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公开(公告)号：US20050175509A1
公开(公告)日：2005-08-11
申请号：US10515602
申请日：2003-12-19
CPC分类号： C12Q1/006 , C12Q1/004 , G01N2333/904
摘要： The present invention relates to a biosensor which comprises an electrode system including at least one pair of electrodes, at least one insulating base plate for supporting the electrode system, a first reaction layer provided at least on a working electrode of the electrode system, including an organic compound having a functional group capable of bonding or being adsorbed to an electrode and a hydrophobic hydrocarbon group, a second reaction layer provided on the first reaction layer, including an amphiphilic lipid capable of bonding or being adsorbed to a hydrophobic portion of the first reaction layer, and a reagent system carried in a two-component membrane composed of the first and second reaction layers, including at least membrane-binding type pyrroquinoline quinone-dependent glucose dehydrogenase and an electron mediator.
摘要翻译： 本发明涉及一种生物传感器，其包括电极系统，该电极系统包括至少一对电极，至少一个用于支撑电极系统的绝缘基板，至少设置在电极系统的工作电极上的第一反应层， 具有能够键合或吸附到电极和疏水性烃基的官能团的有机化合物，设置在第一反应层上的第二反应层，包括能够键合或吸附到第一反应的疏水部分的两亲性脂质 以及由第一反应层和第二反应层构成的双组分膜中携载的至少包含膜结合型吡喹啉醌依赖性葡萄糖脱氢酶和电子介体的试剂系统。
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公开(公告)号：US07238160B2
公开(公告)日：2007-07-03
申请号：US10512939
申请日：2004-01-16
申请人： Yuko Taniike , Mariko Miyashita , Shin Ikeda , Toshihiko Yoshioka
发明人： Yuko Taniike , Mariko Miyashita , Shin Ikeda , Toshihiko Yoshioka
IPC分类号： A61B5/00
CPC分类号： A61B5/6843 , A61B5/14532 , A61B5/150022 , A61B5/150259 , A61B5/150358 , A61B5/150412 , A61B5/150748 , A61B5/150954 , A61B5/15107 , A61B5/15117 , A61B5/15125 , A61B5/1519 , A61B5/157 , A61B5/417
摘要： The present invention relates to a biological component measurement apparatus set, in which a puncture mechanism for puncturing skin of a subject to collect a sample blood is integrated with a biosensor measurement apparatus. The puncture mechanism includes a puncture needle, and a cap which is detachably engaged with a body of the apparatus, wherein the cap has a skin contact surface which is brought into contact with the skin for puncturing. The skin contact surface having an opening through which the puncture needle moves to puncture the skin, and is shaped so as to fit a surface shape of the skin to be punctured. The set includes a plurality of different caps each corresponding to a different sample collection site so that a plurality of different sample collection sites can be selected.
摘要翻译： 生物成分测定装置技术领域本发明涉及一种生物成分测定装置，其特征在于，将生物体测定装置与被检体的皮肤刺穿用于收集血样的穿刺机构一体化。 穿刺机构包括穿刺针和与装置的主体可拆卸地接合的帽，其中，所述帽具有与皮肤接触以进行穿刺的皮肤接触表面。 皮肤接触表面具有穿刺针穿过的穿刺孔，并且被成形为适合要刺穿的皮肤的表面形状。 该集合包括多个不同的盖，每个不同的盖对应于不同的采样站点，从而可以选择多个不同的样本采集站点。
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公开(公告)号：US20050159678A1
公开(公告)日：2005-07-21
申请号：US10512939
申请日：2004-01-16
申请人： Yuko Taniike , Mariko Miyashita , Shin Ikeda , Toshihiko Yoshioka
发明人： Yuko Taniike , Mariko Miyashita , Shin Ikeda , Toshihiko Yoshioka
CPC分类号： A61B5/6843 , A61B5/14532 , A61B5/150022 , A61B5/150259 , A61B5/150358 , A61B5/150412 , A61B5/150748 , A61B5/150954 , A61B5/15107 , A61B5/15117 , A61B5/15125 , A61B5/1519 , A61B5/157 , A61B5/417
摘要： The present invention relates to a biological component measurement apparatus set, in which a puncture mechanism for puncturing skin of a subject to collect a sample blood is integrated with a biosensor measurement apparatus, wherein the puncture mechanism comprises at least: a puncture needle; and a cap which is detachably engaged with a body of the apparatus, wherein the cap has a skin contact surface which is brought into contact with the skin for puncturing, the skin contact surface having an opening through which the puncture needle moves to puncture the skin, and being shaped so as to fit a surface shape of the skin to be punctured, and the set comprises a plurality of different such caps each corresponding to a different sample collection site so that a plurality of different sample collection sites can be selected.
摘要翻译： 生物成分测定装置技术领域本发明涉及一种生物体成分测定装置，其特征在于，将生物体成分测定装置与生物传感器测定装置一体化，其中，穿刺机构至少包括：穿刺针， 以及与所述装置的主体可拆卸地接合的帽，其中所述帽具有与皮肤接触以刺穿的皮肤接触表面，所述皮肤接触表面具有穿刺针穿过的穿孔刺穿皮肤 并且被成形为适合要刺穿的皮肤的表面形状，并且该组包括多个不同的这样的帽，每个对应于不同的样本收集位置，使得可以选择多个不同的样本收集位置。
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公开(公告)号：US20060030028A1
公开(公告)日：2006-02-09
申请号：US10312034
申请日：2002-06-14
摘要： A simple-structured biosensor is provided for measuring a substrate in a sample rapidly and highly precisely, without significant influence of a peptide included in the sample. A biosensor for measuring the substrate contained in a sample solution includes one or a plurality of insulating base plate(s) 1; a pair of electrodes including a working electrode 2 and a counter electrode 3 provided on the base plate 1; and a reagent 11 for measurement including a redox enzyme and an electron mediator. The sample solution contains a peptide, and the working electrode 2 includes a metal, and at least a part of a surface of the working electrode 2 is covered with a film 10 of an organic compound containing at least one sulfur atom.
摘要翻译： 提供了一种简单结构的生物传感器，用于在样品中包含的肽的显着影响下快速高度精确地测量样品中的底物。 用于测量包含在样品溶液中的基底的生物传感器包括一个或多个绝缘基板1; 包括设置在基板1上的工作电极2和对置电极3的一对电极; 和包含氧化还原酶和电子介体的测定用试剂11。 样品溶液含有肽，工作电极2包括金属，工作电极2的至少一部分表面被含有至少一个硫原子的有机化合物的膜10覆盖。
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公开(公告)号：US07056425B2
公开(公告)日：2006-06-06
申请号：US10469522
申请日：2002-11-12
IPC分类号： G01N27/327
CPC分类号： G01N33/5438 , C12Q1/001
摘要： To provide an improved biosensor which allows easy addition of whole blood to the sensor and rapid supply of the added whole blood to a filter even in the case of collecting blood by fingertip centesis for measurement, a second air aperture is provided in a sample solution supply pathway including an electrode system and a reaction layer and communicating with a first air aperture on the terminal end side.
摘要翻译： 为了提供一种改进的生物传感器，即使在用于测量的指尖中心收集血液的情况下，也可以容易地将全血添加到传感器中并将添加的全血快速供应到过滤器，在样品溶液供应中提供第二空气孔 路径，其包括电极系统和反应层，并且与终端侧的第一空气孔连通。
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公开(公告)号：US07022218B2
公开(公告)日：2006-04-04
申请号：US10333232
申请日：2002-05-27
申请人： Yuko Taniike , Shin Ikeda , Toshihiko Yoshioka
发明人： Yuko Taniike , Shin Ikeda , Toshihiko Yoshioka
IPC分类号： G01N27/327 , G01N27/26
CPC分类号： C12Q1/001 , C12Q1/006 , C12Q1/26 , G01N27/3272
摘要： The present invention provides a highly sensitive biosensor capable of yielding good response even when the amount of a sample is extremely small. The biosensor of the present invention includes: a first insulating base plate which has a working electrode comprising a plurality of branches and a first counter electrode comprising a plurality of branches, the branches of the working electrode and the first counter electrode being arranged alternately; a second insulating base plate which has a second counter electrode and which is disposed at a position opposite to the first insulating base plate; a reagent system comprising an oxidoreductase; and a sample supply pathway formed between the first and second insulating base plates, wherein the branches of the working electrode and the first counter electrode that are arranged alternately, the second counter electrode, and the reagent system are exposed in the sample supply pathway.
摘要翻译： 本发明提供了一种高灵敏度的生物传感器，即使当样品量非常小时也能够产生良好的响应。 本发明的生物传感器包括：第一绝缘基板，其具有包括多个分支的工作电极和包括多个分支的第一对电极，所述工作电极和所述第一对置电极的分支交替布置; 第二绝缘基板，其具有第二对置电极，并且设置在与所述第一绝缘基板相对的位置; 包含氧化还原酶的试剂系统; 以及形成在第一绝缘基板和第二绝缘基板之间的样品供给路径，其中交替布置的工作电极和第一对电极的分支，第二对电极和试剂系统暴露在样品供应路径中。
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公开(公告)号：US06977032B2
公开(公告)日：2005-12-20
申请号：US10472075
申请日：2002-11-12
IPC分类号： C12Q1/00 , G01N33/49 , G01N27/327
CPC分类号： G01N27/3272 , C12Q1/001 , G01N33/491
摘要： A biosensor including an insulating base plate, an electrode system, a cover for covering the insulating base plate, at least one reaction layer, a sample solution supply pathway communicating with an air aperture at a terminal end side, a sample solution supply part and a filter provided between the sample solution supply pathway and the sample solution supply part to filter hemocytes, an end face and a top face of a primary portion of the filter are exposed and the sample solution supply part is provided adjacently to the primary side portion so as to provide an improved biosensor which allows easy addition of whole blood to the sensor and rapid supply of the added whole blood to a filter even in the case of collecting blood by fingertip centesis for measurement.
摘要翻译： 一种生物传感器，包括绝缘基板，电极系统，用于覆盖绝缘基板的盖，至少一个反应层，与终端侧的空气孔连通的样品溶液供给路径，样品溶液供给部和 提供在样品溶液供应通道和样品溶液供应部分之间以过滤血细胞的过滤器，暴露过滤器的主要部分的端面和顶面，并且将样品溶液供应部分设置成与初级侧部分相邻，以便 提供改进的生物传感器，其允许容易地将全血添加到传感器，并且即使在通过指尖中心收集血液用于测量的情况下将添加的全血快速供应到过滤器。
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公开(公告)号：US20050224345A1
公开(公告)日：2005-10-13
申请号：US10616305
申请日：2003-07-10
IPC分类号： A61B5/00 , G01N27/30 , G01N33/487 , G01N27/26
CPC分类号： G01N33/4875 , A61B5/1486 , A61B2562/0295
摘要： In biosensor system 1, biosensor 2 is mounted in measuring apparatus 3 for quantifying or detecting existence of a targeted substrate in a sample solution. Mounting end portion 20 of biosensor 2 to be mounted in measuring apparatus 3 has an extension of one base plate in the length direction, and further extensions of the other base plate in the width direction. Sensor mounting portion 30 of measuring apparatus 3 has a shape matching up with the shape of mounting end portion 20. Thereby wrong insertion of biosensor 2 in measuring apparatus 3 can be prevented. Further, varying shapes of plural biosensors 5 and 6 to have a common part and a non-common part, such biosensors can be handily measured by one measuring apparatus 7.
摘要翻译： 在生物传感器系统1中，将生物传感器2安装在用于定量或检测样品溶液中目标基板的存在的测量装置3中。 安装在测量装置3中的生物传感器2的安装端部20在长度方向上具有一个基板的延伸部，另一个底板在宽度方向上延伸。 测量装置3的传感器安装部30具有与安装端部20的形状相匹配的形状。从而可以防止生物传感器2错误地插入到测量装置3中。 此外，多个生物传感器5和6的不同形状具有公共部分和非共同部分，可以通过一个测量装置7轻松测量这样的生物传感器。
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59.发明授权公开(公告)号：US07604776B2
公开(公告)日：2009-10-20
申请号：US12113643
申请日：2008-05-01
CPC分类号： G01N35/00069 , G01N35/08 , G01N2035/00544 , Y10T436/111666 , Y10T436/25 , Y10T436/25375
摘要： A reaction of a sample mixture liquid is detected accurately, by allowing a solid reagent to be dissolved and reacted in a liquid sample quickly and accurately. A disc main body, and at least one sample mixing unit provided at the disc main body are provided, and the sample mixing unit is provided with: a liquid sample reserve unit; a reagent chamber capable of disposing a plurality of the solid reagents; and a measurement chamber to which a sample mixture liquid containing a liquid sample and a solid reagent mixed in the reagent chamber is supplied. The reagent chamber has a form which allows a plurality of the solid reagents to be disposed in the direction substantially parallel to the radial direction of the disc in which centrifugal force is generated, or in the direction substantially perpendicular to the radial direction of the disc.
摘要翻译： 通过使固体试剂在液体样品中溶解和反应迅速而准确地准确地检测样品混合液体的反应。 设置盘主体和设置在盘主体上的至少一个样品混合单元，样品混合单元设置有：液体样品储备单元; 能够配置多个固体试剂的试剂室; 以及测量室，供给包含液体试样和混合在试剂室中的固体试剂的样品混合液。 试剂室具有允许多个固体试剂在基本上平行于产生离心力的盘的径向方向或者基本上垂直于盘的径向方向的方向上设置的形式。
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公开(公告)号：US07741125B2
公开(公告)日：2010-06-22
申请号：US10550150
申请日：2005-02-02
IPC分类号： G01N33/18
CPC分类号： C12Q1/001 , B01L3/502715 , B01L3/502746 , B01L2200/143 , B01L2300/0645 , B01L2300/0825 , B01L2300/0887 , B01L2300/105 , B01L2400/0406 , G01N31/22
摘要： A biosensor and a biosensor measuring apparatus whose performance can be easily determined by an ordinary user are provided. A biosensor 100 includes a substrate 1 having a quality deciding section 13 and a sample receiving section 15 provided on the substrate 1 to which a sample is supplied. The quality deciding section 13 includes a moisture absorbing material changed in color through absorption of moisture. The sample receiving section 15 has a reagent section 7 including an enzyme reacted with a test substance as a substrate. The quality deciding section 13 includes a recess 17 formed in the substrate 1, the moisture absorbing material 16 disposed in the recess 17 and a film 18 with no air permeability substantially covering the opening of the recess 17 and closely adhered to the moisture absorbing material 16. Cobalt salt is used as the moisture absorbing material 16.
摘要翻译： 提供一种能够容易地由普通用户确定其性能的生物传感器和生物传感器测量装置。 生物传感器100包括具有质量判定部13的基板1和设置在其上被供给样本的基板1上的样本接收部15。 质量判定部13包括通过吸收水分而变色的吸湿材料。 样品接收部分15具有试剂部分7，其包含与作为基质的测试物质反应的酶。 品质决定部13包括形成在基板1上的凹部17，设置在凹部17中的吸湿材料16和没有透气性的薄膜18，其基本上覆盖凹部17的开口并且紧密地附着在吸湿材料16上 钴盐用作吸湿材料16。
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