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161 条记录 (耗时 0.033 秒)

    Process and apparatus, for electron beam welding of a member partially enclosed in vacuum chamber, and the member formed thereby
    53.
    发明授权
    Process and apparatus, for electron beam welding of a member partially enclosed in vacuum chamber, and the member formed thereby 失效
    用于部分包围在真空室中的部件的电子束焊接的工艺和装置以及由此形成的部件

    公开(公告)号：US5170028A

    公开(公告)日：1992-12-08

    申请号：US564581

    申请日：1990-08-09

    申请人： Takeshi Wada ,  Tatsuo Yonezawa ,  Noboru Umehara ,  Toshio Nemoto ,  Toshio Namatame

    发明人： Takeshi Wada ,  Tatsuo Yonezawa ,  Noboru Umehara ,  Toshio Nemoto ,  Toshio Namatame

    IPC分类号： B23K15/06 ,  H01J37/18

    CPC分类号： H01J37/18 ,  B23K15/06 ,  H01J2237/2005 ,  H01J2237/3104

    摘要： An apparatus for welding of a member to be welded in a vacuum chamber accommodating a part of the member, comprises a housing for defining the vacuum chamber, the housing including upper and lower housings between which the member to be welded is held, the upper and lower housings each having front and rear sides; an electron gun mounted on the upper housing; a drive device for moving the electron gun in a welding direction; an adjustment member or adjustment liner plate disposed on the lower housing for defining spaces allowing a part of the member to be welded to fit in at the front and rear sides of the lower housing so that the entirety of a welding portion of the member is in the vacuum chamber and both sides of the welding line are exposed in vacuum; sealing material for sealing between the housing, the adjustment member or adjustment liner plate and the member to be welded.

    摘要翻译： 一种用于将待焊接的部件焊接在容纳部件的一部分的真空室中的装置，包括用于限定真空室的壳体，所述壳体包括上部和下部壳体，所述待焊接部件保持在其之间， 下壳体各自具有前侧和后侧; 安装在上壳体上的电子枪; 用于沿焊接方向移动电子枪的驱动装置; 设置在下壳体上的调节构件或调节衬板，用于限定允许部件的一部分被焊接以配合在下壳体的前侧和后侧的空间，使得构件的焊接部分的整体处于 真空室和焊接线的两侧在真空中暴露; 密封材料用于在壳体，调节构件或调节衬板与待焊接构件之间进行密封。

    Low temperature sintered ceramic capacitor with a temperature compensating capability, and method of manufacture
    54.
    发明授权
    Low temperature sintered ceramic capacitor with a temperature compensating capability, and method of manufacture 失效
    具有温度补偿能力的低温烧结陶瓷电容器及其制造方法

    公开(公告)号：US4700266A

    公开(公告)日：1987-10-13

    申请号：US945075

    申请日：1986-12-22

    申请人： Hirokazu Chazono ,  Hiroshi Kishi ,  Shunji Murai ,  Masami Fukui ,  Takeshi Wada

    发明人： Hirokazu Chazono ,  Hiroshi Kishi ,  Shunji Murai ,  Masami Fukui ,  Takeshi Wada

    IPC分类号： H01G4/30 ,  C04B35/47 ,  C04B35/49 ,  H01B3/12 ,  H01G4/12 ,  C04B35/46

    CPC分类号： H01G4/1245 ,  C04B35/47 ,  C04B35/49

    摘要： A temperature compensating capacitor of monolithic or multilayered configuration comprising a dielectric ceramic body and at least two electrodes buried therein. The ceramic body is composed of a major ingredient expressed by the formula, {(Sr.sub.1-x Ca.sub.x)O}.sub.k (Ti.sub.1-y Zr.sub.y)O.sub.2, where x, k and y are numerals in the ranges of 0.005 to 0.995 inclusive, 1.00 to 1.04 inclusive, and 0.005 to 0.100 inclusive, respectively. To this major ingredient is added a minor proportion of a mixture of lithium oxide, silicon dioxide, and one or more metal oxides selected from among barium oxide, magnesium oxide, zinc oxide, strontium oxide and calcium oxide. For the fabrication of capacitors the mixture of the above major ingredient and additives in finely divided form are formed into moldings of desired shape and size, each with at least two electrodes buried therein. The moldings and electrodes are cosintered in a reductive or neutral atmosphere and then are reheated at a lower temperature in an oxidative atmosphere. the cosintering temperature can be so low that nickel or like base metal can be employed as the electrode material.

    摘要翻译： 一种单片或多层结构的温度补偿电容器，包括介电陶瓷体和埋在其中的至少两个电极。 陶瓷体由式（{（Sr1-xCax）O} k（Ti1-yZry）O2）表示的主要成分组成，其中x，k和y为0.005〜0.995的数值，1.00〜1.04 分别为0.005〜0.100。 在该主要成分中加入少量的氧化锂，二氧化硅和选自氧化钡，氧化镁，氧化锌，氧化锶和氧化钙中的一种或多种金属氧化物的混合物。 为了制造电容器，将上述主要成分和细分散形式的添加剂的混合物形成为所需形状和尺寸的模制品，其中至少埋设有两个电极。 模制品和电极在还原或中性气氛中共烧结，然后在较低温度下在氧化气氛中再加热。 整个烧结温度可以低到可以使用镍或类似的贱金属作为电极材料。

    Protective group for synthesis of RNA and derivative
    57.
    发明授权
    Protective group for synthesis of RNA and derivative 有权
    用于合成RNA和衍生物的保护基团

    公开(公告)号：US08470987B2

    公开(公告)日：2013-06-25

    申请号：US12882390

    申请日：2010-09-15

    申请人： Takeshi Wada ,  Mamoru Shimizu

    发明人： Takeshi Wada ,  Mamoru Shimizu

    IPC分类号： C07H19/00 ,  C07H21/00

    CPC分类号： C07F9/65586 ,  C07F9/65616 ,  C07F9/65844 ,  C07H19/067 ,  C07H19/167 ,  Y02P20/55

    摘要： A protective group represented by the following general formula (I) (the oxygen atom attached with * represents oxygen atom of 2′-hydroxyl group of a ribonucleoside, a ribonucleotide or a derivative thereof; R1 and R2 both represent hydrogen atom, or represent a halogen atom, a C1-6 alkyl group, or a C1-6 halo-substituted alkyl group; R3 and R4 represent hydrogen atom, a halogen atom, a C1-6 alkyl group, or a C1-6 halo-substituted alkyl group; and R5 and R6 represent a halogen atom, a C1-6 halo-substituted alkyl group, cyano group, nitro group, or the like), which is stable under the reaction conditions of the nucleic acid synthetic cycles and has little steric hindrance, and can be removed under mild conditions using fluoride ions as a base.

    摘要翻译： 由下述通式（I）表示的保护基（与*相连的氧原子表示核糖核苷，2核苷酸或其衍生物的2'-羟基的氧原子; R1和R2均表示氢原子， 卤素原子，C 1-6烷基或C 1-6卤素取代的烷基; R 3和R 4表示氢原子，卤素原子，C 1-6烷基或C 1-6卤素取代的烷基; R5和R6表示卤素原子，C1-6卤代烷基，氰基，硝基等），其在核酸合成循环的反应条件下是稳定的，几乎没有空间位阻， 可以在温和条件下使用氟离子作为基底去除。

    Phosphorylation Reagent
    58.
    发明申请
    Phosphorylation Reagent 审中-公开
    磷酸化试剂

    公开(公告)号：US20120322993A1

    公开(公告)日：2012-12-20

    申请号：US13521156

    申请日：2011-01-19

    申请人： Takeshi Wada ,  Seigo Nagata ,  Koichi Uetake

    发明人： Takeshi Wada ,  Seigo Nagata ,  Koichi Uetake

    IPC分类号： C07H1/02 ,  C07F9/6518

    CPC分类号： C07F9/65188 ,  C07H21/00

    摘要： Disclosed are a novel phosphorylating reagent and related methods. Specifically disclosed is a compound represented by general formula (A). In the formula, WG1 and WG2 independently represent a cyano group, a nitro group, a halogen atom, an alkylsulfonyl group or an arylsulfonyl group; X1, X2, X3 and X4 independently represent CR or N; and R represents H, a methyl group, a halogen atom, a trifluoromethyl group, a cyano group, a nitro group, an alkoxycarbonyl group, a carbamoyl group, a monoalkylcarbamoyl group, a dialkylcarbamoyl group, a sulfamoyl group, a monoalkylsulfamoyl group, a dialkylsulfamoyl group, or an alkylsulfonyl group.

    摘要翻译： 公开了一种新型磷酸化试剂及相关方法。 具体公开的是由通式（A）表示的化合物。 在该式中，WG1和WG2独立地表示氰基，硝基，卤素原子，烷基磺酰基或芳基磺酰基; X1，X2，X3和X4独立地表示CR或N; R表示H，甲基，卤素原子，三氟甲基，氰基，硝基，烷氧基羰基，氨基甲酰基，单烷基氨基甲酰基，二烷基氨基甲酰基，氨磺酰基，单烷基氨磺酰基， 二烷基氨磺酰基或烷基磺酰基。

    PROCESS FOR PRODUCING LIPOSOMES BY TWO-STEP EMULSIFICATION METHOD UTILIZING OUTER AQUEOUS PHASE CONTAINING SPECIFIC DISPERSING AGENT, PROCESS FOR PRODUCING LIPOSOME DISPERSION OR DRY POWDER THEREOF USING THE PROCESS FOR PRODUCING LIPOSOMES, AND LIPOSOME DISPERSION OR DRY POWDER THEREOF PRODUCED THEREBY
    59.
    发明申请
    PROCESS FOR PRODUCING LIPOSOMES BY TWO-STEP EMULSIFICATION METHOD UTILIZING OUTER AQUEOUS PHASE CONTAINING SPECIFIC DISPERSING AGENT, PROCESS FOR PRODUCING LIPOSOME DISPERSION OR DRY POWDER THEREOF USING THE PROCESS FOR PRODUCING LIPOSOMES, AND LIPOSOME DISPERSION OR DRY POWDER THEREOF PRODUCED THEREBY 审中-公开
    使用含有特定分散剂的外部水相的生产液体的方法，使用生产脂质体的方法生产脂质体分散剂或干粉的方法，以及生产脂质体的脂肪分散剂或干粉。

    公开(公告)号：US20120100207A1

    公开(公告)日：2012-04-26

    申请号：US13380225

    申请日：2010-06-02

    申请人： Yasuyuki Motokui ,  Takeshi Wada ,  Takeshi Isoda

    发明人： Yasuyuki Motokui ,  Takeshi Wada ,  Takeshi Isoda

    IPC分类号： A61K9/127 ,  A61P35/00 ,  A61K31/365 ,  A61K31/7068 ,  B82Y5/00

    CPC分类号： A61K9/1277 ,  A61K8/14 ,  A61K47/10 ,  A61K47/26 ,  A61K47/28 ,  A61K47/36 ,  A61K47/42 ,  A61Q19/00

    摘要： [Problem] To provide a process for producing liposomes, a liposome dispersion or a dry powder of the dispersion by a two-step emulsification method using an additive (dispersing agent) by which a liposome dispersion and a dry powder thereof which can inhibit leakage of an encapsulated drug or the like from liposomes even in the long-term storage and can be stably used over a long period of time are obtained. [Solution to problem] A process for producing liposomes by a two-step emulsification method characterized by using, in the secondary emulsification step, an outer aqueous phase containing a dispersing agent which forms no molecular self-aggregate or a dispersing agent which exclusively forms molecular self-aggregates having a volume mean particle diameter of not more than 10 nm (said dispersing agent being referred to as a “specific dispersing agent” hereinafter), and a process for producing a liposome dispersion or a dry powder thereof utilizing the process for producing liposomes. The specific dispersing agent preferably contains at least one of gelatin, albumin, dextran and a polyalkylene oxide-based compound.

    摘要翻译： [问题]提供一种通过使用添加剂（分散剂）的两步乳化法制备分散体的脂质体分散体或干粉的方法，通过该添加剂（分散剂）可以抑制可抑制渗透的脂质体分散体和干粉 即使在长期储存中也可以从长期储存中得到脂质体的包封药物等，能够长时间稳定地使用。 [问题的解决方案]通过两步乳化法制造脂质体的方法，其特征在于，在二次乳化步骤中，使用含有不分子自聚集体的分散剂的外部水相或仅形成分子的分散剂 体积平均粒径不大于10nm的自聚集体（所述分散剂在下文中称为“特定分散剂”），以及利用该方法生产脂质体分散体或其干粉的方法 脂质体。 特定的分散剂优选含有明胶，白蛋白，葡聚糖和聚环氧烷类化合物中的至少一种。

    TARGET NUCLEIC ACID MEASURING APPARATUS
    60.
    发明申请
    TARGET NUCLEIC ACID MEASURING APPARATUS 审中-公开
    目标核酸测量装置

    公开(公告)号：US20100248348A1

    公开(公告)日：2010-09-30

    申请号：US12692059

    申请日：2010-01-22

    申请人： Kaneyasu Ohkawa ,  Yoshinobu Akimoto ,  Mari Nakamoto ,  Takeshi Wada

    发明人： Kaneyasu Ohkawa ,  Yoshinobu Akimoto ,  Mari Nakamoto ,  Takeshi Wada

    IPC分类号： C12M1/34

    CPC分类号： C12Q1/6851 ,  B01L7/52 ,  C12Q2537/165

    摘要： The present invention relates to calculation of an amount equivalent to an initial template amount in a test sample by fitting a theoretical expression to an amount equivalent to an amplification amount of target nucleic acid for each thermal cycle number, wherein the theoretical expression includes an environmental coefficient as an exponent parameter and a parameter of the amount equivalent to the initial template amount, and includes at least one parameter among an amount equivalent to a saturation amount upon the target nucleic acid amplification, a reaction acceleration coefficient, and a reaction inhibition coefficient.

    摘要翻译： 本发明涉及通过将理论表达式与每个热循环次数的靶核酸的扩增量相当的量来计算与试验样品中的初始模板量相当的量，其中理论表达式包括环境系数 作为指数参数和等于初始模板量的量的参数，并且包括与靶核酸扩增相当的饱和量的量，反应加速系数和反应抑制系数中的至少一个参数。