公开(公告)号：US10696705B2

公开(公告)日：2020-06-30

申请号：US16063367

申请日：2016-12-16

Applicant: Glycom A/S

Inventor： Martin Matwiejuk ,  Pierre Chassagne ,  Markus Jondelius Hederos

IPC: C07H1/06 ,  C07H13/04 ,  A61K31/702 ,  A23L33/125 ,  A23L33/00

Abstract: The invention relates to crystalline polymorphs of lacto-N-tetraose (LNT) and methods for making the same for use in pharmaceutical compositions, nutritional formulations and food supplements.

公开(公告)号：US09902984B2

公开(公告)日：2018-02-27

申请号：US14915421

申请日：2014-09-05

Applicant: Glycom A/S

Inventor： Gyula Dekany ,  Pauline Peltier-Pain ,  Dóra Molnár-Gábor ,  Markus Hederos

IPC: C12P19/18 ,  C07H3/02 ,  C07H3/06 ,  C12P19/04 ,  C12P19/00 ,  C07H1/00

CPC classification number: C12P19/18 ,  C07H1/00 ,  C07H3/02 ,  C07H3/06 ,  C12P19/00 ,  C12P19/04 ,  C12Y302/01051

Abstract: The present application discloses a method of making a mixture of 2′-FL and DFL in high yield by culturing, with lactose, a genetically modified cell having a recombinant gene that encodes a single fucosyl transferase. The resulting mixture of 2′-FL and DFL can be subjected to hydrolysis initiated by an acid or mediated by a fucosidase to produce fucose in high yields.

公开(公告)号：US20170340654A1

公开(公告)日：2017-11-30

申请号：US15532747

申请日：2015-12-04

Applicant: Glycom A/S

Inventor： Pierre CHASSAGNE ,  Martin MATWIEJUK ,  Markus HEDEROS ,  Györgyi OSZTROVSZKY ,  Gyula DEKANY

IPC: A61K31/702 ,  C07H3/06 ,  C07H1/06

CPC classification number: A61K31/702 ,  A61K31/7024 ,  C07H1/06 ,  C07H3/06 ,  C07H15/18 ,  Y02A50/473

Abstract: Crystalline difucosyllactose, useful in a pharmaceutical composition and a nutritional composition, is disclosed.

公开(公告)号：US20160346303A1

公开(公告)日：2016-12-01

申请号：US15034593

申请日：2015-10-29

Applicant: GLYCOM A/S

Inventor： Thierry HENNET ,  Bruce MCCONNELL ,  Emma SALOMONSSON ,  Louise Kristine VIGSNAES

IPC: A61K31/702 ,  A23C9/20 ,  A23L33/21

CPC classification number: A61K31/702 ,  A23C9/206 ,  A23L33/21 ,  A23V2002/00 ,  A61K31/7004 ,  A61K31/7012 ,  A61P1/04 ,  A61K2300/00

Abstract: The application relates to synthetic compositions containing one or more human milk mono- or oligosaccharides for use treating irritable bowel syndrome.

Abstract translation: 本申请涉及含有一种或多种用于治疗肠易激综合征的人乳单糖或寡糖的合成组合物。

公开(公告)号：US09187513B2

公开(公告)日：2015-11-17

申请号：US14111131

申请日：2012-04-11

Applicant: Ioannis Vrasidas ,  Gyula Dekany ,  Ågnes Jánosi ,  Markus Hederos ,  Christoph Röhrig

Inventor： Ioannis Vrasidas ,  Gyula Dekany ,  Ågnes Jánosi ,  Markus Hederos ,  Christoph Röhrig

IPC: C07H1/00 ,  C07H5/06 ,  C07H15/18 ,  C07H13/04

CPC classification number: C07H5/06 ,  C07H13/04 ,  C07H15/18

Abstract: A compound of the formula (1) wherein R1 is a group removable by hydrogenolysis, and wherein R2 is OH or R2 is —NHR3 wherein R3 is a group removable by hydrogenolysis. The compound can be made from fructose by a Heyns-rearrangement. The compound can be used then to make free D-mannosamine or its salts, D-mannosamine building blocks and mannosamine containing oligo- or polysaccharides, N-acetyl-D-mannosamine and its hydrates and solvates, neuraminic acid derivatives, and viral neuraminidase inhibitors.

Abstract translation: 式（1）的化合物，其中R 1是通过氢解除去的基团，并且其中R 2是OH或R 2是-NHR 3，其中R 3是通过氢解除去的基团。 该化合物可以由Heyns重排的果糖制成。 然后可以使用该化合物制备游离的D-甘露糖胺或其盐，D-甘露糖胺结构单元和含有甘露糖胺的寡糖或多糖，N-乙酰基-D-甘露糖胺及其水合物和溶剂合物，神经氨酸衍生物和病毒神经氨酸酶抑制剂 。

公开(公告)号：US08927698B2

公开(公告)日：2015-01-06

申请号：US13263716

申请日：2010-04-07

Applicant: Gyula Dékany ,  Istvan Bajza ,  Julien Boutet ,  Ignacio Pérez Figueroa ,  Markus Hederos ,  Ferenc Horvath ,  Piroska Kovács-Pénzes ,  Lars Kröger ,  Johan Olsson ,  Christoph Röhrig ,  Andreas Schroven ,  Ioannis Vrasidas

Inventor： Gyula Dékany ,  Istvan Bajza ,  Julien Boutet ,  Ignacio Pérez Figueroa ,  Markus Hederos ,  Ferenc Horvath ,  Piroska Kovács-Pénzes ,  Lars Kröger ,  Johan Olsson ,  Christoph Röhrig ,  Andreas Schroven ,  Ioannis Vrasidas

IPC: C07H3/06 ,  C07H15/203 ,  C07H15/26 ,  C07H1/00 ,  C07H15/04

CPC classification number: C07H3/06 ,  C07H1/00 ,  C07H15/04 ,  C07H15/203

Abstract: The present invention relates to an improved synthesis of a trisaccharide of the formula, novel intermediates used in the synthesis and the preparation of the intermediates.

Abstract translation: 本发明涉及下式的三糖的改进合成：用于合成和制备中间体的新型中间体。

公开(公告)号：US08901291B2

公开(公告)日：2014-12-02

申请号：US13698430

申请日：2011-05-19

Applicant: Julien Boutet ,  Gyula Dekany ,  Ágnes Jànosi ,  Gergely Pipa ,  Ferenc Horvàth ,  Krisztián Kovàcs ,  Ignacio Pérez Figueroa ,  Markus Hederos ,  Andreas Schroven ,  Ioannis Vrasidas ,  Piroska Kovács-Pénzes ,  Christian Risinger ,  Sándor Demkò ,  Lars Kröger ,  Christoph Röhrig

Inventor： Julien Boutet ,  Gyula Dekany ,  Ágnes Jànosi ,  Gergely Pipa ,  Ferenc Horvàth ,  Krisztián Kovàcs ,  Ignacio Pérez Figueroa ,  Markus Hederos ,  Andreas Schroven ,  Ioannis Vrasidas ,  Piroska Kovács-Pénzes ,  Christian Risinger ,  Sándor Demkò ,  Lars Kröger ,  Christoph Röhrig

IPC: C07H1/06 ,  C07H3/02 ,  C07H3/08

CPC classification number: C07H3/02 ,  C07H1/06 ,  C07H3/08

Abstract: The present application discloses a method for the crystallization of fucose, characterized in that the crystallization is carried out from a mixture comprising fucose and at least one 6-deoxy sugar selected from 6-deoxy-talose and 6-deoxy-gulose. In one embodiment, the mixture comprises fucose and 6-deoxy-talose.

Abstract translation: 本申请公开了一种岩藻糖结晶方法，其特征在于从包含岩藻糖和至少一种选自6-脱氧 - 托洛糖和6-脱氧 - 古洛糖的6-脱氧糖的混合物中进行结晶。 在一个实施方案中，混合物包含岩藻糖和6-脱氧 - 托洛糖。

公开(公告)号：US08889637B2

公开(公告)日：2014-11-18

申请号：US13701085

申请日：2011-06-01

Applicant: Károly Ágoston ,  István Bajza ,  Gyula Dekany ,  Péter Trinka ,  Ágnes Ágoston ,  Gábor Kádár ,  Sándor Demkó ,  Ignacio Figueroa-Pérez ,  Markus Hederos ,  Ferenc Horváth ,  Andreas Schroven ,  Ioannis Vrasidas ,  Piroska Kovács-Pénzes ,  Christian Risinger ,  László Kalmár ,  Gergely Pipa ,  Julien Boutet ,  Lars Kröger ,  Christoph Röhrig

Inventor： Károly Ágoston ,  István Bajza ,  Gyula Dekany ,  Péter Trinka ,  Ágnes Ágoston ,  Gábor Kádár ,  Sándor Demkó ,  Ignacio Figueroa-Pérez ,  Markus Hederos ,  Ferenc Horváth ,  Andreas Schroven ,  Ioannis Vrasidas ,  Piroska Kovács-Pénzes ,  Christian Risinger ,  László Kalmár ,  Gergely Pipa ,  Julien Boutet ,  Lars Kröger ,  Christoph Röhrig

IPC: A61K31/70 ,  C07H1/00 ,  C07H3/06 ,  A23L1/09 ,  A23L1/30 ,  C07H1/06

CPC classification number: C07H3/06 ,  A23L5/00 ,  A23L7/00 ,  A23L29/30 ,  A23L33/10 ,  A23L33/125 ,  C07H1/06

Abstract: The present invention relates to novel polymorphs of the trisaccharide 2′-O-fucosyllactose (2-FL) of formula (1), methods for producing said polymorphs and their use in pharmaceutical or nutritional compositions.

Abstract translation: 本发明涉及式（1）的三糖2'-O-岩藻糖基乳糖（2-FL）的新型多晶型物，制备所述多晶型物的方法及其在药物或营养组合物中的用途。

公开(公告)号：US20140235848A1

公开(公告)日：2014-08-21

申请号：US14348014

申请日：2012-09-28

Applicant: Glycom A/S

Inventor： Julien BOUTET ,  Nikolay KHANZHIN ,  Filippo BONACCORSI ,  Gyula DEKANY

IPC: C07H9/02 ,  C07H13/04 ,  C07H11/00 ,  C07H13/08

CPC classification number: C07H9/02 ,  C07H1/00 ,  C07H3/02 ,  C07H9/04 ,  C07H11/00 ,  C07H13/04 ,  C07H13/08 ,  Y02P20/55

Abstract: A method that can be used to make a precursor of L-fucose from D-glucose that includes the steps of a) making a compound of formula (1) from D-glucose, formula (1) wherein R1 is acyloxy, and Q is a group (a), (b), (c) or (d), formula (a), (b), (c) or (d) or wherein R1 is OH, and Q is a group (e), (f) or (g); formula (e), (f) or (g) wherein R2 is acyloxy and R3 is a sulphonyl leaving group; and b) producing 6-deoxy-L-talose from the compound of formula (1) formed in step a), wherein the moiety is a highly lipophilic protecting group; compounds according to formula (1), and use of a compound according to formula (1) are provided.

Abstract translation: 一种可用于从D-葡萄糖制备L-岩藻糖的前体的方法，其包括以下步骤：a）从D-葡萄糖制备式（1）化合物，式（1）其中R1为酰氧基，Q为 （a），（b），（c）或（d），式（a），（b），（c）或（d）或其中R 1是OH，Q是基团（e） f）或（g）; 式（e），（f）或（g）其中R 2是酰氧基，R 3是磺酰基离去基团; 和b）从步骤a）中形成的式（1）化合物生产6-脱氧-L-托洛糖，其中所述部分是高亲脂性保护基; 提供了式（1）化合物和使用式（1）化合物。

公开(公告)号：US20140057868A1

公开(公告)日：2014-02-27

申请号：US14000542

申请日：2012-02-21

Applicant: Gyula Dekany ,  Sandor Demkó ,  Andreas Schroven ,  Elise Champion

Inventor： Gyula Dekany ,  Sandor Demkó ,  Andreas Schroven ,  Elise Champion

IPC: A61K31/702

CPC classification number: A61K31/702 ,  C07H3/06 ,  C07H11/04 ,  C07H13/04 ,  C07H15/18

Abstract: A method for the manufacture of a mixture of human milk oligosaccharides is disclosed. The method involves the catalytic hydrogenolysis of compounds of the general formula 1 and 2. The use of compounds of general formula 1 and 2 in the manufacture of human milk oligosaccharides is also disclosed.

Abstract translation: 公开了一种制造人乳寡糖混合物的方法。 该方法涉及通式1和化合物2的催化氢解。还公开了通式1和化合物2在制造人乳低聚糖中的用途。