guoliang Li ,  Ashok V. Krishnamoorthy

IPC: H04B10/12 ,  G02B6/26 ,  G02B5/18

CPC classification number: H04J14/02 ,  G02B6/29308 ,  H04B10/506 ,  H04B10/572

Abstract: An optical source uses feedback to maintain a substantially fixed spacing between adjacent wavelengths in a set of wavelengths in a wavelength comb output by the optical source. In particular, a set of light sources in the optical source provide optical signals having the set of wavelengths. Moreover, the optical signals are output at diffraction angles of an optical device in the optical source (such as an echelle grating), and optical detectors in the optical source determine optical metrics associated with the optical signals. Furthermore, control logic in the optical source provides control signals to the set of light sources based on the determined optical metrics.

Abstract translation: 光源使用反馈来维持由光源输出的波长梳输出中的一组波长中的相邻波长之间的基本上固定的间隔。 特别地，光源中的一组光源提供具有该组波长的光信号。 此外，光信号以光源（例如梯形光栅）中的光学装置的衍射角输出，并且光源中的光学检测器确定与光信号相关联的光学度量。 此外，光源中的控制逻辑基于所确定的光学量度向光源组提供控制信号。

公开(公告)号：US08543354B2

公开(公告)日：2013-09-24

申请号：US12914969

申请日：2010-10-28

Applicant: Ying Luo ,  Rebecca K. Gottlieb ,  Meena Ramachandran ,  Chia-Hung Chiu ,  Nandita Dangui-Patel ,  Michael Kremliovsky ,  Jefferson Rose

Inventor： Ying Luo ,  Rebecca K. Gottlieb ,  Meena Ramachandran ,  Chia-Hung Chiu ,  Nandita Dangui-Patel ,  Michael Kremliovsky ,  Jefferson Rose

IPC: G06F17/18

CPC classification number: G01N33/66 ,  A61B5/0017 ,  A61B5/002 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/6849 ,  A61B5/7207

Abstract: Disclosed are methods, apparatuses, etc. for glucose sensor signal stability analysis. In certain example embodiments, a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient may be obtained. Based at least partly on the series of samples, at least one metric may be determined to assess an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time. A reliability of the at least one sensor signal to respond to the blood glucose level of the patient may be assessed based at least partly on the at least one metric assessing an underlying trend. Other example embodiments are disclosed herein.

公开(公告)号：US20110320166A1

公开(公告)日：2011-12-29

申请号：US12914969

申请日：2010-10-28

Applicant: Ying Luo ,  Rebecca K. Gottlieb ,  Meena Ramachandran ,  Chia-Hung Chiu ,  Nandita Dangui-Patel ,  Michael Kremliovsky ,  Jefferson Rose

Inventor： Ying Luo ,  Rebecca K. Gottlieb ,  Meena Ramachandran ,  Chia-Hung Chiu ,  Nandita Dangui-Patel ,  Michael Kremliovsky ,  Jefferson Rose

IPC: G06F19/00 ,  G06F17/18

CPC classification number: G01N33/66 ,  A61B5/0017 ,  A61B5/002 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/6849 ,  A61B5/7207

Abstract: Disclosed are methods, apparatuses, etc. for glucose sensor signal stability analysis. In certain example embodiments, a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient may be obtained. Based at least partly on the series of samples, at least one metric may be determined to assess an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time. A reliability of the at least one sensor signal to respond to the blood glucose level of the patient may be assessed based at least partly on the at least one metric assessing an underlying trend. Other example embodiments are disclosed herein.

Abstract translation: 公开了用于葡萄糖传感器信号稳定性分析的方法，装置等。 在某些示例性实施例中，可以获得响应于患者的血糖水平的至少一个传感器信号的一系列样本。 至少部分地基于一系列样本，可以确定至少一个度量以评估至少一个传感器信号对患者随着时间的血糖水平的响应性的变化的潜在趋势。 可以至少部分地基于评估潜在趋势的至少一个度量来评估至少一个传感器信号对患者的血糖水平的响应的可靠性。 本文公开了其它示例性实施例。

公开(公告)号：US20110235159A1

公开(公告)日：2011-09-29

申请号：US12845700

申请日：2010-07-28

Applicant: LI-JIA YAN ,  YING LUO ,  KUAN-HONG HSIEH ,  CHUN-WEI PAN

Inventor： LI-JIA YAN ,  YING LUO ,  KUAN-HONG HSIEH ,  CHUN-WEI PAN

IPC: G02F1/167

CPC classification number: G09G3/344 ,  G02F1/167 ,  G02F2001/1678 ,  G02F2201/52 ,  G09G3/2003

Abstract: An electrophoretic display device includes a common electrode, an electrophoresis layer, and pixel electrodes. The electrophoretic layer includes cavities, with each cavity arranged between one of the pixel electrodes and the common electrode, and comprises suspension fluid, first type charged particles, and second type charged particles. The first type charged particles and the second type charged particles are dispersed in the suspension fluid. Three cavities constitute a pixel unit. The first type charged particles and the second type charged particles in each of the three cavities constituting the pixel unit are one of red, green, and blue particles, and one of yellow, magenta, and cyan particles, respectively.

Abstract translation: 电泳显示装置包括公共电极，电泳层和像素电极。 电泳层包括空腔，其中每个空腔布置在像素电极和公共电极之一之间，并且包括悬浮液，第一类型带电粒子和第二类型带电粒子。 第一种带电粒子和第二类带电粒子分散在悬浮液中。 三个腔体构成像素单元。 构成像素单元的三个空穴中的每一个中的第一种带电粒子和第二类带电粒子分别是红色，绿色和蓝色粒子之一，以及黄色，品红色和青色粒子之一。

公开(公告)号：US08017469B2

公开(公告)日：2011-09-13

申请号：US12357057

申请日：2009-01-21

Applicant: Tien-Ying Luo ,  Gauri V. Karve ,  Daniel G. Tekleab

Inventor： Tien-Ying Luo ,  Gauri V. Karve ,  Daniel G. Tekleab

IPC: H01L21/8238

CPC classification number: H01L21/823857 ,  H01L21/823807 ,  H01L21/823814 ,  H01L29/1054 ,  H01L29/4958 ,  H01L29/4966 ,  H01L29/513 ,  H01L29/517 ,  H01L29/6659 ,  H01L29/66651 ,  H01L29/7833

Abstract: A method and apparatus are described for integrating dual gate oxide (DGO) transistor devices (50, 52) and core transistor devices (51, 53) on a single substrate (15) having a silicon germanium channel layer (21) in the PMOS device areas (112, 113), where each DGO transistor device (50, 52) includes a metal gate (25), an upper gate oxide region (60, 84) formed from a second, relatively higher high-k metal oxide layer (24), and a lower gate oxide region (58, 84) formed from a first relatively lower high-k layer (22), and where each core transistor device (51, 53) includes a metal gate (25) and a core gate dielectric layer (72, 98) formed from only the second, relatively higher high-k metal oxide layer (24).

Abstract translation: 描述了用于在PMOS器件中具有硅锗沟道层（21）的单个衬底（15）上集成双栅极氧化物（DGO）晶体管器件（50,52）和核心晶体管器件（51,53）的方法和装置 区域（112,113），其中每个DGO晶体管器件（50,52）包括金属栅极（25），由第二相对较高的高k金属氧化物层（24）形成的上部栅极氧化物区域（60,84） ）和由第一相对较低的高k层（22）形成的下栅极氧化物区域（58,84），并且其中每个核心晶体管器件（51,53）包括金属栅极（25）和芯栅极电介质 仅由第二相对较高的高k金属氧化物层（24）形成的层（72,98）。

公开(公告)号：US07829447B2

公开(公告)日：2010-11-09

申请号：US11419304

申请日：2006-05-19

Applicant: Leo Mathew ,  Rode R. Mora ,  Tab A. Stephens ,  Tien Ying Luo

Inventor： Leo Mathew ,  Rode R. Mora ,  Tab A. Stephens ,  Tien Ying Luo

IPC: H01L21/22 ,  H01L21/38

CPC classification number: H01L29/785 ,  H01L29/66795 ,  Y10S438/942

Abstract: Forming structures such as fins in a semiconductor layer according to a pattern formed by oxidizing a sidewall of a layer of oxidizable material. In one embodiment, source/drain pattern structures and a fin pattern structures are patterned in the oxidizable layer. The fin pattern structure is then masked from an oxidation process that grows oxide on the sidewalls of the channel pattern structure and the top surface of the source/drain pattern structures. The remaining oxidizable material of the channel pattern structure is subsequently removed leaving a hole between two portions of the oxide layer. These two portions are used in one embodiment as a mask for patterning the semiconductor layer to form two fins. This patterning also leaves the source/drain structures connected to the fins.

Abstract translation: 根据通过氧化可氧化材料层的侧壁形成的图案在半导体层中形成诸如翅片的结构。 在一个实施例中，在可氧化层中图案化源极/漏极图案结构和鳍状图案结构。 然后从在沟道图案结构的侧壁和源极/漏极图案结构的顶表面上生长氧化物的氧化过程掩蔽鳍状图案结构。 随后去除沟道图案结构的剩余可氧化材料，留下氧化物层的两个部分之间的孔。 这两个部分在一个实施例中用作用于图案化半导体层以形成两个散热片的掩模。 该图案化还使得源极/漏极结构连接到鳍片。

公开(公告)号：US20080272411A1

公开(公告)日：2008-11-06

申请号：US11744581

申请日：2007-05-04

Applicant: Xiangzheng Bo ,  Tien Ying Luo ,  Kurt H. Junker ,  Paul A. Grudowski ,  Venkat R. Kolagunta

Inventor： Xiangzheng Bo ,  Tien Ying Luo ,  Kurt H. Junker ,  Paul A. Grudowski ,  Venkat R. Kolagunta

IPC: H01L29/78 ,  H01L21/3205

CPC classification number: H01L29/7843 ,  H01L21/268 ,  H01L21/3105 ,  H01L21/3185 ,  H01L29/6659 ,  H01L29/7833

Abstract: A semiconductor device has at least two tensile stressor layers that are cured with UV radiation. A second tensile stressor layer is formed after a first stressor layer. In some examples, the tensile stressor layers include silicon nitride and hydrogen. In some examples, the second tensile stressor layer has a greater shrinkage percentage due to the curing than the first tensile stressor layer. In one form, the second tensile stressor layer after the curing exerts a greater tensile stress than the first tensile stressor layer. The tensile stressors layers are utilized to improve carrier mobility in an N-channel transistor and thus enhance transistor performance. In one form a single group of overlying tensile stressor layers is provided with each layer being increasingly thicker and having increasingly more hydrogen prior to being cured. In other embodiments multiple overlying groups are formed, each group having a similar repeating depth and hydrogen profile.

Abstract translation: 半导体器件具有至少两个用UV辐射固化的拉伸应力层。 在第一应力层之后形成第二拉伸应力层。 在一些实例中，拉伸应力层包括氮化硅和氢。 在一些实例中，第二拉伸应力层由于固化而比第一拉伸应力层具有更大的收缩率。 在一种形式中，固化后的第二拉伸应力层比第一拉伸应力层具有更大的拉伸应力。 拉伸应力层用于改善N沟道晶体管中的载流子迁移率，从而提高晶体管性能。 在一种形式中，提供单组上覆的拉伸应力层，每层越来越厚，并且在固化之前具有越来越多的氢。 在其它实施方案中，形成多个重叠的基团，每个基团具有相似的重复深度和氢分布。

公开(公告)号：US20080108098A1

公开(公告)日：2008-05-08

申请号：US11867504

申请日：2007-10-04

Applicant: Cindy Leo ,  Ying Luo ,  Xiang Xu ,  Simon Yu

Inventor： Cindy Leo ,  Ying Luo ,  Xiang Xu ,  Simon Yu

IPC: C12Q1/48

CPC classification number: C12N9/1205 ,  C12Q1/485 ,  G01N33/5041 ,  G01N2500/02

Abstract: The present invention provides compositions and methods for modulating cell proliferation, survival, morphology, and migration. Nucleic acids encoding proteins, and proteins so encoded which are capable of modulating proliferation, survival, morphology, and migration in mammalian cells are provided. Compositions and methods for the treatment of disorders related to cell proliferation, survival, morphology and migration are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions are methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating proliferation, survival, morphology, and migration in mammalian cells.

Abstract translation: 本发明提供调节细胞增殖，存活，形态和迁移的组合物和方法。 提供了编码蛋白质的核酸和如此编码的能够调节哺乳动物细胞中增殖，存活，形态和迁移的蛋白质。 还提供了用于治疗与细胞增殖，存活，形态和迁移相关的病症的组合物和方法。 还提供了预防和预防这种疾病的方法。 还提供组合物是用于诊断和预测这些疾病的方法。 进一步提供了用于鉴定能够调节哺乳动物细胞中增殖，存活，形态和迁移的生物活性剂的测定。

公开(公告)号：US20080101663A1

公开(公告)日：2008-05-01

申请号：US11554861

申请日：2006-10-31

Applicant: PETER Z. LO ,  BEHNAM BAVARIAN ,  YING LUO

Inventor： PETER Z. LO ,  BEHNAM BAVARIAN ,  YING LUO

IPC: G06K9/00

CPC classification number: G06K9/0008 ,  G06K9/001

Abstract: A method for level three feature extraction from a print image extracts features associated with a selected ridge segment using a gray-level image under the guidance of at least one binary image. The level three features are a sequence of vectors each corresponding to a different level three characteristic and each representing a sequence of values at selected points on a print image. The level three features are stored and used for level three matching of two prints. During the matching stage, ridge segments are correlated against each other by shifting or a dynamic programming method to determine a measure of similarity between the print images.

Abstract translation: 用于从打印图像提取三级特征的方法在至少一个二进制图像的引导下使用灰度级图像提取与所选择的脊段相关联的特征。 三级特征是一系列向量，每个矢量各自对应于不同的三级特征，每一个表示在打印图像上的选定点处的值序列。 三级功能被存储并用于两个打印的三级匹配。 在匹配阶段，通过移位或动态规划方法，脊段彼此相关，以确定打印图像之间的相似性度量。