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    METHOD OF EVALUATING PHARMACEUTICAL PREPARATION CONTAINING LULICONAZOLE AND INDEX SUBSTANCE
    51.
    发明申请
    METHOD OF EVALUATING PHARMACEUTICAL PREPARATION CONTAINING LULICONAZOLE AND INDEX SUBSTANCE 有权
    评价含有LULICONAZOLE和INDEX物质的药物制剂的方法

    公开(公告)号：US20150168357A1

    公开(公告)日：2015-06-18

    申请号：US14592695

    申请日：2015-01-08

    申请人： POLA PHARMA INC. ,  NIHON NOHYAKU CO., LTD.

    发明人： Takaaki Masuda ,  Hiroshi Yamaguchi

    IPC分类号： G01N30/02

    CPC分类号： C07D409/06 ,  A61K9/08 ,  A61K31/4178 ,  A61K47/34 ,  G01N30/02 ,  G01N2030/027 ,  G01N2030/8813

    摘要： Disclosed is a method of evaluating stability of a pharmaceutical preparation containing luliconazole. The method includes measuring an amount of production of an SE form of luliconazole represented by following formula (2), an amount of production of a Z form of luliconazole represented by following formula (3) and an amount of production of an amide form of luliconazole represented by following formula (1) after storage under a severe condition or an accelerated condition, and judging that the stability of the pharmaceutical preparation is high if each of the amount of production of the SE form, the amount of production of the Z form and the amount of production of the amide form is not more than 5% by weight with respect to a compounded amount of luliconazole.

    摘要翻译： 本发明公开了一种评价含有luliconazole的药物制剂的稳定性的方法。 该方法包括测定由下式（2）表示的SE形式的Luliconazole的产生量，由下式（3）表示的Z形式的luliconazole的产生量和luliconazole的酰胺形式的产生量 在严格条件或加速条件下储存后，用下列公式（1）表示，并且如果SE形式的生产量，Z形的生产量和 酰胺形式的产生量相对于配制量的luliconazole不超过5重量％。

    Methods of isolating peptides using surface-free affinity purification
    52.
    发明授权
    Methods of isolating peptides using surface-free affinity purification 有权
    使用无表面亲和纯化分离肽的方法

    公开(公告)号：US09056895B1

    公开(公告)日：2015-06-16

    申请号：US13886978

    申请日：2013-05-03

    申请人： WELLSPRING CLINICAL LAB, INC.

    发明人： Calvin Wiese

    IPC分类号： G01N30/02 ,  C07K1/22 ,  C07K1/20 ,  C07K1/36 ,  G01N30/00 ,  G01N33/566

    CPC分类号： C07K1/22 ,  C07K1/145 ,  C07K1/20 ,  C07K1/34 ,  C07K1/36 ,  G01N30/00 ,  G01N30/02 ,  G01N33/566 ,  Y10T436/25375

    摘要： The present invention, referred to as Surface-Free Affinity Purification (SFAP), relates to a system and method for purifying low abundance peptides, including digested plasma proteins. SFAP combines the components and processes of Surface-Free Isolation, Specific Competitive Elution, Dual Epitope Isolation and Protective Solvents in the purification of low abundance proteins, all of which may be performed in a single column. This column is a constant volume Diafiltration Column equipped with stirring that can be driven by an HPLC. Digested plasma may be injected into the Diafiltration Column by the HPLC. Immunoglobulins, Specific Competitive Elutants, Protective Solvents are injected in a series of injections that result in the purified peptides bound to the surfaces of a very-low volume hydrophobic reversed phase trap from which they can be easily injected into mass spectrometry detection instruments.

    摘要翻译： 称为无表面亲和纯化（SFAP）的本发明涉及用于纯化低丰度肽（包括消化的血浆蛋白）的系统和方法。 SFAP在低丰度蛋白质的纯化中结合了无表面免除隔离，特异性竞争性洗脱，双重表位分离和保护性溶剂的组分和过程，所有这些都可以在单一柱中进行。 该柱是装有可以通过HPLC驱动的搅拌的恒定体积的渗滤柱。 可以通过HPLC将消化的血浆注入渗析柱。 免疫球蛋白，特异性竞争性洗脱剂，保护性溶剂以一系列注射进行注射，其导致纯化的肽结合到非常低体积的疏水性反相捕获物的表面，从而可以将它们轻松地注入质谱检测仪器。

    RELATIVE VALUATION METHOD FOR NAPHTHA STREAMS
    54.
    发明申请
    RELATIVE VALUATION METHOD FOR NAPHTHA STREAMS 有权
    海相流相关估值方法

    公开(公告)号：US20150112610A1

    公开(公告)日：2015-04-23

    申请号：US14589257

    申请日：2015-01-05

    申请人： SAUDI ARABIAN OIL COMPANY

    发明人： Omer Refa KOSEOGLU

    IPC分类号： G01N33/28 ,  G01N30/02

    CPC分类号： G01N33/2829 ,  C10G35/00 ,  C10G35/24 ,  C10G2300/1044 ,  C10G2300/305 ,  C10G2400/02 ,  G01N30/02 ,  G01N2030/025 ,  G06F19/704

    摘要： A system and a method for determining the relative value of a naphtha product includes reforming the naphtha into fractions at a predetermined constant research octane number (RON), conducting PIONA analysis on the reformate, after which modules or steps are performed to assign the feed quality, assign the total liquid yields, assign raw product yields, normalize the assigned raw product yields, assign a value to one or more fractions, and calculate a total value of the naphtha stream. The method is repeated on samples of different crude oils in order to provide relative values at the predetermined RON for comparison purposes.

    摘要翻译： 用于确定石脑油产品的相对值的系统和方法包括以预定的恒定研究辛烷值（RON）将石脑油重整成级分，对重整产物进行PIONA分析，之后执行模块或步骤以分配进料质量 ，分配总液体产量，分配原始产品产量，归一化所分配的原始产品产量，将值分配给一个或多个馏分，并计算石脑油流的总值。 对不同原油的样品重复该方法，以便为了比较而在预定的RON中提供相对值。

    CORROSION PROTECTION IN TUBING USED IN CHROMATOGRAPHY
    58.
    发明申请
    CORROSION PROTECTION IN TUBING USED IN CHROMATOGRAPHY 审中-公开
    用于色谱中的管道中的腐蚀保护

    公开(公告)号：US20150048015A1

    公开(公告)日：2015-02-19

    申请号：US14382900

    申请日：2013-03-04

    申请人： Waters Technologies Corporation

    发明人： Kurt D. Joudrey ,  Trudeau D. Steven ,  Paul Keenan ,  Joseph A. Luongo ,  Daniel J. McCormick ,  Eugene Berthiaume

    IPC分类号： B01D15/22 ,  G01N30/60

    CPC分类号： B01D15/22 ,  B01D15/08 ,  B01D15/40 ,  G01N30/02 ,  G01N30/56 ,  G01N30/60 ,  G01N30/6004 ,  G01N30/6026 ,  G01N2030/027 ,  G01N2030/6013

    摘要： An apparatus for use in a liquid chromatography system includes a chromatography port and a tubing assembly having a chromatography tube coupled at one end to the chromatography port. The end of the tube has an end face covered with a corrosion-resistant material, for example, gold. The corrosion-resistant nature of the material protects the end of the tube from corrosion or erosion, which improves the quality and reliability of a seal between the end face of the tube and a sealing surface of the port. Alternatively, or in addition to covering the end face of the tube with the corrosion-resistant material, a gasket covered with or made of the corrosion-resistant material can be disposed between the end face of the tube and the port. This gasket extends the reach of the tube to facilitate bottoming out the tube within the port.

    摘要翻译： 用于液相色谱系统的装置包括色谱端口和管组件，该管组件具有在一端与色谱端口相连的色谱管。 管的端部具有覆盖有耐腐蚀材料（例如金）的端面。 材料的耐腐蚀性能保护管的端部不受腐蚀或腐蚀，这提高了管的端面和端口的密封表面之间的密封的质量和可靠性。 或者，或者除了用耐腐蚀材料覆盖管的端面之外，可以在管的端面和端口之间设置由耐腐蚀材料覆盖或由其制成的垫圈。 该垫圈延伸管的到达，以便于在端口内从底部出来。