-
公开(公告)号：US10407655B2
公开(公告)日：2019-09-10
申请号：US15403944
申请日：2017-01-11
Applicant: President and Fellows of Harvard College
Inventor： Christopher David Hinojosa , Josiah Sliz , Daniel Levner , Guy Thompson , Hubert Geisler , Jose Fernandez-Alcon , Donald E. Ingber
Abstract: Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.
-
公开(公告)号：US20190106665A1
公开(公告)日：2019-04-11
申请号：US16134746
申请日：2018-09-18
Applicant: President and Fellows of Harvard College
Inventor： Donald E. Ingber , Anthony Bahinski , Robert Cunningham , Josue A. Goss , Geraldine A. Hamilton , Christopher David Hinojosa , Daniel Levner , Kevin Kit Parker
IPC: C12M3/06 , G01N33/50 , B01L3/00 , B01L9/00 , C12M1/42 , C12M1/00 , A01N1/02 , C12M1/34 , C12M3/00
Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.
-
53.发明申请公开(公告)号：US20180024110A1
公开(公告)日：2018-01-25
申请号：US15694577
申请日：2017-09-01
Applicant: President and Fellows of Harvard College
Inventor： Daniel Levner , Christopher David Hinojosa , Andries D. van der Meer , Marinke van der Helm , Abhishek Jain , Donald Elliot Ingber , Marjon Zamani
IPC: G01N33/483 , G01N15/08 , B01L3/00
CPC classification number: G01N33/4833 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L2300/0654 , B01L2300/0877 , B01L2300/0883 , B01L2400/0457 , B01L2400/0487 , B01L2400/082 , B01L2400/084 , B01L2400/086 , G01N15/0826 , G01N33/50 , G01N33/5005 , G01N2015/0065
Abstract: Systems and methods for measuring dynamic hydraulic conductivity and permeability associated with a cell layer are disclosed. Some systems include a microfluidic device, one or more working-fluid reservoirs, and one or more fluid-resistance element. The microfluidic device includes a first microchannel, a second microchannel, and a barrier therebetween. The barrier includes a cell layer adhered thereto. The working fluids are delivered to the microfluidic device. The fluid-resistance elements are coupled to one or more of the fluid paths and provide fluidic resistance to cause a pressure drop across the fluid-resistance elements. Mass transfer occurs between the first microchannel and the second microchannel, which is indicative of the hydraulic conductivity and/or dynamic permeability associated with the cells.
-
54.发明申请公开(公告)号：US20180008980A1
公开(公告)日：2018-01-11
申请号：US15694557
申请日：2017-09-01
Applicant: President and Fellows of Harvard College
Inventor： Daniel Levner , Christopher David Hinojosa , Andries D. van der Meer , Marinke van der Helm , Abhishek Jain , Donald Elliot Ingber , Marjon Zamani
IPC: B01L3/00 , G01N33/483 , G01N33/50
CPC classification number: G01N33/4833 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L2300/0654 , B01L2300/0877 , B01L2300/0883 , B01L2400/0457 , B01L2400/0487 , B01L2400/082 , B01L2400/084 , B01L2400/086 , G01N15/0826 , G01N33/50 , G01N33/5005 , G01N2015/0065
Abstract: Systems and methods for measuring dynamic hydraulic conductivity and permeability associated with a cell layer are disclosed. Some systems include a microfluidic device, one or more working-fluid reservoirs, and one or more fluid-resistance element. The microfluidic device includes a first microchannel, a second microchannel, and a barrier therebetween. The barrier includes a cell layer adhered thereto. The working fluids are delivered to the microfluidic device. The fluid-resistance elements are coupled to one or more of the fluid paths and provide fluidic resistance to cause a pressure drop across the fluid-resistance elements. Mass transfer occurs between the first microchannel and the second microchannel, which is indicative of the hydraulic conductivity and/or dynamic permeability associated with the cells.
-
公开(公告)号：US09855554B2
公开(公告)日：2018-01-02
申请号：US14906335
申请日：2014-07-22
Applicant: President and Fellows of Harvard College
Inventor： Donald E. Ingber , Daniel Levner , Guy Thompson, II , Christopher David Hinojosa
CPC classification number: B01L3/502715 , B01L3/502707 , B01L3/56 , B01L2200/027 , B01L2200/0684 , B01L2200/0689 , B01L2200/12 , B01L2300/0645 , B01L2300/0816 , B01L2300/0874 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0655
Abstract: According to aspects of the present invention, a cartridge assembly for transporting fluid into or out of one or more fluidic devices includes a first layer and a second layer. The first layer includes a first surface. The first surface includes at least one partial channel disposed thereon. The second layer abuts the first surface, thereby forming a channel from the at least one partial channel. At least one of the first layer and the second layer is a resilient layer formed from a pliable material. At least one of the first layer and the second layer includes a via hole. The via hole is aligned with the channel to pass fluid thereto. The via hole is configured to pass fluid through the first layer or the second layer substantially perpendicularly to the channel. Embossments are also used to define aspects of a fluidic channel.
-
Patent Agency Ranking
公开(公告)号：US20170121663A1
公开(公告)日：2017-05-04
申请号：US15403949
申请日：2017-01-11
Applicant: President and Fellows of Harvard College
Inventor： Christopher David Hinojosa , Josiah Sliz , Daniel Levner , Guy Thompson , Hubert Geisler , Jose Fernandez-Alcon , Donald E. Ingber
CPC classification number: C12M23/16 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L2200/027 , B01L2200/0605 , B01L2200/0684 , B01L2300/044 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/14 , B01L2400/0487 , B01L2400/084 , B82Y15/00 , C12M21/08 , C12M33/12 , C12M41/00 , C12M41/40 , C12M41/46 , G01N33/5005
Abstract: Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.
-
公开(公告)号：US20170121658A1
公开(公告)日：2017-05-04
申请号：US15403942
申请日：2017-01-11
Applicant: President and Fellows of Harvard College
Inventor： Christopher David Hinojosa , Josiah Sliz , Daniel Levner , Guy Thompson , Hubert Geisler , Jose Fernandez-Alcon , Donald E. Ingber
CPC classification number: C12M23/16 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L2200/027 , B01L2200/0605 , B01L2200/0684 , B01L2300/044 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/14 , B01L2400/0487 , B01L2400/084 , B82Y15/00 , C12M21/08 , C12M33/12 , C12M41/00 , C12M41/40 , C12M41/46 , G01N33/5005
Abstract: Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.
-
公开(公告)号：US20160136646A1
公开(公告)日：2016-05-19
申请号：US14899106
申请日：2014-06-26
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Donald E. Ingber , Christopher David Hinojosa , Daniel Levner , Josh Isaac Nielsen Resnikoff , Guy Thompson, III
CPC classification number: B01L3/563 , B01J19/0093 , B01J2219/00813 , B01J2219/00988 , B01L3/502715 , B01L2200/025 , B01L2200/027 , B01L2200/04 , B01L2200/0684 , B01L2200/0689 , B01L2200/10 , B01L2200/141 , B01L2300/047 , B01L2300/069 , B01L2300/0861 , B01L2300/0864 , B01L2300/0887 , B01L2300/089 , B01L2300/12 , B01L2300/123 , B01L2300/16 , C12M23/16 , C12M23/40 , C12M29/00
Abstract: An interconnect adaptor for connecting a microfluidic device to a fluidic system. The interconnect adapter includes a base substrate and a nozzle array. The base substrate includes a first side and a second side. The nozzle array includes two or more nozzles extending away from the base substrate. Each nozzle includes an opening with a channel extending therefrom. The channels are configured to transport fluid between the microfluidic device and the fluidic system. Each of the nozzles is configured to be inserted into a respective hole in the microfluidic device, in some embodiments, the insertion forms a radially sealed connection between each nozzle and respective hole when the nozzles are inserted a predetermined distance into the respective holes.
Abstract translation: 用于将微流体装置连接到流体系统的互连适配器。 互连适配器包括基底基板和喷嘴阵列。 基底基板包括第一面和第二面。 喷嘴阵列包括远离基底基板延伸的两个或更多个喷嘴。 每个喷嘴包括具有从其延伸的通道的开口。 通道构造成在微流体装置和流体系统之间输送流体。 每个喷嘴构造成插入到微流体装置的相应孔中，在一些实施例中，当喷嘴在相应的孔中插入预定距离时，插入形成每个喷嘴与相应孔之间的径向密封连接。
-
公开(公告)号：US20150209783A1
公开(公告)日：2015-07-30
申请号：US14424195
申请日：2013-09-04
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Donald E. Ingber , Geraldine A. Hamilton , Daniel Levner , Christopher Hinojosa , Daniel Patterson
CPC classification number: B01L3/502723 , B01D17/085 , B01D19/0031 , B01D63/088 , B01D71/36 , B01D2325/38 , B01L3/502715 , B01L2200/0684 , B01L2300/06 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2300/0874 , B01L2300/0877 , B01L2300/0887 , C12M23/16 , C12M23/24 , C12M23/36
Abstract: A microfluidic system includes a microfluidic device connected to a bubble trap device whereby fluid flowing to the microfluidic device passes through the bubble trap device to remove gas bubbles prior to entering the microfluidic device. The bubble trap can include a separation chamber and an exhaust chamber separated by a hydrophobic porous membrane and gas bubbles in the fluid entering the separation chamber pass through the hydrophobic porous membrane into the exhaust chamber while the fluid remains in the separation chamber. The bubble trap can be formed by bonding a first body portion to a first side of the hydrophobic porous membrane and bonding a second body portion to a second side of the hydrophobic porous membrane. The exhaust chamber can be connected to an elongated exhaust channel that limits the evaporation losses of the fluid through the hydrophobic porous membrane.
Abstract translation: 微流体系统包括连接到气泡捕获装置的微流体装置，由此流到微流体装置的流体通过气泡捕获装置以在进入微流体装置之前去除气泡。 气泡阱可以包括由疏水性多孔膜隔开的分离室和排气室，并且进入分离室的流体中的气泡在流体保留在分离室中时通过疏水性多孔膜进入排气室。 可以通过将第一主体部分接合到疏水性多孔膜的第一侧并将第二主体部分结合到疏水性多孔膜的第二侧来形成气泡捕获器。 排气室可以连接到细长的排气通道，其限制流体通过疏水多孔膜的蒸发损失。
-
公开(公告)号：US20150005188A1
公开(公告)日：2015-01-01
申请号：US14366486
申请日：2012-12-21
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Daniel Levner , Jehyuk Lee , George M. Church , Michael Super
IPC: C12Q1/68
CPC classification number: C12Q1/6837 , C12Q1/6804 , C12Q1/6816 , G01N33/53 , G01N2458/10 , C12Q2535/122 , C12Q2537/143 , C12Q2563/107 , C12Q2563/179 , C12Q2565/514
Abstract: The inventions provided herein relate to detection reagents, compositions, methods, and kits comprising the detection reagents for use in detection, identification, and/or quantification of analytes in a sample. Such detection reagents and methods described herein allow multiplexing of many more labeled species in the same procedure than conventional methods, in which multiplexing is limited by the number of available and practically usable colors.
Abstract translation: 本文提供的发明涉及包含用于样品中分析物的检测，鉴定和/或定量的检测试剂的检测试剂，组合物，方法和试剂盒。 本文所述的这种检测试剂和方法允许以与常规方法相同的方法复用多个标记的物质，其中多路复用受可用和实际可用颜色的数量限制。
-
-
-
-
-
-
-
-
-
Search Results
79
records
(took 0.035 seconds)
