公开(公告)号：US20070135392A1

公开(公告)日：2007-06-14

申请号：US11482458

申请日：2006-07-07

Applicant: Michael Wendt ,  Hong Ding ,  Sheela Thomas ,  Steven Elmore ,  Wang Shen ,  Daniel Dickman ,  David Augeri

Inventor： Michael Wendt ,  Hong Ding ,  Sheela Thomas ,  Steven Elmore ,  Wang Shen ,  Daniel Dickman ,  David Augeri

IPC: A61K31/655 ,  A61K31/44 ,  C07D213/53 ,  C07D207/30

CPC classification number: C07C311/41 ,  C07C63/48 ,  C07C63/49 ,  C07C65/26 ,  C07C65/28 ,  C07C205/58 ,  C07C229/52 ,  C07C229/56 ,  C07C233/81 ,  C07C311/13 ,  C07C311/18 ,  C07C311/21 ,  C07C311/37 ,  C07C311/44 ,  C07C323/20 ,  C07C323/25 ,  C07C323/62 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/10 ,  C07C2603/18 ,  C07C2603/74 ,  C07D207/30 ,  C07D213/53 ,  C07D215/12 ,  C07D215/48 ,  C07D333/34

Abstract: Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds and methods of treating diseases during which are expressed the Mcl-1 protein are disclosed.

Abstract translation: 公开了抑制抗细胞凋亡Mcl-1蛋白活性的化合物，含有该化合物的组合物和治疗疾病的方法，其表达为Mcl-1蛋白。

公开(公告)号：US20060258657A1

公开(公告)日：2006-11-16

申请号：US11202827

申请日：2005-08-12

Applicant: Milan Bruncko ,  Hong Ding ,  Steven Elmore ,  Aaron Kunzer ,  Christopher Lynch ,  William McClellan ,  Cheol-Min Park ,  Andrew Petros ,  Xiaohong Song ,  Xilu Wang ,  Noah Tu ,  Michael Wendt ,  Alexander Shoemaker ,  Michael Mitten

Inventor： Milan Bruncko ,  Hong Ding ,  Steven Elmore ,  Aaron Kunzer ,  Christopher Lynch ,  William McClellan ,  Cheol-Min Park ,  Andrew Petros ,  Xiaohong Song ,  Xilu Wang ,  Noah Tu ,  Michael Wendt ,  Alexander Shoemaker ,  Michael Mitten

IPC: A61K31/53 ,  A61K31/506 ,  A61K31/497 ,  A61K31/501 ,  A61K31/4745 ,  C07D471/02

CPC classification number: C07D207/24 ,  C07D211/20 ,  C07D211/26 ,  C07D211/48 ,  C07D211/70 ,  C07D211/72 ,  C07D213/38 ,  C07D213/70 ,  C07D213/74 ,  C07D213/81 ,  C07D215/12 ,  C07D257/04 ,  C07D277/36 ,  C07D295/155 ,  C07D295/185 ,  C07D295/30 ,  C07D307/22 ,  C07D309/20 ,  C07D333/20 ,  C07D333/34 ,  C07D401/12 ,  C07D403/12 ,  C07D487/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.

公开(公告)号：US20060163541A1

公开(公告)日：2006-07-27

申请号：US11240697

申请日：2005-09-30

Applicant: Brian Wayton ,  Hong Ding ,  Michael Cox

Inventor： Brian Wayton ,  Hong Ding ,  Michael Cox

IPC: B05D1/02 ,  H01B1/12

CPC classification number: C09D5/002 ,  C08G18/4063 ,  C08G18/6229 ,  C08G18/672 ,  C08G18/686 ,  C08G2150/50 ,  C08K3/013 ,  C08K3/04 ,  C08K5/0025 ,  C09D5/24 ,  C09D167/06 ,  C09D175/04 ,  C09D175/14 ,  C08L67/06

Abstract: The present invention provides for a sealer/primer that is generally cured at low bake temperatures. The composition utilizes a resin system to provide both conductivity and adhesion of the coating onto plastic substrates. The present invention uses a polyester, such as one that includes unsaturated polyester, in combination with other resins, including an acrylic, crosslinking agent and conductive pigment to create a conductive primer that can be cured at low temperatures. The composition can be applied through traditional application equipment, seals the surface of the substrate to which it is applied, and cures to an acceptable surface for further processing, such as painting.

公开(公告)号：US06361801B1

公开(公告)日：2002-03-26

申请号：US09120699

申请日：1998-07-22

Applicant: Hong Ding ,  Michael M. Carpenter ,  Shih-ruey T. Chen ,  Nicholas F. Vozza ,  Fu-Mei Chen Lin ,  Jennifer R. Parsons

Inventor： Hong Ding ,  Michael M. Carpenter ,  Shih-ruey T. Chen ,  Nicholas F. Vozza ,  Fu-Mei Chen Lin ,  Jennifer R. Parsons

IPC: A61K711

CPC classification number: C07C211/21 ,  A61K8/817 ,  A61Q5/06 ,  C08F220/06 ,  C08F220/14 ,  C08F226/02 ,  Y10S424/01 ,  Y10S424/02

Abstract: The present invention is directed to alkyl allyl amine monomers and their use as a polymerizate in a low VOC hair spray formulation. The hair spray formulation preferably includes a polymerizate of an alkyl allyl amine monomer, preferably an alkyl diallyl amine monomer alone or in combination with other known monomers. The hair spray formulation preferentially satisfies low VOC requirements while maintaining characteristics desired in a hair fixative product.

Abstract translation: 本发明涉及烷基烯丙基胺单体及其在低VOC喷发剂中作为聚合物的用途。 喷发剂优选包括单独的烷基烯丙基胺单体，优选烷基二烯丙基胺单体或与其它已知单体组合的聚合物。 喷发剂优先满足低VOC要求，同时保持头发固定产品中所需的特性。

公开(公告)号：US5491200A

公开(公告)日：1996-02-13

申请号：US171523

申请日：1993-12-22

Applicant: Frank W. Harris ,  Hong Ding

Inventor： Frank W. Harris ,  Hong Ding

IPC: C08G73/14 ,  C08L77/00 ,  C08L79/08 ,  C08G69/00 ,  C08G69/48

CPC classification number: C08L77/00 ,  C08G73/14 ,  C08L79/08

Abstract: Polyimides serve as reinforcing rigid-backbone segments in nylon 6 copolymers. In a first embodiment, the copolymers are prepared from polyimides containing acylated caprolactam moieties pendant therefrom which provide sites for polycaprolactam grafts. In a second embodiment, polyimide oligomers end-capped with acyl-activated caprolactam rings permit the formation of block caprolactam copolymers that include polyimide reinforcing segments. The polyimide/nylon 6 copolymers have properties superior to those of nylon 6 and can also serve as compatibilizing agents.

Abstract translation: 聚酰亚胺在尼龙6共聚物中用作增强刚性骨架链段。 在第一个实施方案中，共聚物由聚酰亚胺制备，所述聚酰亚胺含有从其悬挂的酰化己内酰胺部分，其提供聚己内酰胺移植物的位点。 在第二个实施方案中，用酰基活化的己内酰胺环封端的聚酰亚胺低聚物允许形成包括聚酰亚胺加强段的嵌段己内酰胺共聚物。 聚酰亚胺/尼龙6共聚物具有优于尼龙6的性能，也可以用作相容剂。

公开(公告)号：US09872859B2

公开(公告)日：2018-01-23

申请号：US15437878

申请日：2017-02-21

Applicant: Upal Roy ,  Hong Ding ,  Madhavan Nair

Inventor： Upal Roy ,  Hong Ding ,  Madhavan Nair

IPC: A61K31/536 ,  A61K47/48

CPC classification number: A61K31/536 ,  A61K47/60 ,  A61K47/68 ,  A61K47/6849 ,  A61K47/6907 ,  C07K16/30

Abstract: The present invention provides novel, long-acting nanoformulated drugs and targeted drug delivery methods, and uses thereof. In one embodiment, the nanoformulated drug is a retroviral drug. In one embodiment, the nanoformulated composition comprises a nanocarrier with one or more incorporated drugs. In an exemplary embodiment, the drug is efavirenz (EFV). In a further embodiment, the nanocarrier is associated with an agent for targeting microfold cells (M-cells). In a specific embodiment, the targeting agent binds to an M-cell marker known as glycoprotein 2 (GP2). Via this mechanism, the nanodrug is targeted toward GALT.

公开(公告)号：US08586754B2

公开(公告)日：2013-11-19

申请号：US12793418

申请日：2010-06-03

Applicant: Milan Bruncko ,  Hong Ding ,  George A. Doherty ,  Steven W. Elmore ,  Lisa Hasvold ,  Laura Hexamer ,  Aaron R. Kunzer ,  Robert A. Mantei ,  William J. McClellan ,  Chang H. Park ,  Cheol-Min Park ,  Andrew M. Petros ,  Xiaohong Song ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-Fu Tao ,  Gary T. Wang ,  Le Wang ,  Xilu Wang ,  Michael D. Wendt ,  Todd M. Hansen

Inventor： Milan Bruncko ,  Hong Ding ,  George A. Doherty ,  Steven W. Elmore ,  Lisa Hasvold ,  Laura Hexamer ,  Aaron R. Kunzer ,  Robert A. Mantei ,  William J. McClellan ,  Chang H. Park ,  Cheol-Min Park ,  Andrew M. Petros ,  Xiaohong Song ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-Fu Tao ,  Gary T. Wang ,  Le Wang ,  Xilu Wang ,  Michael D. Wendt ,  Todd M. Hansen

IPC: C07D209/32 ,  C07D401/10

CPC classification number: C07D215/14 ,  A61K31/496 ,  A61K31/5377 ,  A61K45/06 ,  C07D209/20 ,  C07D209/32 ,  C07D211/96 ,  C07D213/64 ,  C07D215/20 ,  C07D217/16 ,  C07D231/56 ,  C07D235/26 ,  C07D249/04 ,  C07D295/125 ,  C07D295/13 ,  C07D295/14 ,  C07D295/155 ,  C07D309/08 ,  C07D309/14 ,  C07D309/32 ,  C07D401/12 ,  C07D405/12 ,  C07D417/12 ,  C07D487/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：US08563735B2

公开(公告)日：2013-10-22

申请号：US12631404

申请日：2009-12-04

Applicant: Milan Bruncko ,  Hong Ding ,  George A. Doherty ,  Steven W. Elmore ,  Lisa Hasvold ,  Laura Hexamer ,  Aaron Kunzer ,  Robert A. Mantei ,  William J. McClellan ,  Chang H. Park ,  Cheol-Min Park ,  Andrew M. Petros ,  Xiaohong Song ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-Fu Tao ,  Gary T. Wang ,  Le Wang ,  Xilu Wang ,  Michael D. Wendt

Inventor： Milan Bruncko ,  Hong Ding ,  George A. Doherty ,  Steven W. Elmore ,  Lisa Hasvold ,  Laura Hexamer ,  Aaron Kunzer ,  Robert A. Mantei ,  William J. McClellan ,  Chang H. Park ,  Cheol-Min Park ,  Andrew M. Petros ,  Xiaohong Song ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-Fu Tao ,  Gary T. Wang ,  Le Wang ,  Xilu Wang ,  Michael D. Wendt

IPC: C07D401/10 ,  C07D213/62 ,  C07D307/02

CPC classification number: C07D401/12 ,  A61K31/407 ,  A61K31/495 ,  A61K31/496 ,  A61K31/501 ,  A61K31/5377 ,  A61K45/06 ,  C07D209/08 ,  C07D209/32 ,  C07D211/58 ,  C07D211/96 ,  C07D213/64 ,  C07D215/20 ,  C07D217/16 ,  C07D231/56 ,  C07D235/26 ,  C07D241/04 ,  C07D249/04 ,  C07D295/125 ,  C07D295/14 ,  C07D295/155 ,  C07D309/04 ,  C07D309/14 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D413/06 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：US20120214796A1

公开(公告)日：2012-08-23

申请号：US13458968

申请日：2012-04-27

Applicant: Hong Ding ,  Steven W. Elmore ,  Laura A. Hexamer ,  Aaron R. Kunzer ,  Cheol-Min Park ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Michael D. Wendt

Inventor： Hong Ding ,  Steven W. Elmore ,  Laura A. Hexamer ,  Aaron R. Kunzer ,  Cheol-Min Park ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Michael D. Wendt

IPC: A61K31/18 ,  A61K31/495 ,  A61K31/55 ,  A61K31/439 ,  A61K31/5377 ,  A61K31/496 ,  A61P35/00 ,  A61K31/451

CPC classification number: C07D211/58 ,  C07C311/51 ,  C07C2601/14 ,  C07C2603/74 ,  C07D295/112 ,  C07D295/195 ,  C07D417/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：US08173811B2

公开(公告)日：2012-05-08

申请号：US12800702

申请日：2010-05-19

Applicant: Milan Bruncko ,  Hong Ding ,  Steven Elmore ,  Aaron Kunzer ,  Christopher L. Lynch ,  William McClellan ,  Cheol-Min Park ,  Andrew Petros ,  Xiaohong Song ,  Xilu Wang ,  Noah Tu ,  Michael Wendt

Inventor： Milan Bruncko ,  Hong Ding ,  Steven Elmore ,  Aaron Kunzer ,  Christopher L. Lynch ,  William McClellan ,  Cheol-Min Park ,  Andrew Petros ,  Xiaohong Song ,  Xilu Wang ,  Noah Tu ,  Michael Wendt

IPC: C07D235/02

CPC classification number: C07D295/155 ,  C07D207/24 ,  C07D211/20 ,  C07D211/26 ,  C07D211/48 ,  C07D211/70 ,  C07D211/72 ,  C07D213/38 ,  C07D213/70 ,  C07D213/74 ,  C07D213/81 ,  C07D215/12 ,  C07D257/04 ,  C07D277/36 ,  C07D295/185 ,  C07D295/30 ,  C07D307/22 ,  C07D309/20 ,  C07D333/20 ,  C07D333/34 ,  C07D401/12 ,  C07D403/12 ,  C07D487/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.

Abstract translation: 公开了抑制抗凋亡蛋白家族成员的活性的化合物，含有化合物的组合物和该化合物用于制备用于治疗疾病的药物的用途，其中发生表达一种或多种抗凋亡蛋白家族成员。