Polymerase chain reaction apparatus
    51.
    发明授权
    Polymerase chain reaction apparatus 有权
    聚合酶链反应装置

    公开(公告)号:US08663976B2

    公开(公告)日:2014-03-04

    申请号:US13039630

    申请日:2011-03-03

    IPC分类号: C12M1/34 C12M3/00

    摘要: A polymerase chain reaction (“PCR”) apparatus includes a PCR chip holder which accommodates and supports a PCR chip, a housing which supports ends of the PCR chip holder, a temperature control element which moves perpendicularly with respect to the PCR chip holder in a space between the housing and the PCR chip holder in the housing, and an elastic unit which elastically biases the temperature control element toward the PCR chip holder, between the temperature control element and the housing. The temperature control element includes a top surface which is selectively contacted to a bottom surface of the PCR chip.

    摘要翻译: 聚合酶链式反应(“PCR”)装置包括:一个PCR芯片保持器,其容纳和支持PCR芯片;支撑PCR芯片保持器端部的壳体;一个相对于PCR芯片保持器垂直移动的温度控制元件 壳体和壳体中的PCR芯片保持器之间的空间以及在温度控制元件和壳体之间弹性地将温度控制元件朝向PCR芯片保持器偏置的弹性单元。 温度控制元件包括选择性地接触PCR芯片的底表面的顶表面。

    Sensing switch and detecting method using the same
    54.
    发明授权
    Sensing switch and detecting method using the same 失效
    感应开关及使用其的检测方法

    公开(公告)号:US07510865B2

    公开(公告)日:2009-03-31

    申请号:US11347185

    申请日:2006-02-03

    IPC分类号: C12M1/34

    CPC分类号: G01N33/54373

    摘要: Provided are a sensing switch and a sensing method using the same. The sensing switch includes: a substrate; a supporter on the substrate; a sensing plate that is connected to a side of the supporter and is in parallel with the substrate by a predetermined distance; a receptor binding region on an upper surface of an end portion of the sensing plate; an electric or magnetic field generation device that induces deflection of the sensing plate when a receptor bound to the receptor binding region is selectively bound to an electrically or magnetically active ligand; and a pair of switching electrodes that are separated by a predetermined distance and is connected when the sensing plate contacts the substrate due to the deflection of the sensing plate. A target material need not be labelled, a signal processing of a fluorescent or electrical detection signal using an analysis apparatus is not required, and a signal can be directly decoded by confirming whether a current flows through the switch.

    摘要翻译: 提供了一种感测开关和使用该感测开关的感测方法。 感测开关包括:基板; 底物上的支撑物; 感测板,其与所述支撑体的一侧连接并且与所述基板平行预定距离; 在感测板的端部的上表面上的受体结合区域; 当与受体结合区结合的受体选择性地结合到电或磁性活性配体时,引起感测板偏转的电场或磁场产生装置; 以及一对分离预定距离的开关电极,并且当感测板由于感测板的偏转而与基板接触时被连接。 目标材料不需要标注,不需要使用分析装置的荧光或电检测信号的信号处理,并且可以通过确认电流是否流过开关直接解码信号。

    Sensitivity enhanced biomolecule field effect transistor
    56.
    发明申请
    Sensitivity enhanced biomolecule field effect transistor 有权
    灵敏度增强的生物分子场效应晶体管

    公开(公告)号:US20050199917A1

    公开(公告)日:2005-09-15

    申请号:US11057642

    申请日:2005-02-14

    CPC分类号: G01N27/4145

    摘要: There is provided a biomolecule FET enhancing a sensitivity. The biomolecule FET includes a substrate, first and second impurity regions formed on both sides of the substrate, and doped with impurities of a polarity opposite to that of the substrate, a gate formed on the substrate and being in contact with the first and second impurity regions, and a probe biomolecule attached to the gate. A region of the gate adjacent to the first impurity region is wider than a region thereof adjacent to the second impurity region. A density of the probe biomolecule attached to the surface of the gate is increased, and when detecting a level of hybridization of the probe biomolecule and the target biomolecule, its sensitivity is improved.

    摘要翻译: 提供了提高灵敏度的生物分子FET。 生物分子FET包括基板,形成在基板两侧的第一和第二杂质区,并且掺杂极性与基板极性相反的杂质;形成在基板上并与第一和第二杂质接触的栅极 区域,以及连接到门的探针生物分子。 与第一杂质区相邻的栅极的区域比与第二杂质区相邻的区域宽。 附着在栅极表面的探针生物分子的密度增加,并且当检测到探针生物分子和靶生物分子的杂交水平时,其灵敏度得到改善。

    Microfluidic device for electrically regulating the pH of a fluid therein and method of regulating the pH of a fluid in a microfluidic device using the same
    57.
    发明授权
    Microfluidic device for electrically regulating the pH of a fluid therein and method of regulating the pH of a fluid in a microfluidic device using the same 有权
    用于电调节其中流体pH值的微流体装置及使用其调节微流体装置中的流体pH值的方法

    公开(公告)号:US08293095B2

    公开(公告)日:2012-10-23

    申请号:US11472182

    申请日:2006-06-21

    IPC分类号: G01N27/44

    CPC分类号: G05D21/02

    摘要: Provided is a microfluidic device for electrically regulating the pH of a fluid comprising: a first chamber comprising a first electrode; a second chamber comprising a second electrode; a third chamber comprising a third electrode, a metal ion exchange membrane between the first and second chambers; and a hydrogen ion exchange membrane between the first or second chamber and the third chamber.

    摘要翻译: 提供一种用于电流调节流体pH的微流体装置,包括:第一室,包括第一电极; 第二室,包括第二电极; 第三室,包括第三电极,在第一和第二室之间的金属离子交换膜; 以及在第一或第二室与第三室之间的氢离子交换膜。